Format

Send to:

Choose Destination
    • Showing Current items.

    CXCL2 C-X-C motif chemokine ligand 2 [ Homo sapiens (human) ]

    Gene ID: 2920, updated on 22-Aug-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    MicroRNA-532-5p is a prognostic marker and inhibits the aggressive phenotypes of osteosarcoma through targeting CXCL2.

    MicroRNA-532-5p is a prognostic marker and inhibits the aggressive phenotypes of osteosarcoma through targeting CXCL2.
    Ma Y, Zhao HX, Shi YJ, Cheng MG.

    08/21/2021
    Increased expression of CXCL2 in ACPA-positive rheumatoid arthritis and its role in osteoclastogenesis.

    Increased expression of CXCL2 in ACPA-positive rheumatoid arthritis and its role in osteoclastogenesis.
    Wang X, Sun L, He N, An Z, Yu R, Li C, Li Y, Li Y, Liu X, Fang X, Zhao J.,

    08/7/2021
    Association between the rs9131 and rs3806792 polymorphisms of the CXCL2 gene and the risk of HBV-related hepatocellular carcinoma in a Guangxi population.

    Association between the rs9131 and rs3806792 polymorphisms of the CXCL2 gene and the risk of HBV-related hepatocellular carcinoma in a Guangxi population.
    Lu Y, Zeng J, Yang S, Hu Z, Li L, Yu H, Qin X., Free PMC Article

    06/26/2021
    The CXCL2/IL8/CXCR2 Pathway Is Relevant for Brain Tumor Malignancy and Endothelial Cell Function.

    The CXCL2/IL8/CXCR2 Pathway Is Relevant for Brain Tumor Malignancy and Endothelial Cell Function.
    Urbantat RM, Blank A, Kremenetskaia I, Vajkoczy P, Acker G, Brandenburg S., Free PMC Article

    04/24/2021
    Identification of a four immune-related genes signature based on an immunogenomic landscape analysis of clear cell renal cell carcinoma.

    Identification of a four immune-related genes signature based on an immunogenomic landscape analysis of clear cell renal cell carcinoma.
    Gao X, Yang J, Chen Y.

    04/3/2021
    Omental adipocytes promote peritoneal metastasis of gastric cancer through the CXCL2-VEGFA axis.

    Omental adipocytes promote peritoneal metastasis of gastric cancer through the CXCL2-VEGFA axis.
    Natsume M, Shimura T, Iwasaki H, Okuda Y, Hayashi K, Takahashi S, Kataoka H., Free PMC Article

    02/27/2021
    A-kinase interacting protein 1 might serve as a novel biomarker for worse prognosis through the interaction of chemokine (C-X-C motif) ligand 1/chemokine (C-X-C motif) ligand 2 in acute myeloid leukemia.

    A-kinase interacting protein 1 might serve as a novel biomarker for worse prognosis through the interaction of chemokine (C-X-C motif) ligand 1/chemokine (C-X-C motif) ligand 2 in acute myeloid leukemia.
    Hao X, Gu M, Sun J, Cong L., Free PMC Article

    12/19/2020
    These results show that CXCL2 attenuates osteoblast differentiation through inhibition of the ERK1/2 signaling pathway.

    CXCL2 attenuates osteoblast differentiation by inhibiting the ERK1/2 signaling pathway.
    Yang Y, Zhou X, Li Y, Chen A, Liang W, Liang G, Huang B, Li Q, Jin D.

    07/11/2020
    Overexpressing CXCL2 by lentivirus also apparently inhibited the size and weight of subcutaneous tumours in nude mice and CXCL2 induced HCC cell apoptosis via both nuclear and mitochondrial apoptosis pathways.

    Overexpression of CXCL2 inhibits cell proliferation and promotes apoptosis in hepatocellular carcinoma.
    Ding J, Xu K, Zhang J, Lin B, Wang Y, Yin S, Xie H, Zhou L, Zheng S., Free PMC Article

    04/6/2019
    We identified CXCL2, an immune-related chemokine, decreased in hepatocellular carcinoma and the regulation mechanism may be controlled by methylation

    Identification of genes and pathways, including the CXCL2 axis, altered by DNA methylation in hepatocellular carcinoma.
    Subat S, Mogushi K, Yasen M, Kohda T, Ishikawa Y, Tanaka H.

    03/9/2019
    Results show that the expression of CXCL1 and CXCL2 in tumor cells and tumor-infiltrated CD11b+ myeloid cells is critically involved in the promotion of the generation of monocytic myeloid-derived suppressor cells (mo-MDSC) from bone marrow cells. CXCL1 and CXCL2 were found to specifically promote the expansion of mo-MDSC rather than granulocytic MDSC (G-MDSC).

    Chemokine (C-X-C motif) ligand 1 and CXCL2 produced by tumor promote the generation of monocytic myeloid-derived suppressor cells.
    Shi H, Han X, Sun Y, Shang C, Wei M, Ba X, Zeng X., Free PMC Article

    01/5/2019
    These results show that AKIP1 is crucial in cervical cancer angiogenesis and growth by elevating the levels of the NF-kappaB-dependent chemokines CXCL1, CXCL2, and CXCL8.

    AKIP1 promotes angiogenesis and tumor growth by upregulating CXC-chemokines in cervical cancer cells.
    Zhang W, Wu Q, Wang C, Yang L, Liu P, Ma C.

    11/3/2018
    The studies revealed that, although overall structural and oligomerization features of CXCL3 and CXCL2 are similar, prominent differences were observed in their surface characteristics, thus implicating a functional divergence.

    Molecular cloning and biophysical characterization of CXCL3 chemokine.
    Gulati K, Gangele K, Agarwal N, Jamsandekar M, Kumar D, Poluri KM.

    07/28/2018
    Taken together, the data of the present study demonstrated that TcpC can induce MIP2 production, which may contribute to the characteristic histological change associated with pyelonephritis.

    TcpC secreting uropathogenic E. coli promoted kidney cells to secrete MIP-2 via p38 MAPK pathway.
    He Y, Fang J, Zhang C, Pan J, Jin Q, Yang Y, Wang L, Wang B, Zhang D, Pan J.

    04/28/2018
    Functional effects data suggested that recombinant human CXCL2 significantly enhanced the migration, invasion ability of SMMC7721 hepatocellular carcinoma cells, and weakened adhesion ability.

    Type conversion of secretomes in a 3D TAM2 and HCC cell co-culture system and functional importance of CXCL2 in HCC.
    Lu Y, Li S, Ma L, Li Y, Zhang X, Peng Q, Mo C, Huang L, Qin X, Liu Y., Free PMC Article

    01/20/2018
    Reduced rate of sickle-related complications in Brazilian patients carrying HbF-promoting alleles at the BCL11A and HMIP-2 loci

    Reduced rate of sickle-related complications in Brazilian patients carrying HbF-promoting alleles at the BCL11A and HMIP-2 loci.
    Leonardo FC, Brugnerotto AF, Domingos IF, Fertrin KY, de Albuquerque DM, Bezerra MA, Araújo AS, Saad ST, Costa FF, Menzel S, Conran N, Thein SL.

    05/6/2017
    Results identify the CXCL2/MIF-CXCR2 axis as an important mediator in MDSC recruitment and as predictors in bladder cancer.

    CXCL2/MIF-CXCR2 signaling promotes the recruitment of myeloid-derived suppressor cells and is correlated with prognosis in bladder cancer.
    Zhang H, Ye YL, Li MX, Ye SB, Huang WR, Cai TT, He J, Peng JY, Duan TH, Cui J, Zhang XS, Zhou FJ, Wang RF, Li J.

    04/22/2017
    Chronic inflammation contributes to the change of CXCL12 DNA methylation in buccal cells and that DNA methylation profile of CXCL12 promoter plays important role in development and progression of periodontal disease.

    Association of CXCL12 gene promoter methylation with periodontitis in patients with diabetes mellitus type 2.
    Grdović N, Rajić J, Petrović SM, Dinić S, Uskoković A, Mihailović M, Jovanović JA, Tolić A, Pucar A, Milašin J, Vidaković M.

    04/8/2017
    Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population

    Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population.
    Kim SK, Chung JH, Park HJ, Kang SW, Lim DJ, Byun SH, Baek DG, Ko HY, Lew BL, Baik HH, Sim WY.

    06/11/2016
    high GRO-beta expression correlates with poor prognosis and contributes to ovarian cancer tumorigenesis and metastasis.

    Overexpression of Growth-Related Oncogene-β Is Associated with Tumorigenesis, Metastasis, and Poor Prognosis in Ovarian Cancer.
    Ye Q, Zhai X, Wang W, Zhang S, Zhu H, Wang D, Wang C., Free PMC Article

    02/27/2016
    In this review, a genetic variant in CXCL12 is described that is associated with type 2 diabetes mellitus and its complications.

    Significance of CXCL12 in type 2 diabetes mellitus and its associated complications.
    Karimabad MN, Hassanshahi G.

    11/28/2015
    We have demonstrated that GRObeta, as an oncogene product, contributed to tumorigenesis and metastasis of HCC

    Clinical significance of serum expression of GROβ in hepatocellular carcinoma.
    Li Y, Wang Y, Zhang P.

    11/21/2015
    Our results demonstrated that resistance to anti-proliferative effects of CXCR2 may also arise from feedback increases in MIP-2 secretion.

    Autocrine control of MIP-2 secretion from metastatic breast cancer cells is mediated by CXCR2: a mechanism for possible resistance to CXCR2 antagonists.
    Erin N, Nizam E, Tanrıöver G, Köksoy S.

    11/21/2015
    autophagy is required for Hepatitis B virus-induced NF-kappaB activation and release of IL-6, IL-8, and CXCL2 in Hepatocytes

    Autophagy Mediates HBx-Induced Nuclear Factor-κB Activation and Release of IL-6, IL-8, and CXCL2 in Hepatocytes.
    Luo MX, Wong SH, Chan MT, Yu L, Yu SS, Wu F, Xiao Z, Wang X, Zhang L, Cheng AS, Ng SS, Chan FK, Cho CH, Yu J, Sung JJ, Wu WK.

    09/26/2015
    The results link CXCL1 and CXCL2 chemokines with bone marrow adiposity and implicate CXCR2 signaling in promoting effects of marrow fat on progression of skeletal tumors in bone.

    Marrow adipocyte-derived CXCL1 and CXCL2 contribute to osteolysis in metastatic prostate cancer.
    Hardaway AL, Herroon MK, Rajagurubandara E, Podgorski I., Free PMC Article

    06/20/2015
    firstprevious page of 3 nextlast
    Support Center