| Glycine Decarboxylase (GLDC) Plays a Crucial Role in Regulating Energy Metabolism, Invasion, Metastasis and Immune Escape for Prostate Cancer. | Glycine Decarboxylase (GLDC) Plays a Crucial Role in Regulating Energy Metabolism, Invasion, Metastasis and Immune Escape for Prostate Cancer.
Chen MK, Xiao ZY, Huang ZP, Xue KY, Xia H, Zhou JW, Liao DY, Liang ZJ, Xie X, Wei QZ, Zhong L, Yang JK, Liu CD, Liu Y, Zhao SC., Free PMC Article | 11/1/2023 |
| GLDC promotes colorectal cancer metastasis through epithelial-mesenchymal transition mediated by Hippo signaling pathway. | GLDC promotes colorectal cancer metastasis through epithelial-mesenchymal transition mediated by Hippo signaling pathway.
Yu H, Hu X, Zhang Y, Wang J, Ni Z, Wang Y, Zhu H. | 09/6/2023 |
| Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children. | Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children.
Krupenko SA, Cole SA, Hou R, Haack K, Laston S, Mehta NR, Comuzzie AG, Butte NF, Voruganti VS., Free PMC Article | 08/13/2022 |
| GLDC overexpression significantly induced cell autophagy, whereas GLDC downregulation reduced cell autophagy. Of note, GLDC is the post-transcriptional target of miR-30d-5p. GLDC overexpression could rescue miR-30d-5p-mediated cell metastasis and increase autophagy. | Glycine decarboxylase induces autophagy and is downregulated by miRNA-30d-5p in hepatocellular carcinoma.
Zhuang H, Wu F, Wei W, Dang Y, Yang B, Ma X, Han F, Li Y., Free PMC Article | 04/25/2020 |
| we identified a new alternative splicing isoform of GLDC, truncated GLDCV1, and demonstrated that GLDCV1 possesses similar biological activities to GLDCfl on regulating CSCs and tumorigenesis. | Identification of a new GLDC gene alternative splicing variant and its protumorigenic roles in lung cancer.
Yuan Y, Sun L, Wang X, Chen J, Jia M, Zou Y, Sa H, Cai Y, Xu Y, Sun C, Guo Y, Li H, Ma K. | 04/18/2020 |
| These findings reveal a critical role of GLDC in sustaining the proliferation of neuroblastoma cells with high-level GLDC expression and suggest that MYCN amplification is a biomarker for GLDC-based therapeutic strategies against high-risk neuroblastoma. | Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity.
Alptekin A, Ye B, Yu Y, Poole CJ, van Riggelen J, Zha Y, Ding HF., Free PMC Article | 03/14/2020 |
| Collectively, GLDC regulates cellular antiviral response and orchestrates viral growth. GLDC is a functional susceptibility gene to severe influenza in humans. | Identification and characterization of GLDC as host susceptibility gene to severe influenza.
Zhou J, Wang D, Wong BH, Li C, Poon VK, Wen L, Zhao X, Chiu MC, Liu X, Ye Z, Yuan S, Sze KH, Chan JF, Chu H, To KK, Yuen KY., Free PMC Article | 08/10/2019 |
| these findings suggest that GLDC-mediated regulation of glycolysis and controlling AGE accumulation is related to maintenance and induction of pluripotency. | Glycine decarboxylase regulates the maintenance and induction of pluripotency via metabolic control.
Kang PJ, Zheng J, Lee G, Son D, Kim IY, Song G, Park G, You S. | 07/20/2019 |
| Our data indicate that GLDC downregulation decreases reactive oxygen species mediated ubiquitination of cofilin to enhance hepatocellular carcinoma progression and intrahepatic metastasis | Downregulation of glycine decarboxylase enhanced cofilin-mediated migration in hepatocellular carcinoma cells.
Zhuang H, Li Q, Zhang X, Ma X, Wang Z, Liu Y, Yi X, Chen R, Han F, Zhang N, Li Y. | 06/29/2019 |
| A novel compound heterozygous variant was identified in the GLDC gene in a Chinese family with non-ketotic hyperglycinemia | A novel compound heterozygous variant identified in GLDC gene in a Chinese family with non-ketotic hyperglycinemia.
Lin Y, Zheng Z, Sun W, Fu Q., Free PMC Article | 12/22/2018 |
| it was concluded that elevated serum GLDC may increase lung cancer risk, and that smoking, GLDC, the miR29 family and DNMT signaling pathways may serve an important role in early malignant transformation during the development of lung cancer. | Serum glycine dehydrogenase is associated with increased risk of lung cancer and promotes malignant transformation by regulating DNA methyltransferases expression.
Wei HY, Feng R, Shao H, Feng B, Liu HQ, Men JL, Zou W. | 11/3/2018 |
| a comprehensive functional and structural analysis of 19 GLDC missense variants identified in a cohort of 26 nonketotic hyperglycinemia patients was performed | Nonketotic hyperglycinemia: Functional assessment of missense variants in GLDC to understand phenotypes of the disease.
Bravo-Alonso I, Navarrete R, Arribas-Carreira L, Perona A, Abia D, Couce ML, García-Cazorla A, Morais A, Domingo R, Ramos MA, Swanson MA, Van Hove JLK, Ugarte M, Pérez B, Pérez-Cerdá C, Rodríguez-Pombo P. | 02/24/2018 |
| The position and frequency of the breakpoint for CNVs correlated with intron size and presence of Alu elements. Missense mutations, most often recurring, were the most common type of disease-causing mutation in AMT | The genetic basis of classic nonketotic hyperglycinemia due to mutations in GLDC and AMT.
Coughlin CR 2nd, Swanson MA, Kronquist K, Acquaviva C, Hutchin T, Rodríguez-Pombo P, Väisänen ML, Spector E, Creadon-Swindell G, Brás-Goldberg AM, Rahikkala E, Moilanen JS, Mahieu V, Matthijs G, Bravo-Alonso I, Pérez-Cerdá C, Ugarte M, Vianey-Saban C, Scharer GH, Van Hove JL. | 12/9/2017 |
| We show that the combination of GLDC and HIF-1alpha expression is an independent prognostic factor in early-stage lung non-small cell cancer | Glycine decarboxylase and HIF-1α expression are negative prognostic factors in primary resected early-stage non-small cell lung cancer.
Berezowska S, Galván JA, Langer R, Bubendorf L, Savic S, Gugger M, Schmid RA, Marti TM. | 03/18/2017 |
| Data indicate no mutation was found in glycine cleavage system protein-H (GCSH) and suggest that mutations in both glycine decarboxylase (GLDC) and aminomethyltransferase (AMT) are the main cause of glycine encephalopathy in Malaysian population. | Mutation analysis of glycine decarboxylase, aminomethyltransferase and glycine cleavage system protein-H genes in 13 unrelated families with glycine encephalopathy.
Azize NA, Ngah WZ, Othman Z, Md Desa N, Chin CB, Md Yunus Z, Mohan A, Hean TS, Syed Zakaria SZ, Lock-Hock N. | 08/29/2015 |
| study reports a novel mutation, c.2296G>T (p.Gly766Cys), in exon 19 of the glycine decarboxylase (GLDC) gene in a consanguineous Indian couple with a history of 4 neonatal deaths | A novel glycine decarboxylase gene mutation in an Indian family with nonketotic hyperglycinemia.
Love JM, Prosser D, Love DR, Chintakindi KP, Dalal AB, Aggarwal S. | 10/18/2014 |
| Identification of a splice acceptor site mutation and five different non-synonymous variants in GLDC were found in patients with neural tube defects. | Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans.
Narisawa A, Komatsuzaki S, Kikuchi A, Niihori T, Aoki Y, Fujiwara K, Tanemura M, Hata A, Suzuki Y, Relton CL, Grinham J, Leung KY, Partridge D, Robinson A, Stone V, Gustavsson P, Stanier P, Copp AJ, Greene ND, Tominaga T, Matsubara Y, Kure S., Free PMC Article | 11/24/2012 |
| Study shows that glycine metabolism and the metabolic enzyme glycine decarboxylase (GLDC) drive tumor-initiating cells and tumorigenesis in non-small cell lung cancer. | Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.
Zhang WC, Shyh-Chang N, Yang H, Rai A, Umashankar S, Ma S, Soh BS, Sun LL, Tai BC, Nga ME, Bhakoo KK, Jayapal SR, Nichane M, Yu Q, Ahmed DA, Tan C, Sing WP, Tam J, Thirugananam A, Noghabi MS, Pang YH, Ang HS, Mitchell W, Robson P, Kaldis P, Soo RA, Swarup S, Lim EH, Lim B. | 03/17/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| a histidine-to-aspartic acid change at amino acid position 371 (p. His371Asp mutation) in the glycine decarboxylase in a non-ketotic hyperglycemia patient. | Non-ketotic hyperglycinemia with a novel GLDC mutation in a Taiwanese child.
Chang CY, Lin SP, Lin HY, Chuang CK, Ho CS, Hsu CH. | 01/21/2010 |
| Observational study of genotype prevalence. (HuGE Navigator) | Comprehensive mutation analysis of GLDC, AMT, and GCSH in nonketotic hyperglycinemia.
Kure S, Kato K, Dinopoulos A, Gail C, DeGrauw TJ, Christodoulou J, Bzduch V, Kalmanchey R, Fekete G, Trojovsky A, Plecko B, Breningstall G, Tohyama J, Aoki Y, Matsubara Y. | 03/13/2008 |
| Single nucleotide substitution that abolishes the initiator methionine codon of the GLDC gene is associated with glycine encephalopathy | A single nucleotide substitution that abolishes the initiator methionine codon of the GLDC gene is prevalent among patients with glycine encephalopathy in Jerusalem.
Boneh A, Korman SH, Sato K, Kanno J, Matsubara Y, Lerer I, Ben-Neriah Z, Kure S. | 01/21/2010 |
| forty different gene alterations in the GLDC gene were identified in patients with glycine encephalopathy | Genetic heterogeneity of the GLDC gene in 28 unrelated patients with glycine encephalopathy.
Conter C, Rolland MO, Cheillan D, Bonnet V, Maire I, Froissart R. | 01/21/2010 |
| Three adults with mild hyperglycinemia, infantile hypotonia, mental retardation, behavioral hyperirritability, and aggressive outbursts were screened for glycine decarboxylase mutations; two novel missense mutations were found. | Glycine decarboxylase mutations: a distinctive phenotype of nonketotic hyperglycinemia in adults.
Dinopoulos A, Kure S, Chuck G, Sato K, Gilbert DL, Matsubara Y, Degrauw T. | 01/21/2010 |
| The mutation in this nonketotic hyperglycinemia kindred led to missplicing and reduced GLDC (glycine decarboxylase) expression. | Mild glycine encephalopathy (NKH) in a large kindred due to a silent exonic GLDC splice mutation.
Flusser H, Korman SH, Sato K, Matsubara Y, Galil A, Kure S. | 01/21/2010 |