| A novel BRF1 mutation in two middle-aged siblings with cerebellofaciodental syndrome. | A novel BRF1 mutation in two middle-aged siblings with cerebellofaciodental syndrome.
Zhao X, Lan Y, Miao J, Li G, Sun W, Qiu X, Zhu S, Zhu Z., Free PMC Article | 03/5/2023 |
| TFIIB-related factor 1 is a nucleolar protein that promotes RNA polymerase I-directed transcription and tumour cell growth. | TFIIB-related factor 1 is a nucleolar protein that promotes RNA polymerase I-directed transcription and tumour cell growth.
Wang J, Chen Q, Wang X, Zhao S, Deng H, Guo B, Zhang C, Song X, Deng W, Zhang T, Ni H. | 01/28/2023 |
| tRNA biogenesis and specific aminoacyl-tRNA synthetases regulate senescence stability under the control of mTOR. | tRNA biogenesis and specific aminoacyl-tRNA synthetases regulate senescence stability under the control of mTOR.
Guillon J, Coquelet H, Leman G, Toutain B, Petit C, Henry C, Boissard A, Guette C, Coqueret O., Free PMC Article | 02/19/2022 |
| Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches. | Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches.
Anuraga G, Tang WC, Phan NN, Ta HDK, Liu YH, Wu YF, Lee KH, Wang CY., Free PMC Article | 12/4/2021 |
| Cerebellofaciodental syndrome in an adult patient: Expanding the phenotypic and natural history characteristics. | Cerebellofaciodental syndrome in an adult patient: Expanding the phenotypic and natural history characteristics.
Honjo RS, Castro MAA, Ferraciolli SF, Soares Junior LAV, Pastorino AC, Bertola DR, Miyake N, Matsumoto N, Kim CA. | 08/14/2021 |
| Expanding the phenotype of cerebellar-facial-dental syndrome: Two siblings with a novel variant in BRF1. | Expanding the phenotype of cerebellar-facial-dental syndrome: Two siblings with a novel variant in BRF1.
Valenzuela I, Codina M, Fernández-Álvarez P, Mur P, Valle L, Tizzano EF, Cuscó I. | 06/26/2021 |
| The transcription factor Sp1 modulates RNA polymerase III gene transcription by controlling BRF1 and GTF3C2 expression in human cells. | The transcription factor Sp1 modulates RNA polymerase III gene transcription by controlling BRF1 and GTF3C2 expression in human cells.
Peng F, Zhou Y, Wang J, Guo B, Wei Y, Deng H, Wu Z, Zhang C, Shi K, Li Y, Wang X, Shore P, Zhao S, Deng W., Free PMC Article | 01/2/2021 |
| BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration. | BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration.
Loveridge CJ, Slater S, Campbell KJ, Nam NA, Knight J, Ahmad I, Hedley A, Lilla S, Repiscak P, Patel R, Salji M, Fleming J, Mitchell L, Nixon C, Strathdee D, Neilson M, Ntala C, Bryson S, Zanivan S, Edwards J, Robson CN, Goodyear CS, Blyth K, Leung HY., Free PMC Article | 11/28/2020 |
| Runx2 mediates the deregulation of Brf1 and Pol III genes and its abnormal expression predicts the worse prognosis of breast cancer. | The significance of Runx2 mediating alcohol-induced Brf1 expression and RNA Pol III gene transcription.
Hong Z, Fang Z, Lei J, Shi G, Zhang Y, He Z, Li B W, Zhong S., Free PMC Article | 05/2/2020 |
| Recent studies have demonstrated that Brf1 is overexpressed in most ER+ (estrogen receptor positive) cases of breast cancer and the change in cellular levels of Brf1 reflects the therapeutic efficacy and prognosis of this disease. It suggests that Brf1 may be a potential diagnosis biomarker and a therapeutic target of alcohol-associated breast cancer. | Alcohol Intake and Abnormal Expression of Brf1 in Breast Cancer.
Huang C, Zhang Y, Zhong S., Free PMC Article | 04/25/2020 |
| A derivative of TIS11b called R9-ZnC(S334D), by combining N-terminal domain deletion, serine-to-aspartate substitution at position 334 to enhance the function of the protein and fusion to the cell-penetrating peptide polyarginine R9. R9-ZnC(S334D) not only blunted secretion of vascular endothelial growth factor (VEGF) but also inhibited proliferation, migration, invasion, and anchorage-independent growth of breast cancer. | Targeting AU-rich element-mediated mRNA decay with a truncated active form of the zinc-finger protein TIS11b/BRF1 impairs major hallmarks of mammary tumorigenesis.
Rataj F, Planel S, Denis J, Roelants C, Filhol O, Guyon L, Feige JJ, Cherradi N. | 12/21/2019 |
| results provide evidence that AMD surveils poly(A)(+) Replication-dependent histone mRNAs via BRF1-mediated degradation under physiological conditions. | AU-rich element-mediated mRNA decay via the butyrate response factor 1 controls cellular levels of polyadenylated replication-dependent histone mRNAs.
Ryu I, Kim YK., Free PMC Article | 12/14/2019 |
| These findings uncover a novel mechanism for the regulation of BRF1 and reveal RNF12 as an important regulator of Pol III-dependent transcription. | RNF12 catalyzes BRF1 ubiquitination and regulates RNA polymerase III-dependent transcription.
Wang F, Zhao K, Yu S, Xu A, Han W, Mei Y., Free PMC Article | 04/13/2019 |
| These results indicate an interaction between Brf1 and ER alpha, which synergistically regulates the transcription of Pol III genes. | Role of Brf1 interaction with ERα, and significance of its overexpression, in human breast cancer.
Fang Z, Yi Y, Shi G, Li S, Chen S, Lin Y, Li Z, He Z, Li W, Zhong S., Free PMC Article | 07/28/2018 |
| In an analysis of families with a history of colorectal cancer, we associated germline mutations in BRF1 with predisposition to colorectal cancer. Seven of the identified variants (1 detected in 2 families) affected BRF1 mRNA splicing, protein stability, or expression and/or function. | Association Between Germline Mutations in BRF1, a Subunit of the RNA Polymerase III Transcription Complex, and Hereditary Colorectal Cancer.
Bellido F, Sowada N, Mur P, Lázaro C, Pons T, Valdés-Mas R, Pineda M, Aiza G, Iglesias S, Soto JL, Urioste M, Caldés T, Balbín M, Blay P, Rueda D, Durán M, Valencia A, Moreno V, Brunet J, Blanco I, Navarro M, Calin GA, Borck G, Puente XS, Capellá G, Valle L. | 04/21/2018 |
| Site-directed mutagenesis combined with kinase assays and specific phosphosite immunodetection identified Ser-54 (S54) and Ser-334 (S334) as PKA target amino acids in vitro and in vivo. Phosphomimetic mutation of the C-terminal S334 markedly increased TIS11b half-life and, unexpectedly, enhanced TIS11b activity on mRNA decay. | The cAMP pathway regulates mRNA decay through phosphorylation of the RNA-binding protein TIS11b/BRF1.
Rataj F, Planel S, Desroches-Castan A, Le Douce J, Lamribet K, Denis J, Feige JJ, Cherradi N., Free PMC Article | 09/9/2017 |
| Mutations in BRF1 cause severe short stature, remarkably delayed bone age, dysmorphic features, cerebellar hypoplasia and cognitive dysfunction inherited in an autosomal recessive pattern. | BRF1 mutations in a family with growth failure, markedly delayed bone age, and central nervous system anomalies.
Jee YH, Sowada N, Markello TC, Rezvani I, Borck G, Baron J., Free PMC Article | 06/3/2017 |
| Brf1 expression is increased in human HCC cases, which is correlated with shorter survival times. | The significance of Brf1 overexpression in human hepatocellular carcinoma.
Zhong Q, Xi S, Liang J, Shi G, Huang Y, Zhang Y, Levy D, Zhong S., Free PMC Article | 01/28/2017 |
| BRF1 mutations that reduce protein activity cause neurodevelopmental anomalies, suggesting that BRF1-mediated Pol III transcription is required for normal cerebellar and cognitive development. | BRF1 mutations alter RNA polymerase III-dependent transcription and cause neurodevelopmental anomalies.
Borck G, Hög F, Dentici ML, Tan PL, Sowada N, Medeira A, Gueneau L, Thiele H, Kousi M, Lepri F, Wenzeck L, Blumenthal I, Radicioni A, Schwarzenberg TL, Mandriani B, Fischetto R, Morris-Rosendahl DJ, Altmüller J, Reymond A, Nürnberg P, Merla G, Dallapiccola B, Katsanis N, Cramer P, Kubisch C., Free PMC Article | 09/26/2015 |
| hnRNP F is a co-factor in a subset of tristetraprolin/BRF1/BRF2-mediated mRNA decay. | hnRNP F complexes with tristetraprolin and stimulates ARE-mRNA decay.
Reznik B, Clement SL, Lykke-Andersen J., Free PMC Article | 02/21/2015 |
| these observations are in favor of a cell- and context-dependent regulation of Tis11b by hypoxia, which then contributes to modulation of angiogenesis. | A novel function of Tis11b/BRF1 as a regulator of Dll4 mRNA 3'-end processing.
Desroches-Castan A, Cherradi N, Feige JJ, Ciais D., Free PMC Article | 02/11/2012 |
| Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression. | Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression.
Zhong S, Machida K, Tsukamoto H, Johnson DL., Free PMC Article | 03/5/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | An integrative method for scoring candidate genes from association studies: application to warfarin dosing.
Tatonetti NP, Dudley JT, Sagreiya H, Butte AJ, Altman RB., Free PMC Article | 12/5/2010 |
| results identify a human Pol III isoform and isoform-specific functions in the regulation of cell growth and transformation | Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation.
Haurie V, Durrieu-Gaillard S, Dumay-Odelot H, Da Silva D, Rey C, Prochazkova M, Roeder RG, Besser D, Teichmann M., Free PMC Article | 04/19/2010 |
| deregulation of Brf1 and Brf2 expression could be a key mechanism responsible for the observed deregulation of RNA pol III transcription in cancer cells | Differential expression of the TFIIIB subunits Brf1 and Brf2 in cancer cells.
Cabarcas S, Jacob J, Veras I, Schramm L., Free PMC Article | 01/21/2010 |