| Docking interactions determine early cleavage events in insulin proteolysis by pepsin: Experiment and simulation. | Docking interactions determine early cleavage events in insulin proteolysis by pepsin: Experiment and simulation.
Koliński M, Kmiecik S, Dec R, Piejko M, Mak P, Dzwolak W. | 12/5/2020 |
| The Hydration Shell of Monomeric and Dimeric Insulin Studied by Terahertz Time-Domain Spectroscopy. | The Hydration Shell of Monomeric and Dimeric Insulin Studied by Terahertz Time-Domain Spectroscopy.
Wang P, Wang X, Liu L, Zhao H, Qi W, He M., Free PMC Article | 09/12/2020 |
| Top-down analyses of protonated insulin cations of charge states of 4+, 5+, or 6+ were performed by exposing the isolated precursor ions to a beam of helium cations with kinetic energy of more than 6 keV, in a technique termed charge transfer dissociation. | Top-Down Charge Transfer Dissociation (CTD) of Gas-Phase Insulin: Evidence of a One-Step, Two-Electron Oxidation Mechanism.
Li P, Kreft I, Jackson GP., Free PMC Article | 08/24/2019 |
| The structural dynamics of insulin hexamer dissociation were studied by the photoinduced temperature jump technique and monitored by time-resolved X-ray scattering. The process of hexamer dissociation was found to involve several transient intermediates, including an expanded hexamer and an unstable tetramer. | Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering.
Rimmerman D , Leshchev D , Hsu DJ , Hong J , Abraham B , Kosheleva I , Henning R , Chen LX ., Free PMC Article | 07/28/2018 |
| Insulin signaling role in skeletal muscle atrophy and autophagy in in transition and postpartum period | Insulin signaling and skeletal muscle atrophy and autophagy in transition dairy cows either overfed energy or fed a controlled energy diet prepartum.
Mann S, Abuelo A, Nydam DV, Leal Yepes FA, Overton TR, Wakshlag JJ. | 12/24/2016 |
| Structural changes consistent with protein partitioning to the membrane interior and adsorption to a gel phase model lipid bilayer were observed under conditions where the native fold of the protein is significantly destabilised. | Interaction of partially denatured insulin with a DSPC floating lipid bilayer.
Dennison AJ, Jones RA, Staniforth RA, Parnell AJ. | 10/22/2016 |
| Differences between human and bovine insulin kinetics under shear | Comparison of Human and Bovine Insulin Amyloidogenesis under Uniform Shear.
McBride SA, Tilger CF, Sanford SP, Tessier PM, Hirsa AH. | 05/28/2016 |
| increased sensitivity to glucose clearance and skeletal muscle insulin signaling during dietary restriction | Insulin secretion and signaling in response to dietary restriction and subsequent re-alimentation in cattle.
Keogh K, Kenny DA, Kelly AK, Waters SM. | 05/7/2016 |
| Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY and insulin signaling pathways. | Gene expression profiling of hormonal regulation related to the residual feed intake of Holstein cattle.
Xi YM, Yang Z, Wu F, Han ZY, Wang GL. | 11/28/2015 |
| Raman spectra of amino acids by Density Functional Theory method have been calculated. Experimental Raman spectra of insulin has been done. The simulated Raman spectrum of insulin is obtained from amino acid spectrum. | Quantum-mechanical DFT calculation supported Raman spectroscopic study of some amino acids in bovine insulin.
Tah B, Pal P, Roy S, Dutta D, Mishra S, Ghosh M, Talapatra GB. | 01/10/2015 |
| Contains Binding kinetics for insulin binding | Changes in bovine mammary insulin binding during pregnancy and lactation.
Campbell PG, Frey DM, Baumrucker CR. | 10/20/2014 |
| Using synchrotron radiation (SR), the crystal structures of T6 bovine insulin complexed with Ni(2+) and Cu(2+) were solved to 1.50 and 1.45 A resolution, respectively. | Towards accurate structural characterization of metal centres in protein crystals: the structures of Ni and Cu T(6) bovine insulin derivatives.
Frankaer CG, Mossin S, Ståhl K, Harris P., Free PMC Article | 09/6/2014 |
| Thermodynamics of insulin unfolding have been quantified by differential scanning calorimetry and thermal unfolding measurements to determine the extent and nature of their stabilization of the insulin hexamer. | Thermodynamic contributions to the stability of the insulin hexamer.
Lisi GP, Png CY, Wilcox DE. | 08/9/2014 |
| The present study examined the effect of insulin-mediated activation of the mammalian target of rapamycin complex 1 (MTORC1) signaling network on the proliferation of primary culture of theca-interstitial (T-I) cells. | Stimulatory effect of insulin on theca-interstitial cell proliferation and cell cycle regulatory proteins through MTORC1 dependent pathway.
Palaniappan M, Menon B, Menon KM., Free PMC Article | 08/10/2013 |
| In-situ spectroscopic investigation of ultrasonic assisted unfolding and aggregation of insulin. | In-situ spectroscopic investigation of ultrasonic assisted unfolding and aggregation of insulin.
Pfeiffer H, Chatziathanasiou N, Verstraeten B, Meersman F, Glorieux C, Heremans K, Wevers M. | 03/23/2013 |
| Insulin-induced activation of phosphoinositide 3-kinase~mammalian target of rapamycin pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth. | Insulin-induced neurite-like process outgrowth: acceleration of tau protein synthesis via a phosphoinositide 3-kinase~mammalian target of rapamycin pathway.
Nemoto T, Yanagita T, Satoh S, Maruta T, Kanai T, Murakami M, Wada A. | 02/2/2013 |
| normal and reversed supramolecular chirality of insulin fibrils | Normal and reversed supramolecular chirality of insulin fibrils probed by vibrational circular dichroism at the protofilament level of fibril structure.
Kurouski D, Dukor RK, Lu X, Nafie LA, Lednev IK., Free PMC Article | 01/26/2013 |
| Structural changes of insulin crystals in sequential dehydration process. | In-situ confocal Raman observation of structural changes of insulin crystals in sequential dehydration process.
Zeng G, Shou JJ, Li KK, Zhang YH. | 12/22/2012 |
| The structure of insulin fibrils was characterized by deep ultraviolet resonance Raman (DUVRR) and Nuclear Magnetic Resonance (NMR) spectroscopy combined with hydrogen-deuterium exchange. | Disulfide bridges remain intact while native insulin converts into amyloid fibrils.
Kurouski D, Washington J, Ozbil M, Prabhakar R, Shekhtman A, Lednev IK., Free PMC Article | 10/13/2012 |
| The gas-phase basicity of the peptide charge state and ligand drive the type of complexes bovine insulin forms with various amino sugars, irrespective of their structural differences. | Differential interactions of isomeric amino sugars with insulin studied under electrospray ionisation mass spectrometry.
Nagaveni V, Sravani M, Prabhakar S, Vairamani M. | 03/17/2012 |
| Exogenous recombinant bovine somatotropin did not affect plasma concentrations of IGF-I and insulin, however, it did improve post-thaw sperm membrane integrity. | Effect of recombinant bovine somatotropin on plasma concentrations of insulin-like growth factor I, insulin and membrane integrity of bull spermatozoa.
Vieira MB, Bianchi I, Madeira EM, Roll VF, Oliveira CA, Viau P, Pivato I, Severo NC, Del Pino FA, Schneider A, Corrêa MN. | 06/4/2011 |
| Tyrosine, phenylalanine, and cysteine in glycated insulin were the main residues for oxidative modifications. | Oxidative modifications in glycated insulin.
Guedes S, Vitorino R, Domingues MR, Amado F, Domingues P. | 09/27/2010 |
| DEPP is a novel insulin-regulatory molecule expressed abundantly in insulin-sensitive tissues including white adipose tissue and liver. | Insulin-mediated regulation of decidual protein induced by progesterone (DEPP) in adipose tissue and liver.
Kuroda Y, Kuriyama H, Kihara S, Kishida K, Maeda N, Hibuse T, Nishizawa H, Matsuda M, Funahashi T, Shimomura I. | 07/5/2010 |
| These results suggest that Akt plays a major role in Na(+)/K(+)-ATPase intracellular translocation and thus in alveolar fluid reabsorption. | Insulin regulates alveolar epithelial function by inducing Na+/K+-ATPase translocation to the plasma membrane in a process mediated by the action of Akt.
Comellas AP, Kelly AM, Trejo HE, Briva A, Lee J, Sznajder JI, Dada LA., Free PMC Article | 06/28/2010 |
| Long-term hyperketonemia, especially combined with puerperal metritis, interacts with secretion of insulin and whole-body IR, and results in a significant delay in PP ovarian activity in dairy cows. | Periparturient insulin secretion and whole-body insulin responsiveness in dairy cows showing various forms of ketone pattern with or without puerperal metritis.
Kerestes M, Faigl V, Kulcsár M, Balogh O, Földi J, Fébel H, Chilliard Y, Huszenicza G. | 01/25/2010 |