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    ICOS inducible T cell costimulator [ Homo sapiens (human) ]

    Gene ID: 29851, updated on 22-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The Expression and Prognostic Significance of ICOS in NSCLC Integrated Pan-Cancer and Multi-Omics Analyses.

    The Expression and Prognostic Significance of ICOS in NSCLC Integrated Pan-Cancer and Multi-Omics Analyses.
    Chen M, Yan X, Hong B, Xiao Y, Qian Y., Free PMC Article

    04/18/2024
    Transcriptional profile and immune infiltration in colorectal cancer reveal the significance of inducible T-cell costimulator as a crucial immune checkpoint molecule.

    Transcriptional profile and immune infiltration in colorectal cancer reveal the significance of inducible T-cell costimulator as a crucial immune checkpoint molecule.
    Chu J, Wu Y, Qu Z, Zhuang J, Liu J, Han S, Wu W, Han S., Free PMC Article

    03/22/2024
    Non-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development.

    Non-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development.
    Kim T, Martínez-Bonet M, Wang Q, Hackert N, Sparks JA, Baglaenko Y, Koh B, Darbousset R, Laza-Briviesca R, Chen X, Aguiar VRC, Chiu DJ, Westra HJ, Gutierrez-Arcelus M, Weirauch MT, Raychaudhuri S, Rao DA, Nigrovic PA., Free PMC Article

    03/13/2024
    Synovial inducible costimulator is correlated with severity in knee osteoarthritis.

    Synovial inducible costimulator is correlated with severity in knee osteoarthritis.
    Yang L, Ma J, Niu P, Zhang B, Wang Z.

    03/6/2024
    Molecular and clinical characterization of ICOS expression in breast cancer through large-scale transcriptome data.

    Molecular and clinical characterization of ICOS expression in breast cancer through large-scale transcriptome data.
    Wang P, Zhang Q, Zhang H, Shao J, Zhang H, Wang Z., Free PMC Article

    01/3/2024
    Expression and prognosis of inducible T-cell co-stimulator and its ligand in Chinese stage I-III lung adenocarcinoma patients.

    Expression and prognosis of inducible T-cell co-stimulator and its ligand in Chinese stage I-III lung adenocarcinoma patients.
    Zhan XK, Liu XK, Zhang S, Chen H., Free PMC Article

    12/4/2023
    ICOS gene polymorphisms in systemic lupus erythematosus: A case-control study.

    ICOS gene polymorphisms in systemic lupus erythematosus: A case-control study.
    Houssaini H, Bouallegui E, Abida O, Tahri S, Elloumi N, Hachicha H, Marzouk S, Bahloul Z, Masmoudi H, Fakhfakh R.

    10/23/2023
    CCR9/CXCR5 Co-Expressing CD4 T Cells Are Increased in Primary Sjogren's Syndrome and Are Enriched in PD-1/ICOS-Expressing Effector T Cells.

    CCR9/CXCR5 Co-Expressing CD4 T Cells Are Increased in Primary Sjögren's Syndrome and Are Enriched in PD-1/ICOS-Expressing Effector T Cells.
    Hinrichs AC, Kruize AA, Lafeber FPJG, Leavis HL, van Roon JAG., Free PMC Article

    08/19/2023
    MiR-29a-3p negatively regulates circulating Tfh memory cells in patients with Graves' disease by targeting ICOS.

    MiR-29a-3p negatively regulates circulating Tfh memory cells in patients with Graves' disease by targeting ICOS.
    Liu Y, Wang X, Luan W, Zou J, Xing J, Wang S, Peng H.

    04/6/2023
    Identification of novel NFKB1 and ICOS frameshift variants in patients with CVID.

    Identification of novel NFKB1 and ICOS frameshift variants in patients with CVID.
    Liu A, Liu Q, Leng S, Zhang X, Feng Q, Peng J, Feng G., Free PMC Article

    03/11/2023
    Expression of ICOS in the salivary glands of patients with primary Sjogren's syndrome and its molecular mechanism.

    Expression of ICOS in the salivary glands of patients with primary Sjogren's syndrome and its molecular mechanism.
    Li P, Jin Y, Zhao R, Xue Z, Ji J., Free PMC Article

    10/15/2022
    Specific transcriptional programs differentiate ICOS from CD28 costimulatory signaling in human Naive CD4(+) T cells.

    Specific transcriptional programs differentiate ICOS from CD28 costimulatory signaling in human Naïve CD4(+) T cells.
    Gigliotti CL, Boggio E, Favero F, Incarnato D, Santoro C, Oliviero S, Rojo JM, Zucchelli S, Persichetti F, Baldanzi G, Dianzani U, Corà D., Free PMC Article

    10/1/2022
    [Expression and Significance of PD-1 and ICOS in Patients with Primary Immune Thrombocytopenia].

    [Expression and Significance of PD-1 and ICOS in Patients with Primary Immune Thrombocytopenia].
    Fu Z, Qu W, Shao ZH, Wang HQ, Xing LM, Dong XF, Liu ZY, Li XN, Zhang Y, Ding SX.

    08/27/2022
    Mesenchymal stem cells regulate type 2 innate lymphoid cells via regulatory T cells through ICOS-ICOSL interaction.

    Mesenchymal stem cells regulate type 2 innate lymphoid cells via regulatory T cells through ICOS-ICOSL interaction.
    Fan X, Xu ZB, Li CL, Zhang HY, Peng YQ, He BX, Liu XQ, Chen DH, Chen D, Akdis CA, Fu QL., Free PMC Article

    03/19/2022
    Vaccine-induced ICOS(+)CD38(+) circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways.

    Vaccine-induced ICOS(+)CD38(+) circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways.
    Herati RS, Silva LV, Vella LA, Muselman A, Alanio C, Bengsch B, Kurupati RK, Kannan S, Manne S, Kossenkov AV, Canaday DH, Doyle SA, Ertl HCJ, Schmader KE, Wherry EJ., Free PMC Article

    03/5/2022
    A Patient with Novel ICOS Mutation Presented with Progressive Loss of B Cells.

    A Patient with Novel ICOS Mutation Presented with Progressive Loss of B Cells.
    Sefer AP, Charbonnier LM, Kasap N, Akcam B, Demirkol YK, Eltan SB, Ozen A, Karakoc-Aydiner E, Baris S.

    01/15/2022
    Impaired Differentiation of Highly Proliferative ICOS(+)-Tregs Is Involved in the Transition from Low to High Disease Activity in Systemic Lupus Erythematosus (SLE) Patients.

    Impaired Differentiation of Highly Proliferative ICOS(+)-Tregs Is Involved in the Transition from Low to High Disease Activity in Systemic Lupus Erythematosus (SLE) Patients.
    Kälble F, Wu L, Lorenz HM, Zeier M, Schaier M, Steinborn A., Free PMC Article

    10/30/2021
    Distinct changes of in BTLA, ICOS, PD-1, and TIGIT expression on peripheral blood and decidual CD8+ T cells in women with unexplained recurrent spontaneous abortiondagger.

    Distinct changes of in BTLA, ICOS, PD-1, and TIGIT expression on peripheral blood and decidual CD8+ T cells in women with unexplained recurrent spontaneous abortion†.
    Liang Q, Tong L, Xiang L, Shen S, Pan C, Liu C, Zhang H.

    10/23/2021
    An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression.

    An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression.
    Sainson RCA, Thotakura AK, Kosmac M, Borhis G, Parveen N, Kimber R, Carvalho J, Henderson SJ, Pryke KL, Okell T, O'Leary S, Ball S, Van Krinks C, Gamand L, Taggart E, Pring EJ, Ali H, Craig H, Wong VWY, Liang Q, Rowlands RJ, Lecointre M, Campbell J, Kirby I, Melvin D, Germaschewski V, Oelmann E, Quaratino S, McCourt M.

    10/9/2021
    Chromosome 2q33genetic polymorphisms in Tunisian endemic pemphigus foliaceus.

    Chromosome 2q33genetic polymorphisms in Tunisian endemic pemphigus foliaceus.
    Abida O, Bahloul E, Ben Jmaa M, Sellami K, Zouidi F, Fakhfakh R, Mahfoudh N, Turki H, Masmoudi H., Free PMC Article

    06/12/2021
    Transmembrane domain-mediated Lck association underlies bystander and costimulatory ICOS signaling.

    Transmembrane domain-mediated Lck association underlies bystander and costimulatory ICOS signaling.
    Wan Z, Shao X, Ji X, Dong L, Wei J, Xiong Z, Liu W, Qi H., Free PMC Article

    06/5/2021
    ICOS(+) Tregs: A Functional Subset of Tregs in Immune Diseases.

    ICOS(+) Tregs: A Functional Subset of Tregs in Immune Diseases.
    Li DY, Xiong XZ., Free PMC Article

    05/1/2021
    [High expression of ICOS on CD4(+) T cells and ICOSL on CD19(+) B cells in peripheral blood and its positive correlation with TRAb in Graves' disease].

    [High expression of ICOS on CD4(+) T cells and ICOSL on CD19(+) B cells in peripheral blood and its positive correlation with TRAb in Graves' disease].
    Chen X, Wang F, Cong X, Shen Q, Chen L.

    01/2/2021
    High CD3 and ICOS and low TIM-3 expression predict favourable survival in resected oesophageal squamous cell carcinoma.

    High CD3 and ICOS and low TIM-3 expression predict favourable survival in resected oesophageal squamous cell carcinoma.
    Hong MH, Shin SJ, Shin SK, Kim DJ, Zo JI, Shim YM, Lee SE, Cho BC, Park SY, Choi YL, Kim HR., Free PMC Article

    12/12/2020
    Role of Inducible Co-Stimulator (ICOS) in cancer immunotherapy.

    Role of Inducible Co-Stimulator (ICOS) in cancer immunotherapy.
    Amatore F, Gorvel L, Olive D.

    10/31/2020
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