| Lysine acetyltransferase KAT2A modulates ferroptosis during colorectal cancer development. | Lysine acetyltransferase KAT2A modulates ferroptosis during colorectal cancer development.
Xu Z, Wang X, Yu P, Zhang Y, Huang L, Mao E, Han Y. | 04/8/2024 |
| Integrative analysis of histone acetyltransferase KAT2A in human cancer. | Integrative analysis of histone acetyltransferase KAT2A in human cancer.
Li H, Li C, Yang LZ, Liu J. | 01/3/2024 |
| RBL2-E2F-GCN5 guide cell fate decisions during tissue specification by regulating cell-cycle-dependent fluctuations of non-cell-autonomous signaling. | RBL2-E2F-GCN5 guide cell fate decisions during tissue specification by regulating cell-cycle-dependent fluctuations of non-cell-autonomous signaling.
Militi S, Nibhani R, Jalali M, Pauklin S. | 10/13/2023 |
| Regulatory mechanisms of GCN5 in osteogenic differentiation of MSCs in periodontitis. | Regulatory mechanisms of GCN5 in osteogenic differentiation of MSCs in periodontitis.
Lu W, Zhang L, Ji K, Ding L, Wu G., Free PMC Article | 06/23/2023 |
| Succinylation of CTBP1 mediated by KAT2A suppresses its inhibitory activity on the transcription of CDH1 to promote the progression of prostate cancer. | Succinylation of CTBP1 mediated by KAT2A suppresses its inhibitory activity on the transcription of CDH1 to promote the progression of prostate cancer.
Zhou J, Yan X, Liu Y, Yang J. | 03/7/2023 |
| H1.0 induces paclitaxel-resistance genes expression in ovarian cancer cells by recruiting GCN5 and androgen receptor. | H1.0 induces paclitaxel-resistance genes expression in ovarian cancer cells by recruiting GCN5 and androgen receptor.
Kohli A, Huang SL, Chang TC, Chao CC, Sun NK., Free PMC Article | 08/13/2022 |
| Long noncoding RNA LBX2-AS1 promotes colorectal cancer progression via binding with PTBP1 and stabilizing KAT2A expression. | Long noncoding RNA LBX2-AS1 promotes colorectal cancer progression via binding with PTBP1 and stabilizing KAT2A expression.
Zhao A, Wang Y, Lin F, Bai K, Gu C. | 05/21/2022 |
| General Control Nonrepressed Protein 5 Modulates Odontogenic Differentiation Through NF-kappaB Pathway in Tumor Necrosis Factor-alpha-Mediated Impaired Human Dental Pulp Stem Cells. | General Control Nonrepressed Protein 5 Modulates Odontogenic Differentiation Through NF-κB Pathway in Tumor Necrosis Factor-α-Mediated Impaired Human Dental Pulp Stem Cells.
Xiao J, Zheng Y, Zhang W, Zhang Y, Cao P, Liang Y, Bao L, Shi S, Feng X. | 04/16/2022 |
| KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia. | KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia.
Arede L, Foerner E, Wind S, Kulkarni R, Domingues AF, Giotopoulos G, Kleinwaechter S, Mollenhauer-Starkl M, Davison H, Chandru A, Asby R, Samarista R, Gupta S, Forte D, Curti A, Scheer E, Huntly BJP, Tora L, Pina C., Free PMC Article | 03/12/2022 |
| P300/CBP-associated factor (PCAF)-mediated acetylation of Fascin at lysine 471 inhibits its actin-bundling activity and tumor metastasis in esophageal cancer. | P300/CBP-associated factor (PCAF)-mediated acetylation of Fascin at lysine 471 inhibits its actin-bundling activity and tumor metastasis in esophageal cancer.
Cheng YW, Zeng FM, Li DJ, Wang SH, He JZ, Guo ZC, Nie PJ, Wu ZY, Shi WQ, Wen B, Xu XE, Liao LD, Li ZM, Wu JY, Zhan J, Zhang HQ, Chang ZJ, Zhang K, Xu LY, Li EM., Free PMC Article | 02/5/2022 |
| A preliminary study of KAT2A on cGAS-related immunity in inflammation amplification of systemic lupus erythematosus. | A preliminary study of KAT2A on cGAS-related immunity in inflammation amplification of systemic lupus erythematosus.
Tang Y, Li X, Wei Y, Sun Y, Yang Y, Zhang X, Gao Z, Liu J, Zhuang Q., Free PMC Article | 02/5/2022 |
| KAT2A-mediated AR translocation into nucleus promotes abiraterone-resistance in castration-resistant prostate cancer. | KAT2A-mediated AR translocation into nucleus promotes abiraterone-resistance in castration-resistant prostate cancer.
Lu D, Song Y, Yu Y, Wang D, Liu B, Chen L, Li X, Li Y, Cheng L, Lv F, Zhang P, Xing Y., Free PMC Article | 01/29/2022 |
| Autophagic degradation of KAT2A/GCN5 promotes directional migration of vascular smooth muscle cells by reducing TUBA/alpha-tubulin acetylation. | Autophagic degradation of KAT2A/GCN5 promotes directional migration of vascular smooth muscle cells by reducing TUBA/α-tubulin acetylation.
Ouyang C, Mu J, Lu Q, Li J, Zhu H, Wang Q, Zou MH, Xie Z., Free PMC Article | 10/2/2021 |
| The lncRNA PVT1 regulates nasopharyngeal carcinoma cell proliferation via activating the KAT2A acetyltransferase and stabilizing HIF-1alpha. | The lncRNA PVT1 regulates nasopharyngeal carcinoma cell proliferation via activating the KAT2A acetyltransferase and stabilizing HIF-1α.
Wang Y, Chen W, Lian J, Zhang H, Yu B, Zhang M, Wei F, Wu J, Jiang J, Jia Y, Mo F, Zhang S, Liang X, Mou X, Tang J., Free PMC Article | 07/3/2021 |
| In-vitro acetylation of SARS-CoV and SARS-CoV-2 nucleocapsid proteins by human PCAF and GCN5. | In-vitro acetylation of SARS-CoV and SARS-CoV-2 nucleocapsid proteins by human PCAF and GCN5.
Hatakeyama D, Masuda T, Miki R, Ohtsuki S, Kuzuhara T., Free PMC Article | 05/22/2021 |
| Buffering noise: KAT2A modular contributions to stabilization of transcription and cell identity in cancer and development. | Buffering noise: KAT2A modular contributions to stabilization of transcription and cell identity in cancer and development.
Arede L, Pina C. | 04/24/2021 |
| Elevated GCN5 expression confers tamoxifen resistance by upregulating AIB1 expression in ER-positive breast cancer. | Elevated GCN5 expression confers tamoxifen resistance by upregulating AIB1 expression in ER-positive breast cancer.
Oh JH, Lee JY, Kim KH, Kim CY, Jeong DS, Cho Y, Nam KT, Kim MH. | 03/28/2021 |
| Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure. | Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure.
Toma-Fukai S, Hibi R, Naganuma T, Sakai M, Saijo S, Shimizu N, Matsumoto M, Shimizu T., Free PMC Article | 03/13/2021 |
| [Expression and Mechanism of KAT2A and CDK4/CDK6 in Children with Acute Leukemia]. | [Expression and Mechanism of KAT2A and CDK4/CDK6 in Children with Acute Leukemia].
Xiao MF, Huang YM, Lu Z, Lin ZP. | 10/24/2020 |
| GCN-5/PGC-1alpha signaling is activated and associated with metabolism in Cyclin E1-driven high grade serous ovarian cancer | GCN-5/PGC-1α signaling is activated and associated with metabolism in cyclin E1-driven ovarian cancer.
Guo T, Li B, Gu C, Chen X, Han M, Liu X, Xu C., Free PMC Article | 08/12/2020 |
| KAT2A is highly expressed in human pancreatic ductal adenocarcinoma (PDAC) specimens and positively correlated with advanced stages of PDAC and short patients' survival. KAT2A expression in PDAC specimens is correlated with 14-3-3zeta expression, and KAT2A regulates H3K79 succinylation in the promoter region of YWHAZ to promote YWHAZ mRNA and 14-3-3zeta expression, thereby preventing beta-catenin degradation. | KAT2A succinyltransferase activity-mediated 14-3-3ζ upregulation promotes β-catenin stabilization-dependent glycolysis and proliferation of pancreatic carcinoma cells.
Tong Y, Guo D, Yan D, Ma C, Shao F, Wang Y, Luo S, Lin L, Tao J, Jiang Y, Lu Z, Xing D. | 07/4/2020 |
| GCN5 has a role in maintaining all trans retinoic acid -resistance in non-acute promyelocytic leukemia acute myeloid leukemia | The acetyltransferase GCN5 maintains ATRA-resistance in non-APL AML.
Kahl M, Brioli A, Bens M, Perner F, Kresinsky A, Schnetzke U, Hinze A, Sbirkov Y, Stengel S, Simonetti G, Martinelli G, Petrie K, Zelent A, Böhmer FD, Groth M, Ernst T, Heidel FH, Scholl S, Hochhaus A, Schenk T. | 06/6/2020 |
| These results revealed a novel mechanism of E7 function whereby elevated GCN5 acetylates histones and c-Myc to regulate E2F1 expression and cell cycle progression. | The lysine acetyltransferase GCN5 contributes to human papillomavirus oncoprotein E7-induced cell proliferation via up-regulating E2F1.
Qiao L, Zhang Q, Zhang W, Chen JJ., Free PMC Article | 12/7/2019 |
| GCAWKR bound WDR5 and KAT2A and acted as a molecular scaffold of WDR5/KAT2A complexes, modulating the affinity for WDR5/KAT2A complexes in the target gene's promoter region. Thus, our data defined a mechanism of lncRNA-mediated carcinogenesis in gastric cancer (GC), suggesting new therapeutic targets in GC. | lncRNA GCAWKR Promotes Gastric Cancer Development by Scaffolding the Chromatin Modification Factors WDR5 and KAT2A.
Ma M, Zhang Y, Weng M, Hu Y, Xuan Y, Hu Y, Lv K., Free PMC Article | 09/7/2019 |
| these data demonstrated the negative effect of up-regulated GCN5 in IL-6-induced metastasis and EMT in prostate cancer (PCa) cells through PI3K/PTEN/Akt signaling pathway down-regulating Egr-1 expression | GCN5 inhibition prevents IL-6-induced prostate cancer metastases through PI3K/PTEN/Akt signaling by inactivating Egr-1.
Shao G, Liu Y, Ma T, Zhang L, Yuan M, Zhao S., Free PMC Article | 07/20/2019 |