| GRB7 plays a promoting role in the progression of gastric cancer. | GRB7 plays a promoting role in the progression of gastric cancer.
Zhu G, Cai H, Xiao Q, Zeng S, Jiang X, Liu D., Free PMC Article | 01/3/2024 |
| Knockdown of growth factor receptor bound protein 7 suppresses angiogenesis by inhibiting the secretion of vascular endothelial growth factor A in ovarian cancer cells. | Knockdown of growth factor receptor bound protein 7 suppresses angiogenesis by inhibiting the secretion of vascular endothelial growth factor A in ovarian cancer cells.
Xu Q, Liu Z, Zhu ZQ, Fan Y, Chen R, Xie XH, Cheng M., Free PMC Article | 02/19/2022 |
| Upregulated GRB7 promotes proliferation and tumorigenesis of Bladder Cancer via Phospho-AKT Pathway. | Upregulated GRB7 promotes proliferation and tumorigenesis of Bladder Cancer via Phospho-AKT Pathway.
Zheng Y, Pei Y, Yang L, Zeng Z, Wang J, Xie G, Wang L, Yuan J., Free PMC Article | 11/13/2021 |
| Growth factor receptor bound protein-7 regulates proliferation, cell cycle, and mitochondrial apoptosis of thyroid cancer cells via MAPK/ERK signaling. | Growth factor receptor bound protein-7 regulates proliferation, cell cycle, and mitochondrial apoptosis of thyroid cancer cells via MAPK/ERK signaling.
Tang H, Yang P, Yang X, Peng S, Hu X, Bao G. | 03/20/2021 |
| GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma. | GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma.
Gotovac JR, Liu DS, Yates MJ, Milne JV, Macpherson AA, Simpson KJ, Eslick GD, Mitchell C, Duong CP, Phillips WA, Clemons NJ., Free PMC Article | 12/19/2020 |
| In vitro phosphorylation of the Grb7SH2 domain indicates only one of the available tyrosine residues is phosphorylated, suggesting the same phosphorylation pattern could be relevant in the full length protein. | Characterization of the full-length human Grb7 protein and a phosphorylation representative mutant.
Bradford AM, Koirala R, Park CK, Lyons BA. | 06/20/2020 |
| this is a review about the molecular, functional, and clinical aspects of Grb7 in erythroblastic leukemia viral oncogene homolog family-mediated cancer family-mediated cancer development and malignancy with the aim to reveal alternative and effective therapeutic strategies.[review] | Grb7, a Critical Mediator of EGFR/ErbB Signaling, in Cancer Development and as a Potential Therapeutic Target.
Chu PY, Tai YL, Shen TL., Free PMC Article | 01/11/2020 |
| It was identified that silencing of miR193a3p through hypermethylation can promote HER2 positive breast cancer progress by targeting GRB7, ERK1/2 and FOXM1 signaling. | Epigenetically altered miR‑193a‑3p promotes HER2 positive breast cancer aggressiveness by targeting GRB7.
Tang Y, Yang S, Wang M, Liu D, Liu Y, Zhang Y, Zhang Q., Free PMC Article | 08/24/2019 |
| MiR-193a-3p not only modulated GRB7 but also ERBB4. | Methylation-associated silencing of miR-193a-3p promotes ovarian cancer aggressiveness by targeting GRB7 and MAPK/ERK pathways.
Chen K, Liu MX, Mak CS, Yung MM, Leung TH, Xu D, Ngu SF, Chan KK, Yang H, Ngan HY, Chan DW., Free PMC Article | 12/22/2018 |
| Our results indicated that Grb7 over-expression may facilitate invasion and inhibit apoptosis in cervical cancer | Grb7 is over-expressed in cervical cancer and facilitate invasion and inhibit apoptosis in cervical cancer cells.
Zhao HB, Zhang XF, Jia XL, Wang HB. | 06/2/2018 |
| data shows that GRB7 expression in invasive breast cancer correlates with markers of a more aggressive phenotype, including HER2 overexpression, a greater degree of HER2 amplification, ER negativity, and p53 positivity | GRB7 Expression and Correlation With HER2 Amplification in Invasive Breast Carcinoma.
Bivin WW, Yergiyev O, Bunker ML, Silverman JF, Krishnamurti U. | 05/5/2018 |
| The crystal structure of a stapled bicyclic peptide inhibitor G7-B1 in complex with the Grb7-SH2 domain. | Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Gunzburg MJ, Kulkarni K, Watson GM, Ambaye ND, Del Borgo MP, Brandt R, Pero SC, Perlmutter P, Wilce MC, Wilce JA., Free PMC Article | 04/21/2018 |
| Grb7 protein Ras-associating domain oligomerization has been reported. | Grb7 protein RA domain oligomerization.
Godamudunage MP, Foster A, Warren D, Lyons BA., Free PMC Article | 04/7/2018 |
| Study provided a direct link between the signal adapter protein Grb7, anti-apoptotic protein Hax1 isoform 1, and Caspase3-mediated apoptosis pathways, and suggests that besides modulating cell migration and signal transduction, Grb7 may also participate in Hax1-related apoptosis pathways mediated by Caspase3. | Grb7 and Hax1 may colocalize partially to mitochondria in EGF-treated SKBR3 cells and their interaction can affect Caspase3 cleavage of Hax1.
Qian L, Bradford AM, Cooke PH, Lyons BA., Free PMC Article | 12/16/2017 |
| Suggest close relationship between Grb7 gene amplification and GRB7 protein overexpression in human ovarian cancer. Immunohistochemistry might have limited diagnostic value in these tumors compared to fluorescence in situ hybridization. | Grb7 gene amplification and protein expression by FISH and IHC in ovarian cancer.
Zeng M, Yang Z, Hu X, Liu Y, Yang X, Ran H, Li Y, Li X, Yu Q., Free PMC Article | 09/24/2016 |
| Grb7 was found to be significantly related to the biological classification of breast cancer | Validation of analytical breast cancer microarray analysis in medical laboratory.
Darweesh AS, Louka ML, Hana M, Rashad S, El-Shinawi M, Sharaf-Eldin A, Kassim SK. | 11/21/2015 |
| apo Grb7 SH2 domain crystallized in the trigonal space group P63, whereas the G7-B1-Grb7 SH2 domain complex crystallized in the monoclinic space group P21 | Preparation of crystals for characterizing the Grb7 SH2 domain before and after complex formation with a bicyclic peptide antagonist.
Ambaye ND, Gunzburg MJ, Traore DA, Del Borgo MP, Perlmutter P, Wilce MC, Wilce JA., Free PMC Article | 11/22/2014 |
| The data reveal that Grb7 plays an important role in breast cancer progression, beyond the context of HER2+ve cell types | Context-dependent role of Grb7 in HER2+ve and triple-negative breast cancer cell lines.
Lim RC, Price JT, Wilce JA. | 09/20/2014 |
| Grb7 protein interacts with Filamin-a, an actin-crosslinking component of the cell cytoskeleton. | Grb7 and Filamin-a associate and are colocalized to cell membrane ruffles upon EGF stimulation.
Paudyal P, Shrestha S, Madanayake T, Shuster CB, Rohrschneider LR, Rowland A, Lyons BA., Free PMC Article | 06/14/2014 |
| Data suggest that calmodulin controls Grb7-mediated cell migration. | Deletion of the calmodulin-binding domain of Grb7 impairs cell attachment to the extracellular matrix and migration.
García-Palmero I, Villalobo A. | 09/21/2013 |
| Data propose the phosphorylation state of Grb7-SH2 domain tyrosine residues could control Grb7 dimerization, and dimerization may be an important regulatory step in Grb7 binding to RTKs such as erbB2. | Dimerization in the Grb7 protein.
Peterson TA, Benallie RL, Bradford AM, Pias SC, Yazzie J, Lor SN, Haulsee ZM, Park CK, Johnson DL, Rohrschneider LR, Spuches A, Lyons BA., Free PMC Article | 12/8/2012 |
| GRB7 is a context-dependent oncogene, which modulates the ERBB2 signaling pathway through enhanced phosphorylation of ERBB2 and Akt. | Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene.
Saito M, Kato Y, Ito E, Fujimoto J, Ishikawa K, Doi A, Kumazawa K, Matsui A, Takebe S, Ishida T, Azuma S, Mochizuki H, Kawamura Y, Yanagisawa Y, Honma R, Imai J, Ohbayashi H, Goshima N, Semba K, Watanabe S. | 08/11/2012 |
| propose that CaM inhibits the translocation of Grb7 to the nucleus after binding to its CaM-BD and therefore occluding its overlapping NLS | Calmodulin regulates the translocation of Grb7 into the nucleus.
García-Palmero I, Villalobo A. | 07/21/2012 |
| A series of Grb7 SH2 domain-binding nonphosphorylated peptides in the yeast two-hybrid system, were identified. | Novel nonphosphorylated peptides with conserved sequences selectively bind to Grb7 SH2 domain with affinity comparable to its phosphorylated ligand.
Zhang D, Shao C, Hu S, Ma S, Gao Y., Free PMC Article | 06/2/2012 |
| GRB7 protein over-expression is an independent adverse prognostic factor in human breast cancer | GRB7 protein over-expression and clinical outcome in breast cancer.
Ramsey B, Bai T, Hanlon Newell A, Troxell M, Park B, Olson S, Keenan E, Luoh SW. | 11/26/2011 |