| Automated Image Analysis Reveals Different Localization of Synaptic Gephyrin C4 Splice Variants. | Automated Image Analysis Reveals Different Localization of Synaptic Gephyrin C4 Splice Variants.
Liebsch F, Eggersmann FR, Merkler Y, Kloppenburg P, Schwarz G., Free PMC Article | 01/14/2023 |
| Artemisinin-treatment in pre-symptomatic APP-PS1 mice increases gephyrin phosphorylation at Ser270: a modification regulating postsynaptic GABAAR density. | Artemisinin-treatment in pre-symptomatic APP-PS1 mice increases gephyrin phosphorylation at Ser270: a modification regulating postsynaptic GABA(A)R density.
Kiss E, Kins S, Gorgas K, Orlik M, Fischer C, Endres K, Schlicksupp A, Kirsch J, Kuhse J. | 01/22/2022 |
| Study unravels the critical role for cellular signal transduction pathways in determining gephyrin SUMOylation, phosphorylation and acetylation at identified residues to regulate its scaffolding properties at specific postsynaptic sites and in turn regulating GABAergic function and plasticity. | Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission.
Ghosh H, Auguadri L, Battaglia S, Simone Thirouin Z, Zemoura K, Messner S, Acuña MA, Wildner H, Yévenes GE, Dieter A, Kawasaki H, O Hottiger M, Zeilhofer HU, Fritschy JM, Tyagarajan SK., Free PMC Article | 09/8/2018 |
| Ablation of gephyrin result in the forebrain-specific loss of postsynaptic gamma2-GABAA receptors, reduces LTP and network excitability in the dentate gyrus. | Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice.
O'Sullivan GA, Jedlicka P, Chen HX, Kalbouneh H, Ippolito A, Deller T, Nawrotzki RA, Kuhse J, Kalaidzidis YL, Kirsch J, Schwarzacher SW, Betz H. | 12/24/2016 |
| adult mice lacking interleukin-1 receptor 1 (IL-1R1) exhibit increased expression of both the excitatory scaffolding protein postsynaptic density-95 (PSD-95) and inhibitory scaffolding proteingephyrin, respectively, in the hippocampus. | Absence of interleukin-1 receptor 1 increases excitatory and inhibitory scaffolding protein expression and microglial activation in the adult mouse hippocampus.
Avdic U, Chugh D, Osman H, Chapman K, Jackson J, Ekdahl CT., Free PMC Article | 06/11/2016 |
| The results demonstrate that formation of GABAergic synapses containing a postsynaptic gephyrin scaffold is crucial for morphological differentiation, synaptic integration, and long-term survival of adult-born granule cells/ | Postsynaptic gephyrin clustering controls the development of adult-born granule cells in the olfactory bulb.
Deprez F, Pallotto M, Vogt F, Grabiec M, Virtanen MA, Tyagarajan SK, Panzanelli P, Fritschy JM. | 05/21/2016 |
| Data suggest that KIF5 regulates gephyrin sorting by a mechanism that involves GSK3 activity. | GSK3 and KIF5 regulate activity-dependent sorting of gephyrin between axons and dendrites.
Rathgeber L, Gromova KV, Schaefer I, Breiden P, Lohr C, Kneussel M. | 09/26/2015 |
| Pin1-dependent signaling represents a mechanism to modulate GABAergic transmission by regulating NL2/gephyrin interaction. | Pin1-dependent signalling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interaction.
Antonelli R, Pizzarelli R, Pedroni A, Fritschy JM, Del Sal G, Cherubini E, Zacchi P., Free PMC Article | 07/25/2015 |
| These results reveal a homeostatic mechanism through which activity regulates the dynamics and function of perisomatic inhibitory synapses, and they identify a CaMKII-dependent phosphorylation site on gephyrin. | Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation.
Flores CE, Nikonenko I, Mendez P, Fritschy JM, Tyagarajan SK, Muller D., Free PMC Article | 04/25/2015 |
| study reveals that palmitoylation of gephyrin by DHHC-12 contributes to dynamic and functional modulation of GABAergic synapses | Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapses.
Dejanovic B, Semtner M, Ebert S, Lamkemeyer T, Neuser F, Lüscher B, Meier JC, Schwarz G., Free PMC Article | 02/28/2015 |
| Within this network, collybistin can adopt open/active and closed/inactive conformations to act as a switchable adaptor that links gephyrin to plasma membrane phosphoinositides. | A conformational switch in collybistin determines the differentiation of inhibitory postsynapses.
Soykan T, Schneeberger D, Tria G, Buechner C, Bader N, Svergun D, Tessmer I, Poulopoulos A, Papadopoulos T, Varoqueaux F, Schindelin H, Brose N., Free PMC Article | 11/8/2014 |
| these findings suggest that gephyrin may be a key factor in BDNF-dependent GABAAR regulation in the amygdala. | Gephyrin plays a key role in BDNF-dependent regulation of amygdala surface GABAARs.
Mou L, Dias BG, Gosnell H, Ressler KJ., Free PMC Article | 08/16/2014 |
| Immunoelectron and confocal microscopy reveal that postsynaptic membrane specializations can be formed in the absence of gephyrin. | Inhibitory postsynaptic membrane specializations are formed in gephyrin-deficient mice.
O'Sullivan GA, Hofer W, Betz H. | 01/21/2010 |
| gephyrin has splice-specific functions in molybdenum cofactor biosynthesis | Splice-specific functions of gephyrin in molybdenum cofactor biosynthesis.
Smolinsky B, Eichler SA, Buchmeier S, Meier JC, Schwarz G. | 01/21/2010 |
| Data suggest that the loss of neurotransmitter receptor clustering at inhibitory synapses causes the early lethality of gephyrin deficient mice. | Rescue of molybdenum cofactor biosynthesis in gephyrin-deficient mice by a Cnx1 transgene.
Grosskreutz Y, Betz H, Kneussel M. | 01/21/2010 |
| gephyrin is required for the membrane insertion/stabilization of the GABAAR gamma2 subunit as well as for its subsequent localization in the postsynaptic membrane | Glycinergic and GABAergic synaptic transmission are differentially affected by gephyrin in spinal neurons.
van Zundert B, Castro P, Aguayo LG. | 01/21/2010 |
| Gephyrin is critical for glycine receptor clustering in hippocampal neurons. | Gephyrin is critical for glycine receptor clustering but not for the formation of functional GABAergic synapses in hippocampal neurons.
Lévi S, Logan SM, Tovar KR, Craig AM., Free PMC Article | 01/21/2010 |
| Endogenous gephyrin undergoes proline-directed phosphorylation, which is followed by the recruitment of the peptidyl-prolyl isomerase Pin1. | Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function.
Zita MM, Marchionni I, Bottos E, Righi M, Del Sal G, Cherubini E, Zacchi P., Free PMC Article | 01/21/2010 |