| The Role of G Protein-Coupled Receptor Kinase 6 Regulation in Inflammation and Pain. | The Role of G Protein-Coupled Receptor Kinase 6 Regulation in Inflammation and Pain.
Stegen M, Frey UH., Free PMC Article | 01/11/2023 |
| M2 macrophages-derived exosomal miR-3917 promotes the progression of lung cancer via targeting GRK6. | M2 macrophages-derived exosomal miR-3917 promotes the progression of lung cancer via targeting GRK6.
Song S, Zhao Y, Wang X, Tong X, Chen X, Xiong Q. | 12/10/2022 |
| Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport. | Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport.
Vistrup-Parry M, Sneddon WB, Bach S, Strømgaard K, Friedman PA, Mamonova T., Free PMC Article | 08/28/2021 |
| Characterization of the G protein-coupled receptor kinase 6 promoter reveals a functional CREB binding site. | Characterization of the G protein-coupled receptor kinase 6 promoter reveals a functional CREB binding site.
Stegen M, Engler A, Ochsenfarth C, Manthey I, Peters J, Siffert W, Frey UH., Free PMC Article | 08/28/2021 |
| GRK6 S-nitrosylation at cys 474 enhances its kinase activity toward alpha-syn phosphorylation at S129. | S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease.
Wu W, Sung CC, Yu P, Li J, Chung KKK., Free PMC Article | 07/25/2020 |
| MiR-19b-3p attenuates IL-1beta induced extracellular matrix degradation and inflammatory injury in chondrocytes by targeting GRK6. | MiR-19b-3p attenuates IL-1β induced extracellular matrix degradation and inflammatory injury in chondrocytes by targeting GRK6.
Duan L, Duan D, Wei W, Sun Z, Xu H, Guo L, Wu X. | 11/23/2019 |
| Hypermethylation of the GRK6 gene promoter suppressed binding of C/EBPalpha, thereby contributing to the promotion of cell migration and invasion. | Hypermethylation of the G protein-coupled receptor kinase 6 (GRK6) promoter inhibits binding of C/EBPα, and GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells.
Yao S, Wu D, Chen J, Wang P, Lv X, Huang J., Free PMC Article | 11/16/2019 |
| GRK6 overexpression can significantly enhance tumor proliferation and invasion, which was consistent with clinical findings. | Overexpression of G Protein-Coupled Receptor Kinase 6 (GRK6) Is Associated with Progression and Poor Prognosis of Papillary Thyroid Carcinoma.
Che X, Zhang G, Zhang X, Xue J., Free PMC Article | 10/6/2018 |
| demonstrate for the first time exosomal enrichment of G-protein-coupled receptor kinase (GRK) 5 and GRK6, both of which regulate Src and IGF-IR signaling and have been implicated in cancer. | c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes.
DeRita RM, Zerlanko B, Singh A, Lu H, Iozzo RV, Benovic JL, Languino LR., Free PMC Article | 11/4/2017 |
| Genetic variation in OXTR and GRK6 is associated with the amount of oxytocin required as well as the duration of labor and risk for cesarean delivery among women undergoing induction of labor near term. | The association of single-nucleotide polymorphisms in the oxytocin receptor and G protein-coupled receptor kinase 6 (GRK6) genes with oxytocin dosing requirements and labor outcomes.
Grotegut CA, Ngan E, Garrett ME, Miranda ML, Ashley-Koch AE, Swamy GK., Free PMC Article | 09/23/2017 |
| This work demonstrates the importance of GRK6 in regulation of hematopoietic stem cell self-renewal and reveals its potential role in participation of stress response. | GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal.
Le Q, Yao W, Chen Y, Yan B, Liu C, Yuan M, Zhou Y, Ma L., Free PMC Article | 09/2/2017 |
| Decreased expression of GRK6 may serve as an independent predictor of overall survival in lung adenocarcinoma. | Prognostic value of decreased GRK6 expression in lung adenocarcinoma.
Yao S, Zhong L, Liu J, Feng J, Bian T, Zhang Q, Chen J, Lv X, Chen J, Liu Y. | 02/18/2017 |
| The expression of GRK6 mRNA and protein was significantly lower in hypopharyngeal squamous cell carcinoma than in corresponding adjacent non-tumor tissues. This was associated with aberrant methylation of the gene. | Aberrant GRK6 promoter methylation is associated with poor prognosis in hypopharyngeal squamous cell carcinoma.
Qiu X, Chen J, Zhang Z, You Y, Wang Z. | 10/22/2016 |
| Our results imply that GRK6 may not play a role in the pathophysiology of schizophrenia among Han Chinese | Association study of common variants within the G protein-coupled receptor kinase 6 gene and schizophrenia susceptibility in Han Chinese.
Tang W, Cai J, Yi Z, Zhang Y, Lu W, Zhang C. | 09/20/2014 |
| these results indicate that GRK6 complexes with AGS3-Galphai2 to regulate CXCR2-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane. | G Protein-coupled receptor kinase-6 interacts with activator of G protein signaling-3 to regulate CXCR2-mediated cellular functions.
Singh V, Raghuwanshi SK, Smith N, Rivers EJ, Richardson RM., Free PMC Article | 04/19/2014 |
| GRK6 plays a predominant role in phosphorylation of FFA receptor (FFA)4. | Mechanisms of homologous and heterologous phosphorylation of FFA receptor 4 (GPR120): GRK6 and PKC mediate phosphorylation of Thr³⁴⁷, Ser³⁵⁰, and Ser³⁵⁷ in the C-terminal tail.
Burns RN, Singh M, Senatorov IS, Moniri NH., Free PMC Article | 03/29/2014 |
| results suggested that GRK6 overexpression plays an important role in hepatocellular carcinoma | GRK6 expression in patients with hepatocellular carcinoma.
Li YP. | 08/10/2013 |
| Downregulation of GRK6 expression enhances CXCR4 signaling and promoted medulloblastoma cell migration. | Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration.
Yuan L, Zhang H, Liu J, Rubin JB, Cho YJ, Shu HK, Schniederjan M, MacDonald TJ., Free PMC Article | 06/22/2013 |
| A reduced cortical concentration of GRK6 in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia. | Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.
Bychkov ER, Ahmed MR, Gurevich VV, Benovic JL, Gurevich EV., Free PMC Article | 06/16/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesAssociation study of 182 candidate genes in anorexia nervosa.
Pinheiro AP, Bulik CM, Thornton LM, Sullivan PF, Root TL, Bloss CS, Berrettini WH, Schork NJ, Kaye WH, Bergen AW, Magistretti P, Brandt H, Crawford S, Crow S, Fichter MM, Goldman D, Halmi KA, Johnson C, Kaplan AS, Keel PK, Klump KL, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Yokoyama K, Urashima M, Ohkido I, Kono T, Yoshida T, Muramatsu M, Niu T, Hosoya T. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 06/30/2010 |
| inhibition of GRK6 represents a uniquely targeted novel therapeutic strategy in human multiple myeloma. | Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6.
Tiedemann RE, Zhu YX, Schmidt J, Yin H, Shi CX, Que Q, Basu G, Azorsa D, Perkins LM, Braggio E, Fonseca R, Bergsagel PL, Mousses S, Stewart AK., Free PMC Article | 03/29/2010 |
| A number of double mutations of GRK6 kinase within helices 3, 9, and 10 reduced phosphorylation of the beta2 adrenergic receptor and rhodopsin compared to wild-type GRK6 kinase. | Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation.
Baameur F, Morgan DH, Yao H, Tran TM, Hammitt RA, Sabui S, McMurray JS, Lichtarge O, Clark RB., Free PMC Article | 03/22/2010 |
| Recruitment of beta-Arrestin 2, but not beta-Arrestin 1, to the active WHIM-mutant receptor is delayed compared to the WT CXCR4 receptor and Grk6 fails to associate with the WHIM-mutant receptor. | Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor.
McCormick PJ, Segarra M, Gasperini P, Gulino AV, Tosato G., Free PMC Article | 03/22/2010 |
| Results identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 during Wnt signaling. | G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.
Chen M, Philipp M, Wang J, Premont RT, Garrison TR, Caron MG, Lefkowitz RJ, Chen W., Free PMC Article | 02/8/2010 |