| Hypoxia Induces M2 Macrophages to Express VSIG4 and Mediate Cardiac Fibrosis After Myocardial Infarction. | Hypoxia Induces M2 Macrophages to Express VSIG4 and Mediate Cardiac Fibrosis After Myocardial Infarction.
Wang Y, Zhang Y, Li J, Li C, Zhao R, Shen C, Liu W, Rong J, Wang Z, Ge J, Shi B., Free PMC Article | 05/12/2023 |
| VSIG4-expressing tumor-associated macrophages impair anti-tumor immunity. | VSIG4-expressing tumor-associated macrophages impair anti-tumor immunity.
Jung K, Jeon YK, Jeong DH, Byun JM, Bogen B, Choi I. | 10/15/2022 |
| VSIG4 Attenuates NLRP3 and Ameliorates Neuroinflammation via JAK2-STAT3-A20 Pathway after Intracerebral Hemorrhage in Mice. | VSIG4 Attenuates NLRP3 and Ameliorates Neuroinflammation via JAK2-STAT3-A20 Pathway after Intracerebral Hemorrhage in Mice.
Ji N, Wu L, Shi H, Li Q, Yu A, Yang Z. | 04/16/2022 |
| CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. | CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease.
Duan Y, Chu H, Brandl K, Jiang L, Zeng S, Meshgin N, Papachristoforou E, Argemi J, Mendes BG, Wang Y, Su H, Sun W, Llorente C, Hendrikx T, Liu X, Hosseini M, Kisseleva T, Brenner DA, Bataller R, Ramachandran P, Karin M, Fu W, Schnabl B., Free PMC Article | 01/22/2022 |
| VSIG4(+) peritoneal macrophages induce apoptosis of double-positive thymocyte via the secretion of TNF-alpha in a CLP-induced sepsis model resulting in thymic atrophy. | VSIG4(+) peritoneal macrophages induce apoptosis of double-positive thymocyte via the secretion of TNF-α in a CLP-induced sepsis model resulting in thymic atrophy.
Cho HY, Yang YG, Jeon Y, Lee CK, Choi I, Lee SW., Free PMC Article | 09/25/2021 |
| Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue. | Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue.
Hall BM, Gleiberman AS, Strom E, Krasnov PA, Frescas D, Vujcic S, Leontieva OV, Antoch MP, Kogan V, Koman IE, Zhu Y, Tchkonia T, Kirkland JL, Chernova OB, Gudkov AV., Free PMC Article | 08/28/2021 |
| Microglial V-set and immunoglobulin domain-containing 4 protects against ischemic stroke in mice by suppressing TLR4-regulated inflammatory response. | Microglial V-set and immunoglobulin domain-containing 4 protects against ischemic stroke in mice by suppressing TLR4-regulated inflammatory response.
Lyu Q, Pang X, Zhang Z, Wei Y, Hong J, Chen H. | 09/5/2020 |
| The results indicated that Vsig4 expression was markedly down-regulated in fatty livers of nonalcoholic fatty liver disease patients and obese mice. | Expression of Vsig4 attenuates macrophage-mediated hepatic inflammation and fibrosis in high fat diet (HFD)-induced mice.
Li Y, Sun JP, Wang J, Lu WH, Xie LY, Lv J, Li HX, Yang SF. | 07/11/2020 |
| CRIg mediates the capture of Trypanosoma congolense parasites by Kupffer cells, which is essential for parasitemia control and host survival. | CRIg plays an essential role in intravascular clearance of bloodborne parasites by interacting with complement.
Liu G, Fu Y, Yosri M, Chen Y, Sun P, Xu J, Zhang M, Sun D, Strickland AB, Mackey ZB, Shi M., Free PMC Article | 05/2/2020 |
| These findings reveal that VSIG4 plays an essential role in negative regulation of macrophage-driven intracellular inflammation. | VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages.
Huang X, Feng Z, Jiang Y, Li J, Xiang Q, Guo S, Yang C, Fei L, Guo G, Zheng L, Wu Y, Chen Y., Free PMC Article | 04/11/2020 |
| CRIg expression in the lung and its role in the lung innate immunity. | Inhibition of Macrophage Complement Receptor CRIg by TRIM72 Polarizes Innate Immunity of the Lung.
Nagre N, Cong X, Terrazas C, Pepper I, Schreiber JM, Fu H, Sill JM, Christman JW, Satoskar AR, Zhao X., Free PMC Article | 07/27/2019 |
| Kupffer cells play a critical role in inducing regulatory T cells and establishing immune tolerance against oral antigens via VSIG4 signaling. | V-set and Ig domain-containing 4 (VSIG4)-expressing hepatic F4/80(+) cells regulate oral antigen-specific responses in mouse.
Shin W, Jeon Y, Choi I, Kim YJ. | 01/26/2019 |
| VSIG4 activates the PI3K/Akt-STAT3 pathway, leading to pyruvate dehydrogenase kinase-2 (PDK2) upregulation and subsequent phosphorylation of pyruvate dehydrogenase, which results in reduction in pyruvate/acetyl-CoA conversion, mitochondrial reactive oxygen species secretion, and macrophage inhibition. | VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism.
Li J, Diao B, Guo S, Huang X, Yang C, Feng Z, Yan W, Ning Q, Zheng L, Chen Y, Wu Y., Free PMC Article | 09/8/2018 |
| Thus, environmental cues instruct tissue-resident macrophages to express CRIg, which functions as an immune checkpoint molecule to regulate adaptive immunity and promote immune tolerance. | CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells.
Yuan X, Yang BH, Dong Y, Yamamura A, Fu W., Free PMC Article | 07/21/2018 |
| VSIG4 signaling provides an anti-immune evasion mechanism that prevents the outgrowth of intracellular bacteria in macrophages | Extracellular stimulation of VSIG4/complement receptor Ig suppresses intracellular bacterial infection by inducing autophagy.
Kim KH, Choi BK, Kim YH, Han C, Oh HS, Lee DG, Kwon BS., Free PMC Article | 12/30/2017 |
| These findings reveal a pattern recognition role for CRIg in the direct capture of circulating Gram-positive bacteria from the bloodstream via binding to bacterial teichoic acid. | CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria.
Zeng Z, Surewaard BG, Wong CH, Geoghegan JA, Jenne CN, Kubes P. | 08/26/2017 |
| plays a negative role in helper T cell-dependent antibody isotype switching | Endogenous VSIG4 negatively regulates the helper T cell-mediated antibody response.
Jung K, Seo SK, Choi I. | 02/27/2016 |
| The macrophage-expressed VSIG4 may act to alleviate renal tubulointerstitial injury via inhibition of T cell infiltration and secretion of inflammation related factors. | Costimulatory molecule VSIG4 exclusively expressed on macrophages alleviates renal tubulointerstitial injury in VSIG4 KO mice.
Li Y, Wang YQ, Wang DH, Hou WP, Zhang Y, Li M, Li FR, Mu J, Du X, Pang F, Yuan FH. | 02/28/2015 |
| complement receptor of the immunoglobulin superfamily-L-factor H protects glomerular mesangial cells from complement-mediated injury and proliferative lesions | A novel CRIg-targeted complement inhibitor protects cells from complement damage.
Qiao Q, Teng X, Wang N, Lu R, Guo L, Zhang X, Du Y, Wang W, Chen S, Wu Q, He G, Wang Y, Hu W. | 01/31/2015 |
| CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner. | CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner.
Kim KH, Choi BK, Song KM, Cha KW, Kim YH, Lee H, Han IS, Kwon BS. | 05/4/2013 |
| CRIg plays an important role in regulating virus-induced Kupffer cell death and depletion of these cells from the liver sinusoidal lumen | CRIg mediates early Kupffer cell responses to adenovirus.
He JQ, Katschke KJ Jr, Gribling P, Suto E, Lee WP, Diehl L, Eastham-Anderson J, Ponakala A, Komuves L, Egen JG, van Lookeren Campagne M. | 04/6/2013 |
| we showed that a complement receptor of the Ig superfamily (CRIg, also known as Z39Ig), a receptor for complement fragments (C3b and iC3b), was expressed on a subset of intestinal macrophages in murine and human large intestine | Phenotypic and functional profiles of CRIg (Z39Ig)-expressing macrophages in the large intestine.
Tanaka M, Nagai T, Usami M, Hasui K, Takao S, Matsuyama T. | 07/21/2012 |
| The interstitial inflammatory cell infiltration and tubular lesion of VSIG4(-/-); urethral obstruction operation mice were increased, with the expression of TGF-beta1 increased and MMP-2 reduced. VSIG4 may play a role in inhibiting interstitial fibrosis. | [Effects of costimulatory molecule VSIG4 exclusively expression in macrophage on renal interstitial fibrosis].
Li Y, Wang YQ, Li M, Zhang Y, Li FR, Wang ZH, Qi W, Yuan FH. | 09/20/2010 |
| Results report the identification and characterization of a Complement Receptor of the Immunoglobulin superfamily, CRIg, that binds complement fragments C3b and iC3b. | CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens.
Helmy KY, Katschke KJ Jr, Gorgani NN, Kljavin NM, Elliott JM, Diehl L, Scales SJ, Ghilardi N, van Lookeren Campagne M. | 01/21/2010 |
| CRIg thus identifies a subset of tissue resident macrophages capable of increased phagocytosis of complement C3-coated particles, a function critical for immune clearance | Complement receptor of the Ig superfamily enhances complement-mediated phagocytosis in a subpopulation of tissue resident macrophages.
Gorgani NN, He JQ, Katschke KJ Jr, Helmy KY, Xi H, Steffek M, Hass PE, van Lookeren Campagne M. | 01/21/2010 |