| ASK1-ER stress pathway-mediated fibrotic-EV release contributes to the interaction of alveolar epithelial cells and lung fibroblasts to promote mechanical ventilation-induced pulmonary fibrosis. | ASK1-ER stress pathway-mediated fibrotic-EV release contributes to the interaction of alveolar epithelial cells and lung fibroblasts to promote mechanical ventilation-induced pulmonary fibrosis.
Tang R, Mei S, Xu Q, Feng J, Zhou Y, Xing S, He Z, Gao Y., Free PMC Article | 12/31/2022 |
| Thioredoxin-interacting protein deficiency protects against severe acute pancreatitis by suppressing apoptosis signal-regulating kinase 1. | Thioredoxin-interacting protein deficiency protects against severe acute pancreatitis by suppressing apoptosis signal-regulating kinase 1.
Liu Y, Li M, Mei C, Cui H, Wang Q, Li D, Song Y, Cui M, He Q, Chen S, Zhu C., Free PMC Article | 11/5/2022 |
| Phosphoproteomics identifies pathways underlying the role of receptor-interaction protein kinase 3 in alcohol-associated liver disease and uncovers apoptosis signal-regulating kinase 1 as a target. | Phosphoproteomics identifies pathways underlying the role of receptor-interaction protein kinase 3 in alcohol-associated liver disease and uncovers apoptosis signal-regulating kinase 1 as a target.
Singh V, Huang E, Pathak V, Willard BB, Allende DS, Nagy LE., Free PMC Article | 07/30/2022 |
| N-acetylgalactosaminyltransferase-4 protects against hepatic ischemia/reperfusion injury by blocking apoptosis signal-regulating kinase 1 N-terminal dimerization. | N-acetylgalactosaminyltransferase-4 protects against hepatic ischemia/reperfusion injury by blocking apoptosis signal-regulating kinase 1 N-terminal dimerization.
Zhou J, Guo L, Ma T, Qiu T, Wang S, Tian S, Zhang L, Hu F, Li W, Liu Z, Hu Y, Wang T, Kong C, Yang J, Zhou J, Li H. | 05/28/2022 |
| ASK1 is a novel molecular target for preventing aminoglycoside-induced hair cell death. | ASK1 is a novel molecular target for preventing aminoglycoside-induced hair cell death.
Ogier JM, Gao Y, Dunne EM, Wilson MA, Ranganathan SC, Tesch GH, Nikolic Paterson DJ, Dabdoub A, Burt RA, Nayagam BA, Lockhart PJ., Free PMC Article | 05/28/2022 |
| ASK1 signaling regulates phase-specific glial interactions during neuroinflammation. | ASK1 signaling regulates phase-specific glial interactions during neuroinflammation.
Guo X, Kimura A, Namekata K, Harada C, Arai N, Takeda K, Ichijo H, Harada T., Free PMC Article | 03/12/2022 |
| Activation of osteoblast ferroptosis via the METTL3/ASK1-p38 signaling pathway in high glucose and high fat (HGHF)-induced diabetic bone loss. | Activation of osteoblast ferroptosis via the METTL3/ASK1-p38 signaling pathway in high glucose and high fat (HGHF)-induced diabetic bone loss.
Lin Y, Shen X, Ke Y, Lan C, Chen X, Liang B, Zhang Y, Yan S. | 02/19/2022 |
| A novel chemical pull-down method for endogenous kinases using analog sensitive kinase allele (ASKA) technology identified an ASK1 interactor in brown adipocytes, receptor-interacting serine/threonine-protein kinase 2 (RIPK2). | ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes.
Takayanagi S, Watanabe K, Maruyama T, Ogawa M, Morishita K, Soga M, Hatta T, Natsume T, Hirano T, Kagechika H, Hattori K, Naguro I, Ichijo H., Free PMC Article | 11/29/2021 |
| FBXW11 deletion alleviates Alzheimer's disease by reducing neuroinflammation and amyloid-beta plaque formation via repression of ASK1 signaling. | FBXW11 deletion alleviates Alzheimer's disease by reducing neuroinflammation and amyloid-β plaque formation via repression of ASK1 signaling.
Sun J, Qin X, Zhang X, Wang Q, Zhang W, Wang M. | 09/11/2021 |
| Interaction of RIPK1 and A20 modulates MAPK signaling in murine acetaminophen toxicity. | Interaction of RIPK1 and A20 modulates MAPK signaling in murine acetaminophen toxicity.
Iorga A, Donovan K, Shojaie L, Johnson H, Kwok J, Suda J, Lee BT, Aghajan M, Shao L, Liu ZX, Dara L., Free PMC Article | 09/4/2021 |
| Milk Fat Globule-Epidermal Growth Factor-Factor 8 Improves Hepatic Steatosis and Inflammation. | Milk Fat Globule-Epidermal Growth Factor-Factor 8 Improves Hepatic Steatosis and Inflammation.
Zhang L, Tian R, Yao X, Zhang XJ, Zhang P, Huang Y, She ZG, Li H, Ji YX, Cai J. | 08/14/2021 |
| Depletion of ASK1 blunts stress-induced senescence in adipocytes. | Depletion of ASK1 blunts stress-induced senescence in adipocytes.
Wueest S, Lucchini FC, Haim Y, Rudich A, Konrad D., Free PMC Article | 07/17/2021 |
| ASK1/p38mediated NLRP3 inflammasome signaling pathway contributes to aberrant retinal angiogenesis in diabetic retinopathy. | ASK1/p38‑mediated NLRP3 inflammasome signaling pathway contributes to aberrant retinal angiogenesis in diabetic retinopathy.
Zou W, Luo S, Zhang Z, Cheng L, Huang X, Ding N, Pan Y, Wu Z., Free PMC Article | 07/17/2021 |
| Apoptosis signal-regulating kinase 1 regulates immune-mediated thrombocytopenia, thrombosis, and systemic shock. | Apoptosis signal-regulating kinase 1 regulates immune-mediated thrombocytopenia, thrombosis, and systemic shock.
Patel P, Shaik NF, Zhou Y, Golla K, McKenzie SE, Naik UP., Free PMC Article | 06/19/2021 |
| Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1/p38MAPKalpha-dependent mechanisms. | Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1/p38MAPKα-dependent mechanisms.
Ma J, Cao H, Rodrigues RM, Xu M, Ren T, He Y, Hwang S, Feng D, Ren R, Yang P, Liangpunsakul S, Sun J, Gao B., Free PMC Article | 05/22/2021 |
| ARRB1 ameliorates liver ischaemia/reperfusion injury via antagonizing TRAF6-mediated Lysine 6-linked polyubiquitination of ASK1 in hepatocytes. | ARRB1 ameliorates liver ischaemia/reperfusion injury via antagonizing TRAF6-mediated Lysine 6-linked polyubiquitination of ASK1 in hepatocytes.
Xu X, Zhang Z, Lu Y, Sun Q, Liu Y, Liu Q, Tian W, Yin Y, Yu H, Sun B., Free PMC Article | 05/15/2021 |
| ASK1 suppresses NK cell-mediated intravascular tumor cell clearance in lung metastasis. | ASK1 suppresses NK cell-mediated intravascular tumor cell clearance in lung metastasis.
Fujimoto M, Kamiyama M, Fuse K, Ryuno H, Odawara T, Furukawa N, Yoshimatsu Y, Watabe T, Prchal-Murphy M, Sexl V, Tahara H, Hayakawa Y, Sato T, Takeda K, Naguro I, Ichijo H., Free PMC Article | 04/13/2021 |
| ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis. | ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis.
Huo J, Xu S, Lam KP., Free PMC Article | 03/13/2021 |
| MicroRNA-146b-5p overexpression attenuates premature ovarian failure in mice by inhibiting the Dab2ip/Ask1/p38-Mapk pathway and gammaH2A.X phosphorylation. | MicroRNA-146b-5p overexpression attenuates premature ovarian failure in mice by inhibiting the Dab2ip/Ask1/p38-Mapk pathway and γH2A.X phosphorylation.
Liu T, Lin J, Chen C, Nie X, Dou F, Chen J, Wang Z, Gong Z., Free PMC Article | 01/23/2021 |
| ASK1 promotes uterine inflammation leading to pathological preterm birth. | ASK1 promotes uterine inflammation leading to pathological preterm birth.
Yoshikawa M, Iriyama T, Suzuki K, Sayama S, Tsuruga T, Kumasawa K, Nagamatsu T, Homma K, Naguro I, Osuga Y, Ichijo H, Fujii T., Free PMC Article | 11/21/2020 |
| ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model. | ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model.
Schuster-Gaul S, Geisler LJ, McGeough MD, Johnson CD, Zagorska A, Li L, Wree A, Barry V, Mikaelian I, Jih LJ, Papouchado BG, Budas G, Hoffman HM, Feldstein AE., Free PMC Article | 11/21/2020 |
| High fat diet-fed adipocyte-specific ASK1 knockout mice reveal increased UCP1 protein levels in inguinal adipose tissue concomitant with elevated energy expenditure, reduced obesity and ameliorated glucose tolerance. | ASK1 inhibits browning of white adipose tissue in obesity.
Lucchini FC, Wueest S, Challa TD, Item F, Modica S, Borsigova M, Haim Y, Wolfrum C, Rudich A, Konrad D., Free PMC Article | 07/25/2020 |
| Trim69 might be a functionally essential inhibitor of ASK1 activation during the pathogenesis of hippocampal inflammation and apoptosis | Targeting Trim69 alleviates high fat diet (HFD)-induced hippocampal injury in mice by inhibiting apoptosis and inflammation through ASK1 inactivation.
Li LJ, Zheng JC, Kang R, Yan JQ. | 07/11/2020 |
| FBXW5 facilitated the addition of Lys63-linked ubiquitin to ASK1 and thus exacerbated ASK1-c-Jun N-terminal kinase/p38 MAPK signaling, inflammation, and lipid accumulation. | F-box/WD Repeat-Containing Protein 5 Mediates the Ubiquitination of Apoptosis Signal-Regulating Kinase 1 and Exacerbates Nonalcoholic Steatohepatitis in Mice.
Bai L, Chen MM, Chen ZD, Zhang P, Tian S, Zhang Y, Zhu XY, Liu Y, She ZG, Ji YX, Li H. | 07/4/2020 |
| ASK1 can be dephosphorylated in tyrosine residue(s) by SHP-1. SHP-1 could bind to and dephosphorylate ASK1 to inhibit its activation, thus repressing apoptosis. | SHP-1 inhibits renal ischemia reperfusion injury via dephosphorylating ASK1 and suppressing apoptosis.
Tian H, Tan R, Ye B, Yan S, Sui M, Zhao W, Zhang L, Zhu Y, Zeng L. | 05/2/2020 |