| Arginase 1 expression is increased during hepatic stellate cell activation and facilitates collagen synthesis. | Arginase 1 expression is increased during hepatic stellate cell activation and facilitates collagen synthesis.
Zhang M, Wu Z, Salas SS, Aguilar MM, Trillos-Almanza MC, Buist-Homan M, Moshage H. | 06/28/2023 |
| Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus | Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus.
Pernow J, Kiss A, Tratsiakovich Y, Climent B., Free PMC Article | 07/16/2016 |
| Arg1 expression, which is abundant in polarized M2 cells, is associated with strain/genotype differences from different pathways. | Genotype-Associated Arginase 1 Expression in Rat Peritoneal Macrophages Induced by Toxoplasma gondii.
Zhang Q, He L, Kong L, Zhang Y, Chen H, An R, Wang L, Wang W, Xu X, Zhang A, Cai Y, Li M, Wen H, Luo Q, Shen J. | 04/30/2016 |
| Intermittent hypoxia increases expression levels of arginase I and II proteins in adult rats. | Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia.
Nara A, Nagai H, Shintani-Ishida K, Ogura S, Shimosawa T, Kuwahira I, Shirai M, Yoshida K. | 10/24/2015 |
| Arginase promotes endothelial dysfunction and hypertension in obesity by reducing arginine bioavailability. | Arginase promotes endothelial dysfunction and hypertension in obese rats.
Johnson FK, Peyton KJ, Liu XM, Azam MA, Shebib AR, Johnson RA, Durante W., Free PMC Article | 07/25/2015 |
| Lower activity and expression levels of iNOS and higher activity and expression levels of arginase-1 in rat alveolar macrophages were found to be linked to the susceptibility of T. gondii infection in these cells | Lower expression of inducible nitric oxide synthase and higher expression of arginase in rat alveolar macrophages are linked to their susceptibility to Toxoplasma gondii infection.
Zhao ZJ, Zhang J, Wei J, Li Z, Wang T, Yi SQ, Shen JL, Yang TB, Hide G, Lun ZR., Free PMC Article | 01/11/2014 |
| arginase 1 and 2 inhibition augmented iNOS-dependent NO production that resulted in suppression of IL-1beta-induced vascular smooth muscle cell proliferation in a cGMP-dependent manner | Arginase inhibition reduces interleukin-1β-stimulated vascular smooth muscle cell proliferation by increasing nitric oxide synthase-dependent nitric oxide production.
Yoon J, Ryoo S. | 08/31/2013 |
| Diabetes-induced increases in arginase I were involved in the diabetes-induced impairment of retinal blood flow by a mechanism involving vascular endothelial cell dysfunction. | The role of arginase I in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes.
Elms SC, Toque HA, Rojas M, Xu Z, Caldwell RW, Caldwell RB., Free PMC Article | 08/31/2013 |
| Report utility of arginase-1 for monitoring drug-induced liver injury in rat model. | A performance evaluation of three drug-induced liver injury biomarkers in the rat: alpha-glutathione S-transferase, arginase 1, and 4-hydroxyphenyl-pyruvate dioxygenase.
Bailey WJ, Holder D, Patel H, Devlin P, Gonzalez RJ, Hamilton V, Muniappa N, Hamlin DM, Thomas CE, Sistare FD, Glaab WE. | 06/1/2013 |
| Arginase and methylated arginine derivatives appear to be essential modulators of the inflammatory response in the acute phase of a multiple sclerosis model. | Modulation of nitric oxide synthase by arginase and methylated arginines during the acute phase of experimental multiple sclerosis.
Ljubisavljevic S, Stojanovic I, Pavlovic R, Sokolovic D, Pavlovic D, Cvetkovic T, Stevanovic I. | 03/30/2013 |
| findings indicate that the levels of arginase 1 and 2 varied among organs, suggesting that the arginase isoforms may play organ-specific roles in the urea cycle | Immunohistochemical study of arginase 1 and 2 in various tissues of rats.
Choi S, Park C, Ahn M, Lee JH, Shin T. | 02/16/2013 |
| This study suggested that the increased level of arginase-1 in SCI is associated with an increase in macrophages and reactive astrocytes, possibly contributing to the modulation of inflammation during the course of SCI. | Immunohistochemical study of arginase-1 in the spinal cords of rats with clip compression injury.
Ahn M, Lee C, Jung K, Kim H, Moon C, Sim KB, Shin T. | 11/17/2012 |
| investigation of arginase I/II expression in peritoneal macrophages of obese/lean Zucker diabetic rats, influence of arginine concentration on arginase expression in macrophages, and role of arginine/arginases in alpha-TNF/nitric oxide synthesis | Arginine availability modulates arginine metabolism and TNFα production in peritoneal macrophages from Zucker Diabetic Fatty rats.
Breuillard C, Belabed L, Bonhomme S, Blanc-Quintin MC, Neveux N, Couderc R, De Bandt JP, Cynober L, Darquy S. | 10/13/2012 |
| we postulate that the increased level of arginase-1, which is partly from M2 macrophages, contributes to the modulation of neuroinflammation in experimental autoimmune encephalomyelitis lesions | Immunohistochemical study of arginase-1 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis.
Ahn M, Yang W, Kim H, Jin JK, Moon C, Shin T. | 09/22/2012 |
| The data suggested that NO signaling is disrupted in neonatal rat pups exposed to even moderate hyperoxia due to increased arginase I and II activity and consequent decreased bioavailability of the substrate L-arginine. | Role of arginase in impairing relaxation of lung parenchyma of hyperoxia-exposed neonatal rats.
Ali NK, Jafri A, Sopi RB, Prakash YS, Martin RJ, Zaidi SI., Free PMC Article | 06/23/2012 |
| Cerebral enzymatic activities, mRNA and protein expression of arginase and DDAH were determined in African trypanosomiasis model of rat. | Cerebral changes occurring in arginase and dimethylarginine dimethylaminohydrolase (DDAH) in a rat model of sleeping sickness.
Amrouni D, Meiller A, Gautier-Sauvigné S, Piraud M, Bouteille B, Vincendeau P, Buguet A, Cespuglio R., Free PMC Article | 07/9/2011 |
| Arginase contributes significantly to L-proline supply for collagen synthesis in rat fibroblasts, in which arginase I is the predominant isoenzyme | Species differences in expression pattern of arginase isoenzymes and differential effects of arginase inhibition on collagen synthesis in human and rat pulmonary fibroblasts.
Warnken M, Haag S, Matthiesen S, Juergens UR, Racké K. | 07/26/2010 |
| These findings reveal the basis for thrombin induction of endothelial arginase I and indicate that arginase inhibition may be an attractive therapeutic alternative in the setting of arterial thrombosis and its associated endothelial dysfunction. | Thrombin induces endothelial arginase through AP-1 activation.
Zhu W, Chandrasekharan UM, Bandyopadhyay S, Morris SM Jr, DiCorleto PE, Kashyap VS., Free PMC Article | 05/31/2010 |
| study shows that increased arginase activity is not restricted to large vessels in SHRs and suggests that cardiac arginase activity is hemodynamic sensitive | Misregulation of the arginase pathway in tissues of spontaneously hypertensive rats.
Bagnost T, Berthelot A, Alvergnas M, Miguet-Alfonsi C, André C, Guillaume Y, Demougeot C. | 03/1/2010 |
| Data indicate that iNOS-dependent S-nitrosylation of arginase 1 and the increase in arginase activity lead to eNOS uncoupling, contributing to the nitroso-redox imbalance, endothelial dysfunction, and vascular stiffness observed in vascular aging. | Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats.
Kim JH, Bugaj LJ, Oh YJ, Bivalacqua TJ, Ryoo S, Soucy KG, Santhanam L, Webb A, Camara A, Sikka G, Nyhan D, Shoukas AA, Ilies M, Christianson DW, Champion HC, Berkowitz DE., Free PMC Article | 01/21/2010 |
| upregulation of Arg I and increased synthesis of polyamines play an important role in the conditioning lesion effect, and spermidine is sufficient to promote optic nerve regeneration in vivo | Increased synthesis of spermidine as a result of upregulation of arginase I promotes axonal regeneration in culture and in vivo.
Deng K, He H, Qiu J, Lorber B, Bryson JB, Filbin MT., Free PMC Article | 01/21/2010 |
| CAT1, CAT2, DDAH2, and arginase-1 expression in renal resistance vessels is regulated through the AT(1) receptor. | AT(1) receptor activation regulates the mRNA expression of CAT1, CAT2, arginase-1, and DDAH2 in preglomerular vessels from angiotensin II hypertensive rats.
Hultström M, Helle F, Iversen BM. | 01/21/2010 |
| Arginase promotes neointima formation in rat injured carotid arteries. | Arginase promotes neointima formation in rat injured carotid arteries.
Peyton KJ, Ensenat D, Azam MA, Keswani AN, Kannan S, Liu XM, Wang H, Tulis DA, Durante W., Free PMC Article | 01/21/2010 |
| Pharmacological inhibition of arginase in adult spontaneously hypertensive rats decreases blood pressure and improves the reactivity of resistance vessels. | Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat.
Bagnost T, Berthelot A, Bouhaddi M, Laurant P, André C, Guillaume Y, Demougeot C. | 01/21/2010 |
| diabetes-induced impairment of vasorelaxation to acetylcholine was correlated with increases in reactive oxygen species and arginase activity and arginase I expression in aorta and liver. | Diabetes-induced coronary vascular dysfunction involves increased arginase activity.
Romero MJ, Platt DH, Tawfik HE, Labazi M, El-Remessy AB, Bartoli M, Caldwell RB, Caldwell RW., Free PMC Article | 01/21/2010 |