| Mechanism and Effect of HNF4alpha Decrease in a Rat Model of Cirrhosis and Liver Failure. | Mechanism and Effect of HNF4α Decrease in a Rat Model of Cirrhosis and Liver Failure.
Melis M, Marino R, Tian J, Johnson C, Sethi R, Oertel M, Fox IJ, Locker J., Free PMC Article | 02/22/2024 |
| [Combinational Overexpression of Foxa3 and Hnf4alpha Enhance the Proliferation and Prolong the Functional Maintenance of Primary Hepatocytes]. | [Combinational Overexpression of Foxa3 and Hnf4α Enhance the Proliferation and Prolong the Functional Maintenance of Primary Hepatocytes].
Fan JY, Dama G, Liu YL, Guo WY, Lin JT. | 11/3/2023 |
| Targeted Activation of HNF4alpha by AMPK Inhibits Apoptosis and Ameliorates Neurological Injury Caused by Cardiac Arrest in Rats. | Targeted Activation of HNF4α by AMPK Inhibits Apoptosis and Ameliorates Neurological Injury Caused by Cardiac Arrest in Rats.
Zhan H, Zhang Q, Zhang C, Cheng J, Yang Y, Liu C, Li S, Wang C, Yang J, Ge H, Zhou D, Li B, Wei H, Hu C., Free PMC Article | 09/1/2023 |
| HNF4A Negatively Regulated Posterior Capsular Opacification via Transcriptional Inhibition of MMP2. | HNF4A Negatively Regulated Posterior Capsular Opacification via Transcriptional Inhibition of MMP2.
Hu C, Jing R, Wen C, Qi T, Bai X, Wang Y, Shao Y, Pei C. | 06/19/2023 |
| hsa-miR-34a-5p Ameliorates Hepatic Ischemia/Reperfusion Injury Via Targeting HNF4alpha. | hsa-miR-34a-5p Ameliorates Hepatic Ischemia/Reperfusion Injury Via Targeting HNF4α.
Zheng X, Wang G, Yuan J, Li N, Yan B, Yan J, Sheng Y., Free PMC Article | 07/30/2022 |
| Immunohistochemical detection of hepatocyte nuclear factor-4alpha in vertebrates. | Immunohistochemical detection of hepatocyte nuclear factor-4α in vertebrates.
Jiang S, Tanaka T, Yagami R, Hasegawa G, Umezu H, Fujiyoshi Y, Kodama T, Naito M, Ajioka Y. | 11/22/2021 |
| Genetic and Epigenetic Modification of Rat Liver Progenitor Cells via HNF4alpha Transduction and 5' Azacytidine Treatment: An Integrated miRNA and mRNA Expression Profile Analysis. | Genetic and Epigenetic Modification of Rat Liver Progenitor Cells via HNF4α Transduction and 5' Azacytidine Treatment: An Integrated miRNA and mRNA Expression Profile Analysis.
Bolleyn J, Rombaut M, Nair N, Branson S, Heymans A, Chuah M, VandenDriessche T, Rogiers V, De Kock J, Vanhaecke T., Free PMC Article | 03/20/2021 |
| Maternal Malnutrition Affects Hepatic Metabolism through Decreased Hepatic Taurine Levels and Changes in HNF4A Methylation. | Maternal Malnutrition Affects Hepatic Metabolism through Decreased Hepatic Taurine Levels and Changes in HNF4A Methylation.
Du JE, You YA, Kwon EJ, Kim SM, Lee J, Han KH, Kim YJ., Free PMC Article | 03/6/2021 |
| The endoplasmic reticulum stress, confirmed at ultrastructure level, plays an important role in pathogenesis of HFD-induced hepatic steatosis. HNF4alpha downregulation as well as increased expression of hs-CRP and TNF-alpha enforce the concept of interplay between ER stress, hepatic subclinical inflammation, and disturbed gene expression regulation in the pathogenesis of HFD-induced hepatic steatosis. | Molecular and ultrastructure study of endoplasmic reticulum stress in hepatic steatosis: role of hepatocyte nuclear factor 4α and inflammatory mediators.
Abo El-Khair SM, Ghoneim FM, Shabaan DA, Elsamanoudy AZ. | 02/15/2020 |
| coordinated upregulation of genes encoding CRP, interleukin-6 (IL-6), HNF1alpha, and HNF4alpha in the livers and white adipose tissue (WAT) of chronic renal failure rats, as compared to the pair-fed and control animals. | Hepatocyte nuclear factors as possible C-reactive protein transcriptional inducer in the liver and white adipose tissue of rats with experimental chronic renal failure.
Sucajtys-Szulc E, Debska-Slizien A, Rutkowski B, Milczarek R, Pelikant-Malecka I, Sledzinski T, Swierczynski J, Szolkiewicz M., Free PMC Article | 11/3/2018 |
| HNF4alpha constrains proliferation, migration, and maltransformation of hepatic progenitors. | Inhibitory effects of HNF4α on migration/maltransformation of hepatic progenitors: HNF4α-overexpressing hepatic progenitors for liver repopulation.
Wang P, Cong M, Liu T, Xu H, Wang L, Sun G, Yang A, Zhang D, Huang J, Sun Y, Zhao W, Ma H, Jia J, You H., Free PMC Article | 05/5/2018 |
| Transplantation of HNF4A overexpressing immortalized human hepatocytes (IHH) resulted in better liver function and survival of rats with acute liver failure (ALF) compared with IHH. HNF4A improved hepatic differentiation of IHH. Transplantation of HNF4A-overexpressing IHH could improve the liver function and survival in a rat model of ALF. | Hepatocyte nuclear factor 4A improves hepatic differentiation of immortalized adult human hepatocytes and improves liver function and survival.
Hang HL, Liu XY, Wang HT, Xu N, Bian JM, Zhang JJ, Xia L, Xia Q. | 11/4/2017 |
| Tg737 regulates a Wnt/beta-catenin/Snail-HNF4alpha negative feedback circuit, thereby blocking EMT and the malignant transformation of liver stem cells to liver cancer stem cells. | Tg737 regulates epithelial-mesenchymal transition and cancer stem cell properties via a negative feedback circuit between Snail and HNF4α during liver stem cell malignant transformation.
Huang Q, Pu M, Zhao G, Dai B, Bian Z, Tang H, Chen C, Liu W, Qu X, Shen L, Tao K. | 09/30/2017 |
| HNF4alpha-NF-kappaB feedback circuit including miR-124, miR-7, and miR-21 identified in hepatocellular carcinoma | Hepatocyte nuclear factor 4α-nuclear factor-κB feedback circuit modulates liver cancer progression.
Ning BF, Ding J, Liu J, Yin C, Xu WP, Cong WM, Zhang Q, Chen F, Han T, Deng X, Wang PQ, Jiang CF, Zhang JP, Zhang X, Wang HY, Xie WF. | 01/3/2015 |
| Apoc3 expression is regulated by HNF4a and COUP-TFII but not by retinoic acid in rat hepatocytes. | The expression of Apoc3 mRNA is regulated by HNF4α and COUP-TFII, but not acute retinoid treatments, in primary rat hepatocytes and hepatoma cells.
Howell M, Li R, Zhang R, Li Y, Chen W, Chen G. | 09/27/2014 |
| Dietary medium chain triglycerides prevent alcohol-induced hepatic lipid accumulation by preserving HNF4alpha levels in liver. | Preservation of hepatocyte nuclear factor-4α contributes to the beneficial effect of dietary medium chain triglyceride on alcohol-induced hepatic lipid dyshomeostasis in rats.
Li Q, Zhong W, Qiu Y, Kang X, Sun X, Tan X, Zhao Y, Sun X, Jia W, Zhou Z., Free PMC Article | 12/28/2013 |
| HNF-1alpha, HNF-4alpha and FOXA2 transcriptional factors are involved in diabetes-induced overexpression of Slc2a2 gene in the liver and kidney. | Hepatocyte nuclear factors 1α/4α and forkhead box A2 regulate the solute carrier 2A2 (Slc2a2) gene expression in the liver and kidney of diabetic rats.
David-Silva A, Freitas HS, Okamoto MM, Sabino-Silva R, Schaan BD, Machado UF. | 12/28/2013 |
| Methyl donor deficiency impairs fatty acid oxidation through PGC-1alpha hypomethylation and decreased ER-alpha, ERR-alpha, and HNF-4alpha in the rat liver. | Methyl donor deficiency impairs fatty acid oxidation through PGC-1α hypomethylation and decreased ER-α, ERR-α, and HNF-4α in the rat liver.
Pooya S, Blaise S, Moreno Garcia M, Giudicelli J, Alberto JM, Guéant-Rodriguez RM, Jeannesson E, Gueguen N, Bressenot A, Nicolas B, Malthiery Y, Daval JL, Peyrin-Biroulet L, Bronowicki JP, Guéant JL. | 12/8/2012 |
| Data suggest that environmentally induced epigenetic changes at the Hnf4a enhancer alter its interaction with the P2 promoter, and consequently determine T2D risk. | Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.
Sandovici I, Smith NH, Nitert MD, Ackers-Johnson M, Uribe-Lewis S, Ito Y, Jones RH, Marquez VE, Cairns W, Tadayyon M, O'Neill LP, Murrell A, Ling C, Constância M, Ozanne SE., Free PMC Article | 06/18/2011 |
| The hepatic expression and activity of PPARalpha, SREBP-1, and hepatocyte nuclear factor-4alpha (HNF-4alpha) were investigated in sedentary rats, were investigated. | Effect of dietary saturated fatty acids on HNF-4α DNA binding activity and ApoCIII mRNA in sedentary rat liver.
Ceccarelli V, Nocentini G, Riccardi C, Ayroldi E, Di Nardo P, Roberti R, Binaglia L, Vecchini A. | 04/2/2011 |
| analysis of isoform-specific expression of the human, mouse and rat HNF1A, HNF1B and HNF4A genes | Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes.
Harries LW, Brown JE, Gloyn AL., Free PMC Article | 05/3/2010 |
| These findings suggest that the direct suppression of very low density lipoprotein secretion by dietary n-3 polyunsaturated fatty acids delivered to the liver in chylomicron remnants is mediated via decreased expression of HNF-4alpha. | Suppression of VLDL secretion by cultured hepatocytes incubated with chylomicron remnants enriched in n-3 polyunsaturated fatty acids is regulated by hepatic nuclear factor-4alpha.
López-Soldado I, Avella M, Botham KM. | 01/21/2010 |
| DHEA production is regulated by PGC-1alpha, ERRalpha, and HNF4alpha | Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha.
Grasfeder LL, Gaillard S, Hammes SR, Ilkayeva O, Newgard CB, Hochberg RB, Dwyer MA, Chang CY, McDonnell DP., Free PMC Article | 01/21/2010 |
| cAMP and glucose signaling converge on a complex containing ChREBP, HNF4alpha, and CBP, and cAMP acts by disrupting this transcriptional complex assembled by glucose-derived signals | cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4alpha, and CBP.
Burke SJ, Collier JJ, Scott DK. | 01/21/2010 |
| downregulation of Tcf4 at the time of cloacal separation into rectum and urethra might be related to the development of anorectal malformations. | Spatiotemporal pattern analysis of transcription factor 4 in the developing anorectum of the rat embryo with anorectal malformations.
Zhang T, Bai YZ, Wang da J, Jia HM, Yuan ZW, Wang WL. | 01/21/2010 |