| Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma. | Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma.
Wu Q, Li X, Long M, Xie X, Liu Q., Free PMC Article | 11/3/2023 |
| Novel LAMC2 fusion protein has tumor-promoting properties in ovarian carcinoma. | Novel LAMC2 fusion protein has tumor-promoting properties in ovarian carcinoma.
Daisuke H, Kato H, Fukumura K, Mayeda A, Miyagi Y, Seiki M, Koshikawa N., Free PMC Article | 12/25/2021 |
| hsa_circ_001653 up-regulates NR6A1 expression and elicits gastric cancer progression by binding to microRNA-377. | hsa_circ_001653 up-regulates NR6A1 expression and elicits gastric cancer progression by binding to microRNA-377.
Zhou W, Jiang R, Wang Y, Li Y, Sun Z, Zhao H. | 10/23/2021 |
| the role of NR6A1 in the lipogenesis in HepG2 cells | NR6A1 regulates lipid metabolism through mammalian target of rapamycin complex 1 in HepG2 cells.
Wang Y, Wan X, Hao Y, Zhao Y, Du L, Huang Y, Liu Z, Wang Y, Wang N, Zhang P., Free PMC Article | 06/20/2020 |
| GCNF acts as a transcriptional repressor in the regulation of OCT4 gene expression through cooperative interaction with three NR binding elements in pluripotent NCCIT cells. | GCNF regulates OCT4 expression through its interactions with nuclear receptor binding elements in NCCIT cells.
Park SW, Do HJ, Choi W, Kim JH, Song H, Seo HG, Kim JH. | 10/13/2018 |
| the genes, and up-regulated 64% in undifferentiated hES cells. In addition, GCNF also showed a regulatory gene pattern that is different from RA treatment during hES cell differentiation | Germ Cell Nuclear Factor (GCNF) Represses Oct4 Expression and Globally Modulates Gene Expression in Human Embryonic Stem (hES) Cells.
Wang H, Wang X, Xu X, Kyba M, Cooney AJ., Free PMC Article | 10/8/2016 |
| Findings show a role for Gcnf as a regulator of iPS cell pluripotency gene expression. It also demonstrates that reactivation of the Gcnf gene may serve as a marker to distinguish completely reprogrammed iPS cells from incompletely pluripotent cells. | Epigenetic reprogramming of the germ cell nuclear factor gene is required for proper differentiation of induced pluripotent cells.
Wang H, Wang X, Xu X, Zwaka TP, Cooney AJ., Free PMC Article | 01/17/2015 |
| Our results show that cellular levels of NR6A1 are correlated with disease progression in prostate cancer. | Expression screening of cancer/testis genes in prostate cancer identifies NR6A1 as a novel marker of disease progression and aggressiveness.
Mathieu R, Evrard B, Fromont G, Rioux-Leclercq N, Godet J, Cathelineau X, Guillé F, Primig M, Chalmel F. | 07/27/2013 |
| These experiments confirmed that NR6A1 works as a regulator for hypocretin transcription. | Transcriptional regulation of the hypocretin/orexin gene by NR6A1.
Tanaka S, Kodama T, Nonaka T, Toyoda H, Arai M, Fukazawa M, Honda Y, Honda M, Mignot E., Free PMC Article | 01/15/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.
Letra A, Menezes R, Govil M, Fonseca RF, McHenry T, Granjeiro JM, Castilla EE, Orioli IM, Marazita ML, Vieira AR., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| down-regulation of CREMtau-mediated gene expression by GCNF | Germ cell nuclear factor relieves cAMP-response element modulator tau-mediated activation of the testis-specific promoter of human mitochondrial glycerol-3-phosphate dehydrogenase.
Rajkovic M, Middendorff R, Wetzel MG, Frkovic D, Damerow S, Seitz HJ, Weitzel JM. | 01/21/2010 |
| characterization of a novel nuclear protein, referred to as RAP80, that interacts with the retinoid-related testis-associated receptor | RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor.
Yan Z, Kim YS, Jetten AM. | 01/21/2010 |
| RTR mRNA was expressed in the human placental choriocarcinoma cell lines BeWo, JAR, and JEG-3. | Characterization of the expression of the retinoid-related, testis-associated receptor (RTR) in trophoblasts.
Mehta DV, Kim YS, Dixon D, Jetten AM. | 01/21/2010 |