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    Canx calnexin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29144, updated on 9-Oct-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The authors demonstrate that the Genetic Absence Epilepsy Rat from Strasbourg (GAERS) missense mutation located in the Cav3.2 III-IV linker alters the Cav3.2/calnexin interaction, resulting in an increased surface expression of the channel and a concomitant elevation in calcium influx.

    The Cacna1h mutation in the GAERS model of absence epilepsy enhances T-type Ca<sup>2+</sup> currents by altering calnexin-dependent trafficking of Ca<sub>v</sub>3.2 channels.
    Proft J, Rzhepetskyy Y, Lazniewska J, Zhang FX, Cain SM, Snutch TP, Zamponi GW, Weiss N., Free PMC Article

    The mechanism underlying these effects may involve the direct binding of PPARgamma to the pre-miR-711 promoter for the upregulation of miR-711, which may induce ER stress-mediated cardiomyocyte apoptosis via calnexin.

    Enhanced MiR-711 transcription by PPARĪ³ induces endoplasmic reticulum stress-mediated apoptosis targeting calnexin in rat cardiomyocytes after myocardial infarction.
    Zhao N, Mi L, Zhang X, Xu M, Yu H, Liu Z, Liu X, Guan G, Gao W, Wang J.

    Therefore, these results indicate that obesity down-regulates CNX and CRT expressions and their activities and diabetes up-regulates the expressions and activities of CNX and CRT. Our findings clearly suggest that metabolic syndrome affects the lectin-like chaperones in the CNX/CRT cycle at both the activity and expression levels.

    Stratified analysis of lectin-like chaperones in the folding disease-related metabolic syndrome rat model.
    Hirano M, Imagawa A, Totani K.

    calnexin localizes to the neuronal cell membrane & this recruitment is regulated in an NMDA receptor-dependent manner. immunoisolation of vesicles revealed co-localization of GluA2 and calnexin in post-ER intracellular membrane components.

    NMDA receptor-dependent recruitment of calnexin to the neuronal plasma membrane.
    Itakura M, Tsujimura J, Yamamori S, Ohkido T, Takahashi M.

    endoplasmic reticulum stress has effects on group VIA phospholipase A2 in beta cells that include tyrosine phosphorylation and increased association with calnexin

    Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexin.
    Song H, Rohrs H, Tan M, Wohltmann M, Ladenson JH, Turk J., Free PMC Article

    Transmembrane segments prevent surface expression of sodium channel Nav1.8 and promote calnexin-dependent channel degradation

    Transmembrane segments prevent surface expression of sodium channel Nav1.8 and promote calnexin-dependent channel degradation.
    Li Q, Su YY, Wang H, Li L, Wang Q, Bao L., Free PMC Article

    two new complementary roles for calcineurin in the regulation of the early UPR (Unfolded Protein Responses)

    Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs.
    Bollo M, Paredes RM, Holstein D, Zheleznova N, Camacho P, Lechleiter JD., Free PMC Article

    Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

    Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators.., Free PMC Article

    Observational study of gene-disease association. (HuGE Navigator)

    Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators., NORDIL investigators., BRIGHT Consortium.., Free PMC Article

    Data give novel evidence that CyCAP regulates the post-translational modification of tissue transglutaminase through its colocalization with calnexin in endoplasmic reticulum.

    Cyclophilin C-associated protein/Mac-2 binding protein colocalizes with calnexin and regulates the expression of tissue transglutaminase.
    Kong W, Lin BW, Li S, Longaker MT, Lorenz HP.

    mixed disulfides with the ERp57 oxidoreductase act in conjunction with calreticulin/calnexin chaperones as normal early Tg folding intermediates

    Mixed-disulfide folding intermediates between thyroglobulin and endoplasmic reticulum resident oxidoreductases ERp57 and protein disulfide isomerase.
    Di Jeso B, Park YN, Ulianich L, Treglia AS, Urbanas ML, High S, Arvan P., Free PMC Article

    These results suggest that MCF-7 resistance to endoplasmic reticulum stress-induced apoptosis is partially mediated by the expression level of calnexin which in turn controls its sub-cellular localization, and its association with Bap31.

    Regulation of calnexin sub-cellular localization modulates endoplasmic reticulum stress-induced apoptosis in MCF-7 cells.
    Delom F, Fessart D, Chevet E.

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