| Inhibition of perilipin 2 attenuates cerebral ischemia/reperfusion injury by blocking NLRP3 inflammasome activation both in vivo and in vitro. | Inhibition of perilipin 2 attenuates cerebral ischemia/reperfusion injury by blocking NLRP3 inflammasome activation both in vivo and in vitro.
Liu XY, Li QS, Yang WH, Qiu Y, Zhang FF, Mei XH, Yuan QW, Sui RB. | 05/10/2023 |
| Perilipin 2 downregulation in beta cells impairs insulin secretion under nutritional stress and damages mitochondria. | Perilipin 2 downregulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria.
Mishra A, Liu S, Promes J, Harata M, Sivitz W, Fink B, Bhardwaj G, O'Neill BT, Kang C, Sah R, Strack S, Stephens S, King T, Jackson L, Greenberg AS, Anokye-Danso F, Ahima RS, Ankrum J, Imai Y., Free PMC Article | 02/19/2022 |
| New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery. | New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery.
Angelini G, Castagneto Gissey L, Del Corpo G, Giordano C, Cerbelli B, Severino A, Manco M, Basso N, Birkenfeld AL, Bornstein SR, Genco A, Mingrone G, Casella G., Free PMC Article | 11/21/2020 |
| Endoplasmic reticulum stress induced by either palmitate, tunicamycin, or thapsigargin led to the degradation of Plin2, an important lipid droplet binding protein. | Palmitate mediated diacylglycerol accumulation causes endoplasmic reticulum stress, Plin2 degradation, and cell death in H9C2 cardiomyoblasts.
Akoumi A, Haffar T, Mousterji M, Kiss RS, Bousette N. | 07/15/2017 |
| It has been demonstrated that ADRP is critically important during fetal lung maturation as it regulates the alveolar lipid homeostasis. | Evidence for decreased lipofibroblast expression in hypoplastic rat lungs with congenital diaphragmatic hernia.
Friedmacher F, Fujiwara N, Hofmann AD, Takahashi H, Gosemann JH, Puri P. | 06/6/2015 |
| Increased LIF expression after prenatal treatment with ATRA in nitrofen-induced PH suggests that ATRA may have a therapeutic potential in attenuating CDH-associated PH by stimulating alveolar development. | Prenatal retinoic acid increases lipofibroblast expression in hypoplastic rat lungs with experimental congenital diaphragmatic hernia.
Friedmacher F, Fujiwara N, Hofmann AD, Takahashi H, Alvarez LA, Gosemann JH, Puri P. | 01/24/2015 |
| This study demonstrates, for the first time, the presence of OXPAT and TIP47 transcripts in rat hepatocytes, as well as their up-regulation with lipid accumulation. | PAT protein mRNA expression in primary rat hepatocytes: Effects of exposure to fatty acids.
Grasselli E, Voci A, Pesce C, Canesi L, Fugassa E, Gallo G, Vergani L. | 12/16/2011 |
| Results indicate involvement of OXPAT and ADRP in muscular lipid accumulation and type 2 diabetes. | Adipocyte differentiation-related protein and OXPAT in rat and human skeletal muscle: involvement in lipid accumulation and type 2 diabetes mellitus.
Minnaard R, Schrauwen P, Schaart G, Jorgensen JA, Lenaers E, Mensink M, Hesselink MK. | 01/21/2010 |
| In steatotic hepatocytes ADRP selectively stains the surface of macrovesicular and microvesicular lipid droplets. | Adipose differentiation-related protein is a reliable lipid droplet marker in alcoholic fatty liver of rats.
Mak KM, Ren C, Ponomarenko A, Cao Q, Lieber CS. | 01/21/2010 |
| Essential for accumulation of triglycerides in cytosolic lipid droplets. Increase inhibits VLDL. Decrease increases sorting of fatty acids to beta-oxidation and promotes secretion of apoB-48 VLDL1. | Adipocyte differentiation-related protein promotes fatty acid storage in cytosolic triglycerides and inhibits secretion of very low-density lipoproteins.
Magnusson B, Asp L, Boström P, Ruiz M, Stillemark-Billton P, Lindén D, Borén J, Olofsson SO. | 01/21/2010 |
| Adipose differentiation related protein induces lipid accumulation and lipid droplet formation in hepatic stellate cells. | Adipose differentiation related protein induces lipid accumulation and lipid droplet formation in hepatic stellate cells.
Fukushima M, Enjoji M, Kohjima M, Sugimoto R, Ohta S, Kotoh K, Kuniyoshi M, Kobayashi K, Imamura M, Inoguchi T, Nakamuta M, Nawata H. | 01/21/2010 |
| result indicates that ADRP has two independent domains related to its localization and lipid droplet biogenesis; the unique property found in the present study may be related to physiological function of ADRP [ADRP] | Adipose differentiation-related protein has two independent domains for targeting to lipid droplets.
Nakamura N, Fujimoto T. | 01/21/2010 |