| SNX10 promoted liver IR injury by facilitating macrophage M1 polarization via NLRP3 inflammasome activation. | SNX10 promoted liver IR injury by facilitating macrophage M1 polarization via NLRP3 inflammasome activation.
Wu D, Wang Y, Xu J, Wang D, Zhang J, Meng L, Hu Y, Wang P, Lin J, Zhou S. | 02/15/2024 |
| Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells. | Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells.
Bao W, You Y, Ni J, Hou H, Lyu J, Feng G, Wang Y, You K, Zhang S, Zhang L, Cao X, Wang X, Li H, Li H, Xu J, Liu C, Luo X, Du P, Chen D, Shen X., Free PMC Article | 09/6/2023 |
| Overexpression Pattern of miR-301b in Osteosarcoma and Its Relevance with Osteosarcoma Cellular Behaviors via Modulating SNX10. | Overexpression Pattern of miR-301b in Osteosarcoma and Its Relevance with Osteosarcoma Cellular Behaviors via Modulating SNX10.
Wang Y, Sun N, Zhang Z, Zhou Y, Liu H, Zhou X, Zhang Y, Zhao Y. | 01/28/2023 |
| Osteopetrosis associated with PLEKHM1 and SNX10 genes, both involved in osteoclast vesicular trafficking. | Osteopetrosis associated with PLEKHM1 and SNX10 genes, both involved in osteoclast vesicular trafficking.
Huybrechts Y, Van Hul W. | 10/22/2022 |
| Identification of Key Amino Acid Residues Involved in the Localization of Sorting Nexin 10 and Induction of Vacuole Formation. | Identification of Key Amino Acid Residues Involved in the Localization of Sorting Nexin 10 and Induction of Vacuole Formation.
Xiao B, Liu N, Hou L, Jiang M, Yao D. | 01/22/2022 |
| SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade. | SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade.
Wang X, Ni J, You Y, Feng G, Zhang S, Bao W, Hou H, Li H, Liu L, Zheng M, Wang Y, Zhou H, Shen W, Shen X., Free PMC Article | 12/25/2021 |
| SNX10 and PTGDS are associated with the progression and prognosis of cervical squamous cell carcinoma. | SNX10 and PTGDS are associated with the progression and prognosis of cervical squamous cell carcinoma.
Jiang P, Cao Y, Gao F, Sun W, Liu J, Ma Z, Xie M, Fu S., Free PMC Article | 11/6/2021 |
| SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC. | SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC.
Zhang S, Yang Z, Bao W, Liu L, You Y, Wang X, Shao L, Fu W, Kou X, Shen W, Yuan C, Hu B, Dang W, Nandakumar KS, Jiang H, Zheng M, Shen X., Free PMC Article | 06/12/2021 |
| Sorting Nexin 10 Mediates Metabolic Reprogramming of Macrophages in Atherosclerosis Through the Lyn-Dependent TFEB Signaling Pathway. | Sorting Nexin 10 Mediates Metabolic Reprogramming of Macrophages in Atherosclerosis Through the Lyn-Dependent TFEB Signaling Pathway.
You Y, Bao WL, Zhang SL, Li HD, Li H, Dang WZ, Zou SL, Cao XY, Wang X, Liu LX, Jiang H, Qu LF, Zheng M, Shen X. | 05/22/2021 |
| Does Decreased SNX10 Serve as a Novel Risk Factor in Atrial Fibrillation of the Valvular Heart Disease? - A Case-Control Study. | Does Decreased SNX10 Serve as a Novel Risk Factor in Atrial Fibrillation of the Valvular Heart Disease? - A Case-Control Study.
Yao J, Hou J, Lv L, Song C, Zhang M, Wu Z., Free PMC Article | 05/1/2021 |
| SNX10 gene mutation in infantile malignant osteopetrosis: A case report and literature review.", trans "SNX101. | SNX10 gene mutation in infantile malignant osteopetrosis: A case report and literature review.
Zhou T, Zeng C, Xi Q, Yang Z., Free PMC Article | 03/20/2021 |
| this work revealed that SNX10 controls mTOR activation through regulating chaperone-mediated autophagy-dependent amino-acid metabolism. | Sorting nexin 10 controls mTOR activation through regulating amino-acid metabolism in colorectal cancer.
Le Y, Zhang S, Ni J, You Y, Luo K, Yu Y, Shen X., Free PMC Article | 12/7/2019 |
| Sorting nexin 10 (SNX10) was remarkably down-regulated in colorectal cancer (CRC) tissues which showed the increased activity of chaperone-mediated autophagy (CMA) and decreased expression of cyclin-dependent kinase inhibitor p21(Cip1/WAF1). | Sorting nexin 10 acts as a tumor suppressor in tumorigenesis and progression of colorectal cancer through regulating chaperone mediated autophagy degradation of p21(Cip1/WAF1).
Zhang S, Hu B, You Y, Yang Z, Liu L, Tang H, Bao W, Guan Y, Shen X. | 02/2/2019 |
| Weak expression of SNX10 is linked to poor prognosis, and is a suitable prognostic biomarker of stomach adenocarcinoma. | Prognostic value of sorting nexin 10 weak expression in stomach adenocarcinoma revealed by weighted gene co-expression network analysis.
Zhang J, Wu Y, Jin HY, Guo S, Dong Z, Zheng ZC, Wang Y, Zhao Y., Free PMC Article | 01/12/2019 |
| Sequence analysis of the SNX10 transcript in patients with autosomal recessive osteopetrosis revealed activation of a cryptic splice site in intron 4 resulting in a frame shift and a premature stop (p.S66Nfs * 15). | SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts.
Stattin EL, Henning P, Klar J, McDermott E, Stecksen-Blicks C, Sandström PE, Kellgren TG, Rydén P, Hallmans G, Lönnerholm T, Ameur A, Helfrich MH, Coxon FP, Dahl N, Wikström J, Lerner UH., Free PMC Article | 01/12/2019 |
| In this study, whole exome sequencing (WES) was successfully used in six patients with malignant infantile osteopetrosis (MIOP) and identified mutations in four MIOP-related genes (CLCN7, TCIRG1, SNX10, and TNFRSF11A). | The use of whole exome sequencing for the diagnosis of autosomal recessive malignant infantile osteopetrosis.
Shamriz O, Shaag A, Yaacov B, NaserEddin A, Weintraub M, Elpeleg O, Stepensky P. | 03/17/2018 |
| supplementation with calcium gluconate rescued mice from the rachitic phenotype and extended life span in global Snx10-deficient mice, suggesting that this may be a life-saving component of the clinical approach to Snx10-dependent human osteopetrosis | Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption.
Ye L, Morse LR, Zhang L, Sasaki H, Mills JC, Odgren PR, Sibbel G, Stanley JR, Wong G, Zamarioli A, Battaglino RA., Free PMC Article | 01/2/2016 |
| Data suggest Tyr32 and Arg51 in SNX10 are important for protein stability and play critical roles in vacuolation in osteoclasts; mutation Arg16Leu (seen in autosomal recessive osteopetrosis patients) affects protein-protein interactions of SNX10. | Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis.
Xu T, Xu J, Ye Y, Wang Q, Shu X, Pei D, Liu J. | 07/25/2015 |
| results confirm the involvement of the SNX10 gene in human ARO and identify a new subset with a relatively favorable prognosis as compared to TCIRG1-dependent cases | SNX10 mutations define a subgroup of human autosomal recessive osteopetrosis with variable clinical severity.
Pangrazio A, Fasth A, Sbardellati A, Orchard PJ, Kasow KA, Raza J, Albayrak C, Albayrak D, Vanakker OM, De Moerloose B, Vellodi A, Notarangelo LD, Schlack C, Strauss G, Kühl JS, Caldana E, Lo Iacono N, Susani L, Kornak U, Schulz A, Vezzoni P, Villa A, Sobacchi C. | 10/19/2013 |
| Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation. | Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation.
Xu J, Xu T, Wu B, Ye Y, You X, Shu X, Pei D, Liu J., Free PMC Article | 08/31/2013 |
| Since inhibition of vesicular trafficking is essential for osteoclast formation and activity and SNX10 is involved in vesicular trafficking, these studies may identify a new gene involved in the development of bone diseases including osteoporosis. | SNX10 is required for osteoclast formation and resorption activity.
Zhu CH, Morse LR, Battaglino RA. | 09/22/2012 |
| Identification of SNX10 as a new osteopetrosis associated gene in consanguineous families of Palestinian origin. | An SNX10 mutation causes malignant osteopetrosis of infancy.
Aker M, Rouvinski A, Hashavia S, Ta-Shma A, Shaag A, Zenvirt S, Israel S, Weintraub M, Taraboulos A, Bar-Shavit Z, Elpeleg O. | 08/11/2012 |
| SNX10 regulates the ciliary trafficking of Rab8a, which is a critical regulator of ciliary membrane extension. | A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo.
Chen Y, Wu B, Xu L, Li H, Xia J, Yin W, Li Z, Shi D, Li S, Lin S, Shu X, Pei D., Free PMC Article | 05/26/2012 |
| SNX10 activity may be involved in the regulation of endosome homeostasis | Sorting nexin 10 induces giant vacuoles in mammalian cells.
Qin B, He M, Chen X, Pei D. | 01/21/2010 |