| Expression of USP25 associates with fibrosis, inflammation and metabolism changes in IgG4-related disease. | Expression of USP25 associates with fibrosis, inflammation and metabolism changes in IgG4-related disease.
Jiang P, Jing Y, Zhao S, Lan C, Yang L, Dai X, Luo L, Cai S, Zhu Y, Miller H, Lai J, Zhang X, Zhao X, Wu Y, Yang J, Zhang W, Guan F, Zhong B, Umehara H, Lei J, Dong L, Liu C., Free PMC Article | 04/17/2024 |
| Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection. | Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection.
Teo QW, Wong HH, Heunis T, Stancheva V, Hachim A, Lv H, Siu L, Ho J, Lan Y, Mok CKP, Ulferts R, Sanyal S., Free PMC Article | 12/15/2023 |
| USP25 promotes hepatocellular carcinoma progression by interacting with TRIM21 via the Wnt/beta-catenin signaling pathway. | USP25 promotes hepatocellular carcinoma progression by interacting with TRIM21 via the Wnt/β-catenin signaling pathway.
Liu Y, Ma J, Lu S, He P, Dong W., Free PMC Article | 09/23/2023 |
| USP25 inhibits renal fibrosis by regulating TGFbeta-SMAD signaling pathway in Ang II-induced hypertensive mice. | USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.
Zhao Y, Chen X, Lin Y, Li Z, Su X, Fan S, Chen Y, Wang X, Liang G. | 06/7/2023 |
| USP25 contributes to defective neurogenesis and cognitive impairments. | USP25 contributes to defective neurogenesis and cognitive impairments.
Cai F, Song B, Yang Y, Liao H, Li R, Wang Z, Cao R, Chen H, Wang J, Wu Y, Zhang Y, Song W. | 05/18/2023 |
| Regulation of USP25 by SP1 Associates with Amyloidogenesis. | Regulation of USP25 by SP1 Associates with Amyloidogenesis.
Li R, Song B, Xu L, Zheng J, Pan W, Cai F, Wang J, Wu Y, Song W. | 04/27/2023 |
| USP25 UPREGULATION BOOSTS GSDMD -MEDIATED PYROPTOSIS OF ACINAR CELLS IN ACUTE PANCREATITIS. | USP25 UPREGULATION BOOSTS GSDMD -MEDIATED PYROPTOSIS OF ACINAR CELLS IN ACUTE PANCREATITIS.
Lv H, Liu X, Zhou H. | 12/3/2022 |
| Downregulation of deubiquitinating enzyme USP25 promotes the development of allergic rhinitis by enhancing TSLP signaling in the nasal epithelium. | Downregulation of deubiquitinating enzyme USP25 promotes the development of allergic rhinitis by enhancing TSLP signaling in the nasal epithelium.
Chang W, Lv H, Tan L, Gao Z, Liu P, Qin D, Zhang W, Xu Y., Free PMC Article | 10/15/2022 |
| Deubiquitination of TNKS1 Regulates Wnt/beta-Catenin to Affect the Expression of USP25 to Promote the Progression of Glioma. | Deubiquitination of TNKS1 Regulates Wnt/β-Catenin to Affect the Expression of USP25 to Promote the Progression of Glioma.
Tang B, Luo H, Xie S, Pan C, Fu J., Free PMC Article | 04/30/2022 |
| The deubiquitinase USP25 supports colonic inflammation and bacterial infection and promotes colorectal cancer. | The deubiquitinase USP25 supports colonic inflammation and bacterial infection and promotes colorectal cancer.
Wang XM, Yang C, Zhao Y, Xu ZG, Yang W, Wang P, Lin D, Xiong B, Fang JY, Dong C, Zhong B. | 04/23/2022 |
| USP25 Regulates EGFR Fate by Modulating EGF-Induced Ubiquitylation Dynamics. | USP25 Regulates EGFR Fate by Modulating EGF-Induced Ubiquitylation Dynamics.
Niño CA, Wollscheid N, Giangreco G, Maspero E, Polo S., Free PMC Article | 09/11/2021 |
| USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines. | USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines.
Wang H, Meng Q, Ding Y, Xiong M, Zhu M, Yang Y, Su H, Gu L, Xu Y, Shi L, Zhou H, Zhang N. | 07/31/2021 |
| Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells. | Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells.
Shibata N, Ohoka N, Tsuji G, Demizu Y, Miyawaza K, Ui-Tei K, Akiyama T, Naito M. | 11/28/2020 |
| USP25 downregulation by miR-27a-3p contributes to the epithelial-to-mesenchymal transition process, thereby inhibiting the migration and invasion of trophoblast cells, and these findings might provide potential biomarkers for recurrent miscarriage. | The miR-27a-3p/USP25 axis participates in the pathogenesis of recurrent miscarriage by inhibiting trophoblast migration and invasion.
Ding J, Cheng Y, Zhang Y, Liao S, Yin T, Yang J. | 06/6/2020 |
| Our work led to the identification of significant differences between USP25 and USP28 and provided the molecular basis for the development of new and highly specific anti-cancer drugs | Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities.
Sauer F, Klemm T, Kollampally RB, Tessmer I, Nair RK, Popov N, Kisker C. | 10/26/2019 |
| We confirm oligomeric states of USP25 and USP28 in cells and show that modulating oligomerization affects substrate stabilization in accordance with in vitro activity data | Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Gersch M, Wagstaff JL, Toms AV, Graves B, Freund SMV, Komander D., Free PMC Article | 10/26/2019 |
| Polymorphism of SREBF1 gene rs11868035 may increase susceptibility to Parkinson's disease in the northeastern Chinese population, while variant of USP25 gene rs2823357 may have no association with susceptibility to Parkinson's disease in northeastern Chinese. | The polymorphism of SREBF1 gene rs11868035 G/A is associated with susceptibility to Parkinson's disease in a Chinese population.
Lou F, Li M, Liu N, Li X, Ren Y, Luo X. | 09/7/2019 |
| These findings indicate that USP25 promotes stability of HBO1 in bacterial infection thereby enhances HBO1-mediated inflammatory gene transcription. | LPS promotes HBO1 stability via USP25 to modulate inflammatory gene transcription in THP-1 cells.
Long C, Lai Y, Li J, Huang J, Zou C., Free PMC Article | 06/1/2019 |
| the high stabilization of tankyrases in cultured cells by ectopic expression of a constitutive dimer of USP25 supports a biological relevance of this tetramerization/inhibition mechanism. | A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25.
Liu B, Sureda-Gómez M, Zhen Y, Amador V, Reverter D., Free PMC Article | 01/5/2019 |
| Smurf1 overexpression decreases USP25 protein turnover, and the E3 ligase enzymatic activity of Smurf1 is required for USP25 degradation. | Smurf1 restricts the antiviral function mediated by USP25 through promoting its ubiquitination and degradation.
Qian G, Hu X, Li G, Ding Y, Zhu L, Zheng H, Li M, Li Z, Pan J, Li Y, Li G, Yang C, Liu Y, Xie Y, Lv H. | 05/5/2018 |
| USP25 directly interacted with tankyrases to promote their deubiquitination and stabilization and demonstrated that USP25 deficiency could promote the degradation of tankyrases and consequent stabilization of Axin to antagonize Wnt signaling | USP25 regulates Wnt signaling by controlling the stability of tankyrases.
Xu D, Liu J, Fu T, Shan B, Qian L, Pan L, Yuan J., Free PMC Article | 10/14/2017 |
| Results suggest inhibition of Usp25's catalytic activity upon the non-covalent binding of SUMO2 to the Usp25 SUMO-interacting motif, and found that SUMO2 can competitively block the interaction between the Usp25 ubiquitin-binding region and its ubiquitin substrates. | Structural and Functional Investigations of the N-Terminal Ubiquitin Binding Region of Usp25.
Yang Y, Shi L, Ding Y, Shi Y, Hu HY, Wen Y, Zhang N., Free PMC Article | 08/12/2017 |
| We detected SNPs at USP25 with associations of genome-wide significance for Inflammatory Bowel Disease. | Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.
Brant SR, Okou DT, Simpson CL, Cutler DJ, Haritunians T, Bradfield JP, Chopra P, Prince J, Begum F, Kumar A, Huang C, Venkateswaran S, Datta LW, Wei Z, Thomas K, Herrinton LJ, Klapproth JA, Quiros AJ, Seminerio J, Liu Z, Alexander JS, Baldassano RN, Dudley-Brown S, Cross RK, Dassopoulos T, Denson LA, Dhere TA, Dryden GW, Hanson JS, Hou JK, Hussain SZ, Hyams JS, Isaacs KL, Kader H, Kappelman MD, Katz J, Kellermayer R, Kirschner BS, Kuemmerle JF, Kwon JH, Lazarev M, Li E, Mack D, Mannon P, Moulton DE, Newberry RD, Osuntokun BO, Patel AS, Saeed SA, Targan SR, Valentine JF, Wang MH, Zonca M, Rioux JD, Duerr RH, Silverberg MS, Cho JH, Hakonarson H, Zwick ME, McGovern DP, Kugathasan S., Free PMC Article | 06/24/2017 |
| REM Sleep Behavior Disorder patients with homozygous USP25 rs2823357 progressed to synucleinopathies faster than others. | Parkinson's Disease Genetic Loci in Rapid Eye Movement Sleep Behavior Disorder.
Gan-Or Z, Girard SL, Noreau A, Leblond CS, Gagnon JF, Arnulf I, Mirarchi C, Dauvilliers Y, Desautels A, Mitterling T, Cochen De Cock V, Frauscher B, Monaca C, Hogl B, Dion PA, Postuma RB, Montplaisir JY, Rouleau GA. | 03/26/2016 |
| Findings suggest that ubiquitin-specific protease 25 (USP25) as a VRK2 substrate that acts on TRiC deubiquitination. | Vaccinia-Related Kinase 2 Controls the Stability of the Eukaryotic Chaperonin TRiC/CCT by Inhibiting the Deubiquitinating Enzyme USP25.
Kim S, Lee D, Lee J, Song H, Kim HJ, Kim KT., Free PMC Article | 07/25/2015 |