| Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3. | Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3.
Rampuria P, Mosyak L, Root AR, Svenson K, Agostino MJ, LaVallie ER., Free PMC Article | 08/22/2023 |
| Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism. | Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism.
Caveney NA, Tsutsumi N, Garcia KC., Free PMC Article | 08/4/2023 |
| Intestinal neuropod cell GUCY2C regulates visceral pain. | Intestinal neuropod cell GUCY2C regulates visceral pain.
Barton JR, Londregan AK, Alexander TD, Entezari AA, Bar-Ad S, Cheng L, Lepore AC, Snook AE, Covarrubias M, Waldman SA., Free PMC Article | 03/6/2023 |
| Meconium Ileus due to GUCY2C gene mutations in three unrelated South Indian families. | Meconium Ileus due to GUCY2C gene mutations in three unrelated South Indian families.
Varkki S, Benjamin AT, Athiyarath R, Danda S, Sowmya R, Connett G. | 04/30/2022 |
| Intestinal Guanylate Cyclase-C mRNA Expression in Duodenum and Colon of Children. | Intestinal Guanylate Cyclase-C mRNA Expression in Duodenum and Colon of Children.
Cohen MB, Gold BD, Xanthakos SA, CaJacob N, Weissman T, Bartolini W, Boinpally R, Mallick M, Reasner DS, O'Dea CR, Kwak H, Ge P. | 03/5/2022 |
| Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction. | Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction.
Satoh T, Wang L, Espinosa-Diez C, Wang B, Hahn SA, Noda K, Rochon ER, Dent MR, Levine AR, Baust JJ, Wyman S, Wu YL, Triantafyllou GA, Tang Y, Reynolds M, Shiva S, Hilaire CS, Gomez D, Goncharov DA, Goncharova EA, Chan SY, Straub AC, Lai YC, McTiernan CF, Gladwin MT., Free PMC Article | 01/8/2022 |
| Novel GUCY2C variant causing familial diarrhea in a Mennonite kindred and a potential therapeutic approach. | Novel GUCY2C variant causing familial diarrhea in a Mennonite kindred and a potential therapeutic approach.
Wolfe RM, Mohsen AW, Walsh Vockley C, Bertrand CA, Nicholls RD, Heiman P, Seibold LM, Vockley J, Ghaloul-Gonzalez L., Free PMC Article | 01/8/2022 |
| Mutational landscape of receptor guanylyl cyclase C: Functional analysis and disease-related mutations. | Mutational landscape of receptor guanylyl cyclase C: Functional analysis and disease-related mutations.
Bose A, Banerjee S, Visweswariah SS., Free PMC Article | 11/13/2021 |
| Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity. | Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity.
Pattison AM, Barton JR, Entezari AA, Zalewski A, Rappaport JA, Snook AE, Waldman SA., Free PMC Article | 10/23/2021 |
| Study reveals two discrete neuronal circuits expressing GUCY2C originating in the ventral premammillary nucleus in the hypothalamus and in the ventral tegmental area and substantia nigra in midbrain, which separately project to other sites throughout the brain. | Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin.
Merlino DJ, Barton JR, Charsar BA, Byrne MD, Rappaport JA, Smeyne RJ, Lepore AC, Snook AE, Waldman SA., Free PMC Article | 02/29/2020 |
| The results support a role of guanylate cyclase C signaling and disturbed electrolyte homeostasis in development of IBD. Furthermore, downregulation of metallothioneins in the ileal mucosa of familial GUCY2C diarrhea syndrome patients may contribute to inflammatory bowel disease development, possibly alongside effects from NOD2 risk variants. | Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C-linked familial diarrhea.
Tronstad RR, Polushina T, Brattbakk HR, Stansberg C, von Volkmann HL, Hanevik K, Ellinghaus E, Jørgensen SF, Ersland KM, Pham KD, Gilja OH, Hovdenak N, Hausken T, Vatn MH, Franke A, Knappskog PM, Le Hellard S, Karlsen TH, Fiskerstrand T. | 04/20/2019 |
| Human GUCY2C-targeted murine CAR-T cells promoted antigen-dependent T-cell activation quantified by activation marker upregulation, cytokine production, and killing of GUCY2C-expressing, but not GUCY2C-deficient, cancer cells in vitro GUCY2C CAR-T cells provided long-term protection against lung metastases of murine colorectal cancer cells engineered to express human GUCY2C in a syngeneic mouse model. | Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases.
Magee MS, Abraham TS, Baybutt TR, Flickinger JC Jr, Ridge NA, Marszalowicz GP, Prajapati P, Hersperger AR, Waldman SA, Snook AE., Free PMC Article | 03/30/2019 |
| High Expressions of guanylyl cyclase C is associated with rectal cancer. | Expression of guanylyl cyclase C in tissue samples and the circulation of rectal cancer patients.
Liu Y, Cheng G, Qian J, Ju H, Zhu Y, Stefano M, Keilholz U, Li D., Free PMC Article | 06/9/2018 |
| The findings support that the activating mutation in GUCY2C creates an intestinal environment with a major influence on the microbiota, which could contribute to the increased susceptibility to inflammatory bowel disease in patients with Familial GUCY2C diarrhea syndrome. | Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease.
Tronstad RR, Kummen M, Holm K, von Volkmann HL, Anmarkrud JA, Høivik ML, Moum B, Gilja OH, Hausken T, Baines J, Karlsen TH, Fiskerstrand T, Hov JR. | 06/2/2018 |
| Results demonstrate that GC-C and its ligands, guanylin and uroguanylin are downregulated in ulcerative colitis (UC), and this downregulation is more significant with aggravation of the clinical condition. Therefore, the GC-C signaling pathway may be implicated in the progression of UC. | Expression of guanylate cyclase-C, guanylin, and uroguanylin is downregulated proportionally to the ulcerative colitis disease activity index.
Lan D, Niu J, Miao J, Dong X, Wang H, Yang G, Wang K, Miao Y., Free PMC Article | 01/27/2018 |
| the expression of GCC is maintained throughout the process of tumor progression and formation of metastatic disease. | Consistent expression of guanylyl cyclase-C in primary and metastatic gastrointestinal cancers.
Danaee H, Kalebic T, Wyant T, Fassan M, Mescoli C, Gao F, Trepicchio WL, Rugge M., Free PMC Article | 01/13/2018 |
| To investigate gut motility and hormones before and after a meal in Familial GUCY2C diarrhea syndrome patients and compare with healthy controls | Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation.
von Volkmann HL, Brønstad I, Gilja OH, R Tronstad R, Sangnes DA, Nortvedt R, Hausken T, Dimcevski G, Fiskerstrand T, Nylund K., Free PMC Article | 10/21/2017 |
| Mutations in GUCY2C indicate a role for this receptor in the pathogenesis of sporadic Congenital secretory diarrhea. | Congenital secretory diarrhoea caused by activating germline mutations in GUCY2C.
Müller T, Rasool I, Heinz-Erian P, Mildenberger E, Hülstrunk C, Müller A, Michaud L, Koot BG, Ballauff A, Vodopiutz J, Rosipal S, Petersen BS, Franke A, Fuchs I, Witt H, Zoller H, Janecke AR, Visweswariah SS., Free PMC Article | 07/1/2017 |
| these data support Ad5-GUCY2C-PADRE as a safe and effective vaccination strategy in preclinical models and position Ad5-GUCY2C-PADRE for Phase I clinical testing in colorectal cancer patients. | Preclinical Evaluation of a Replication-Deficient Recombinant Adenovirus Serotype 5 Vaccine Expressing Guanylate Cyclase C and the PADRE T-helper Epitope.
Snook AE, Baybutt TR, Hyslop T, Waldman SA., Free PMC Article | 07/1/2017 |
| Familial GUCY2C diarrhoea syndrome is caused by an activating mutation in the GUCY2C gene, which causes impaired contractility and fluid stagnation in the small bowel | An activating gucy2c mutation causes impaired contractility and fluid stagnation in the small bowel.
von Volkmann HL, Nylund K, Tronstad RR, Hovdenak N, Hausken T, Fiskerstrand T, Gilja OH. | 06/10/2017 |
| Findings show how caloric suppression of the guanylin-GUCY2C signaling axis links obesity to negation of a universal tumor suppressor pathway in colorectal cancer. | Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis.
Lin JE, Colon-Gonzalez F, Blomain E, Kim GW, Aing A, Stoecker B, Rock J, Snook AE, Zhan T, Hyslop TM, Tomczak M, Blumberg RS, Waldman SA., Free PMC Article | 07/2/2016 |
| Data show that individuals affected with meconium ileus (MI) had either homozygous or compound heterozygous variants in enterotoxin receptor GUCY2C. | Meconium ileus in a Lebanese family secondary to mutations in the GUCY2C gene.
Smith A, Bulman DE, Goldsmith C, Bareke E, FORGE Canada Consortium, Majewski J, Boycott KM, Nikkel SM., Free PMC Article | 04/2/2016 |
| High guanylyl cyclase C expression is associated with colon cancer recurrence. | Molecular testing for lymph node metastases as a determinant of colon cancer recurrence: results from a retrospective multicenter study.
Sargent DJ, Shi Q, Gill S, Louvet C, Everson RB, Kellner U, Clancy TE, Pipas JM, Resnick MB, Meyers MO, Wu TT, Huntsman D, Validire P, Farooq U, Pavey ES, Beaudry G, Haince JF, Fradet Y. | 10/17/2015 |
| Transmission disequilibrium tests (TDT), case-control studies and quantitative analyses indicated association between GUC2C with Attention-deficit/hyperactivitydisorder and its core symptoms. | Association between GUC2C and ADHD: evidence from both categorical and quantitative traits.
Liu L, Li H, Wang Y, Yang L, Qian Q, Wang Y. | 09/5/2015 |
| Intestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21. | Intestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21.
Basu N, Saha S, Khan I, Ramachandra SG, Visweswariah SS., Free PMC Article | 03/22/2014 |