| DLEU2/EZH2/GFI1 Axis Regulates the Proliferation and Apoptosis of Human Bone Marrow Mesenchymal Stem Cells. | DLEU2/EZH2/GFI1 Axis Regulates the Proliferation and Apoptosis of Human Bone Marrow Mesenchymal Stem Cells.
Yao Q, He X, Wang J, Liu J, Zhang Q, Zhang J, Bo Y, Lu L. | 03/7/2024 |
| Dose-dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9-induced leukaemic cells. | Dose-dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9-induced leukaemic cells.
Patnana PK, Liu L, Frank D, Nimmagadda SC, Behrens M, Ahmed H, Xie X, Liebmann M, Wei L, Gerdemann A, Thivakaran A, Humpf HU, Klotz L, Dugas M, Varghese J, Trajkovic-Arsic M, Siveke JT, Hanenberg H, Opalka B, Dührsen U, Reinhardt HC, Guenther U, von Bubnoff N, Khandanpour C. | 09/1/2023 |
| Hematopoietic transcription factor GFI1 promotes anchorage independence by sustaining ERK activity in cancer cells. | Hematopoietic transcription factor GFI1 promotes anchorage independence by sustaining ERK activity in cancer cells.
Wang H, Lin Z, Nian Z, Zhang W, Liu W, Yan F, Xiao Z, Wang X, Zhang Z, Ma Z, Liu Z., Free PMC Article | 09/17/2022 |
| GFI1 regulates chromatin state essential in human endothelial-to-haematopoietic transition. | GFI1 regulates chromatin state essential in human endothelial-to-haematopoietic transition.
Kang B, Zhang T, Huang K, Wang T, Li Y, Mai Y, Li J, Dang S, Zhang Z, Huang W, Wang J, Gao M, Wang Y, Pan G., Free PMC Article | 06/11/2022 |
| GFI1 Cooperates with IKZF1/IKAROS to Activate Gene Expression in T-cell Acute Lymphoblastic Leukemia. | GFI1 Cooperates with IKZF1/IKAROS to Activate Gene Expression in T-cell Acute Lymphoblastic Leukemia.
Sun W, Guo J, McClellan D, Poeschla A, Bareyan D, Casey MJ, Cairns BR, Tantin D, Engel ME., Free PMC Article | 04/16/2022 |
| DNA methylation of GFI1 as a mediator of the association between prenatal smoking exposure and ADHD symptoms at 6 years: the Hokkaido Study on Environment and Children's Health. | DNA methylation of GFI1 as a mediator of the association between prenatal smoking exposure and ADHD symptoms at 6 years: the Hokkaido Study on Environment and Children's Health.
Miyake K, Miyashita C, Ikeda-Araki A, Miura R, Itoh S, Yamazaki K, Kobayashi S, Masuda H, Ooka T, Yamagata Z, Kishi R., Free PMC Article | 03/12/2022 |
| GFI1 promotes the proliferation and migration of esophageal squamous cell carcinoma cells through the inhibition of SOCS1 expression. | GFI1 promotes the proliferation and migration of esophageal squamous cell carcinoma cells through the inhibition of SOCS1 expression.
Huang Y, Ruan R, Fang Y, Wu K, Yao L, Zhang R, He W., Free PMC Article | 01/22/2022 |
| The transcription factors GFI1 and GFI1B as modulators of the innate and acquired immune response. | The transcription factors GFI1 and GFI1B as modulators of the innate and acquired immune response.
Fraszczak J, Möröy T. | 10/30/2021 |
| Epigenetic Regulation of Gfi1 in Endocrine-Related Cancers: a Role Regulating Tumor Growth. | Epigenetic Regulation of Gfi1 in Endocrine-Related Cancers: a Role Regulating Tumor Growth.
Ashour N, Angulo JC, González-Corpas A, Orea MJ, Lobo MVT, Colomer R, Colás B, Esteller M, Ropero S., Free PMC Article | 02/27/2021 |
| Gfi1 upregulates c-Myc expression and promotes c-Myc-driven cell proliferation. | Gfi1 upregulates c-Myc expression and promotes c-Myc-driven cell proliferation.
Zhang Y, Dong F., Free PMC Article | 01/16/2021 |
| Human yolk sac-like haematopoiesis generates RUNX1-, GFI1- and/or GFI 1B-dependent blood and SOX17-positive endothelium. | Human yolk sac-like haematopoiesis generates RUNX1-, GFI1- and/or GFI1B-dependent blood and SOX17-positive endothelium.
Bruveris FF, Ng ES, Leitoguinho AR, Motazedian A, Vlahos K, Sourris K, Mayberry R, McDonald P, Azzola L, Davidson NM, Oshlack A, Stanley EG, Elefanty AG., Free PMC Article | 01/2/2021 |
| Evaluation of growth factor independence 1 expression in patients with de novo acute myeloid leukemia. | Evaluation of growth factor independence 1 expression in patients with de novo acute myeloid leukemia.
Salarpour F, Goudarzipour K, Mohammadi MH, Ahmadzadeh A, Faraahi S, Allahbakhshian A, Farsani MA. | 10/3/2020 |
| LSD1-mediated repression of GFI1 super-enhancer plays an essential role in erythroleukemia. | LSD1-mediated repression of GFI1 super-enhancer plays an essential role in erythroleukemia.
Tatsumi G, Kawahara M, Yamamoto R, Hishizawa M, Kito K, Suzuki T, Takaori-Kondo A, Andoh A. | 08/29/2020 |
| The oncogenic role of the transcription factor GFI1 in gastric cancer.GSK3B controls GFI1 expression via phosphorylation of Serine 94 and Serine 98 sites, which leads to SCFFBXW7-mediated polyubiquitination and proteasome degradation. | SCF(FBXW7)/GSK3β-Mediated GFI1 Degradation Suppresses Proliferation of Gastric Cancer Cells.
Kuai X, Li L, Chen R, Wang K, Chen M, Cui B, Zhang Y, Li J, Zhu H, Zhou H, Huang J, Qin J, Wang Z, Wei W, Gao D. | 06/20/2020 |
| We identified and classified a pathogenic GFI1 variant and a likely pathogenic variant in MYO6 which together explain the complex phenotypes seen in this family. | Two monogenic disorders masquerading as one: severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss.
Venugopal P, Gagliardi L, Forsyth C, Feng J, Phillips K, Babic M, Poplawski NK, Rienhoff HY Jr, Schreiber AW, Hahn CN, Brown AL, Scott HS., Free PMC Article | 03/7/2020 |
| Results demonstrate that GFI1 acts as a tumor suppressor gene in colorectal cancer, where deficiency of Gfi1 promotes malignancy in the colon. | Growth Factor-Independent 1 Is a Tumor Suppressor Gene in Colorectal Cancer.
Chen MS, Lo YH, Chen X, Williams CS, Donnelly JM, Criss ZK 2nd, Patel S, Butkus JM, Dubrulle J, Finegold MJ, Shroyer NF., Free PMC Article | 01/25/2020 |
| Gfi1 plays a key role in MM tumor growth, survival, and bone destruction and contributes to bortezomib resistance. | Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis.
Petrusca DN, Toscani D, Wang FM, Park C, Crean CD, Anderson JL, Marino S, Mohammad KS, Zhou D, Silbermann R, Sun Q, Kurihara N, Galson DL, Giuliani N, Roodman GD., Free PMC Article | 01/11/2020 |
| expression of GFI1 is higher in RUNX1/ETO+ AML samples compared to other AML types and that absence of Gfi1 delays the growth of RUNX1/ETO9a+ cells both in vitro and in vivo. | GFI1 is required for RUNX1/ETO positive acute myeloid leukemia.
Marneth AE, Botezatu L, Hönes JM, Israël JCL, Schütte J, Vassen L, Lams RF, Bergevoet SM, Groothuis L, Mandoli A, Martens JHA, Huls G, Jansen JH, Dührsen U, Berg T, Möröy T, Wichmann C, Lo MC, Zhang DE, van der Reijden BA, Khandanpour C., Free PMC Article | 09/14/2019 |
| These results suggest that increasing GFI1 level in leukemic cells with low GFI1 expression level could be a therapeutic approach. | Enforced GFI1 expression impedes human and murine leukemic cell growth.
Hönes JM, Thivakaran A, Botezatu L, Patnana P, Castro SVDC, Al-Matary YS, Schütte J, Fischer KBI, Vassen L, Görgens A, Dührsen U, Giebel B, Khandanpour C., Free PMC Article | 07/6/2019 |
| our results call for a more elaborate stratification of AML patients to ensure proper diagnosis and effective treatment and demonstrate that high GFI1 expression is a reliable and powerful prognostic indicator for CN-AML. | Prognostic significance of high GFI1 expression in AML of normal karyotype and its association with a FLT3-ITD signature.
Volpe G, Walton DS, Grainger DE, Ward C, Cauchy P, Blakemore D, Coleman DJL, Cockerill PN, Garcia P, Frampton J., Free PMC Article | 06/15/2019 |
| Epigenetic changes at the GFI1 were linked to smoking exposure in-utero/in-adulthood and robustly associated with cardio-metabolic risk factors. | Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults.
Parmar P, Lowry E, Cugliari G, Suderman M, Wilson R, Karhunen V, Andrew T, Wiklund P, Wielscher M, Guarrera S, Teumer A, Lehne B, Milani L, de Klein N, Mishra PP, Melton PE, Mandaviya PR, Kasela S, Nano J, Zhang W, Zhang Y, Uitterlinden AG, Peters A, Schöttker B, Gieger C, Anderson D, Boomsma DI, Grabe HJ, Panico S, Veldink JH, van Meurs JBJ, van den Berg L, Beilin LJ, Franke L, Loh M, van Greevenbroek MMJ, Nauck M, Kähönen M, Hurme MA, Raitakari OT, Franco OH, Slagboom PE, van der Harst P, Kunze S, Felix SB, Zhang T, Chen W, Mori TA, Bonnefond A, Heijmans BT, BIOS Consortium, Muka T, Kooner JS, Fischer K, Waldenberger M, Froguel P, Huang RC, Lehtimäki T, Rathmann W, Relton CL, Matullo G, Brenner H, Verweij N, Li S, Chambers JC, Järvelin MR, Sebert S, GLOBAL Meth QTL Consortium., Free PMC Article | 04/6/2019 |
| GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1. | GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1.
Vadnais C, Chen R, Fraszczak J, Yu Z, Boulais J, Pinder J, Frank D, Khandanpour C, Hébert J, Dellaire G, Côté JF, Richard S, Orthwein A, Drobetsky E, Möröy T., Free PMC Article | 12/1/2018 |
| High GFI1 expression is associated with Acute myeloid leukemia. | miRNA-650 exerts anti-leukemia activity by inhibiting cell proliferation through Gfi1 targeting.
Yuan C, Xu L, Du P, Pang J. | 12/1/2018 |
| Differential methylation was observed in the CYP1A1 promoter and AHRR gene body regions between women who smoked throughout pregnancy and non-smokers on the fetal-side of the placenta and in the GFI1 promoter between women who quit smoking while pregnant and non-smokers on the maternal-side of the placenta | Locus-specific DNA methylation in the placenta is associated with levels of pro-inflammatory proteins in cord blood and they are both independently affected by maternal smoking during pregnancy.
van Otterdijk SD, Binder AM, Michels KB., Free PMC Article | 10/27/2018 |
| GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer. | GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer.
Xing W, Xiao Y, Lu X, Zhu H, He X, Huang W, Lopez ES, Wong J, Ju H, Tian L, Zhang F, Xu H, Wang SD, Li X, Karin M, Ren H., Free PMC Article | 02/17/2018 |