| Comprehensive analysis of the clinical and biological significances for chemokine CXCL3 in cholangiocarcinoma. | Comprehensive analysis of the clinical and biological significances for chemokine CXCL3 in cholangiocarcinoma.
Ren H, Yang X, Hou W, Meng J, Luo D, Zhang C., Free PMC Article | 03/20/2024 |
| Elevated expression of CXCL3 in colon cancer promotes malignant behaviors of tumor cells in an ERK-dependent manner. | Elevated expression of CXCL3 in colon cancer promotes malignant behaviors of tumor cells in an ERK-dependent manner.
Cheng Y, Yang X, Liang L, Xin H, Dong X, Li W, Li J, Guo X, Li Y, He J, Zhang C, Wang W., Free PMC Article | 12/6/2023 |
| Chronic restraint stress promotes the tumorigenic potential of oral squamous cell carcinoma cells by reprogramming fatty acid metabolism via CXCL3 mediated Wnt/beta-catenin pathway. | Chronic restraint stress promotes the tumorigenic potential of oral squamous cell carcinoma cells by reprogramming fatty acid metabolism via CXCL3 mediated Wnt/β-catenin pathway.
Lou F, Long H, Luo S, Liu Y, Pu J, Wang H, Ji P, Jin X. | 12/10/2022 |
| Knockdown of CXCL3-inhibited apoptosis and inflammation in lipopolysaccharide-treated BEAS-2B and HPAEC through inactivating MAPKs pathway. | Knockdown of CXCL3-inhibited apoptosis and inflammation in lipopolysaccharide-treated BEAS-2B and HPAEC through inactivating MAPKs pathway.
Wang Y, Pan L. | 07/9/2022 |
| Tumor suppressive lncRNA MEG3 binds to EZH2 and enhances CXCL3 methylation in gallbladder cancer. | Tumor suppressive lncRNA MEG3 binds to EZH2 and enhances CXCL3 methylation in gallbladder cancer.
Li DQ, Ding YR, Che JH, Su Z, Yang WZ, Xu L, Li YJ, Wang HH, Zhou WY. | 06/18/2022 |
| Plasma CXCL3 Levels Are Associated with Tumor Progression and an Unfavorable Colorectal Cancer Prognosis. | Plasma CXCL3 Levels Are Associated with Tumor Progression and an Unfavorable Colorectal Cancer Prognosis.
Cui C, Zhang R, Gu F, Pei Y, Sun L, Huang Y, Niu G, Li J., Free PMC Article | 06/11/2022 |
| Clinical significance and biological functions of chemokine CXCL3 in head and neck squamous cell carcinoma. | Clinical significance and biological functions of chemokine CXCL3 in head and neck squamous cell carcinoma.
Guan J, Weng J, Ren Q, Zhang C, Hu L, Deng W, Lu S, Dong X, Li W, Li Y, Wang W., Free PMC Article | 02/5/2022 |
| Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism. | Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism.
Sun X, He X, Zhang Y, Hosaka K, Andersson P, Wu J, Wu J, Jing X, Du Q, Hui X, Ding B, Guo Z, Hong A, Liu X, Wang Y, Ji Q, Beyaert R, Yang Y, Li Q, Cao Y. | 01/15/2022 |
| Relationship between polymorphisms of CXCL3 gene and preeclampsia. | Relationship between polymorphisms of CXCL3 gene and preeclampsia.
Ren J, Zhang Y, Jia J, Dai L, Wang Y, Zhou B, Zhou R. | 01/15/2022 |
| Expression levels of chemokine (C-X-C motif) ligands CXCL1 and CXCL3 as prognostic biomarkers in rectal adenocarcinoma: evidence from Gene Expression Omnibus (GEO) analyses. | Expression levels of chemokine (C-X-C motif) ligands CXCL1 and CXCL3 as prognostic biomarkers in rectal adenocarcinoma: evidence from Gene Expression Omnibus (GEO) analyses.
Lv QY, Zou HZ, Xu YY, Shao ZY, Wu RQ, Li KJ, Deng X, Gu DN, Jiang HX, Su M, Zou CL., Free PMC Article | 12/18/2021 |
| CXCL3 overexpression affects the malignant behavior of oral squamous cell carcinoma cells via the MAPK signaling pathway. | CXCL3 overexpression affects the malignant behavior of oral squamous cell carcinoma cells via the MAPK signaling pathway.
Weng J, Ren Q, Li Z, Wang W, Guan J. | 10/30/2021 |
| CX3 CL1 promotes tumour cell by inducing tyrosine phosphorylation of cortactin in lung cancer. | CX(3) CL1 promotes tumour cell by inducing tyrosine phosphorylation of cortactin in lung cancer.
Fan M, Wu J, Li X, Jiang Y, Wang X, Bie M, Weng Y, Chen S, Chen B, An L, Zhang M, Huang G, Zhu M, Shi Q., Free PMC Article | 09/18/2021 |
| Gene expression and methylation profiles identified CXCL3 and CXCL8 as key genes for diagnosis and prognosis of colon adenocarcinoma. | Gene expression and methylation profiles identified CXCL3 and CXCL8 as key genes for diagnosis and prognosis of colon adenocarcinoma.
Zhao QQ, Jiang C, Gao Q, Zhang YY, Wang G, Chen XP, Wu SB, Tang J. | 03/13/2021 |
| CXCL3 overexpression promotes the tumorigenic potential of uterine cervical cancer cells via the MAPK/ERK pathway. | CXCL3 overexpression promotes the tumorigenic potential of uterine cervical cancer cells via the MAPK/ERK pathway.
Qi YL, Li Y, Man XX, Sui HY, Zhao XL, Zhang PX, Qu XS, Zhang H, Wang BX, Li J, Qi SF, Jia LL, Luan HY, Zhang CB, Wang WQ. | 03/13/2021 |
| Study demonstrated that CXCL3 is not only considerably upregulated in colon cancer (CC) tumor tissue but also has potential diagnostic value in patients with CC. Survival analysis suggested that CXCL3 may serve as a potential prognostic biomarker in CC. | Diagnostic and prognostic values of C‑X‑C motif chemokine ligand 3 in patients with colon cancer.
Ruan GT, Gong YZ, Liao XW, Wang S, Huang W, Wang XK, Zhu GZ, Liao C, Gao F., Free PMC Article | 02/29/2020 |
| hydrophobic pocket is in the vicinity of GAG binding region of CXCL3, a molecular determinant in leukocyte trafficking | An inter-switch between hydrophobic and charged amino acids generated druggable small molecule binding pocket in chemokine paralog CXCL3.
Gulati K, Gangele K, Kumar D, Poluri KM. | 12/14/2019 |
| Migration, invasion, proliferation and tube-formation capability of HTR-8/SVneo trophoblast cells transfected with siRNA-CXCL3 were suppressed by down-regulation of CXCL3, while those behaviors of HTR-8/SVneo cells transfected with pEZ-CXCL3 were enhanced by upregulation of CXCL3. Nevertheless, the apoptosis of HTR-8/SVneo cells was not affected by either siRNA or overexpression plasmid. | Effects of CXCL3 on migration, invasion, proliferation and tube formation of trophoblast cells.
Wang H, Wang T, Dai L, Cao W, Ye L, Gao L, Zhou B, Zhou R. | 04/13/2019 |
| This report demonstrates that Cxcl3 induces the migration of normal and neoplastic cerebellar precursor cells (GCPs) from the surface to the internal part of the cerebellum, a region where the GCPs differentiate, thus exiting the neoplastic program. In this way Cxcl3 counteracts the growth of medulloblastoma, tumor of the cerebellum originating from the GCPs. | Suppression of Medulloblastoma Lesions by Forced Migration of Preneoplastic Precursor Cells with Intracerebellar Administration of the Chemokine Cxcl3.
Ceccarelli M, Micheli L, Tirone F., Free PMC Article | 03/7/2019 |
| CXCL3 exerts its carcinogenic potential by directly and/or indirectly regulating the downstream signaling pathways and the expression of transcription factors in PCa. | Chemokine CXCL3 mediates prostate cancer cells proliferation, migration and gene expression changes in an autocrine/paracrine fashion.
Xin H, Cao Y, Shao ML, Zhang W, Zhang CB, Wang JT, Liang LC, Shao WW, Qi YL, Li Y, Zhang ZY, Yang Z, Sun YH, Zhang PX, Jia LL, Wang WQ. | 10/27/2018 |
| The studies revealed that, although overall structural and oligomerization features of CXCL3 and CXCL2 are similar, prominent differences were observed in their surface characteristics, thus implicating a functional divergence. | Molecular cloning and biophysical characterization of CXCL3 chemokine.
Gulati K, Gangele K, Agarwal N, Jamsandekar M, Kumar D, Poluri KM. | 07/28/2018 |
| Exogenous CXCL3 induced Erk1/2 and ETS1 phosphorylation and promoted CD133 expression. | CXCL3 contributes to CD133(+) CSCs maintenance and forms a positive feedback regulation loop with CD133 in HCC via Erk1/2 phosphorylation.
Zhang L, Zhang L, Li H, Ge C, Zhao F, Tian H, Chen T, Jiang G, Xie H, Cui Y, Yao M, Li J., Free PMC Article | 04/14/2018 |
| Our findings suggest that CXCL3 and its receptor CXCR2 are overexpressed in prostate cancer cells, prostate epithelial cells and prostate cancer tissues, which may play multiple roles in prostate cancer progression and metastasis. | Overexpression of CXCL3 can enhance the oncogenic potential of prostate cancer.
Gui SL, Teng LC, Wang SQ, Liu S, Lin YL, Zhao XL, Liu L, Sui HY, Yang Y, Liang LC, Wang ML, Li XY, Cao Y, Li FY, Wang WQ. | 01/28/2017 |
| results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy | CXCL3 is a potential target for breast cancer metastasis.
See AL, Chong PK, Lu SY, Lim YP. | 12/20/2014 |
| CXCL3 displays antimicrobial activity against E. coli and S. aureus. | Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.
Yang D, Chen Q, Hoover DM, Staley P, Tucker KD, Lubkowski J, Oppenheim JJ. | 09/24/2014 |
| our results demonstrate the diverse mechanisms by which CXCL2 and CXCL3 mediate normal and asthmatic airway smooth muscle cell migration | Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration.
Al-Alwan LA, Chang Y, Mogas A, Halayko AJ, Baglole CJ, Martin JG, Rousseau S, Eidelman DH, Hamid Q., Free PMC Article | 11/16/2013 |