| Sequestration of eIF4A by angiomotin: A novel mechanism to restrict global protein synthesis in trophoblast cells. | Sequestration of eIF4A by angiomotin: A novel mechanism to restrict global protein synthesis in trophoblast cells.
Basak T, Dey AK, Banerjee R, Paul S, Maiti TK, Ain R. | 12/4/2021 |
| Amot and Yap1 regulate dendrite development by affecting the phosphorylation of S6 kinase and its target S6 ribosomal protein. | Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice.
Rojek KO, Krzemień J, Doleżyczek H, Boguszewski PM, Kaczmarek L, Konopka W, Rylski M, Jaworski J, Holmgren L, Prószyński TJ., Free PMC Article | 12/21/2019 |
| Collectively, we have uncovered that AMOT acts as a YAP stimulator in high glucose level. | AMOT is required for YAP function in high glucose induced liver malignancy.
Liu Y, Lu Z, Shi Y, Sun F. | 12/30/2017 |
| Rho attenuates the interaction between Amot and Nf2 by binding to the coiled-coil domain of Amot. | Rho differentially regulates the Hippo pathway by modulating the interaction between Amot and Nf2 in the blastocyst.
Shi X, Yin Z, Ling B, Wang L, Liu C, Ruan X, Zhang W, Chen L. | 11/18/2017 |
| TFPI-1 interacts with AMOT, which led to a decrease in the phosphorylation of YAP and further increased the genes expression of the proliferation and migration involved. Our results further confirmed that atherosclerosis was a localized disease. | Conditional knockout of TFPI-1 in VSMCs of mice accelerates atherosclerosis by enhancing AMOT/YAP pathway.
Xiao J, Jin K, Wang J, Ma J, Zhang J, Jiang N, Wang H, Luo X, Fei J, Wang Z, Yang X, Ma D. | 11/11/2017 |
| a new function of RNF146 and tankyrase in stabilizing the Crumbs complex through downregulation of AMOT proteins at the apical membrane, is reported. | The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.
Campbell CI, Samavarchi-Tehrani P, Barrios-Rodiles M, Datti A, Gingras AC, Wrana JL. | 08/5/2017 |
| AMOT is a crucial suppressor of lung cancer metastasis and highlight its critical role as a tumor suppressor and its potential as a prognostic biomarker and therapeutic target for lung cancer. | Angiomotin decreases lung cancer progression by sequestering oncogenic YAP/TAZ and decreasing Cyr61 expression.
Hsu YL, Hung JY, Chou SH, Huang MS, Tsai MJ, Lin YS, Chiang SY, Ho YW, Wu CY, Kuo PL. | 10/24/2015 |
| Within the nucleus, Amot-p130 was associated with the transcriptional complex containing Yap and Teads (TEA domain family members) and contributed to the regulation of a subset of Yap target genes, many of which are associated with tumorigenesis. | The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis.
Yi C, Shen Z, Stemmer-Rachamimov A, Dawany N, Troutman S, Showe LC, Liu Q, Shimono A, Sudol M, Holmgren L, Stanger BZ, Kissil JL., Free PMC Article | 03/29/2014 |
| The loss of Angiomotin, together with Angiomotin-like 2, leads to differentiation of inner cell mass cells and compromised peri-implantation development. | Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms.
Leung CY, Zernicka-Goetz M., Free PMC Article | 03/1/2014 |
| The phosphorylation of S176 in the N-terminal domain of Amot is a critical step for activation of the Hippo pathway in adherens junctions and cell polarity disconnects the Hippo pathway from cell-cell adhesion by sequestering Amot from AJs. | Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos.
Hirate Y, Hirahara S, Inoue K, Suzuki A, Alarcon VB, Akimoto K, Hirai T, Hara T, Adachi M, Chida K, Ohno S, Marikawa Y, Nakao K, Shimono A, Sasaki H., Free PMC Article | 02/1/2014 |
| Amot, Amotl1, and Amotl2 are differentially expressed in uterine cells during the peri-implantation period. | Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation.
Matsumoto H, Fukui E, Yoshizawa M, Sato E, Daikoku T. | 06/1/2013 |
| A vaccine targeting angiomotin induces an antibody response which alters tumor vessel permeability and hampers the growth of established tumors. | A vaccine targeting angiomotin induces an antibody response which alters tumor vessel permeability and hampers the growth of established tumors.
Arigoni M, Barutello G, Lanzardo S, Longo D, Aime S, Curcio C, Iezzi M, Zheng Y, Barkefors I, Holmgren L, Cavallo F., Free PMC Article | 08/25/2012 |
| Depletion of Angiomotin in Nf2(-/-) Schwann cells attenuates the Ras-MAPK signaling pathway, impedes cellular proliferation in vitro and tumorigenesis in vivo | A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions.
Yi C, Troutman S, Fera D, Stemmer-Rachamimov A, Avila JL, Christian N, Persson NL, Shimono A, Speicher DW, Marmorstein R, Holmgren L, Kissil JL., Free PMC Article | 06/18/2011 |
| Amot and AmotL1 have similar effects on endothelial migration and tight junction formation in vitro. In vivo Amot appears to control the cell polarity and AmotL1 affects the stability of cell-cell junctions. | Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis.
Zheng Y, Vertuani S, Nyström S, Audebert S, Meijer I, Tegnebratt T, Borg JP, Uhlén P, Majumdar A, Holmgren L. | 01/21/2010 |
| Homo-oligomerization of p80-Amot and hetero-oligomerization of both isoforms are critical for a switch between a migratory and a non-migratory cell phenotype in endothelial cells. | Differential roles of p80- and p130-angiomotin in the switch between migration and stabilization of endothelial cells.
Ernkvist M, Birot O, Sinha I, Veitonmaki N, Nyström S, Aase K, Holmgren L. | 01/21/2010 |
| 75% of Amot knockout mice die between embryonic day 11 (E11) and E11.5 and exhibit severe vascular insufficiency in the intersomitic region as well as dilated vessels in the brain. | Angiomotin regulates endothelial cell migration during embryonic angiogenesis.
Aase K, Ernkvist M, Ebarasi L, Jakobsson L, Majumdar A, Yi C, Birot O, Ming Y, Kvanta A, Edholm D, Aspenström P, Kissil J, Claesson-Welsh L, Shimono A, Holmgren L., Free PMC Article | 01/21/2010 |
| angiomotin, in addition to controlling cell motility, may play a role in the assembly of endothelial cell-cell junctions | Angiomotin regulates endothelial cell-cell junctions and cell motility.
Bratt A, Birot O, Sinha I, Veitonmäki N, Aase K, Ernkvist M, Holmgren L. | 01/21/2010 |
| Angiomotin may promote neoplastic angiogenesis by both stimulating invasion as well as stabilizing established tubes. | Angiomotin expression promotes hemangioendothelioma invasion.
Levchenko T, Bratt A, Arbiser JL, Holmgren L. | 01/21/2010 |
| p80- and p130-angiomotin play coordinating roles in vascular tube formation by affecting cell migration and cell shape, respectively. | p130-angiomotin associates to actin and controls endothelial cell shape.
Ernkvist M, Aase K, Ukomadu C, Wohlschlegel J, Blackman R, Veitonmäki N, Bratt A, Dutta A, Holmgren L. | 01/21/2010 |
| Data show that MUPP1 interacts with angiomotin (Amot), JEAP/Amot-like 1 and MASCOT/Amot-like 2, and that all the Amot/JEAP family proteins also interacted with Patj, a close relative of MUPP1. | Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties.
Sugihara-Mizuno Y, Adachi M, Kobayashi Y, Hamazaki Y, Nishimura M, Imai T, Furuse M, Tsukita S. | 01/21/2010 |