| Targeting activin receptor-like kinase 7 ameliorates adiposity and associated metabolic disorders. | Targeting activin receptor-like kinase 7 ameliorates adiposity and associated metabolic disorders.
Zhao M, Okunishi K, Bu Y, Kikuchi O, Wang H, Kitamura T, Izumi T., Free PMC Article | 03/16/2023 |
| Regulation of metabolic homeostasis by the TGF-beta superfamily receptor ALK7. | Regulation of metabolic homeostasis by the TGF-β superfamily receptor ALK7.
Ibáñez CF. | 10/15/2022 |
| The orphan ligand, activin C, signals through activin receptor-like kinase 7. | The orphan ligand, activin C, signals through activin receptor-like kinase 7.
Goebel EJ, Ongaro L, Kappes EC, Vestal K, Belcheva E, Castonguay R, Kumar R, Bernard DJ, Thompson TB., Free PMC Article | 07/2/2022 |
| Sustained anti-obesity effects of life-style change and anti-inflammatory interventions after conditional inactivation of the activin receptor ALK7. | Sustained anti-obesity effects of life-style change and anti-inflammatory interventions after conditional inactivation of the activin receptor ALK7.
Srivastava RK, Lee ES, Sim E, Sheng NC, Ibáñez CF. | 07/31/2021 |
| ALK7 Promotes Vascular Smooth Muscle Cells Phenotypic Modulation by Negative Regulating PPARgamma Expression. | ALK7 Promotes Vascular Smooth Muscle Cells Phenotypic Modulation by Negative Regulating PPARγ Expression.
Gong FH, Cheng WL, Zhang Q, Chen XL, Cao JL, Yang T, Song WH, Zhao F. | 04/13/2021 |
| Data, including data from studies using knockout mice, suggest that Gdf3-Alk7 axis between adipose tissue macrophages and adipocytes represents previously unrecognized mechanism by which insulin regulates both fat metabolism/lipolysis and adiposity. (Gdf3 = growth differentiation factor-3; Alk7 = activin receptor-like kinase-7) | Insulin Regulates Lipolysis and Fat Mass by Upregulating Growth/Differentiation Factor 3 in Adipose Tissue Macrophages.
Bu Y, Okunishi K, Yogosawa S, Mizuno K, Irudayam MJ, Brown CW, Izumi T. | 09/8/2018 |
| Thus, the authors define a new memory mechanism by which learning reverses microRNA-mediated silencing of the novel plasticity protein ACVR1C via translin/trax. | Learning induces the translin/trax RNase complex to express activin receptors for persistent memory.
Park AJ, Havekes R, Fu X, Hansen R, Tudor JC, Peixoto L, Li Z, Wu YC, Poplawski SG, Baraban JM, Abel T., Free PMC Article | 05/19/2018 |
| ALK7 protects against pathological cardiac hypertrophy in mice. | ALK7 protects against pathological cardiac hypertrophy in mice.
Huang H, Tang Y, Wu G, Mei Y, Liu W, Liu X, Wan N, Liu Y, Huang C. | 09/3/2016 |
| These findings suggest that endogenous expression of ALK7 is necessary to maintain repolarizing K+ currents in ventricular cardiomyocytes, and finally prevent action potential prolongation and ventricular arrhythmia. | Alk7 Depleted Mice Exhibit Prolonged Cardiac Repolarization and Are Predisposed to Ventricular Arrhythmia.
Ying S, Cao H, Hu H, Wang X, Tang Y, Huang C., Free PMC Article | 07/30/2016 |
| ALK7 signaling contributes to diet-induced catecholamine resistance in adipose tissue; ALK7 inhibitors may have therapeutic value in human obesity. | Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity.
Guo T, Marmol P, Moliner A, Björnholm M, Zhang C, Shokat KM, Ibanez CF., Free PMC Article | 05/16/2015 |
| Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development. | Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development.
Miles DC, Wakeling SI, Stringer JM, van den Bergen JA, Wilhelm D, Sinclair AH, Western PS., Free PMC Article | 08/3/2013 |
| Alk7 is involved in modulation of adipose tissue metabolism in response to beta3-adrenergic receptor activation. | Expression of activin receptor-like kinase 7 in adipose tissues.
Murakami M, Shirai M, Ooishi R, Tsuburaya A, Asai K, Hashimoto O, Ogawa K, Nishino Y, Funaba M. | 07/20/2013 |
| Data indicate that activin receptor ALK7-knockout females showed delayed onset of puberty and abnormal estrous cyclicity. | Neuroendocrine control of female reproductive function by the activin receptor ALK7.
Sandoval-Guzmán T, Göngrich C, Moliner A, Guo T, Wu H, Broberger C, Ibáñez CF. | 04/13/2013 |
| Activin receptor-like kinase 7 suppresses lipolysis to accumulate fat in obesity through downregulation of peroxisome proliferator-activated receptor gamma and C/EBPalpha. | Activin receptor-like kinase 7 suppresses lipolysis to accumulate fat in obesity through downregulation of peroxisome proliferator-activated receptor γ and C/EBPα.
Yogosawa S, Mizutani S, Ogawa Y, Izumi T., Free PMC Article | 03/9/2013 |
| Knockdown or pharmacological inhibition of the Nodal/Activin receptor Alk4/7 in cancer stem cells virtually abrogated their self-renewal capacity and in vivo tumorigenicity | Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.
Lonardo E, Hermann PC, Mueller MT, Huber S, Balic A, Miranda-Lorenzo I, Zagorac S, Alcala S, Rodriguez-Arabaolaza I, Ramirez JC, Torres-Ruíz R, Garcia E, Hidalgo M, Cebrián DÁ, Heuchel R, Löhr M, Berger F, Bartenstein P, Aicher A, Heeschen C. | 04/14/2012 |
| GDF3 regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the ALK7 receptor | Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity.
Andersson O, Korach-Andre M, Reissmann E, Ibáñez CF, Bertolino P., Free PMC Article | 01/21/2010 |
| ALK7 plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca(2+) signaling | Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function.
Bertolino P, Holmberg R, Reissmann E, Andersson O, Berggren PO, Ibáñez CF., Free PMC Article | 01/21/2010 |
| ALK7 is the signaling receptor for activin AB and activin B and is responsible for activin-mediated secretion of insulin from pancreatic beta cell line, MIN6. | Activin isoforms signal through type I receptor serine/threonine kinase ALK7.
Tsuchida K, Nakatani M, Yamakawa N, Hashimoto O, Hasegawa Y, Sugino H. | 01/21/2010 |
| ALK7 is not an essential mediator of Nodal signaling during mesendoderm formation and left-right patterning in the mouse but may instead mediate other activities of Nodal and related ligands in the development or function of particular tissues and organs | ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse.
Jörnvall H, Reissmann E, Andersson O, Mehrkash M, Ibáñez CF., Free PMC Article | 01/21/2010 |
| These results indicated that ALK7 is a novel marker specifically expressed during the late phase of adipocyte differentiation. | ALK7 is a novel marker for adipocyte differentiation.
Kogame M, Matsuo S, Nakatani M, Kurisaki A, Nishitani H, Tsuchida K, Sugino H. | 01/21/2010 |