| IL4I1 in M2-like macrophage promotes glioma progression and is a promising target for immunotherapy. | IL4I1 in M2-like macrophage promotes glioma progression and is a promising target for immunotherapy.
Ye F, Wang L, Li Y, Dong C, Zhou L, Xu J., Free PMC Article | 02/16/2024 |
| Knockdown of IL4I1 Improved High Glucose-evoked Insulin Resistance in HepG2 Cells by Alleviating Inflammation and Lipotoxicity Through AHR Activation. | Knockdown of IL4I1 Improved High Glucose-evoked Insulin Resistance in HepG2 Cells by Alleviating Inflammation and Lipotoxicity Through AHR Activation.
Run L, Tian Z, Xu L, Du J, Li N, Wang Q, Sun H. | 11/15/2023 |
| IL4i1 and IDO1: Oxidases that control a tryptophan metabolic nexus in cancer. | IL4i1 and IDO1: Oxidases that control a tryptophan metabolic nexus in cancer.
Zeitler L, Murray PJ., Free PMC Article | 07/7/2023 |
| Human Chorionic Gonadotropin-Stimulated Interleukin-4-Induced-1 (IL4I1) Promotes Human Decidualization via Aryl Hydrocarbon Receptor. | Human Chorionic Gonadotropin-Stimulated Interleukin-4-Induced-1 (IL4I1) Promotes Human Decidualization via Aryl Hydrocarbon Receptor.
Luo JM, Zhang TT, He YY, Luo HN, Hong YQ, Yang ZM., Free PMC Article | 02/28/2023 |
| IL4I1 enhances PD-L1 expression through JAK/STAT signaling pathway in lung adenocarcinoma. | IL4I1 enhances PD-L1 expression through JAK/STAT signaling pathway in lung adenocarcinoma.
Zhu J, Li Y, Lv X. | 01/21/2023 |
| IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike. | IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike.
Gatineau J, Nidercorne C, Dupont A, Puiffe ML, Cohen JL, Molinier-Frenkel V, Niedergang F, Castellano F., Free PMC Article | 10/1/2022 |
| Pan-cancer analysis combined with experimental validation revealed IL4I1 as an immunological and prognostic biomarker. | Pan-cancer analysis combined with experimental validation revealed IL4I1 as an immunological and prognostic biomarker.
Rao D, Yu C, Wang T, Sheng J, Lv E, Liang H, Huang W, Dong H. | 09/24/2022 |
| IL4I1-driven AHR signature: a new avenue for cancer therapy. | IL4I1-driven AHR signature: a new avenue for cancer therapy.
Wang Z, Li T, Mao C, Liu W, Tao Y., Free PMC Article | 03/12/2022 |
| Single-cell analysis revealed that IL4I1 promoted ovarian cancer progression. | Single-cell analysis revealed that IL4I1 promoted ovarian cancer progression.
Zhao H, Teng Y, Hao W, Li J, Li Z, Chen Q, Yin C, Yue W., Free PMC Article | 12/11/2021 |
| Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis. | Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis.
Xu T, Liu J, Xia Y, Wang Z, Li X, Gao Q., Free PMC Article | 12/4/2021 |
| What role for AHR activation in IL4I1-mediated immunosuppression ? | What role for AHR activation in IL4I1-mediated immunosuppression ?
Castellano F, Prevost-Blondel A, Cohen JL, Molinier-Frenkel V., Free PMC Article | 08/7/2021 |
| IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression. | IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression.
Sadik A, Somarribas Patterson LF, Öztürk S, Mohapatra SR, Panitz V, Secker PF, Pfänder P, Loth S, Salem H, Prentzell MT, Berdel B, Iskar M, Faessler E, Reuter F, Kirst I, Kalter V, Foerster KI, Jäger E, Guevara CR, Sobeh M, Hielscher T, Poschet G, Reinhardt A, Hassel JC, Zapatka M, Hahn U, von Deimling A, Hopf C, Schlichting R, Escher BI, Burhenne J, Haefeli WE, Ishaque N, Böhme A, Schäuble S, Thedieck K, Trump S, Seiffert M, Opitz CA. | 05/8/2021 |
| Lnc-C/EBPbeta Modulates Differentiation of MDSCs Through Downregulating IL4i1 With C/EBPbeta LIP and WDR5. | Lnc-C/EBPβ Modulates Differentiation of MDSCs Through Downregulating IL4i1 With C/EBPβ LIP and WDR5.
Gao Y, Shang W, Zhang D, Zhang S, Zhang X, Zhang Y, Yang R., Free PMC Article | 10/3/2020 |
| these data show that IL4I1+ cells shape the T-cell compartment and are associated with a higher risk of poor outcome in melanoma, supporting a key role for IL4I1 in immune evasion. | Emerging Role of IL-4-Induced Gene 1 as a Prognostic Biomarker Affecting the Local T-Cell Response in Human Cutaneous Melanoma.
Ramspott JP, Bekkat F, Bod L, Favier M, Terris B, Salomon A, Djerroudi L, Zaenker KS, Richard Y, Molinier-Frenkel V, Castellano F, Avril MF, Prévost-Blondel A. | 09/14/2019 |
| the presence of IL4I1 during T-cell activation decreases early signaling events downstream of t-cell receptor stimulation, resulting in global T-cell inhibition which is more pronounced when there is CD28 costimulation. | IL4-induced gene 1 is secreted at the immune synapse and modulates TCR activation independently of its enzymatic activity.
Aubatin A, Sako N, Decrouy X, Donnadieu E, Molinier-Frenkel V, Castellano F. | 11/10/2018 |
| Data showed proteome changes in alveolar epithelial cells type II exposed to an infection with A. fumigatus with IL4I1 showing the most prominent increase in abundance both, in terms of relative abundance as well as activity. Also, in the infected lungs, there was levels of IL4I1 metabolic products. | Quantitative Analysis of Proteome Modulations in Alveolar Epithelial Type II Cells in Response to Pulmonary Aspergillus fumigatus Infection.
Seddigh P, Bracht T, Molinier-Frenkel V, Castellano F, Kniemeyer O, Schuster M, Weski J, Hasenberg A, Kraus A, Poschet G, Hager T, Theegarten D, Opitz CA, Brakhage AA, Sitek B, Hasenberg M, Gunzer M., Free PMC Article | 07/21/2018 |
| reviewed SNPs of the IL4I1 isoform 1, which is expressed in lymphoid tissue; the N92D SNP leads to a hyperactive enzyme, while the R102G mutation is hypomorphic; show that IL4I1 activity is not only directed against phenylalanine, as initially described, but also at a lower level against arginine | Alterations of the immunosuppressive IL4I1 enzyme activity induced by naturally occurring SNP/mutations.
Molinier-Frenkel V, Mestivier D, Castellano F. | 01/28/2017 |
| The immunosuppressive enzyme IL4I1 expressed differentially in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells. | Differential expression of the immunosuppressive enzyme IL4I1 in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells.
Scarlata CM, Celse C, Pignon P, Ayyoub M, Valmori D. | 04/18/2015 |
| IL4I1 upregulation in human Th17 cells limits their TCR-mediated expansion not only by blocking the molecular pathway involved in the activation of the IL-2 promoter, but also by maintaining high levels of Tob1, which impairs entry into the cell cycle. | IL-4-induced gene 1 maintains high Tob1 expression that contributes to TCR unresponsiveness in human T helper 17 cells.
Santarlasci V, Maggi L, Mazzoni A, Capone M, Querci V, Rossi MC, Beltrame L, Cavalieri D, De Palma R, Liotta F, Cosmi L, Maggi E, Romagnani S, Annunziato F. | 05/10/2014 |
| IL4I1 plays a distinct role compared to other antibacterial enzymes produced by mononuclear phagocytes. | Antibacterial properties of the mammalian L-amino acid oxidase IL4I1.
Puiffe ML, Lachaise I, Molinier-Frenkel V, Castellano F., Free PMC Article | 06/29/2013 |
| participates in the downregulation of Th1 inflammation | Dichotomy between factors inducing the immunosuppressive enzyme IL-4-induced gene 1 (IL4I1) in B lymphocytes and mononuclear phagocytes.
Marquet J, Lasoudris F, Cousin C, Puiffe ML, Martin-Garcia N, Baud V, Chereau F, Farcet JP, Molinier-Frenkel V, Castellano F., Free PMC Article | 11/6/2010 |
| strong IL4I1 expression is associated with B-cell lymphomas. | The novel immunosuppressive enzyme IL4I1 is expressed by neoplastic cells of several B-cell lymphomas and by tumor-associated macrophages.
Carbonnelle-Puscian A, Copie-Bergman C, Baia M, Martin-Garcia N, Allory Y, Haioun C, Crémades A, Abd-Alsamad I, Farcet JP, Gaulard P, Castellano F, Molinier-Frenkel V., Free PMC Article | 01/21/2010 |
| hIL4I1 inhibited the proliferation of CD3-stimulated T lymphocytes with a similar effect on CD4(+) and CD8(+) T cells. In contrast, memory T cells were more strongly affected by hIL4I1 and its catabolite H(2)O(2) than naive T cells | Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation.
Boulland ML, Marquet J, Molinier-Frenkel V, Möller P, Guiter C, Lasoudris F, Copie-Bergman C, Baia M, Gaulard P, Leroy K, Castellano F. | 01/21/2010 |
| is activated in primary mediastinal large B-cell lymphoma, which might be due to a constitutive activation of a cytokine signaling pathway | Interleukin 4-induced gene 1 is activated in primary mediastinal large B-cell lymphoma.
Copie-Bergman C, Boulland ML, Dehoulle C, Möller P, Farcet JP, Dyer MJ, Haioun C, Roméo PH, Gaulard P, Leroy K. | 01/21/2010 |
| genomic structure, cDNA sequence, chromosome location and RNA expression in immune tissues | Characterization of the human homolog of the IL-4 induced gene-1 (Fig1).
Chavan SS, Tian W, Hsueh K, Jawaheer D, Gregersen PK, Chu CC. | 01/21/2010 |