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    IGF1 insulin like growth factor 1 [ Bos taurus (cattle) ]

    Gene ID: 281239, updated on 3-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    [The lipidosis of the liver of dairy cows: Part 1 - Role of insulin and the Growth Hormone-IGF-1 axis].

    [The lipidosis of the liver of dairy cows: Part 1 - Role of insulin and the Growth Hormone-IGF-1 axis].
    Martens H.

    06/12/2023
    Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.

    Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.
    Willhelm BR, Ticiani E, Campagnolo K, Rodrigues JL, Roberts AJ, Anderson GB, Bertolini M.

    01/29/2022
    Insulin-like growth factor-1 induces IRE1-XBP1-dependent endoplasmic reticulum biogenesis in bovine mammary epithelial cells.

    Insulin-like growth factor-1 induces IRE1-XBP1-dependent endoplasmic reticulum biogenesis in bovine mammary epithelial cells.
    Sharmin MM, Hayashi S, Miyaji M, Ishizaki H, Matsuyama H, Haga S, Yonekura S.

    10/30/2021
    the addition of PAPP-A did not affect embryo yield and blastocyst survival, higher IGF-1 levels may affect embryo competence through differential expression of genes involved in lipid metabolism, oocyte competence, and mitochondrial function.

    Use of pregnancy-associated plasma protein-A during oocyte in vitro maturation increases IGF-1 and affects the transcriptional profile of cumulus cells and embryos from Nelore cows.
    Giroto AB, Fontes PK, Franchi FF, Dos Santos PH, Razza EM, Nogueira MFG, Maioli MA, Nogueira GP, Nunes GB, Mingoti GZ, Mareco EA, Castilho ACS.

    07/11/2020
    This study showed that the IGF-1 SnaBI TT appears to be associated with fewer days to ovulation and lesser calving to conseption interval of lactating dairy cows and had an additive association with the GHR AluI T allele on indicators for improvement of fertility.

    Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows.
    Silva Silveira PA, Butler WR, da Silva TC, Barros CC, Corrêa MN, Schneider A.

    05/2/2020
    LncRNA H19 participated in the regulation of the proliferation and apoptosis of male germline stem cells via the IGF-1 signaling pathway

    H19 regulates the proliferation of bovine male germline stem cells via IGF-1 signaling pathway.
    Lei Q, Pan Q, Li N, Zhou Z, Zhang J, He X, Peng S, Li G, Sidhu K, Chen S, Hua J.

    10/5/2019
    plasma insulin-like peptide 3, testosterone, inhibin, and insulin-like growth factor-I have a relationship with scrotal circumference and testicular weight in Japanese Black beef bull calves

    Relationships of plasma insulin-like peptide 3, testosterone, inhibin, and insulin-like growth factor-I concentrations with scrotal circumference and testicular weight in Japanese Black beef bull calves.
    Sakase M, Kitagawa K, Kibushi M, Kawate N, Weerakoon WWPN, Hannan MA, Kohama N, Tamada H., Free PMC Article

    02/9/2019
    These results suggest that reduced secretions of IGF-I, INSL3, and inhibin surrounding puberty may be associated with semen aberration in beef bulls.

    Plasma IGF-I, INSL3, testosterone, inhibin concentrations and scrotal circumferences surrounding puberty in Japanese Black beef bulls with normal and abnormal semen.
    Weerakoon WWPN, Sakase M, Kawate N, Hannan MA, Kohama N, Tamada H.

    10/13/2018
    IGF1/RsaI was associated with average daily weight gain in cattle.

    Polymorphism of Insulin-like Growth Factor 1 Gene (IGF1/TasI, IGF1/SnaBI, IGF1/RsaI) and the Association with Daily Gain of Pesisir Cattle Local Breed from West Sumatera, Indonesia.
    Yurnalis, Arnim, Putra DE.

    12/23/2017
    Thus CR suppresses the hypertrophic PGC1alpha-4/IGF-1/AKT1 pathway while promoting activation of the calpain system.

    Reduced skeletal muscle fiber size following caloric restriction is associated with calpain-mediated proteolysis and attenuation of IGF-1 signaling.
    Lu Y, Bradley JS, McCoski SR, Gonzalez JM, Ealy AD, Johnson SE., Free PMC Article

    08/26/2017
    Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.

    Interrelationships between ovarian follicles grown in culture and possible mediators.
    Sirotkin AV, Florkovičová Koničková I, Schaeffer HJ, Laurincik J, Harrath AH.

    07/22/2017
    IGF1 single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.

    Genetic effects of FASN, PPARGC1A, ABCG2 and IGF1 revealing the association with milk fatty acids in a Chinese Holstein cattle population based on a post genome-wide association study.
    Li C, Sun D, Zhang S, Yang S, Alim MA, Zhang Q, Li Y, Liu L., Free PMC Article

    07/8/2017
    It has been shown that several specific genes which are differentially regulated, including IGF-1, might impact dairy fertility.

    Transcriptomics of liver and muscle in Holstein cows genetically divergent for fertility highlight differences in nutrient partitioning and inflammation processes.
    Moran B, Cummins SB, Creevey CJ, Butler ST., Free PMC Article

    05/27/2017
    There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.

    Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows.
    Hax LT, Schneider A, Jacometo CB, Mattei P, da Silva TC, Farina G, Corrêa MN.

    05/13/2017
    Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.

    Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.
    Chung HY, Choi YJ, Park HN, Davis ME.

    04/23/2016
    The association of IGF1, GH, and PIT1 markers with growth and reproductive traits were assessed.

    Effect of IGF1, GH, and PIT1 markers on the genetic parameters of growth and reproduction traits in Canchim cattle.
    Grossi Ddo A, Buzanskas ME, Grupioni NV, de Paz CC, Regitano LC, de Alencar MM, Schenkel FS, Munari DP.

    02/27/2016
    These findings strongly support the concept that IGF-1 upregulates LHR expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.

    Insulin-like growth factor-1 regulates the expression of luteinizing hormone receptor and steroid production in bovine granulosa cells.
    Rawan AF, Yoshioka S, Abe H, Acosta TJ.

    12/5/2015
    Insulin-induced glucose uptake in lactating bovine mammary epithelial cells may involve the phosphatidylinositide 3-kinase- but not mitogen-activated protein kinase-mediated signaling pathways.

    Insulin stimulates glucose uptake via a phosphatidylinositide 3-kinase-linked signaling pathway in bovine mammary epithelial cells.
    Zhao K, Liu HY, Zhou MM, Zhao FQ, Liu JX.

    10/24/2015
    Data show that individuals with insulin-like growth factor I (IGF-1) allele C had a significantly higher performance in production traits.

    Polymorphism in the 5ꞌ-UTR of the insulin-like growth factor I gene associated with production traits in Chinese cattle.
    Zhang LZ, Ren G, Hua LS, Lan XY, Lei CZ, Chen H.

    06/27/2015
    Uterine concentrations of IGFBPs are cycle stage specific and also suggests IGF1-dependent and -independent functions for IGFBPs during a time of major change in the developing embryo.

    Insulin-like growth factor and insulin-like growth factor-binding proteins in the bovine uterus throughout the oestrous cycle.
    Costello LM, O'Boyle P, Diskin MG, Hynes AC, Morris DG.

    12/6/2014
    This study evaluated the relationship of IGF-I levels to several other determinants of feed intake in Red Angus cross cattle.

    An examination of the association of serum IGF-I concentration, potential candidate genes, and fiber type composition with variation in residual feed intake in progeny of Red Angus sires divergent for maintenance energy EPD.
    Welch CM, Thornton KJ, Murdoch GK, Chapalamadugu KC, Schneider CS, Ahola JK, Hall JB, Price WJ, Hill RA.

    08/9/2014
    Production and reproduction traits in Holstein cattle associated with single nucleotide polymorphisms in the IGF1 gene.

    SNP exploring in the middle and terminal regions of the IGF-1 gene and association with production and reproduction traits in Holstein cattle.
    Abdolmohammadi A, Zamani P.

    05/24/2014
    There is a strong association between putative favorable allelic variants (SNP) of neuropeptide Y, leptin, and IGF-1 genes, and residual feed intake, when animals were grazing on a high-quality, high-availability pasture.

    Association of SNP of neuropeptide Y, leptin, and IGF-1 genes with residual feed intake in confinement and under grazing condition in Angus cattle.
    Trujillo AI, Casal A, Peñagaricano F, Carriquiry M, Chilibroste P.

    04/5/2014
    Direct additive genetic correlations suggest that selection for greater IGF-I concentration could lead to increased conception rate and calving rate, and decreased age at first calving in heifers.

    Effects of selection for blood serum IGF-I concentration on reproductive performance of female Angus beef cattle.
    Zhang X, Davis ME, Moeller SJ, Ottobre JS.

    04/5/2014
    We found that IGF-I stimulated chondrocyte biosynthesis similarly when delivered by either exogenous or endogenous means.

    Endogenous versus exogenous growth factor regulation of articular chondrocytes.
    Shi S, Chan AG, Mercer S, Eckert GJ, Trippel SB., Free PMC Article

    01/25/2014
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