| Expression of Oatp2 in the Brain and Liver of Alzheimer Disease Mouse Model. | Expression of Oatp2 in the Brain and Liver of Alzheimer Disease Mouse Model.
Wen J, Zhao M, Liu L. | 03/6/2021 |
| This finding is consistent with the metabolism of regorafenib occurring via two competing pathways, and the lack of Oatp1b2 results in decreased clearance of Regorafenib. | Interaction Between Sex and Organic Anion-Transporting Polypeptide 1b2 on the Pharmacokinetics of Regorafenib and Its Metabolites Regorafenib-N-Oxide and Regorafenib-Glucuronide in Mice.
Fu Q, Chen M, Anderson JT, Sun X, Hu S, Sparreboom A, Baker SD., Free PMC Article | 08/1/2020 |
| Experiments testing the cellular uptake of androgens suggest that testosterone is an excellent substrate of OATP1B3 and cells expressing a doxycycline-inducible SLCO1B3 construct had greater uptake of a clinically relevant concentration of 3H-testosterone . When compared with Slco1b2 (-/-) mice, Slco1b2 (-/-)/hSLCO1B3 knockins had greater greater hepatic uptakeand lower plasma exposure to 3H-testosterone | Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx.
Sissung TM, Ley AM, Strope JD, McCrea EM, Beedie S, Peer CJ, Shukla S, van Velkinburgh J, Reece K, Troutman S, Campbell T, Fernandez E, Huang P, Smith J, Thakkar N, Venzon DJ, Brenner S, Lee W, Merino M, Luo J, Jager W, Price DK, Chau CH, Figg WD., Free PMC Article | 04/21/2018 |
| important roles for OATP1A/1B in transporter-mediated uptake and disposition of doxorubicin, are reported. | Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.
Lee HH, Leake BF, Kim RB, Ho RH., Free PMC Article | 05/13/2017 |
| Protection against phalloidin hepatotoxicity by oleanolic acid involves activation of Nrf2 and suppression of Oatp1b2. | Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2.
Lu YF, Liu J, Wu KC, Klaassen CD., Free PMC Article | 02/18/2017 |
| the combination of NASH-associated decrease in compensatory Oatp transporters and Oatp1b2 genetic loss caused a synergistic increase in pravastatin plasma and tissue concentrations in kidney and muscle | Synergistic interaction between genetics and disease on pravastatin disposition.
Clarke JD, Hardwick RN, Lake AD, Lickteig AJ, Goedken MJ, Klaassen CD, Cherrington NJ., Free PMC Article | 05/16/2015 |
| Data indicate that organic anion-transporting polypeptides Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces) enzymes, which caused higher conversion of irinotecan to SN-38 in plasma, potentially complicating pharmacokinetic analyses. | OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.
Iusuf D, Ludwig M, Elbatsh A, van Esch A, van de Steeg E, Wagenaar E, van der Valk M, Lin F, van Tellingen O, Schinkel AH. | 02/21/2015 |
| These findings showed that deficiency of Oatp1b transporters alters the absorption, distribution, and elimination of hydroxyurea. | Organic anion transporting polypeptide 1B transporters modulate hydroxyurea pharmacokinetics.
Walker AL, Lancaster CS, Finkelstein D, Ware RE, Sparreboom A., Free PMC Article | 02/15/2014 |
| Oatp1c1 deficiency has an effect on thyroid hormone metabolism and action in the mouse brain | Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain.
Mayerl S, Visser TJ, Darras VM, Horn S, Heuer H. | 04/21/2012 |
| This study indicates that Oatp1b2 has a major role in the hepatic uptake of unconjugated bile acids. | Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice.
Csanaky IL, Lu H, Zhang Y, Ogura K, Choudhuri S, Klaassen CD., Free PMC Article | 03/5/2011 |
| Cloning of the full coding region of oatp1b2 revealed the presence of two novel splice variants. Interestingly, these splice variants were significantly expressed in organs such as the kidney, but much less in liver. | Identification, expression, and functional characterization of full-length and splice variants of murine organic anion transporting polypeptide 1b2.
Meyer Zu Schwabedissen HE, Ware JA, Tirona RG, Kim RB. | 03/1/2010 |
| In the liver, histone H3 in the proximal promoter of Oatp1b2 is hyperacetylated, whereas acetylation in the kidney and the cerebrum is minimal. | Analysis of DNA methylation and histone modification profiles of liver-specific transporters.
Imai S, Kikuchi R, Kusuhara H, Yagi S, Shiota K, Sugiyama Y. | 01/21/2010 |
| Report critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp1b2 uptake transporter in mouse liver. | Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.
Cheng X, Klaassen CD., Free PMC Article | 01/21/2010 |
| Review summarizes the evidence for the important role of mouse liver-specific organic anion transporting polypeptide Oatpb2 in drug deposition and hepatotoxicity. | Role of the murine organic anion-transporting polypeptide 1b2 (Oatp1b2) in drug disposition and hepatotoxicity.
Evers R, Chu XY. | 01/21/2010 |