| Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication. | Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
Cho C, Ganser C, Uchihashi T, Kato K, Song JJ., Free PMC Article | 12/20/2023 |
| MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2. | MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2.
Sun T, Liu Z. | 09/12/2023 |
| ATAD2 Upregulation Promotes Tumor Growth and Angiogenesis in Endometrial Cancer and Is Associated with Its Immune Infiltration. | ATAD2 Upregulation Promotes Tumor Growth and Angiogenesis in Endometrial Cancer and Is Associated with Its Immune Infiltration.
Wang C, Yin Y, Sun Z, Wang Y, Li F, Wang Y, Zhang Z, Chen X., Free PMC Article | 12/17/2022 |
| Tumor-Promoting ATAD2 and Its Preclinical Challenges. | Tumor-Promoting ATAD2 and Its Preclinical Challenges.
Liu H, Wen Q, Yan S, Zeng W, Zou Y, Liu Q, Zhang G, Zou J, Zou X., Free PMC Article | 09/3/2022 |
| Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA + ATPase domain and bromodomain. | Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA + ATPase domain and bromodomain.
Nayak A, Kumar S, Singh SP, Bhattacharyya A, Dixit A, Roychowdhury A. | 07/16/2022 |
| Effect of chronic intermittent hypoxia-induced HIF-1alpha/ATAD2 expression on lung cancer stemness. | Effect of chronic intermittent hypoxia-induced HIF-1α/ATAD2 expression on lung cancer stemness.
Hao S, Li F, Jiang P, Gao J., Free PMC Article | 06/11/2022 |
| ATAD2 controls chromatin-bound HIRA turnover. | ATAD2 controls chromatin-bound HIRA turnover.
Wang T, Perazza D, Boussouar F, Cattaneo M, Bougdour A, Chuffart F, Barral S, Vargas A, Liakopoulou A, Puthier D, Bargier L, Morozumi Y, Jamshidikia M, Garcia-Saez I, Petosa C, Rousseaux S, Verdel A, Khochbin S., Free PMC Article | 03/26/2022 |
| ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors. | ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors.
Tong Y, Li J, Peng M, Qian Q, Shi W, Chen Z, Liu B. | 03/19/2022 |
| ATAD2 interacts with C/EBPbeta to promote esophageal squamous cell carcinoma metastasis via TGF-beta1/Smad3 signaling. | ATAD2 interacts with C/EBPβ to promote esophageal squamous cell carcinoma metastasis via TGF-β1/Smad3 signaling.
Cao LJ, Zhang YJ, Dong SQ, Li XZ, Tong XT, Chen D, Wu ZY, Zheng XH, Xue WQ, Jia WH, Zhang JB., Free PMC Article | 11/6/2021 |
| Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain. | Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain.
Evans CM, Phillips M, Malone KL, Tonelli M, Cornilescu G, Cornilescu C, Holton SJ, Gorjánácz M, Wang L, Carlson S, Gay JC, Nix JC, Demeler B, Markley JL, Glass KC., Free PMC Article | 10/16/2021 |
| MiR-200b-5p inhibits proliferation of ovarian cancer cells by targeting ATAD2 and regulating PI3K/AKT signaling pathway. | MiR-200b-5p inhibits proliferation of ovarian cancer cells by targeting ATAD2 and regulating PI3K/AKT signaling pathway.
Wang AQ, Lv M, Xu YH, Xie PM, Dong YY. | 07/3/2021 |
| Silence of ATAD2 inhibits proliferation of colorectal carcinoma via the Rb-E2F1 signaling. | Silence of ATAD2 inhibits proliferation of colorectal carcinoma via the Rb-E2F1 signaling.
Wang JH, Yu TT, Li Y, Hao YP, Han L, Xu KY, Xu P. | 04/24/2021 |
| Integrated Bioinformatics Analysis of the Clinical Value and Biological Function of ATAD2 in Hepatocellular Carcinoma. | Integrated Bioinformatics Analysis of the Clinical Value and Biological Function of ATAD2 in Hepatocellular Carcinoma.
Meng X, Wang L, Zhu B, Zhang J, Guo S, Li Q, Zhang T, Zheng Z, Wu G, Zhao Y., Free PMC Article | 03/13/2021 |
| MicroRNA-302 represses epithelial-mesenchymal transition and cisplatin resistance by regulating ATAD2 in ovarian carcinoma. | MicroRNA-302 represses epithelial-mesenchymal transition and cisplatin resistance by regulating ATAD2 in ovarian carcinoma.
Ge T, Liu T, Guo L, Chen Z, Lou G. | 03/13/2021 |
| Kinesin family member 15 promotes cancer stem cell phenotype and malignancy via reactive oxygen species imbalance in hepatocellular carcinoma. | Kinesin family member 15 promotes cancer stem cell phenotype and malignancy via reactive oxygen species imbalance in hepatocellular carcinoma.
Li Q, Qiu J, Yang H, Sun G, Hu Y, Zhu D, Deng Z, Wang X, Tang J, Jiang R. | 01/9/2021 |
| Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2. | Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2.
Zhou L, Yang C, Zhang N, Zhang X, Zhao T, Yu J. | 11/28/2020 |
| ATAD2 predicts poor outcomes in patients with ovarian cancer and is a marker of proliferation. | ATAD2 predicts poor outcomes in patients with ovarian cancer and is a marker of proliferation.
Liu Q, Liu H, Li L, Dong X, Ru X, Fan X, Wen T, Liu J., Free PMC Article | 10/24/2020 |
| HIF1alpha-dependent upregulation of ATAD2 promotes proliferation and migration of stomach cancer cells in response to hypoxia. | HIF1α-dependent upregulation of ATAD2 promotes proliferation and migration of stomach cancer cells in response to hypoxia.
Nayak A, Roy AD, Rout N, Singh SP, Bhattacharyya A, Roychowdhury A. | 09/26/2020 |
| Mutual Balance of Histone Deacetylases 1 and 2 and the Acetyl Reader ATAD2 Regulates the Level of Acetylation of Histone H4 on Nascent Chromatin of Human Cells. | Mutual Balance of Histone Deacetylases 1 and 2 and the Acetyl Reader ATAD2 Regulates the Level of Acetylation of Histone H4 on Nascent Chromatin of Human Cells.
Lazarchuk P, Hernandez-Villanueva J, Pavlova MN, Federation A, MacCoss M, Sidorova JM., Free PMC Article | 08/29/2020 |
| Data reported for the first time that the expression of ANCCA was highly induced by DNAdamaging chemotherapy agents such as carboplatin, doxorubicin and mitomycin C, as well as ionizing radiation. Its knockdown sensitizes triplenegative breast cancer cells to carboplatin. | Targeting bromodomain protein ANCCA/ATAD2 enhances the efficacy of DNA‑damaging chemotherapy agents and radiation.
Duan Z, Andrews NP, Chen CZ, Fan M, Wang J, Shen J, Li JJ, Chen HW. | 06/6/2020 |
| Overexpression of miR-186 attenuates retinoblastoma via the inactivation of the Hedgehog signaling pathway by downregulating ATAD2. | Overexpression of microRNA-186 inhibits angiogenesis in retinoblastoma via the Hedgehog signaling pathway by targeting ATAD2.
Wu S, Han M, Zhang C. | 06/6/2020 |
| Molecular dynamics simulations indicate that the formation of the disulfide bridge in the ATPase family, AAA domain-containing protein 2 (ATAD2) bromodomain does not alter the structure of the folded state or flexibility of the acetyllysine binding pocket. | Disulfide bridge formation influences ligand recognition by the ATAD2 bromodomain.
Gay JC, Eckenroth BE, Evans CM, Langini C, Carlson S, Lloyd JT, Caflisch A, Glass KC., Free PMC Article | 03/21/2020 |
| correlation between ATAD2 expression and glycometabolism in cancers | ATAD2 expression increases [18F]Fluorodeoxyglucose uptake value in lung adenocarcinoma via AKT-GLUT1/HK2 pathway.
Sun T, Du B, Diao Y, Li X, Chen S, Li Y., Free PMC Article | 02/8/2020 |
| Elevated PLK4 expression was observed in high grade glioblastoma (GBM) patients and was associated with poor prognosis. PLK4 expression was markedly elevated by the exogenous overexpression of ATAD2 in GBM cells. Results suggested that the ATAD2dependent transcriptional regulation of PLK4 promoted cell proliferation and tumorigenesis. | Polo‑like kinase 4 promotes tumorigenesis and induces resistance to radiotherapy in glioblastoma.
Wang J, Zuo J, Wang M, Ma X, Gao K, Bai X, Wang N, Xie W, Liu H., Free PMC Article | 07/6/2019 |
| The ATAD2 as a potential therapeutic target for angiogenesis in colorectal cancer. | ATAD2 silencing decreases VEGFA secretion through targeting has-miR-520a to inhibit angiogenesis in colorectal cancer.
Hong S, Chen S, Wang X, Sun D, Yan Z, Tai J, Bi M. | 03/30/2019 |