| The purpose of this study was to clarify the assembly of taurine transporter (TauT/Slc6a6) and PSD-95/Disc-large/Zo-1 (PDZ) domain of Na(+)-H(+) exchanger regulatory factor 1 as a regulatory mechanism of Slc6a6-mediated GABA transport activity | Assembly of Taurine Transporter (Slc6a6) with Na(+)-H(+) Exchanger Regulatory Factor 1 (Slc9a3r1) Improves GABA Transport Activity by Increasing the Maximum Transport Velocity.
Tachikawa M, Yokoyama R, Akanuma SI, Hosoya KI. | 09/1/2018 |
| investigation of role of nitric oxide (NO) in regulation of functional activity of taurine transporter in renal brush border | Functional impairment of rat taurine transporter by activation of nitrogen oxide through superoxide.
Koo TS, Kwon HJ, Kim MH, Kim DD, Shim CK, Chung SJ, Chong S. | 01/12/2013 |
| Glucose causes dysfunction of taurine uptake and downregulation of TAUT gene expression in cultured rat cardiomyocytes. | [Hyperglycemia inhibited taurine transport and taurine transporter gene expression in cultured rat cardiomyocytes].
Shi YR, Gao L, Wang SH, Pang YZ, Tang C. | 12/8/2012 |
| TauT (along with system A) plays a cytoprotective role in stressed syncytiotrophoblasts. TauT-knockdown using siRNA revealed that TauT is a major contributor to taurine uptake by TR-TBT 18d-1 cells under normal conditions. | Roles of TauT and system A in cytoprotection of rat syncytiotrophoblast cell line exposed to hypertonic stress.
Nishimura T, Sai Y, Fujii J, Muta M, Iizasa H, Tomi M, Deureh M, Kose N, Nakashima E. | 02/26/2011 |
| prevents cardiomyocyte death by inhibiting NADPH oxidase-mediated calpain activation | Taurine prevents cardiomyocyte death by inhibiting NADPH oxidase-mediated calpain activation.
Li Y, Arnold JM, Pampillo M, Babwah AV, Peng T. | 01/21/2010 |
| [(14)C]guanidinoacetate was taken up by brain parenchymal cells in a concentrative manner most likely via taurine transporter and creatine transporter | The blood-brain barrier transport and cerebral distribution of guanidinoacetate in rats: involvement of creatine and taurine transporters.
Tachikawa M, Kasai Y, Yokoyama R, Fujinawa J, Ganapathy V, Terasaki T, Hosoya K. | 01/21/2010 |
| SNAT2 expression is constitutively low in neurons under physiological conditions but potently induced, together with the taurine transporter TauT, in response to depletion of neutral amino acids | SNAT2 amino acid transporter is regulated by amino acids of the SLC6 gamma-aminobutyric acid transporter subfamily in neocortical neurons and may play no role in delivering glutamine for glutamatergic transmission.
Grewal S, Defamie N, Zhang X, De Gois S, Shawki A, Mackenzie B, Chen C, Varoqui H, Erickson JD., Free PMC Article | 01/21/2010 |
| Data suggest that rat Slc6a6/TauT has the ability to use GABA as a substrate and Slc6a6/TauT-mediated GABA transport appears to be present at the inner blood-retinal barrier. | Function of taurine transporter (Slc6a6/TauT) as a GABA transporting protein and its relevance to GABA transport in rat retinal capillary endothelial cells.
Tomi M, Tajima A, Tachikawa M, Hosoya K. | 01/21/2010 |
| study demonstrates the transcription and translation of the taurine transporter in culture of vascular smooth muscle cells in vitro | Taurine transporter is expressed in vascular smooth muscle cells.
Liao XB, Zhou XM, Li JM, Tan ZP, Liu LM, Zhang W, Tan H, Lu Y, Yuan LQ. | 01/21/2010 |
| Data demonstrate that rat hippocampal neurons express the taurine transporter. | Taurine transporter regulation in hippocampal neurons.
Olson JE, Martinho E Jr. | 01/21/2010 |
| Data suggest that TauT gene expression is regulated by Ton EBP and plays a role in cell survival. | TauT gene expression is regulated by TonEBP and plays a role in cell survival.
Ito T, Fujio Y, Uozumi Y, Matsuda T, Maeda M, Takahashi K, Azuma J. | 01/21/2010 |
| involved with p53 in renal development and apoptosis | Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells.
Han X, Patters AB, Chesney RW. | 01/21/2010 |
| findings indicated that both myocytes and nonmyocytes expressed an identical taurine transporter with a Michaelis-Menten constant of 20-21 microM and that a higher taurine content in myocytes may be associated with a higher V(max) | Taurine transporter in primary cultured neonatal rat heart cells: a comparison between cardiac myocytes and nonmyocytes.
Takahashi K, Azuma M, Yamada T, Ohyabu Y, Takahashi K, Schaffer SW, Azuma J. | 01/21/2010 |