| GALNT3 protects against phosphate-induced calcification in vascular smooth muscle cells by enhancing active FGF23 and inhibiting the wnt/beta-catenin signaling pathway. | GALNT3 protects against phosphate-induced calcification in vascular smooth muscle cells by enhancing active FGF23 and inhibiting the wnt/β-catenin signaling pathway.
Guo L, Wang Y, Li S, Zhou L, Li D. | 11/13/2023 |
| The EMT-Related Genes GALNT3 and OAS1 are Associated with Immune Cell Infiltration and Poor Prognosis in Lung Adenocarcinoma. | The EMT-Related Genes GALNT3 and OAS1 are Associated with Immune Cell Infiltration and Poor Prognosis in Lung Adenocarcinoma.
Luo D, Fang M, Shao L, Wang J, Liang Y, Chen M, Gui X, Yan J, Wang W, Yu L, Fan X, Wu Q. | 11/8/2023 |
| Polypeptide N-acetylgalactosamine transferase 3: a post-translational writer on human health. | Polypeptide N-acetylgalactosamine transferase 3: a post-translational writer on human health.
Garay YC, Cejas RB, Lorenz V, Zlocowski N, Parodi P, Ferrero FA, Angeloni G, García VA, Sendra VG, Lardone RD, Irazoqui FJ. | 10/1/2022 |
| Relationship between rs7586085, GALNT3 and CCDC170 gene polymorphisms and the risk of osteoporosis among the Chinese Han population. | Relationship between rs7586085, GALNT3 and CCDC170 gene polymorphisms and the risk of osteoporosis among the Chinese Han population.
Zhang J, Cai Q, Chen W, Huang M, Guan R, Jin T., Free PMC Article | 04/23/2022 |
| LncRNA PSMA3-AS1 promotes cell proliferation, migration, and invasion in ovarian cancer by activating the PI3K/Akt pathway via the miR-378a-3p/GALNT3 axis. | LncRNA PSMA3-AS1 promotes cell proliferation, migration, and invasion in ovarian cancer by activating the PI3K/Akt pathway via the miR-378a-3p/GALNT3 axis.
Xu Z, Jin H, Duan X, Liu H, Zhao X, Fan S, Wang Y, Yao T. | 11/22/2021 |
| Hyperphosphatemic familial tumoral calcinosis caused by a novel variant in the GALNT3 gene. | Hyperphosphatemic familial tumoral calcinosis caused by a novel variant in the GALNT3 gene.
Mahjoubi F, Ghadir M, Samanian S, Heydari I, Honardoost M. | 04/13/2021 |
| miR-885-5p inhibits proliferation and metastasis by targeting IGF2BP1 and GALNT3 in human intrahepatic cholangiocarcinoma. | miR-885-5p inhibits proliferation and metastasis by targeting IGF2BP1 and GALNT3 in human intrahepatic cholangiocarcinoma.
Lixin S, Wei S, Haibin S, Qingfu L, Tiemin P. | 01/23/2021 |
| GalNAc-T3 and MUC1, a combined predictor of prognosis and recurrence in solitary pulmonary adenocarcinoma initially diagnosed as malignant solitary pulmonary nodule (</= 3 cm). | GalNAc-T3 and MUC1, a combined predictor of prognosis and recurrence in solitary pulmonary adenocarcinoma initially diagnosed as malignant solitary pulmonary nodule (≤ 3 cm).
Xie Q, Li F, Zhao S, Guo T, Li Z, Fang L, Wang S, Liu W, Gu C. | 10/31/2020 |
| Loss of GALNT3 in trophoblast stem cells and mammary epithelial cells induces epithelial mesenchymal transition. GALNT3 promotes O-GalNAc modification and cell surface localization of E-cadherin. | GALNT3 Maintains the Epithelial State in Trophoblast Stem Cells.
Raghu D, Mobley RJ, Shendy NAM, Perry CH, Abell AN., Free PMC Article | 05/9/2020 |
| GALNT3 gene significantly correlated with osteoporosis and the low expression of GALNT3 gene can promote the occurrence and deterioration of osteoporosis. | Research on correlation between GALNT3 gene and osteoporosis.
Wang XY, Yang B, Liu CS, Fu J, Qiao L, Chen J, Zhang RF. | 11/2/2019 |
| We confirmed that GALNT3 gene ablation leads to strong and rather compensatory GALNT6 upregulation in EOC cells. Moreover, double GALNT3/T6 suppression was significantly associated with stronger inhibitory effects on EOC cell proliferation, migration, and invasion, and accordingly displayed a significant increase in animal survival rates compared with GALNT3-ablated and control (Ctrl) EOC cells. | The polypeptide GALNT6 Displays Redundant Functions upon Suppression of its Closest Homolog GALNT3 in Mediating Aberrant O-Glycosylation, Associated with Ovarian Cancer Progression.
Sheta R, Bachvarova M, Macdonald E, Gobeil S, Vanderhyden B, Bachvarov D., Free PMC Article | 08/31/2019 |
| A novel homozygote P85Rfs*6 (c.254_255delCT) mutation in polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) was identified in both siblings. | Hyperphosphatemic Familial Tumoral Calcinosis in Two Siblings with a Novel Mutation in GALNT3 Gene: Experience from Southern Turkey.
Kışla Ekinci RM, Gürbüz F, Balcı S, Bişgin A, Taştan M, Yüksel B, Yılmaz M., Free PMC Article | 04/27/2019 |
| The results highlight a novel mechanistic pathway connecting BRAFV600E to aberrant glycosylation in colorectal cancer through GALNT3. | Oncogenic BRAFV600E drives expression of MGL ligands in the colorectal cancer cell line HT29 through N-acetylgalactosamine-transferase 3.
Sahasrabudhe NM, Lenos K, van der Horst JC, Rodríguez E, van Vliet SJ. | 03/30/2019 |
| These results indicate that elevated GALNT3 and B3GNT3 expression in PCSCs regulate stemness through modulating CSC markers. | Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells.
Barkeer S, Chugh S, Karmakar S, Kaushik G, Rauth S, Rachagani S, Batra SK, Ponnusamy MP., Free PMC Article | 03/9/2019 |
| Findings indicate that linc01296/miR-26a/GALNT3 axis involves in the progression of CRC cells, illuminating the possible mechanism mediated by O-glycosylated MUC1 via PI3K/AKT pathway. | LINC01296/miR-26a/GALNT3 axis contributes to colorectal cancer progression by regulating O-glycosylated MUC1 via PI3K/AKT pathway.
Liu B, Pan S, Xiao Y, Liu Q, Xu J, Jia L., Free PMC Article | 02/16/2019 |
| GalNAc-T3 was highly expressed by motile spermatozoa and the expression correlated positively with the classical semen parameters. | Expression of the O-Glycosylation Enzyme GalNAc-T3 in the Equatorial Segment Correlates with the Quality of Spermatozoa.
Nygaard MB, Herlihy AS, Jeanneau C, Nielsen JE, Bennett EP, Jørgensen N, Clausen H, Mandel U, Rajpert-De Meyts E, Almstrup K., Free PMC Article | 12/22/2018 |
| Study shows that ZEB2 negatively regulates a GalNAc-transferase (GALNT3) that is involved in O-glycosylation adds another layer of complexity to the role of ZEB2 in cancer progression and metastasis. | Genome-wide analysis of endogenously expressed ZEB2 binding sites reveals inverse correlations between ZEB2 and GalNAc-transferase GALNT3 in human tumors.
Balcik-Ercin P, Cetin M, Yalim-Camci I, Odabas G, Tokay N, Sayan AE, Yagci T. | 11/24/2018 |
| Giantin-knockout zebrafish exhibit hyperostosis and ectopic calcium deposits, recapitulating phenotypes of hyperphosphatemic familial tumoral calcinosis, a disease caused by mutations in GALNT3. These data reveal a new feature of Golgi homeostasis: the ability to regulate glycosyltransferase expression to generate a functional proteoglycome. | Giantin-knockout models reveal a feedback loop between Golgi function and glycosyltransferase expression.
Stevenson NL, Bergen DJM, Skinner REH, Kague E, Martin-Silverstone E, Robson Brown KA, Hammond CL, Stephens DJ., Free PMC Article | 07/21/2018 |
| study supports an essential role of GALNT3 in Epithelial ovarian cancer dissemination, including its implication in modulating post-translational modifications and EOC metabolism | A metabolic labeling approach for glycoproteomic analysis reveals altered glycoprotein expression upon GALNT3 knockdown in ovarian cancer cells.
Sheta R, Woo CM, Roux-Dalvai F, Fournier F, Bourassa S, Droit A, Bertozzi CR, Bachvarov D., Free PMC Article | 11/25/2017 |
| The acetylated residues on ppGalNAc-T3 function as control points for enzyme activity, and high level of GlcNAc glycosides promote a synergistic regulatory mechanism, leading to a metabolically disordered state. | Functional control of polypeptide GalNAc-transferase 3 through an acetylation site in the C-terminal lectin domain.
Lorenz V, Cejas RB, Bennett EP, Nores GA, Irazoqui FJ. | 11/4/2017 |
| This study identified GALNT3 as a novel gene that rendered patients susceptible to coronary artery disease (CAD), and the A allele of a disease-associated variant rs4621175 linked reduced CAD risk through decreased GALNT3 expression. | Variant in GALNT3 Gene Linked with Reduced Coronary Artery Disease Risk in Chinese Population.
Guo L, Li D, Li M, Li L, Huang Y. | 09/23/2017 |
| Study indicates that loss of GALNT3 occurs in poorly differentiated PDAC, which is associated with the increased aggressiveness and altered glycosylation of ErbB family proteins. | Loss of N-acetylgalactosaminyltransferase 3 in poorly differentiated pancreatic cancer: augmented aggressiveness and aberrant ErbB family glycosylation.
Chugh S, Meza J, Sheinin YM, Ponnusamy MP, Batra SK., Free PMC Article | 06/24/2017 |
| The presence of lectin domain T3lec or T4lec during ppGalNAc-T2 and ppGalNAc-T3 catalytic reaction had a clear inhibitory effect on GalNAc-T activity. | Extrinsic Functions of Lectin Domains in O-N-Acetylgalactosamine Glycan Biosynthesis.
Lorenz V, Ditamo Y, Cejas RB, Carrizo ME, Bennett EP, Clausen H, Nores GA, Irazoqui FJ., Free PMC Article | 05/27/2017 |
| GalNAc-T3 might play a role in the pathogenesis of early stage oral squamous cell carcinoma recurrence | Strong expression of polypeptide N-acetylgalactosaminyltransferase 3 independently predicts shortened disease-free survival in patients with early stage oral squamous cell carcinoma.
Harada Y, Izumi H, Noguchi H, Kuma A, Kawatsu Y, Kimura T, Kitada S, Uramoto H, Wang KY, Sasaguri Y, Hijioka H, Miyawaki A, Oya R, Nakayama T, Kohno K, Yamada S., Free PMC Article | 02/18/2017 |
| MGAT5 expression is a potential independent adverse prognostic biomarker for recurrence and survival of patients with ccRCC after nephrectomy. | β1,6-N-acetylglucosaminyltransferase V predicts recurrence and survival of patients with clear-cell renal cell carcinoma after surgical resection.
Liu Y, Liu H, Liu W, Zhang W, An H, Xu J. | 08/27/2016 |