| Soluble adenylyl cyclase contributes to imiquimod-mediated inflammation and is a potential therapeutic target in psoriasis. | Soluble adenylyl cyclase contributes to imiquimod-mediated inflammation and is a potential therapeutic target in psoriasis.
You J, Reilly MD, Eljalby M, Bareja R, Yusupova M, Vyas NS, Bang J, Ding W, Desman G, Miller LS, Elemento O, Granstein RD, Zippin JH., | 09/12/2023 |
| Effect of Soluble Adenylyl Cyclase (ADCY10) Inhibitors on the LH-Stimulated cAMP Synthesis in Mltc-1 Leydig Cell Line. | Effect of Soluble Adenylyl Cyclase (ADCY10) Inhibitors on the LH-Stimulated cAMP Synthesis in Mltc-1 Leydig Cell Line.
Nguyen TMD, Filliatreau L, Klett D, Hai NV, Duong NT, Combarnous Y., Free PMC Article | 05/29/2021 |
| This study showed that sAC is essential for lysosomal acidification in addition to its other roles in cell physiology. | Soluble adenylyl cyclase is essential for proper lysosomal acidification.
Rahman N, Ramos-Espiritu L, Milner TA, Buck J, Levin LR., Free PMC Article | 11/26/2017 |
| sAC is a regulator of gene expression involved in aldosterone signaling and an important regulator of endothelial stiffness. | Soluble adenylyl cyclase in vascular endothelium: gene expression control of epithelial sodium channel-α, Na+/K+-ATPase-α/β, and mineralocorticoid receptor.
Schmitz B, Nedele J, Guske K, Maase M, Lenders M, Schelleckes M, Kusche-Vihrog K, Brand SM, Brand E. | 06/7/2014 |
| cAMP pathways are compartmentalized in sperm, with Gs proteins and transmembrane adenyl cyclase in the head and Adcy10 and PKA in the flagellum. | Compartmentalization of distinct cAMP signaling pathways in mammalian sperm.
Wertheimer E, Krapf D, de la Vega-Beltran JL, Sánchez-Cárdenas C, Navarrete F, Haddad D, Escoffier J, Salicioni AM, Levin LR, Buck J, Mager J, Darszon A, Visconti PE., Free PMC Article | 02/15/2014 |
| sAC is necessary for normal glucose-stimulated insulin secretion in vitro and in vivo. | CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor.
Zippin JH, Chen Y, Straub SG, Hess KC, Diaz A, Lee D, Tso P, Holz GG, Sharp GW, Levin LR, Buck J., Free PMC Article | 01/25/2014 |
| Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body. | Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body.
Lee YS, Tresguerres M, Hess K, Marmorstein LY, Levin LR, Buck J, Marmorstein AD., Free PMC Article | 01/28/2012 |
| Soluble adenylyl cyclase is required for activation of sperm but does not have a direct effect on hyperactivation. | Soluble adenylyl cyclase is required for activation of sperm but does not have a direct effect on hyperactivation.
Marquez B, Suarez SS. | 01/21/2010 |
| External Ca2+ binds an unidentified extracellular protein that is required for HCO3(-) to engage cyclic AMP-mediated activation of motility. | External Ca2+ acts upstream of adenylyl cyclase SACY in the bicarbonate signaled activation of sperm motility.
Carlson AE, Hille B, Babcock DF., Free PMC Article | 01/21/2010 |
| These results suggest that NO regulation of MMP-9 secreted from macrophages may occur chemically by reactive nitrogen species-mediated protein modification, biologically through soluble guanylyl-cyclase. | Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways.
Ridnour LA, Windhausen AN, Isenberg JS, Yeung N, Thomas DD, Vitek MP, Roberts DD, Wink DA., Free PMC Article | 01/21/2010 |
| The role of nitric oxide synthase 3 in the activation of soluble guanylyl cyclase in platelets is reported. | Stimulatory roles of nitric-oxide synthase 3 and guanylyl cyclase in platelet activation.
Marjanovic JA, Li Z, Stojanovic A, Du X. | 01/21/2010 |
| sperm-specific Na+/H+ exchanger is required for the expression of full-length soluble adenylyl cyclase | A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC).
Wang D, Hu J, Bobulescu IA, Quill TA, McLeroy P, Moe OW, Garbers DL., Free PMC Article | 01/21/2010 |
| Soluble guanylyl cyclase expression is reduced in experimental asthma contributing to the observed airway hyperreactivity. | Soluble guanylyl cyclase expression is reduced in allergic asthma.
Papapetropoulos A, Simoes DC, Xanthou G, Roussos C, Gratziou C. | 01/21/2010 |
| Plays a critical role in cAMP signaling in spermatozoa; defective cAMP production prevents engagement of multiple components of capacitation resulting in male infertility. | Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization.
Xie F, Garcia MA, Carlson AE, Schuh SM, Babcock DF, Jaiswal BS, Gossen JA, Esposito G, van Duin M, Conti M. | 01/21/2010 |