| TSAd Plays a Major Role in Myo9b-Mediated Suppression of Malignant Pleural Effusion by Regulating TH1/TH17 Cell Response. | TSAd Plays a Major Role in Myo9b-Mediated Suppression of Malignant Pleural Effusion by Regulating T(H)1/T(H)17 Cell Response.
Yi FS, Zhang X, Zhai K, Huang ZY, Wu XZ, Wu MT, Shi XY, Pei XB, Dong SF, Wang W, Yang Y, Du J, Luo ZT, Shi HZ. | 04/17/2021 |
| The TSAd serves as a critical cell-intrinsic molecule in CD4(+)Foxp3(+) Tregs to regulate the translocation of Lck to mitochondria, cellular activation responses, and the development of immunoregulation following solid organ transplantation. | T Cell-Specific Adaptor Protein Regulates Mitochondrial Function and CD4(+) T Regulatory Cell Activity In Vivo following Transplantation.
Wedel J, Stack MP, Seto T, Sheehan MM, Flynn EA, Stillman IE, Kong SW, Liu K, Briscoe DM., Free PMC Article | 05/23/2020 |
| data suggest that TSAd modulates differentiation of experienced T cells possibly through polarization of CD4+ T cells towards the APC. | Polarity of CD4+ T cells towards the antigen presenting cell is regulated by the Lck adapter TSAd.
Abrahamsen G, Sundvold-Gjerstad V, Habtamu M, Bogen B, Spurkland A., Free PMC Article | 11/2/2019 |
| These results revealed that vascular sprouting and permeability are both controlled through the VEGFR2-TSAd-c-Src signaling pathway in a subset of tissues, which may be useful in developing strategies to control tissue-specific pathological angiogenesis. | The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation.
Gordon EJ, Fukuhara D, Weström S, Padhan N, Sjöström EO, van Meeteren L, He L, Orsenigo F, Dejana E, Bentley K, Spurkland A, Claesson-Welsh L. | 11/25/2017 |
| Sh2d2a protein deficient mice display reduced clearance of Dm157 MCMV infection in the spleen. | Reduced MCMV Δm157 viral clearance in the absence of TSAd.
Moussa P, Abrahamsen G, Fodil N, Gopalakrishnan RP, Mancini M, Dissen E, Sæther PC, Wiltshire SA, Boivin GA, Caignard G, Spurkland A, Vidal SM., Free PMC Article | 12/19/2015 |
| The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192. | The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
Granum S, Sundvold-Gjerstad V, Gopalakrishnan RP, Berge T, Koll L, Abrahamsen G, Sørlie M, Spurkland A. | 08/15/2015 |
| Results suggest a modulatory role for T cell specific adapter protein SH2D2A in T cell mediated immune surveillance of cancer. | SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice.
Berge T, Grønningsæter IH, Lorvik KB, Abrahamsen G, Granum S, Sundvold-Gjerstad V, Corthay A, Bogen B, Spurkland A., Free PMC Article | 08/30/2014 |
| Data show that tyrosine phosphorylation of VEGF receptor 2 (VEGFR2) facilitates binding of VEGFR2 to the Rous sarcoma (Src) homology 2-domain of T cell-specific adaptor (TSAd), which in turn regulates VEGF-induced activation of the c-Src tyrosine kinase. | VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd.
Sun Z, Li X, Massena S, Kutschera S, Padhan N, Gualandi L, Sundvold-Gjerstad V, Gustafsson K, Choy WW, Zang G, Quach M, Jansson L, Phillipson M, Abid MR, Spurkland A, Claesson-Welsh L., Free PMC Article | 09/29/2012 |
| results show that TSAd, particularly the SH2 domain of TSAd, is essential for the effector functions of T cells. | The effector functions of mature T lymphocytes are impaired in transgenic mice expressing the SH2 domain of TSAd/Lad.
Choi Y, Park E, Ahn E, Park I, Yun Y. | 06/18/2011 |
| TSAd, through its interaction with both Itk and Lck, primes Itk for Lck mediated phosphorylation and thereby regulates CXCL12 induced T cell migration and actin cytoskeleton rearrangements | T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells.
Berge T, Sundvold-Gjerstad V, Granum S, Andersen TC, Holthe GB, Claesson-Welsh L, Andreotti AH, Inngjerdingen M, Spurkland A., Free PMC Article | 01/15/2011 |
| Although Rlk/Itk-binding protein (RIBP) is coexpressed with related adaptor lymphocytes of unknown function X (ALX) protein on both T- and B-lymphocytes during cell development, no redundancy or synergy is found. | The related adaptors, adaptor in lymphocytes of unknown function X and Rlk/Itk-binding protein, have nonredundant functions in lymphocytes.
Perchonock CE, Pajerowski AG, Nguyen C, Shapiro MJ, Shapiro VS. | 01/21/2010 |
| role of TSAd as a critical regulator of T cell death whose absence promotes systemic autoimmunity | Impaired T cell death and lupus-like autoimmunity in T cell-specific adapter protein-deficient mice.
Drappa J, Kamen LA, Chan E, Georgiev M, Ashany D, Marti F, King PD., Free PMC Article | 01/21/2010 |
| The major role of T cell-specific adapter protein in peripheral T cell cytoplasm is for activation of LCK protein tyrosine kinase at the outset of T cell receptor signal transduction | Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells.
Marti F, Garcia GG, Lapinski PE, MacGregor JN, King PD., Free PMC Article | 01/21/2010 |
| TSAd appears to contribute to interleukin-2 synthesis at multiple different levels | The emerging role of the T cell-specific adaptor (TSAd) protein as an autoimmune disease-regulator in mouse and man.
Marti F, Lapinski PE, King PD. | 01/21/2010 |