| Exploring the involvement of TASK-1 in the control of isolated rat right atrium function from healthy animals and an experimental model of monocrotaline-induced pulmonary hypertension. | Exploring the involvement of TASK-1 in the control of isolated rat right atrium function from healthy animals and an experimental model of monocrotaline-induced pulmonary hypertension.
Teixeira-Fonseca JL, Joviano-Santos JV, Beserra SS, de Lima Conceição MR, Leal-Silva P, Marques LP, Souza DS, Roman-Campos D. | 11/16/2023 |
| Kcnk3 dysfunction exaggerates the development of pulmonary hypertension induced by left ventricular pressure overload. | Kcnk3 dysfunction exaggerates the development of pulmonary hypertension induced by left ventricular pressure overload.
Lambert M, Mendes-Ferreira P, Ghigna MR, LeRibeuz H, Adão R, Boet A, Capuano V, Rucker-Martin C, Brás-Silva C, Quarck R, Domergue V, Vachiéry JL, Humbert M, Perros F, Montani D, Antigny F. | 02/5/2022 |
| TASK-1 regulates mitochondrial function under hypoxia. | TASK-1 regulates mitochondrial function under hypoxia.
Yu Y, He H, Kang C, Hu K. | 01/29/2022 |
| Restoration of Vitamin D Levels Improves Endothelial Function and Increases TASK-Like K(+) Currents in Pulmonary Arterial Hypertension Associated with Vitamin D Deficiency. | Restoration of Vitamin D Levels Improves Endothelial Function and Increases TASK-Like K(+) Currents in Pulmonary Arterial Hypertension Associated with Vitamin D Deficiency.
Callejo M, Morales-Cano D, Mondejar-Parreño G, Barreira B, Esquivel-Ruiz S, Olivencia MA, Moreno L, Cogolludo A, Perez-Vizcaino F., Free PMC Article | 09/25/2021 |
| TASK-1 channel blockade by AVE1231 increases vasocontractile responses and BP in 1- to 2-week-old but not adult rats. | TASK-1 channel blockade by AVE1231 increases vasocontractile responses and BP in 1- to 2-week-old but not adult rats.
Shvetsova AA, Gaynullina DK, Schmidt N, Bugert P, Lukoshkova EV, Tarasova OS, Schubert R., Free PMC Article | 08/14/2021 |
| Down-regulation of lncRNA Gas5 promotes hypoxia-induced pulmonary arterial smooth muscle cell proliferation by regulating KCNK3 expression. | Down-regulation of lncRNA Gas5 promotes hypoxia-induced pulmonary arterial smooth muscle cell proliferation by regulating KCNK3 expression.
Hao X, Li H, Zhang P, Yu X, Jiang J, Chen S. | 05/15/2021 |
| Expression of p11 and Heteromeric TASK Channels in Rat Carotid Body Glomus Cells and Nerve Growth Factor-differentiated PC12 Cells. | Expression of p11 and Heteromeric TASK Channels in Rat Carotid Body Glomus Cells and Nerve Growth Factor-differentiated PC12 Cells.
Matsuoka H, Pokorski M, Harada K, Yoshimura R, Inoue M., Free PMC Article | 01/23/2021 |
| Muscarinic receptor stimulation induces TASK1 channel endocytosis through a PKC-Pyk2-Src pathway in PC12 cells. | Muscarinic receptor stimulation induces TASK1 channel endocytosis through a PKC-Pyk2-Src pathway in PC12 cells.
Matsuoka H, Harada K, Mashima K, Inoue M. | 12/12/2020 |
| Vitamin D deficiency downregulates TASK-1 channels and induces pulmonary vascular dysfunction. | Vitamin D deficiency downregulates TASK-1 channels and induces pulmonary vascular dysfunction.
Callejo M, Mondejar-Parreño G, Morales-Cano D, Barreira B, Esquivel-Ruiz S, Olivencia MA, Manaud G, Perros F, Duarte J, Moreno L, Cogolludo A, Perez-Vizcaíno F. | 12/5/2020 |
| The first Kcnk3-mutated rat model of pulmonary hypertension is established. KCNK3 loss of function is a key event in pulmonary arterial hypertension pathogenesis. | Characterization of Kcnk3-Mutated Rat, a Novel Model of Pulmonary Hypertension.
Lambert M, Capuano V, Boet A, Tesson L, Bertero T, Nakhleh MK, Remy S, Anegon I, Pechoux C, Hautefort A, Rucker-Martin C, Manoury B, Domergue V, Mercier O, Girerd B, Montani D, Perros F, Humbert M, Antigny F. | 07/11/2020 |
| The CIH-induced transiently upregulation of the TASK-1 expression in the hypoglossal nucleus could be reversed by 5-HT 2A receptor antagonist. | Transient upregulation of TASK-1 expression in the hypoglossal nucleus during chronic intermittent hypoxia is reduced by serotonin 2A receptor antagonist.
Li WY, Wang A, Jin H, Zou Y, Wang Z, Wang W, Kang J. | 05/23/2020 |
| A transmural gradient of K2p3.1 protein expression exists across the left ventricular wall with expression increasing from the epicardial to the endocardial surface, which is likely to contribute to electrical stability of the left ventricular wall. | K(2p) 3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall.
Jones SA, Walton RD, Morton M, Lancaster MK., Free PMC Article | 05/9/2020 |
| Study analyzed TASK-1 and TASK-3 expression in ipsilateral and contralateral dorsal root ganglia and dorsal and ventral spinal cord of naive and formalin-treated or nerve injured rats. Pharmacological and molecular data suggest that TASK-1 and TASK-3 reduce the nociceptive transmission in acute/chronic inflammatory and neuropathic pain suggesting antinociceptive role of these channels in inflammatory and neuropathic pain. | Spinal TASK-1 and TASK-3 modulate inflammatory and neuropathic pain.
García G, Noriega-Navarro R, Martínez-Rojas VA, Gutiérrez-Lara EJ, Oviedo N, Murbartián J. | 03/7/2020 |
| Loss of KCNK3 function and expression is a hallmark of the RV hypertrophy/dysfunction associated with pulmonary hypertension. | Loss of KCNK3 is a hallmark of RV hypertrophy/dysfunction associated with pulmonary hypertension.
Lambert M, Boet A, Rucker-Martin C, Mendes-Ferreira P, Capuano V, Hatem S, Adão R, Brás-Silva C, Hautefort A, Michel JB, Dorfmuller P, Fadel E, Kotsimbos T, Price L, Jourdon P, Montani D, Humbert M, Perros F, Antigny F. | 08/31/2019 |
| Activation of aldehyde dehydrogenase 2 by low concentration of ethanol can reduce myocardial injury and fibrosis caused by diabetes, and its mechanism may be related to the changes of the two-por potassium channel TASK-1 | [Activation of aldehyde dehydrogenase 2 attenuates myocardial injury in diabetic rats by regulating two-pore potassium channel TASK-1].
Zhang H, Tao M, Kang P, Guo J, Xuan L, Tang B, Gao Q, Wang H. | 04/6/2019 |
| Mechanical ventilation (MV) downregulated the TASK-1 channel level in the rat brainstem, and the effect seemed to correlate positively with the tidal volume level, indicating that MV has an effect on the respiratory centre, possibly causing damage to it by increasing neuronal excitability. | The Effect of Mechanical Ventilation on TASK-1 Expression in the Brain in a Rat Model.
Na B, Zhang H, Wang G, Dai L, Xia G., Free PMC Article | 07/21/2018 |
| KCNK3 expression and function were reduced in pulmonary artery smooth muscle cells and endothelial cells in monocrotaline-induced pulmonary hypertension. Long-term KCNK3 inhibition induced distal neomuscularization and early hemodynamic signs of PH. | Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension.
Antigny F, Hautefort A, Meloche J, Belacel-Ouari M, Manoury B, Rucker-Martin C, Péchoux C, Potus F, Nadeau V, Tremblay E, Ruffenach G, Bourgeois A, Dorfmüller P, Breuils-Bonnet S, Fadel E, Ranchoux B, Jourdon P, Girerd B, Montani D, Provencher S, Bonnet S, Simonneau G, Humbert M, Perros F. | 08/27/2016 |
| Renal vascular reactivity is associated with up regulation of renal endothelin receptors type A. | Lipopolysaccharide enhanced renal vascular response to endothelin-1 through ETA overexpression in portal hypertensive rats.
Chuang CL, Huang HC, Chang CC, Lee FY, Wu JC, Lee JY, Hsieh HG, Lee SD. | 09/12/2015 |
| Data indicate that Gja1, Cav3 and Kcnk3 were up-regulated and Hcn2 was down-regulated in hearts of exercise trained Goto-Kakizaki (GK) type 2 diabetic rat compared to sedentary GK controls. | Effects of exercise training on excitation-contraction coupling and related mRNA expression in hearts of Goto-Kakizaki type 2 diabetic rats.
Salem KA, Qureshi MA, Sydorenko V, Parekh K, Jayaprakash P, Iqbal T, Singh J, Oz M, Adrian TE, Howarth FC. | 02/8/2014 |
| In the dorsal horn of the developing rat, TWIK-related acid-sensitive K(+) channels TASK-1 (KCNK3) and TASK-3 (KCNK9) were down-regulated during postnatal development | Transcriptional expression of voltage-gated Na⁺ and voltage-independent K⁺ channels in the developing rat superficial dorsal horn.
Blankenship ML, Coyle DE, Baccei ML., Free PMC Article | 07/27/2013 |
| TASK-1 in rat cardiomyocytes is controlled by endothelin-1 and suggest that the inhibition of TASK-1 via endothelin receptors is mediated by the activation of phospholipase C. | The inhibition of the potassium channel TASK-1 in rat cardiac muscle by endothelin-1 is mediated by phospholipase C.
Schiekel J, Lindner M, Hetzel A, Wemhöner K, Renigunta V, Schlichthörl G, Decher N, Oliver D, Daut J. | 06/8/2013 |
| PKC-mediated KCNK3 internalization required the presence of both 14-3-3beta and a novel potassium channel endocytic motif | The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic trafficking.
Gabriel L, Lvov A, Orthodoxou D, Rittenhouse AR, Kobertz WR, Melikian HE., Free PMC Article | 12/8/2012 |
| H(2)S excites type 1 cells through the inhibition of background (TASK) potassium channels. | Effects of exogenous hydrogen sulphide on calcium signalling, background (TASK) K channel activity and mitochondrial function in chemoreceptor cells.
Buckler KJ., Free PMC Article | 09/22/2012 |
| Results suggest that expression of TASK-2/TASK-3 (but not TASK-1) undergoes age-related changes in dorsal root ganglion (DRG) neurons; TASK-2/TASK-3 (but not TASK-1) likely contribute to resting membrane potential in DRG neurons in neonates/adults. | Age-related changes in two-pore domain acid-sensitive K⁺ channel expression in rat dorsal root ganglion neurons.
Kim GT, Cho YW, Tak HM, Lee JS, Kim EJ, Han J, Kang D. | 05/5/2012 |
| In the rat hippocampus, TASK-1 immunoreactivity was observed in astrocytes within normal and epileptic hippocampus. | Changes in TWIK-related acid sensitive K+-1 and -3 channel expressions from neurons to glia in the hippocampus of temporal lobe epilepsy patients and experimental animal model.
Kim JE, Yeo SI, Ryu HJ, Chung CK, Kim MJ, Kang TC. | 01/28/2012 |