| Organic anion-transporting polypeptides exert strong impact on disposition and toxicity of antitumor drugs. (Review) | The impact of Organic Anion-Transporting Polypeptides (OATPs) on disposition and toxicity of antitumor drugs: Insights from knockout and humanized mice.
Durmus S, van Hoppe S, Schinkel AH. | 01/20/2018 |
| important roles for OATP1A/1B in transporter-mediated uptake and disposition of doxorubicin, are reported. | Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.
Lee HH, Leake BF, Kim RB, Ho RH., Free PMC Article | 05/13/2017 |
| Data indicate that organic anion-transporting polypeptides Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces) enzymes, which caused higher conversion of irinotecan to SN-38 in plasma, potentially complicating pharmacokinetic analyses. | OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.
Iusuf D, Ludwig M, Elbatsh A, van Esch A, van de Steeg E, Wagenaar E, van der Valk M, Lin F, van Tellingen O, Schinkel AH. | 02/21/2015 |
| PDZK1 regulates intracellular trafficking of Oatp1a1. | Oatp1a1 requires PDZK1 to traffic to the plasma membrane by selective recruitment of microtubule-based motor proteins.
Wang WJ, Murray JW, Wolkoff AW., Free PMC Article | 08/16/2014 |
| Loss of Oatp1a1 function exacerbates cholestatic liver injury in mice and suggest that Oatp1a1 plays a unique role in liver adaptive responses to obstructive cholestasis. | Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury.
Zhang Y, Csanaky IL, Cheng X, Lehman-McKeeman LD, Klaassen CD., Free PMC Article | 09/29/2012 |
| Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism. | Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice.
Zhang Y, Limaye PB, Lehman-McKeeman LD, Klaassen CD., Free PMC Article | 08/25/2012 |
| Oatp1a1 is more highly expressed in males than in females. Null mice showed inhibited hepatocyte transporter functions and an altered urinary metabolome. | Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles.
Gong L, Aranibar N, Han YH, Zhang Y, Lecureux L, Bhaskaran V, Khandelwal P, Klaassen CD, Lehman-McKeeman LD. | 12/24/2011 |
| Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. | Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs.
van de Steeg E, Wagenaar E, van der Kruijssen CM, Burggraaff JE, de Waart DR, Elferink RP, Kenworthy KE, Schinkel AH., Free PMC Article | 09/6/2010 |
| Report critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp1a1 uptake transporter in mouse liver. | Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.
Cheng X, Klaassen CD., Free PMC Article | 01/21/2010 |
| organic anion transporting polypeptide-1 (Oatp1) were down-regulated by taurocholate and not affected by cholestyramine feeding | Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo in mice.
Wolters H, Elzinga BM, Baller JF, Boverhof R, Schwarz M, Stieger B, Verkade HJ, Kuipers F. | 01/21/2010 |
| In conclusion, gender-divergent Oatp expression in liver is caused by male-pattern GH secretion pattern and androgens. In kidney, gender-divergent Oatp1a1 expression is exclusively caused by stimulation by androgens. | Endocrine regulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression.
Cheng X, Maher J, Lu H, Klaassen CD. | 01/21/2010 |