| The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation. | The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation.
Stewart N, Daly J, Drummond-Guy O, Krishnamoorthy V, Stark JC, Riley NM, Williams KC, Bertozzi CR, Wisnovsky S., Free PMC Article | 02/27/2024 |
| Histone deacetylation-regulated cell surface Siglec-7 expression promoted megakaryocytic maturation and enhanced platelet-like particle release. | Histone deacetylation-regulated cell surface Siglec-7 expression promoted megakaryocytic maturation and enhanced platelet-like particle release.
Huang YF, Su SC, Chuang HY, Chen HH, Twu YC. | 02/22/2023 |
| Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities. | Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities.
Haas Q, Markov N, Muerner L, Rubino V, Benjak A, Haubitz M, Baerlocher GM, Ng CKY, Münz C, Riether C, Ochsenbein AF, Simon HU, von Gunten S., Free PMC Article | 10/15/2022 |
| Regulation of Siglec-7-mediated varicella-zoster virus infection of primary monocytes by cis-ligands. | Regulation of Siglec-7-mediated varicella-zoster virus infection of primary monocytes by cis-ligands.
Suenaga T, Mori Y, Suzutani T, Arase H. | 06/11/2022 |
| Siglec-7 mediates varicella-zoster virus infection by associating with glycoprotein B. | Siglec-7 mediates varicella-zoster virus infection by associating with glycoprotein B.
Suenaga T, Mori Y, Suzutani T, Arase H. | 05/7/2022 |
| Siglec-7 is an indicator of natural killer cell function in acute myeloid leukemia. | Siglec-7 is an indicator of natural killer cell function in acute myeloid leukemia.
Yang L, Feng Y, Wang S, Jiang S, Tao L, Li J, Wang X. | 01/22/2022 |
| Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells. | Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells.
Yoshimura A, Asahina Y, Chang LY, Angata T, Tanaka H, Kitajima K, Sato C., Free PMC Article | 08/28/2021 |
| Decidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7. | Decidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7.
Vijayan M, Lee CL, Wong VHH, Wang X, Bai K, Wu J, Koistinen H, Seppälä M, Lee KF, Yeung WSB, Ng EHY, Chiu PCN. | 08/7/2021 |
| Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7. | Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7.
Wisnovsky S, Möckl L, Malaker SA, Pedram K, Hess GT, Riley NM, Gray MA, Smith BAH, Bassik MC, Moerner WE, Bertozzi CR., Free PMC Article | 06/19/2021 |
| The conserved arginine residue in all siglecs is essential for Siglec-7 binding to sialic acid. | The conserved arginine residue in all siglecs is essential for Siglec-7 binding to sialic acid.
Yoshimura A, Hatanaka R, Tanaka H, Kitajima K, Sato C. | 04/24/2021 |
| The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression. | The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression.
Zheng Y, Ma X, Su D, Zhang Y, Yu L, Jiang F, Zhou X, Feng Y, Ma F., Free PMC Article | 02/6/2021 |
| Reduced Siglec-7 expression on NK cells predicts NK cell dysfunction in primary hepatocellular carcinoma. | Reduced Siglec-7 expression on NK cells predicts NK cell dysfunction in primary hepatocellular carcinoma.
Tao L, Wang S, Yang L, Jiang L, Li J, Wang X., Free PMC Article | 01/23/2021 |
| Discovery of a new sialic acid binding region that regulates Siglec-7. | Discovery of a new sialic acid binding region that regulates Siglec-7.
Yamakawa N, Yasuda Y, Yoshimura A, Goshima A, Crocker PR, Vergoten G, Nishiura Y, Takahashi T, Hanashima S, Matsumoto K, Yamaguchi Y, Tanaka H, Kitajima K, Sato C., Free PMC Article | 12/12/2020 |
| DNA methylation-mediated Siglec-7 regulation in natural killer cells via two 5' promoter CpG sites. | DNA methylation-mediated Siglec-7 regulation in natural killer cells via two 5' promoter CpG sites.
Huang HT, Su SC, Chiou TJ, Lin YH, Shih YC, Wu YX, Fan TH, Twu YC., Free PMC Article | 11/21/2020 |
| Targeting glycosylated antigens on cancer cells using siglec-7/9-based CAR T-cells. | Targeting glycosylated antigens on cancer cells using siglec-7/9-based CAR T-cells.
Meril S, Harush O, Reboh Y, Matikhina T, Barliya T, Cohen CJ. | 09/12/2020 |
| Siglec-7 is constitutively expressed on human eosinophils and downmodulates eosinophil activation. | Siglec-7 on peripheral blood eosinophils: Surface expression and function.
Legrand F, Landolina N, Zaffran I, Emeh RO, Chen E, Klion AD, Levi-Schaffer F., Free PMC Article | 07/11/2020 |
| Data reported that Siglec-7 was expressed on beta-cells and down-regulated in type 1 and type 2 diabetes and in infiltrating activated immune cells. Furthermore, Siglec-7 seems to play a critical role in the maintenance of an immune-suppressive anti-inflammatory microenvironment, which is lost in diabetes, and may contribute to the manifestation and progression of this metabolic syndrome. | Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.
Dharmadhikari G, Stolz K, Hauke M, Morgan NG, Varki A, de Koning E, Kelm S, Maedler K., Free PMC Article | 12/1/2018 |
| NK cells with Siglec-7neg phenotype possess a high and sustainable killing activity and have the capability to eliminate a NK-resistant leukemia cell and hypersialylated tumor cells | A Developed NK-92MI Cell Line with Siglec-7(neg) Phenotype Exhibits High and Sustainable Cytotoxicity against Leukemia Cells.
Huang CH, Liao YJ, Fan TH, Chiou TJ, Lin YH, Twu YC., Free PMC Article | 09/15/2018 |
| CD56bright NK cells from obese subjects had a reduced expression of Siglec-7 | Siglec-7 expression is reduced on a natural killer (NK) cell subset of obese humans.
Rosenstock P, Horstkorte R, Gnanapragassam VS, Harth J, Kielstein H., Free PMC Article | 07/7/2018 |
| Siglec-7 defines a highly functional natural killer cell subset and inhibits cell-mediated activities. | Siglec-7 Defines a Highly Functional Natural Killer Cell Subset and Inhibits Cell-Mediated Activities.
Shao JY, Yin WW, Zhang QF, Liu Q, Peng ML, Hu HD, Hu P, Ren H, Zhang DZ. | 01/28/2017 |
| Siglec-7 plays a significant role in inhibiting IgE-mediated mast cell activation, but only moderately affects IgE-mediated activation in primary human basophils. | Siglec-7 is an inhibitory receptor on human mast cells and basophils.
Mizrahi S, Gibbs BF, Karra L, Ben-Zimra M, Levi-Schaffer F. | 12/6/2014 |
| These results show that Siglec-7 binds HIV-1 via gp120 and contributes to enhance the susceptibility to infection of CD4 positive T cells and monocyte-derived macrophages. | Sialic acid-binding Ig-like lectin-7 interacts with HIV-1 gp120 and facilitates infection of CD4pos T cells and macrophages.
Varchetta S, Lusso P, Hudspeth K, Mikulak J, Mele D, Paolucci S, Cimbro R, Malnati M, Riva A, Maserati R, Mondelli MU, Mavilio D., Free PMC Article | 07/12/2014 |
| Expression of Siglec-7 and -9 ligands was associated with susceptibility of NK cell-sensitive tumor cells and, unexpectedly, of presumably NK cell-resistant tumor cells to NK cell-mediated cytotoxicity. | Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance.
Jandus C, Boligan KF, Chijioke O, Liu H, Dahlhaus M, Démoulins T, Schneider C, Wehrli M, Hunger RE, Baerlocher GM, Simon HU, Romero P, Münz C, von Gunten S., Free PMC Article | 06/7/2014 |
| Based on upregulated SIGLEC7 expression in blood monocytes during relapse, findings suggest a role for SIGLEC7 in acute disease activity in multiple sclerosis. | SIGLEC1 and SIGLEC7 expression in circulating monocytes of patients with multiple sclerosis.
Malhotra S, Castilló J, Bustamante M, Vidal-Jordana A, Castro Z, Montalban X, Comabella M. | 11/2/2013 |
| Siglec-7 participates in generating a monocyte-mediated inflammatory outcome following pathogen recognition. | Engagement of Siglec-7 receptor induces a pro-inflammatory response selectively in monocytes.
Varchetta S, Brunetta E, Roberto A, Mikulak J, Hudspeth KL, Mondelli MU, Mavilio D., Free PMC Article | 03/2/2013 |