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    GPT glutamic--pyruvic transaminase [ Homo sapiens (human) ]

    Gene ID: 2875, updated on 10-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Role of alanine aminotransferase in the effects of urinary caffeine concentration and its primary metabolite concentration on cognitive function in older adults: Bayesian Kernel Machine regression analysis and mediation analysis.

    Role of alanine aminotransferase in the effects of urinary caffeine concentration and its primary metabolite concentration on cognitive function in older adults: Bayesian Kernel Machine regression analysis and mediation analysis.
    Qin YJ, Wang ZG, Gong JH, Gong JP, Li JH.

    03/7/2024
    Sex Differences in the Association Between AST/ALT and Incidence of Type 2 Diabetes in Japanese Patients with Nonalcoholic Fatty Liver Disease: A Retrospective Cohort Study.

    Sex Differences in the Association Between AST/ALT and Incidence of Type 2 Diabetes in Japanese Patients with Nonalcoholic Fatty Liver Disease: A Retrospective Cohort Study.
    Zhang C, Xu Q, Xu C, Yang K, Xia T, Hasi W, Hao M, Kuang H.

    01/11/2024
    The correlation between serum total bile acid and alanine aminotransferase of pregnant women and the disorders of neonatal hyperbilirubinemia-related amino acid metabolism.

    The correlation between serum total bile acid and alanine aminotransferase of pregnant women and the disorders of neonatal hyperbilirubinemia-related amino acid metabolism.
    Fan X, Rong H, Wang Y, Li M, Song W, Su A, Yu T., Free PMC Article

    01/10/2024
    Alanine aminotransferase to high- density lipoprotein cholesterol ratio is positively correlated with the occurrence of diabetes in the Chinese population: a population-based cohort study.

    Alanine aminotransferase to high- density lipoprotein cholesterol ratio is positively correlated with the occurrence of diabetes in the Chinese population: a population-based cohort study.
    He S, Yu C, Kuang M, Qiu J, Yang R, Zhang S, Sheng G, Zou Y., Free PMC Article

    12/20/2023
    Prevalence and metabolic determinants of abnormal alanine aminotransferase: A cross-sectional study of Iranian adults, 2018-2022.

    Prevalence and metabolic determinants of abnormal alanine aminotransferase: A cross-sectional study of Iranian adults, 2018-2022.
    Asgari S, Molavizadeh D, Tohidi M, Momenan AA, Azizi F, Hadaegh F., Free PMC Article

    08/19/2023
    Genetic and Environmental Influences on Serum Alanine Aminotransferase Level: A Chinese Twin Study.

    Genetic and Environmental Influences on Serum Alanine Aminotransferase Level: A Chinese Twin Study.
    Li J, Kang X, Zhang T, Wang W, Xu C, Duan H, Tian X, Zhang D.

    07/24/2023
    Fasting plasma glucose and alanine aminotransferase on the risk of hepatocellular carcinoma: A nested case-control study.

    Fasting plasma glucose and alanine aminotransferase on the risk of hepatocellular carcinoma: A nested case-control study.
    Zhang L, Wang Z, Chen R, Cheng Z, Yang J, Li J, Li S, Chen Y, Xu L, Hu Y, Bai Y.

    05/19/2023
    Identification of alanine aminotransferase 1 interaction network via iTRAQ-based proteomics in alternating migration, invasion, proliferation and apoptosis of HepG2 cells.

    Identification of alanine aminotransferase 1 interaction network via iTRAQ-based proteomics in alternating migration, invasion, proliferation and apoptosis of HepG2 cells.
    Fu X, Zhang W, Li S, Ling N, Yang Y, Dazhi Z., Free PMC Article

    10/1/2022
    Aspartate aminotransferase to alanine aminotransferase ratio and the risk of diabetic nephropathy progression in patients with type 2 diabetes mellitus: A biopsy-based study.

    Aspartate aminotransferase to alanine aminotransferase ratio and the risk of diabetic nephropathy progression in patients with type 2 diabetes mellitus: A biopsy-based study.
    Wu Y, Liu F.

    08/13/2022
    Nonalcoholic fatty liver disease is a risk factor for glucose intolerance onset in men regardless of alanine aminotransferase status.

    Nonalcoholic fatty liver disease is a risk factor for glucose intolerance onset in men regardless of alanine aminotransferase status.
    Miyake T, Matsuura B, Furukawa S, Yoshida O, Hirooka M, Kumagi T, Ishihara T, Kanzaki S, Nakaguchi H, Miyazaki M, Nakamura Y, Yamamoto Y, Koizumi Y, Tokumoto Y, Takeshita E, Ikeda Y, Abe M, Kitai K, Hiasa Y., Free PMC Article

    02/5/2022
    Bi-directional and temporal relationship between elevated alanine aminotransferase and hypertension in a longitudinal study of Chinese adults.

    Bi-directional and temporal relationship between elevated alanine aminotransferase and hypertension in a longitudinal study of Chinese adults.
    Huang G, Zhou H, Shen C, Sheng Y, Xue R, Dong C, Zhang S.

    12/18/2021
    Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure.

    Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure.
    Maeda D, Kagiyama N, Jujo K, Saito K, Kamiya K, Saito H, Ogasahara Y, Maekawa E, Konishi M, Kitai T, Iwata K, Wada H, Hiki M, Dotare T, Sunayama T, Kasai T, Nagamatsu H, Ozawa T, Izawa K, Yamamoto S, Aizawa N, Yonezawa R, Oka K, Momomura SI, Matsue Y., Free PMC Article

    11/13/2021
    Eating Fast and Until Full Is Associated with Elevated Alanine Aminotransferase Activity in Japanese Schoolchildren: A Cross-Sectional Study.

    Eating Fast and Until Full Is Associated with Elevated Alanine Aminotransferase Activity in Japanese Schoolchildren: A Cross-Sectional Study.
    Minoura A, Ochiai H, Shirasawa T, Nishimura R, Yoshida R, Azuma M, Hoshino H, Kokaze A.

    11/6/2021
    Clinical implications of aminotransferase elevation in hospitalised infants aged 8-90 days with respiratory virus detection.

    Clinical implications of aminotransferase elevation in hospitalised infants aged 8-90 days with respiratory virus detection.
    Kim SG, Oh YN, Lee JK., Free PMC Article

    08/21/2021
    GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms.

    GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms.
    Ward LD, Tu HC, Quenneville CB, Tsour S, Flynn-Carroll AO, Parker MM, Deaton AM, Haslett PAJ, Lotta LA, Verweij N, Ferreira MAR, Regeneron Genetics Center, Geisinger-Regeneron DiscovEHR Collaboration, Baras A, Hinkle G, Nioi P., Free PMC Article

    08/7/2021
    Association of Alanine Aminotransferase With Different Metabolic Phenotypes of Obesity in Children and Adolescents: The CASPIAN-V Study.

    Association of Alanine Aminotransferase With Different Metabolic Phenotypes of Obesity in Children and Adolescents: The CASPIAN-V Study.
    Kelishadi R, Hemati Z, Qorbani M, Motlagh ME, Djalalinia S, Ahadi Z, Shafiee G, Mahdavi Gorabi A, Rastad H, Ziaodini H, Daniali SS, Heshmat R., Free PMC Article

    05/22/2021
    Combined and sequential non-invasive approach to diagnosing non-alcoholic steatohepatitis in patients with non-alcoholic fatty liver disease and persistently normal alanine aminotransferase levels.

    Combined and sequential non-invasive approach to diagnosing non-alcoholic steatohepatitis in patients with non-alcoholic fatty liver disease and persistently normal alanine aminotransferase levels.
    Zheng KI, Liu WY, Pan XY, Ma HL, Zhu PW, Wu XX, Targher G, Byrne C, Wang XD, Chen YP, Lu F, Zheng MH., Free PMC Article

    10/31/2020
    Association between serum liver enzymes and all-cause mortality: The Japan Public Health Center-based Prospective Study.

    Association between serum liver enzymes and all-cause mortality: The Japan Public Health Center-based Prospective Study.
    Yuwaki K, Shimazu T, Yamagiwa Y, Inoue M, Goto A, Yamaji T, Iwasaki M, Sawada N, Tsugane S, JPHC Study Group.

    09/19/2020
    Preoperative elevated serum AST/ALT may be a potential independent predictor of postoperative acute kidney injury in hepatocellular carcinoma patients who have undergone hepatectomy

    A retrospective pilot study to examine the potential of aspartate aminotransferase to alanine aminotransferase ratio as a predictor of postoperative acute kidney injury in patients with hepatocellular carcinoma.
    Xu J, Xia Y, Li S, Cheng X, Hu S, Gao Y, Zhou X, Wang G, Zheng Q.

    01/11/2020
    Lowering the current upper limit of normal of serum alanine aminotransferase may help to identify elderly patients at risk of significant liver disease.

    Lowering the upper limit of serum alanine aminotransferase levels may reveal significant liver disease in the elderly.
    Schmilovitz-Weiss H, Gingold-Belfer R, Grossman A, Issa N, Boltin D, Beloosesky Y, Morag Koren N, Meyerovitch J, Weiss A., Free PMC Article

    12/21/2019
    effect of alanine transaminase on the incidence of type 2 diabetes mellitus

    Independent effect of alanine transaminase on the incidence of type 2 diabetes mellitus, stratified by age and gender: A secondary analysis based on a large cohort study in China.
    Gao F, Huang XL, Jiang XP, Xue M, Li YL, Lin XR, Chen YH, Huang ZM.

    12/7/2019
    High Alanine Transaminase expression is associated with type 2 diabetes mellitus.

    Association of gamma-glutamyl transferase and alanine aminotransferase with type 2 diabetes mellitus incidence in middle-aged Japanese men: 12-year follow up.
    Kaneko K, Yatsuya H, Li Y, Uemura M, Chiang C, Hirakawa Y, Ota A, Tamakoshi K, Aoyama A., Free PMC Article

    10/5/2019
    Elevated serum GPT (alanine aminotransferase) levels are positively and independently associated with T2DM in large scale study of rural Chinese population over 35 years old.

    Relationship between alanine aminotransferase levels and type 2 diabetes mellitus in the general Chinese population.
    Liu A, Chen S, Guo X, Li Z, Zheng L, Sun Y.

    09/14/2019
    A significant joint association of serum uric acid and serum ALT with non-alcoholic fatty liver disease prevalence was observed in all participants, which was slightly stronger in men than in women.

    Joint associations of serum uric acid and ALT with NAFLD in elderly men and women: a Chinese cross-sectional study.
    Yang H, Li D, Song X, Liu F, Wang X, Ma Q, Zhang X, Li X., Free PMC Article

    06/22/2019
    a relationship between NAFLD with high ALT and lower BMD in the general U.S. population

    Nonalcoholic fatty liver disease with elevated alanine aminotransferase levels is negatively associated with bone mineral density: Cross-sectional study in U.S. adults.
    Umehara T., Free PMC Article

    12/22/2018
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