| Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) is downregulated in Invasive ductal carcinoma and potential prognostic marker of breast cancer. | Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) is downregulated in Invasive ductal carcinoma and potential prognostic marker of breast cancer.
Piracha ZZ, Saeed U. | 03/27/2024 |
| Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma. | Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma.
Cheng S, Li C, Liu L, Liu X, Li M, Zhuo J, Wang J, Zheng W, Wang Z., Free PMC Article | 03/13/2024 |
| Aberrant promoter methylation contributes to LRIG1 silencing in basal/triple-negative breast cancer. | Aberrant promoter methylation contributes to LRIG1 silencing in basal/triple-negative breast cancer.
Umeh-Garcia M, O'Geen H, Simion C, Gephart MH, Segal DJ, Sweeney CA., Free PMC Article | 08/13/2022 |
| The transmembrane protein LRIG1 triggers melanocytic tumor development following chemically induced skin carcinogenesis. | The transmembrane protein LRIG1 triggers melanocytic tumor development following chemically induced skin carcinogenesis.
Hoesl C, Fröhlich T, Posch C, Kneitz H, Goebeler M, Schneider MR, Dahlhoff M., Free PMC Article | 04/2/2022 |
| LRIG1 is a positive prognostic marker in Merkel cell carcinoma and Merkel cell carcinoma expresses epithelial stem cell markers. | LRIG1 is a positive prognostic marker in Merkel cell carcinoma and Merkel cell carcinoma expresses epithelial stem cell markers.
Sundqvist B, Sihto H, von Willebrand M, Böhling T, Koljonen V., Free PMC Article | 01/22/2022 |
| LRIG1 is a conserved EGFR regulator involved in melanoma development, survival and treatment resistance. | LRIG1 is a conserved EGFR regulator involved in melanoma development, survival and treatment resistance.
Billing O, Holmgren Y, Nosek D, Hedman H, Hemmingsson O., Free PMC Article | 01/22/2022 |
| Potential Novel Genes for Late-Onset Alzheimer's Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study. | Potential Novel Genes for Late-Onset Alzheimer's Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study.
Kang S, Gim J, Lee J, Gunasekaran TI, Choi KY, Lee JJ, Seo EH, Ko PW, Chung JY, Choi SM, Lee YM, Jeong JH, Park KW, Song MK, Lee HW, Kim KW, Choi SH, Lee DY, Kim SY, Kim H, Kim BC, Ikeuchi T, Lee KH., Free PMC Article | 11/27/2021 |
| Aryl Hydrocarbon Receptor Defect Attenuates Mitogen-Activated Signaling through Leucine-Rich Repeats and Immunoglobulin-like Domains 1 (LRIG1)-Dependent EGFR Degradation. | Aryl Hydrocarbon Receptor Defect Attenuates Mitogen-Activated Signaling through Leucine-Rich Repeats and Immunoglobulin-like Domains 1 (LRIG1)-Dependent EGFR Degradation.
Hsu HL, Chen HK, Tsai CH, Liao PL, Chan YJ, Lee YC, Lee CC, Li CH., Free PMC Article | 10/23/2021 |
| microRNA-1246-containing extracellular vesicles from acute myeloid leukemia cells promote the survival of leukemia stem cells via the LRIG1-meditated STAT3 pathway. | microRNA-1246-containing extracellular vesicles from acute myeloid leukemia cells promote the survival of leukemia stem cells via the LRIG1-meditated STAT3 pathway.
Chen L, Guo Z, Zhou Y, Ni J, Zhu J, Fan X, Chen X, Liu Y, Li Z, Zhou H., Free PMC Article | 07/24/2021 |
| LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes. | LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes.
Herdenberg C, Mutie PM, Billing O, Abdullah A, Strawbridge RJ, Dahlman I, Tuck S, Holmlund C, Arner P, Henriksson R, Franks PW, Hedman H., Free PMC Article | 06/26/2021 |
| LncRNA MAGI2-AS3 inhibits the self-renewal of leukaemic stem cells by promoting TET2-dependent DNA demethylation of the LRIG1 promoter in acute myeloid leukaemia. | LncRNA MAGI2-AS3 inhibits the self-renewal of leukaemic stem cells by promoting TET2-dependent DNA demethylation of the LRIG1 promoter in acute myeloid leukaemia.
Chen L, Fan X, Zhu J, Chen X, Liu Y, Zhou H., Free PMC Article | 05/15/2021 |
| LRIG1 gene copy number analysis by ddPCR and correlations to clinical factors in breast cancer. | LRIG1 gene copy number analysis by ddPCR and correlations to clinical factors in breast cancer.
Faraz M, Tellström A, Ardnor CE, Grankvist K, Huminiecki L, Tavelin B, Henriksson R, Hedman H, Ljuslinder I., Free PMC Article | 02/6/2021 |
| MicroRNA Expression Profiling of Normal and Malignant Human Colonic Stem Cells Identifies miRNA92a as a Regulator of the LRIG1 Stem Cell Gene. | MicroRNA Expression Profiling of Normal and Malignant Human Colonic Stem Cells Identifies miRNA92a as a Regulator of the LRIG1 Stem Cell Gene.
Viswanathan V, Opdenaker L, Modarai S, Fields JZ, Gonye G, Boman BM., Free PMC Article | 01/23/2021 |
| Chronic H. pylori infection stimulates Lrig1-expressing progenitor cells in a cag-dependent manner, and these reprogrammed cells give rise to a full spectrum of differentiated cells. | Targeted mobilization of Lrig1(+) gastric epithelial stem cell populations by a carcinogenic Helicobacter pylori type IV secretion system.
Wroblewski LE, Choi E, Petersen C, Delgado AG, Piazuelo MB, Romero-Gallo J, Lantz TL, Zavros Y, Coffey RJ, Goldenring JR, Zemper AE, Peek RM Jr., Free PMC Article | 04/25/2020 |
| AR directly transactivates LRIG1 through binding to several AR-binding sites. | LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer.
Li Q, Liu B, Chao HP, Ji Y, Lu Y, Mehmood R, Jeter C, Chen T, Moore JR, Li W, Liu C, Rycaj K, Tracz A, Kirk J, Calhoun-Davis T, Xiong J, Deng Q, Huang J, Foster BA, Gokhale A, Chen X, Tang DG., Free PMC Article | 03/7/2020 |
| Low LRIG1 expression is associated with Gastric Carcinogenesis. | Expression of LRIG1, a Negative Regulator of EGFR, Is Dynamically Altered during Different Stages of Gastric Carcinogenesis.
Yu S, Yang M, Lim KM, Cho Y, Kim H, Lee K, Jeong SH, Coffey RJ, Goldenring JR, Nam KT., Free PMC Article | 08/24/2019 |
| Resveratrol can inhibit the growth and proliferation of glioma and promote its apoptosis through upregulating the LRIG1 gene expression, which plays the effect of antiglioma growth, revealing that LRIG1 is a new biological target of resveratrol in antiglioma cell proliferation and growth. | Resveratrol inhibits glioma cell growth via targeting LRIG1.
Liu L, Zhang Y, Zhu K, Song L, Tao M, Huang P, Pan Y. | 08/10/2019 |
| LRIG1 overexpression can antagonize hypoxia-evoked aggressive metastatic phenotype. | LRIG1 acts as a critical regulator of melanoma cell invasion, migration, and vasculogenic mimicry upon hypoxia by regulating EGFR/ERK-triggered epithelial-mesenchymal transition.
Li W, Zhou Y., Free PMC Article | 07/27/2019 |
| The LRIG1 and beta-catenin mediate the functional connection between TTF-1/Nkx2.1 and mutated EGFR. | TTF-1/Nkx2.1 functional connection with mutated EGFR relies on LRIG1 and β-catenin pathways in lung cancer cells.
Zamboni M, Civitareale D. | 05/25/2019 |
| LRIG1 exerts important tumor-suppressive effects in EGFR-mutant NSCLC. | Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR.
Torigoe H, Yamamoto H, Sakaguchi M, Youyi C, Namba K, Sato H, Shien K, Soh J, Suzawa K, Tomida S, Tsukuda K, Miyoshi S, Toyooka S. | 02/2/2019 |
| proposed LRIG1 protein interaction network | A protein interaction network centered on leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) regulates growth factor receptors.
Faraz M, Herdenberg C, Holmlund C, Henriksson R, Hedman H., Free PMC Article | 01/12/2019 |
| MiR-183 overexpression promoted radioresistance of glioblastoma via down-regulating LRIG1 and increasing the activity of EFGR/Akt. | Overexpressed miR-183 promoted glioblastoma radioresistance via down-regulating LRIG1.
Fan H, Yuan R, Cheng S, Xiong K, Zhu X, Zhang Y. | 10/6/2018 |
| LRIG1 is a negative regulator of RET2A and RET2B and is also downregulated in papillary and medullary thyroid carcinoma | LRIG1 negatively regulates RET mutants and is downregulated in thyroid cancer.
Lindquist D, Alsina FC, Herdenberg C, Larsson C, Höppener J, Wang N, Paratcha G, Tarján M, Tot T, Henriksson R, Hedman H., Free PMC Article | 08/25/2018 |
| LRIG1 expression in human GC tissues is inversely correlated with miR-20a and EGFR. | Downregulation of leucine-rich repeats and immunoglobulin-like domains 1 by microRNA-20a modulates gastric cancer multidrug resistance.
Zhou L, Li X, Zhou F, Jin Z, Chen D, Wang P, Zhang S, Zhuge Y, Shang Y, Zou X., Free PMC Article | 04/21/2018 |
| Role of LRIG1 in cancer [review] | LRIGs: A Prognostically Significant Family with Emerging Therapeutic Competence against Cancers.
Malik U, Javed A. | 10/14/2017 |