| MAP3K4 promotes fetal and placental growth by controlling the receptor tyrosine kinases IGF1R/IR and Akt signaling pathway. | MAP3K4 promotes fetal and placental growth by controlling the receptor tyrosine kinases IGF1R/IR and Akt signaling pathway.
Perry CH, Mullins NA, Sweileh RBA, Shendy NAM, Roberto PA, Broadhurst AL, Nelson HA, Miranda-Carboni GA, Abell AN., Free PMC Article | 10/15/2022 |
| MAP3K4 kinase activity dependent control of mouse gonadal sex determinationdagger. | MAP3K4 kinase activity dependent control of mouse gonadal sex determination†.
Shendy NAM, Broadhurst AL, Shoemaker K, Read R, Abell AN., Free PMC Article | 12/25/2021 |
| LncRNA-MAP3K4 regulates vascular inflammation through the p38 MAPK signaling pathway and cis-modulation of MAP3K4. | LncRNA-MAP3K4 regulates vascular inflammation through the p38 MAPK signaling pathway and cis-modulation of MAP3K4.
Zhou H, Simion V, Pierce JB, Haemmig S, Chen AF, Feinberg MW. | 06/19/2021 |
| MAP3K4 activity controls epithelial-to-mesenchymal transition through the ubiquitination and degradation of HDAC6. | MAP3K4 Controls the Chromatin Modifier HDAC6 during Trophoblast Stem Cell Epithelial-to-Mesenchymal Transition.
Mobley RJ, Raghu D, Duke LD, Abell-Hart K, Zawistowski JS, Lutz K, Gomez SM, Roy S, Homayouni R, Johnson GL, Abell AN., Free PMC Article | 12/2/2017 |
| by forming a complex with MEKK4 in skeletal muscle fibers, Gadd45a increases MEKK4 protein kinase activity, which is both sufficient to induce skeletal muscle fiber atrophy and required for Gadd45a-mediated skeletal muscle fiber atrophy. | Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4.
Bullard SA, Seo S, Schilling B, Dyle MC, Dierdorff JM, Ebert SM, DeLau AD, Gibson BW, Adams CM., Free PMC Article | 05/13/2017 |
| Map3k4 haploinsufficiency is the cause of T-associated sex reversal. | Transgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice.
Warr N, Siggers P, Carré GA, Bogani D, Brixey R, Akiyoshi M, Tachibana M, Teboul L, Wells S, Sanderson J, Greenfield A., Free PMC Article | 01/17/2015 |
| suggest a requirement for GADD45gamma in promoting MAP3K4-mediated activation of p38 MAPK signaling in embryonic gonadal somatic cells for testis determination | Gadd45γ and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression.
Warr N, Carre GA, Siggers P, Faleato JV, Brixey R, Pope M, Bogani D, Childers M, Wells S, Scudamore CL, Tedesco M, del Barco Barrantes I, Nebreda AR, Trainor PA, Greenfield A., Free PMC Article | 02/2/2013 |
| regulates epithelial-mesenchymal transition in trophoblast stem cells | MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells.
Abell AN, Jordan NV, Huang W, Prat A, Midland AA, Johnson NL, Granger DA, Mieczkowski PA, Perou CM, Gomez SM, Li L, Johnson GL., Free PMC Article | 10/8/2011 |
| MTK1 plays an important role in the regulation of cell death and is also involved in the pathogenesis of heart failure. | Activation of MTK1/MEKK4 induces cardiomyocyte death and heart failure.
Mizote I, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, Tamai T, Oyabu J, Matsumura Y, Nishida K, Komuro I, Hori M, Otsu K. | 04/12/2010 |
| a role for the signalling pathway in mouse sex determination | Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination.
Bogani D, Siggers P, Brixey R, Warr N, Beddow S, Edwards J, Williams D, Wilhelm D, Koopman P, Flavell RA, Chi H, Ostrer H, Wells S, Cheeseman M, Greenfield A., Free PMC Article | 01/21/2010 |
| Results define MEKK4 as a signaling hub for FGF4 activation of JNK that is required for maintenance of trophoblast stem cells in an undifferentiated state. | Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase.
Abell AN, Granger DA, Johnson NL, Vincent-Jordan N, Dibble CF, Johnson GL., Free PMC Article | 01/21/2010 |
| MEKK4 regulates epithelial-to-mesenchymal transition in the endocardial cushions of the developing heart. | MEKK4 regulates developmental EMT in the embryonic heart.
Stevens MV, Parker P, Vaillancourt RR, Camenisch TD, Stevens MV, Parker P, Vaillancourt RR, Camenisch TD. | 02/6/2009 |
| G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells | G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells.
Bikkavilli RK, Feigin ME, Malbon CC. | 01/21/2010 |
| GSK3beta binding to MEKK4 blocks MEKK4 dimerization that is required for MEKK4 activation, effectively inhibiting MEKK4 stimulation of the JNK and p38 MAPK pathways | MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.
Abell AN, Granger DA, Johnson GL. | 01/21/2010 |
| MEKK4 is the MAPK kinase kinase for TRAF4 regulation of the JNK pathway | MEKK4 is an effector of the embryonic TRAF4 for JNK activation.
Abell AN, Johnson GL. | 01/21/2010 |
| During Th1 differentiation, the GADD45beta/GADD45gamma/MEKK4 pathway integrates upstream signals transduced by both T cell receptor and IL12/STAT4, leading to augmented interferon-gamma production in a process independent of STAT4. | GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells.
Chi H, Lu B, Takekawa M, Davis RJ, Flavell RA., Free PMC Article | 01/21/2010 |
| MEKK4 transcripts was reported in early myocardium, endocardium and in cardiac cushion cells that have executed epithelial to mesenchymal transformation (EMT), suggesting that MEKK4 may function during production of the cushion mesenchyme. | MEKK4 regulates developmental EMT in the embryonic heart.
Stevens MV, Parker P, Vaillancourt RR, Camenisch TD, Stevens MV, Parker P, Vaillancourt RR, Camenisch TD. | 01/21/2010 |
| Hindbrains of exencephalic MEKK4(K1361R) embryos show a striking increase in neuroepithelial cell apoptosis and a dramatic loss of phosphorylation of MKK3 and -6, mitogen-activated protein kinase kinases (MKKs) regulated by MEKK4 in the p38 pathway. | Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo.
Abell AN, Rivera-Perez JA, Cuevas BD, Uhlik MT, Sather S, Johnson NL, Minton SK, Lauder JM, Winter-Vann AM, Nakamura K, Magnuson T, Vaillancourt RR, Heasley LE, Johnson GL., Free PMC Article | 01/21/2010 |
| our results demonstrate a link between MEKK4 and filamin-a that impacts neuronal migration initiation | MEKK4 signaling regulates filamin expression and neuronal migration.
Sarkisian MR, Bartley CM, Chi H, Nakamura F, Hashimoto-Torii K, Torii M, Flavell RA, Rakic P., Free PMC Article | 01/21/2010 |
| MEKK4 plays a critical role in regulating MKK4 activity and apoptotic cell death during neural tube development. | Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.
Chi H, Sarkisian MR, Rakic P, Flavell RA., Free PMC Article | 01/21/2010 |