| a pi-H pathway assembled across the beta-sheets from both subunits in the SOD-dimer protein connecting the two Cu-centers and thus the two half-reactions, is described. | Pathways of electron transfer and proton translocation in the action of superoxide dismutase dimer.
Ramasarma T, Vaigundan D. | 06/20/2020 |
| the present study aims to evaluate the peritoneal fluid impact from infertile women with minimal and mild endometriosis and from fertile control women without endometriosis on SOD1, CAT, GSR gene's expression in experimental bovine oocytes matured in vitro. | Peritoneal fluid of women with endometriosis reduces SOD1 in bovine oocytes in vitro maturation.
Malvezzi H, Da Broi MG, Meola J, Rosa-E-Silva JC, Ferriani RA, Navarro PA. | 04/6/2019 |
| Results indicate that variants of the PRLH and SOD1 genes are associated with heat tolerance in Chinese cattle. | PRLH and SOD1 gene variations associated with heat tolerance in Chinese cattle.
Zeng L, Chen N, Ning Q, Yao Y, Chen H, Dang R, Zhang H, Lei C. | 10/6/2018 |
| The three-dimensional structure of bSOD1 reveals the imidazole ring of His19 localized within 5A from the alpha-carbon of Gly31 providing a structural basis that copper ion, most likely coordinated by His19, catalyzes the specific cleavage reaction | Distinct oxidative cleavage and modification of bovine [Cu- Zn]-SOD by an ascorbic acid/Cu(II) system: Identification of novel copper binding site on SOD molecule.
Uehara H, Luo S, Aryal B, Levine RL, Rao VA., Free PMC Article | 12/23/2017 |
| SOD catalyzes reversal of autoxidation manifesting as its inhibition. SOD saves catechols from autoxidation and extends their bioavailability | New insights of superoxide dismutase inhibition of pyrogallol autoxidation.
Ramasarma T, Rao AV, Devi MM, Omkumar RV, Bhagyashree KS, Bhat SV. | 09/26/2015 |
| antioxidative enzymatic mechanisms in bovine placental tissues are represented by superoxide dismutase 1 and glutathione peroxidase, which show the changes in their expression during improper placental release | The presence of SOD 1 and GSH-Px in bovine retained and properly released foetal membranes.
Kankofer M, Wawrzykowski J, Hoedemaker M. | 02/15/2014 |
| Results sugget thet Copper/Zinc superoxide dismutase (SOD1) may play a role in controlling intraluteal prostaglandin F2alph and reactive oxygen species action during functional and structural luteolysis. | Roles of prostaglandin F2alpha and hydrogen peroxide in the regulation of Copper/Zinc superoxide dismutase in bovine corpus luteum and luteal endothelial cells.
Vu HV, Lee S, Acosta TJ, Yoshioka S, Abe H, Okuda K., Free PMC Article | 06/29/2013 |
| ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1 were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows. | Greater expression of TLR2, TLR4, and IL6 due to negative energy balance is associated with lower expression of HLA-DRA and HLA-A in bovine blood neutrophils after intramammary mastitis challenge with Streptococcus uberis.
Moyes KM, Drackley JK, Morin DE, Loor JJ. | 02/23/2011 |
| Acute elevation of SOD may represent a response of luteal endothelial cells to protect themselves against oxidative stress induced by PGF during functional luteolysis. | Role of nitric oxide in the regulation of superoxide dismutase and prostaglandin F(2alpha) production in bovine luteal endothelial cells.
Lee S, Acosta TJ, Nakagawa Y, Okuda K. | 11/27/2010 |
| At room temperature (25.0 degrees C) and higher, the addition of high concentrations of polymer is found to significantly enhance the affinity of SOD for catalase. | Attractive protein-polymer interactions markedly alter the effect of macromolecular crowding on protein association equilibria.
Jiao M, Li HT, Chen J, Minton AP, Liang Y., Free PMC Article | 11/13/2010 |
| Capillary electrophoresis and mass spectrometry to study the different structures of bovine SOD-1. In both cases, an average molecular mass corresponding to the apo-monomer SOD-1 was calculated. | Capillary electrophoresis/mass spectrometry for the separation and characterization of bovine Cu,Zn-superoxide dismutase.
Borges-Alvarez M, Benavente F, Barbosa J, Sanz-Nebot V. | 08/9/2010 |
| flexibility of the metal sites involved in present a single-crystal X-ray diffraction study of Cu,Zn superoxide dismutase in space group P212121 at 0.57 GPa. The crystal structure (hpSOD) was determined and refined at 2 A degrees resolution. | Flexibility of the Cu,Zn superoxide dismutase structure investigated at 0.57 GPa.
Ascone I, Savino C, Kahn R, Fourme R. | 08/2/2010 |
| expression profile in follicles: oocytes (SOD1 throughout ooplasm & nucleoplasm); cumulus cells (no SOD1 detected); granulosa cells (expressed SOD1); follicular fluid (small follicles show increased amounts of SOD1 in comparison with large follicles) | Profiling of superoxide dismutase isoenzymes in compartments of the developing bovine antral follicles.
Combelles CM, Holick EA, Paolella LJ, Walker DC, Wu Q., Free PMC Article | 08/2/2010 |
| Peroxymonocarbonate (HOOCO(2)(-)) is a key intermediate in the SOD1 peroxidase cycle and identify this species as the precursor of carbonate radical anions. | Direct magnetic resonance evidence for peroxymonocarbonate involvement in the cu,zn-superoxide dismutase peroxidase catalytic cycle.
Bonini MG, Gabel SA, Ranguelova K, Stadler K, Derose EF, London RE, Mason RP., Free PMC Article | 01/21/2010 |
| DNAs tested are simultaneously condensed into a nanoparticle with a specific morphology during SOD1 aggregation, revealing that SOD1 aggregation and DNA condensation are two concurrent phenomena. | Polymorphism of the SOD1-DNA aggregation species can be modulated by DNA.
Jiang W, Zhang B, Yin J, Liu L, Wang L, Liu C. | 01/21/2010 |
| The expression of SOD1 and SOD2 through the course of the estrous cycle is reported. | Expression of superoxide dismutases in the bovine oviduct during the estrous cycle.
Roy M, Gauvreau D, Bilodeau JF. | 01/21/2010 |
| diminished hepatic protein nitration in the SOD1-/- mice was not directly related to plasma nitrite and nitrate concentrations | Role of copper,zinc-superoxide dismutase in catalyzing nitrotyrosine formation in murine liver.
Zhu JH, Zhang X, Roneker CA, McClung JP, Zhang S, Thannhauser TW, Ripoll DR, Sun Q, Lei XG., Free PMC Article | 01/21/2010 |
| The results suggest that under cellular conditions ( approximately 5 mM bicarbonate) zinc-deficient SOD1 peroxidation could play a pathogenic role in neurodegenerative diseases. | Bicarbonate and active site zinc modulate the self-peroxidation of bovine copper-zinc superoxide dismutase.
Gunther MR, Donahue JA. | 01/21/2010 |
| communication between the two monomers of SOD1 such that the binding of one zinc ion per homodimer has a more profound effect on the homodimeric protein structure than the binding of subsequent metal ions | Binding of a single zinc ion to one subunit of copper-zinc superoxide dismutase apoprotein substantially influences the structure and stability of the entire homodimeric protein.
Potter SZ, Zhu H, Shaw BF, Rodriguez JA, Doucette PA, Sohn SH, Durazo A, Faull KF, Gralla EB, Nersissian AM, Valentine JS. | 01/21/2010 |
| Raman spectrum analysis strongly suggests that the His41-mediated hydrogen bond bridge of Cu-Zn superoxide dismutase plays a crucial role in keeping the protein structure suitable for highly efficient catalytic reactions. | Catalytic and structural role of a metal-free histidine residue in bovine Cu-Zn superoxide dismutase.
Toyama A, Takahashi Y, Takeuchi H. | 01/21/2010 |
| The kinetics of thermal dissociation of superoxide dismutase (SOD) was studied in 0.05 M Tris-HCl buffer at pH 7.4 containing 10(-4) M EDTA. | Thermal dissociation and conformational lock of superoxide dismutase.
Hong J, Moosavi-Movahedi AA, Ghourchian H, Amani M, Amanlou M, Chilaka FC. | 01/21/2010 |
| SOD1 mutants gain fatty acid binding abilities based on their structural instability and form cytotoxic granular aggregates | Unsaturated fatty acids induce cytotoxic aggregate formation of amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutants.
Kim YJ, Nakatomi R, Akagi T, Hashikawa T, Takahashi R. | 01/21/2010 |
| Cu,Zn-superoxide dismutase (CuZnSOD) catalyzes the reductive decomposition of S-nitroso-L-glutathione (GSNO) in the presence of thiols such as L-glutathione (GSH). | Binding of polyaminocarboxylate chelators to the active-site copper inhibits the GSNO-reductase activity but not the superoxide dismutase activity of Cu,Zn-superoxide dismutase.
Ye M, English AM. | 01/21/2010 |
| DNA accelerates the formation of SOD1 aggregates and is incorporated into SOD1 aggregates. SOD1 association with DNA, driven by electrostatic interactions, can restrict the orientation of SOD1 molecules and increase a SOD1 population along DNA strands. | DNA is a template for accelerating the aggregation of copper, zinc superoxide dismutase.
Jiang W, Han Y, Zhou R, Zhang L, Liu C. | 01/21/2010 |
| copper- and carbonate radical anion-mediated oxidations have roles in hydrogen peroxide-induced Cu,Zn-superoxide dismutase-centered radical formation | Mechanism of hydrogen peroxide-induced Cu,Zn-superoxide dismutase-centered radical formation as explored by immuno-spin trapping: the role of copper- and carbonate radical anion-mediated oxidations.
Ramirez DC, Gomez Mejiba SE, Mason RP. | 01/21/2010 |