| CYP3A deficiency alters bile acid homeostasis and leads to changes in hepatic susceptibility in rats. | CYP3A deficiency alters bile acid homeostasis and leads to changes in hepatic susceptibility in rats.
Qin X, Zhang Y, Lu J, Huang S, Liu Z, Wang X. | 01/8/2022 |
| Advanced oxidation protein products downregulate CYP1A2 and CYP3A4 expression and activity via the NF-kappaB-mediated signaling pathway in vitro and in vivo. | Advanced oxidation protein products downregulate CYP1A2 and CYP3A4 expression and activity via the NF-κB-mediated signaling pathway in vitro and in vivo.
Xun T, Lin Z, Wang X, Zhan X, Feng H, Gan D, Yang X., Free PMC Article | 08/28/2021 |
| Schisandrin A significantly inhibited CYP3A activity in rat hepatic microsomes | Inhibitory effects of continuous ingestion of Schisandrin A on CYP3A in the rat.
Li WL, Xin HW, Su MW. | 08/6/2018 |
| It shows the highest metabolic activities against enantiomers of carvedilol. | Relative contribution of rat CYP isoforms responsible for stereoselective metabolism of carvedilol.
Iwaki M, Niwa T, Nakamura Y, Kawase A, Komura H. | 05/19/2018 |
| Pre-treatment with breviscapine injection also inhibited the mRNA expression of the hepatic CYP3A4. | Impact of the Herbal Breviscapine on the Pharmacokinetics of Simvastatin in Rats: The Involvement of CYP3A4.
Ju A, Li YY, Qu Z, Li Q. | 03/10/2018 |
| acute Formaldehyde (FA) poisoning suppressed the activities of CYP2C11, CYP2E1, and CYP3A2 and induced the activity of CYP1A2 in rats. And the change of CYP450 activity caused by acute FA poisoning may be associated with FA potential carcinogenic effects on the airways. | The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats.
Xu M, Tang H, Rong Q, Zhang Y, Li Y, Zhao L, Ye G, Shi F, Lv C., Free PMC Article | 03/3/2018 |
| The PE extract also showed a significant potential to reduce CYP3A and CYP2C protein expression by approximately 50%. | Effects of Paeonia emodi on hepatic cytochrome P450 (CYP3A2 and CYP2C11) expression and pharmacokinetics of carbamazepine in rats.
Raish M, Ahmad A, Alkharfy KM, Jan BL, Mohsin K, Ahad A, Al-Jenoobi FI, Al-Mohizea AM. | 02/17/2018 |
| Data suggest that combined treatment with non-nutritive sweetener aspartame and insulin in a rat model of juvenile diabetes induces CYP2E1 in neurons of cerebrum and cerebellum without modifying CYP2E1 in liver, while CYP3A2 is induced in cerebrum/cerebellum and in liver. | Aspartame Administration and Insulin Treatment Altered Brain Levels of CYP2E1 and CYP3A2 in Streptozotocin-Induced Diabetic Rats.
Nosti-Palacios R, Gómez-Garduño J, Molina-Ortiz D, Calzada-León R, Dorado-González VM, Vences-Mejía A. | 01/27/2018 |
| In blast-induced traumatic brain injury there was a significant impact on hepatic expression of CYP3A2. | Impacts of Blast-Induced Traumatic Brain Injury on Expressions of Hepatic Cytochrome P450 1A2, 2B1, 2D1, and 3A2 in Rats.
Ma J, Wang J, Cheng J, Xiao W, Fan K, Gu J, Yu B, Yin G, Wu J, Ren J, Hou J, Jiang Y, Tan Y, Jin W. | 02/18/2017 |
| hepatic expression of CYP4F2 and CYP3A2 genes in streptozotocin rats decreased | α-Tocopherol status and altered expression of α-tocopherol-related proteins in streptozotocin-induced type 1 diabetes in rat models.
Takitani K, Inoue K, Koh M, Miyazaki H, Kishi K, Inoue A, Tamai H. | 03/26/2016 |
| Schizonepetin had significant induction effects on CYP3A1/2 and inhibition effects on CYP1A2, CYP2E1 or CYP2D6 as oriented from the pharmacokinetic profiles of the substrates. | Effects of schizonepetin on activity and mRNA expression of cytochrome p450 enzymes in rats.
Bao B, Geng T, Cao Y, Yao W, Zhang L, Ding A., Free PMC Article | 07/4/2015 |
| Report CYP3A isoenzyme inhibition/induction by classical and atypical neuroleptics. | Effect of classic and atypical neuroleptics on cytochrome P450 3A (CYP3A) in rat liver.
Wójcikowski J, Haduch A, Daniel WA. | 07/20/2013 |
| As(III) decreases CYP1A1, CYP1A2, CYP3A23, and CYP3A2 expression in freshly isolated rat primary hepatocytes. | Inhibition of heme oxygenase-1 partially reverses the arsenite-mediated decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 catalytic activity in isolated rat hepatocytes.
Anwar-Mohamed A, Klotz LO, El-Kadi AO. | 08/11/2012 |
| Induction of CYP3A2/2B1 by phenobarbital significantly increases hepatic production of reactive oxygen species, leading to significantly higher hepatic ischemia reperfusion injury. | Cytochrome P450 induction by phenobarbital exacerbates warm hepatic ischemia-reperfusion injury in rat livers.
Shaik IH, Mehvar R. | 06/14/2010 |
| Data show that the greater AUC0-infinity of tamoxifen after the oral administration of both drugs together could have been attributable to a competitive (intestinal) inhibition of CYP2D subfamily- and 3A1/2-mediated tamoxifen metabolism by ondansetron. | Pharmacokinetic interaction between tamoxifen and ondansetron in rats: non-competitive (hepatic) and competitive (intestinal) inhibition of tamoxifen metabolism by ondansetron via CYP2D subfamily and 3A1/2.
Yang SH, Suh JH, Lee MG. | 02/8/2010 |
| large-for-gestational-age status affects the hepatic expression of CYP3A2 suggesting that further research on this issue is warranted | Expression of CYP3A23/1, CYP3A2, PXR, CAR and HNF4alpha in large-for-gestational-age neonatal rats.
Ni S, Wang X, Wang J, Zeng S, Zhao Z. | 01/21/2010 |
| Report effect of hemodialysis on hepatic cytochrome CYP3a2 functional expression. | Effect of hemodialysis on hepatic cytochrome P450 functional expression.
Michaud J, Nolin TD, Naud J, Dani M, Lafrance JP, Leblond FA, Himmelfarb J, Pichette V. | 01/21/2010 |
| Wild type adenovirus suppressed CYP3A2 and CYC2C11 gene expression during infection. | Molecular and macromolecular alterations of recombinant adenoviral vectors do not resolve changes in hepatic drug metabolism during infection.
Callahan SM, Wonganan P, Croyle MA., Free PMC Article | 01/21/2010 |
| As for liver regeneration, no significant difference was recognized. Regarding the expression of CYP3A2, no change was noted in the 30% graft model; on the other hand, CYP3A2 expression was reduced. | Pharmacokinetics of cyclosporine A after massive hepatectomy: a hint for small-for-size graft in living donor liver transplantation.
Shinohara H, Shimada M, Ogasawara T, Morine Y, Ikemoto T, Imura S, Fujii M. | 01/21/2010 |
| Inhibition of CYP3A11 completely reversed the initial up-regulation of AR signal transduction, measured by an androgen-responsive element chloramphenicol-acetyltransferase reporter gene assay. | Antiepileptic drugs affect neuronal androgen signaling via a cytochrome P450-dependent pathway.
Gehlhaus M, Schmitt N, Volk B, Meyer RP. | 01/21/2010 |
| Immunohistochemical results confirmed a significant decrease in Cyp3a2 and Cyp2c11 protein levels with age. | Hepatic transcript levels for genes coding for enzymes associated with xenobiotic metabolism are altered with age.
Mori K, Blackshear PE, Lobenhofer EK, Parker JS, Orzech DP, Roycroft JH, Walker KL, Johnson KA, Marsh TA, Irwin RD, Boorman GA. | 01/21/2010 |
| the influence of different maintenance temperatures as well as a subsequent incubation at 37 degrees on CYP3A-mediated oxidation by precision-cut liver slices was studied (cyp3a1;cyp3a2) | Role of temperature on protein and mRNA cytochrome P450 3A (CYP3A) isozymes expression and midazolam oxidation by cultured rat precision-cut liver slices.
Rekka E, Evdokimova E, Eeckhoudt S, Labar G, Calderon PB. | 01/21/2010 |