| Polymorphisms in TIE2 and ANGPT-1 genes are associated with protection against diabetic retinopathy in a Brazilian population. | Polymorphisms in TIE2 and ANGPT-1 genes are associated with protection against diabetic retinopathy in a Brazilian population.
Dieter C, Lemos NE, de Faria Corrêa NR, Assmann TS, Pellenz FM, Canani LH, de Almeida Brondani L, Bauer AC, Crispim D., Free PMC Article | 06/3/2023 |
| Increased Angiopoietin-1 and -2 levels in human vitreous are associated with proliferative diabetic retinopathy. | Increased Angiopoietin-1 and -2 levels in human vitreous are associated with proliferative diabetic retinopathy.
Tsai T, Alwees M, Asaad MA, Theile J, Kakkassery V, Dick HB, Schultz T, Joachim SC., Free PMC Article | 02/4/2023 |
| Intracellular angiopoietin-1 promotes TKI-resistance via activation of JAK/STAT5 pathway in chronic myeloid leukemia. | Intracellular angiopoietin-1 promotes TKI-resistance via activation of JAK/STAT5 pathway in chronic myeloid leukemia.
Ma D, Liu P, Hu C, Zhou Z, Wang P, Wang Y, Zhang Y, Ran Y, Li P, Zhao J, Wang J, Zhang C, Tang L. | 01/14/2023 |
| Prognostic value of tumour tissue ANG-1 expression and Ang-1 concentration in patients with non-small-cell lung cancer. | Prognostic value of tumour tissue ANG-1 expression and Ang-1 concentration in patients with non-small-cell lung cancer.
Zalewska-Ziob M, Adamek B, Kasperczyk J, Dobija-Kubica K. | 07/23/2022 |
| Preliminary observations on ANGPT1 and ANGPT2 polymorphisms in systemic sclerosis: ANGPT2 rs2442598 and rs3739390 are associated with disease susceptibility and diffuse disease subtype. | Preliminary observations on ANGPT1 and ANGPT2 polymorphisms in systemic sclerosis: ANGPT2 rs2442598 and rs3739390 are associated with disease susceptibility and diffuse disease subtype.
Michalska-Jakubus M, Rusek M, Kowal M, Krasowska D. | 03/12/2022 |
| Effect of HIV-1 Infection on Angiopoietin 1 and 2 Levels and Measures of Microvascular and Macrovascular Endothelial Dysfunction. | Effect of HIV-1 Infection on Angiopoietin 1 and 2 Levels and Measures of Microvascular and Macrovascular Endothelial Dysfunction.
Thakkar AB, Ma Y, Dela Cruz M, Wu Y, Arechiga V, Swaminathan S, Ganz P, Wu AHB, Scherzer R, Deeks S, Hsue PY., Free PMC Article | 03/5/2022 |
| Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension. | Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension.
Enomoto N, Suzuki S, Hozumi H, Karayama M, Suzuki Y, Furuhashi K, Fujisawa T, Nakamura Y, Odagiri K, Ishikawa T, Kataoka K, Kondoh Y, Maekawa M, Inui N, Watanabe H, Suda T., Free PMC Article | 12/18/2021 |
| Serum Angiopoietin-1 and -2 and VEGF are associated with severe disease in vivax malaria. | Serum Angiopoietin-1 and -2 and VEGF are associated with severe disease in vivax malaria.
Gowda SH, Anghan H, Mishra H, Chosdol K, Bhatt M, Kumar V, Ranjan P, Aggarwal P, Wig N, Soneja M. | 12/18/2021 |
| Intrinsic differences in the mechanisms of Tie2 binding to angiopoietins exploited by directed evolution to create an Ang2-selective ligand trap. | Intrinsic differences in the mechanisms of Tie2 binding to angiopoietins exploited by directed evolution to create an Ang2-selective ligand trap.
Bate N, Lodge J, Brindle NPJ., Free PMC Article | 12/4/2021 |
| Macrophages enhance lipopolysaccharide induced apoptosis via Ang1 and NF-kappaB pathways in human umbilical vein endothelial cells. | Macrophages enhance lipopolysaccharide induced apoptosis via Ang1 and NF-κB pathways in human umbilical vein endothelial cells.
Cai GL, Yang ZX, Guo DY, Hu CB, Yan ML, Yan J., Free PMC Article | 11/22/2021 |
| Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes. | Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes.
Bhatraju PK, Cohen M, Nagao RJ, Morrell ED, Kosamo S, Chai XY, Nance R, Dmyterko V, Delaney J, Christie JD, Liu KD, Mikacenic C, Gharib SA, Liles WC, Zheng Y, Christiani DC, Himmelfarb J, Wurfel MM., Free PMC Article | 10/16/2021 |
| The ratio of plasma angiopoietin-2 to angiopoietin-1 as a prognostic biomarker in patients with sepsis. | The ratio of plasma angiopoietin-2 to angiopoietin-1 as a prognostic biomarker in patients with sepsis.
Seol CH, Yong SH, Shin JH, Lee SH, Leem AY, Park MS, Kim YS, Chung KS. | 10/9/2021 |
| Prognostic role of plasma level of angiopoietin-1, angiopoietin-2, and vascular endothelial growth factor in hepatocellular carcinoma. | Prognostic role of plasma level of angiopoietin-1, angiopoietin-2, and vascular endothelial growth factor in hepatocellular carcinoma.
Choi GH, Jang ES, Kim JW, Jeong SH., Free PMC Article | 09/18/2021 |
| Angiopoietin-1 is associated with a decreased risk of lymph node metastasis in early stage cervical cancer. | Angiopoietin-1 is associated with a decreased risk of lymph node metastasis in early stage cervical cancer.
Cai E, Yang D, Zhang Y, Cai J, Sun S, Yang P, Huang Y, Han Q, Xiong Z, Wang S. | 08/14/2021 |
| Localization of angiotensin-(1-7) and Mas receptor in the rat ovary throughout the estrous cycle. | Localization of angiotensin-(1-7) and Mas receptor in the rat ovary throughout the estrous cycle.
Pereira VM, Reis FM, Cassali GD, Santos SHS, Casalechi M, Santos RAS, Reis AM. | 07/10/2021 |
| Activated hepatic stellate cells promote angiogenesis in hepatocellular carcinoma by secreting angiopoietin-1. | Activated hepatic stellate cells promote angiogenesis in hepatocellular carcinoma by secreting angiopoietin-1.
Lin N, Meng L, Lin J, Chen S, Zhang P, Chen Q, Lin Y. | 05/15/2021 |
| Gene expression in the Angiopoietin/TIE axis is altered in peripheral tissue of ovarian cancer patients: A prospective observational study. | Gene expression in the Angiopoietin/TIE axis is altered in peripheral tissue of ovarian cancer patients: A prospective observational study.
Kinnen A, Klaschik S, Neumann C, Egger EK, Mustea A, Soehle M, Frede S, Velten M, Coburn M, Hilbert T. | 04/17/2021 |
| Association of Angiopoietin Dysregulation in Placental Malaria with Adverse Birth Outcomes. | Association of Angiopoietin Dysregulation in Placental Malaria with Adverse Birth Outcomes.
Singh PP, Bhandari S, Sharma RK, Singh N, Bharti PK., Free PMC Article | 04/3/2021 |
| Tie2 kinase inhibitor exhibited specificity to inhibit Ang-1-, but not Ang-2-, induced HUVEC migration. Overall, these findings suggest that the pro-angiogenic activities of CMC EVs are principally mediated by Ang-1-Tie2 signaling. | Pro-Angiogenic Actions of CMC-Derived Extracellular Vesicles Rely on Selective Packaging of Angiopoietin 1 and 2, but Not FGF-2 and VEGF.
Wysoczynski M, Pathan A, Moore JB 4th, Farid T, Kim J, Nasr M, Kang Y, Li H, Bolli R., Free PMC Article | 07/25/2020 |
| The Ang1 induced the dissociation of the tyrosine phosphatase SHP-1 from the Tie2 receptor and increased the binding of SHP-1 to JAK1, JAK2, and STAT3, which are IL-6 downstream signaling proteins. | Angiopoietin 1 attenuates interleukin-6-induced endothelial cell permeability through SHP-1.
Yun JH, Han MH, Jeong HS, Lee DH, Cho CH. | 06/27/2020 |
| Serum calprotectin and Ang-1 levels were higher, while serum Ang-2 levels were lower in the poor coronary collateral circulation (CCC) group with stable coronary artery disease. | Relationship of serum calprotectin, angiopoietin‑1, and angiopoietin‑2 levels with coronary collateral circulation in patients with stable coronary artery disease.
Demir V, Ede H, Ercan M, Turan Y, Hidayet S, Inandiklioglu N, Erbay AR. | 06/20/2020 |
| Serum levels of Ang1, Ang2 and VEGF are differentially expressed in systemic sclerosis and altered Ang1/Ang2 profile might underlay the aberrant angiogenesis in SSc despite increase in VEGF. | Imbalanced serum levels of Ang1, Ang2 and VEGF in systemic sclerosis: Integrated effects on microvascular reactivity.
Michalska-Jakubus M, Cutolo M, Smith V, Krasowska D. | 05/9/2020 |
| only rs11121615 (CASZ1)reached a nominal significance level of P < .05. Results of original GWAS and replication studies were combined by a meta-analysis, and polymorphisms listed above as well as rs111434909 (ANGPT1) and rs4463578 passed a genome-wide significant threshold. | Polymorphisms of genes involved in inflammation and blood vessel development influence the risk of varicose veins.
Shadrina A, Tsepilov Y, Smetanina M, Voronina E, Seliverstov E, Ilyukhin E, Kirienko A, Zolotukhin I, Filipenko M. | 11/16/2019 |
| These findings suggest that miR-153 suppresses the activity of tumor cells and the migration and tube formation of endothelial cells by silencing ANG1. | miR-153 inhibits the migration and the tube formation of endothelial cells by blocking the paracrine of angiopoietin 1 in breast cancer cells.
Liang H, Ge F, Xu Y, Xiao J, Zhou Z, Liu R, Chen C., Free PMC Article | 10/26/2019 |
| ANGPT1 impairment is associated with angioedema, and ANGPT1 variants can be the basis of Hereditary angioedema. | Mutation of the angiopoietin-1 gene (ANGPT1) associates with a new type of hereditary angioedema.
Bafunno V, Firinu D, D'Apolito M, Cordisco G, Loffredo S, Leccese A, Bova M, Barca MP, Santacroce R, Cicardi M, Del Giacco S, Margaglione M. | 07/20/2019 |