| Nischarin downregulation attenuates cell injury induced by oxidative stress via Wnt signaling. | Nischarin downregulation attenuates cell injury induced by oxidative stress via Wnt signaling.
Guo Z, Huang M, Yuan Y, Guo Y, Song C, Wang H, Dang X. | 10/30/2021 |
| Nischarin inhibits neurite outgrowth by blocking PAK1 activation in neurons. | Inhibition of Nischarin Expression Promotes Neurite Outgrowth through Regulation of PAK Activity.
Ding Y, Li Y, Lu L, Zhang R, Zeng L, Wang L, Zhang X., Free PMC Article | 07/2/2016 |
| Nischarin might be involved in mediating the process of PI3K/PKB pathway-dependent neuronal apoptosis. | The expression pattern of Nischarin after lipopolysaccharides (LPS)-induced neuroinflammation in rats brain cortex.
Wu X, Xu W, Cui G, Yan Y, Wu X, Li L, Tan X, Wu Q, Gu X. | 06/28/2014 |
| The results provide a preliminary survey of the distribution of Nischarin in different regions and cell types in the rat brain. | Nischarin is differentially expressed in rat brain and regulates neuronal migration.
Ding Y, Zhang R, Zhang K, Lv X, Chen Y, Li A, Wang L, Zhang X, Xia Q., Free PMC Article | 08/3/2013 |
| The I(1)imidazoline receptor represents a novel site of action for the cyto/cardio-protective efficacy of TVP1022. | I1 imidazoline receptor: novel potential cytoprotective target of TVP1022, the S-enantiomer of rasagiline.
Barac YD, Bar-Am O, Liani E, Amit T, Frolov L, Ovcharenko E, Angel I, Youdim MB, Binah O., Free PMC Article | 05/11/2013 |
| Taken together, these data support a role for IAA-RP in modulating synaptic transmission in the hippocampus through activation of I-Rs. | Imidazoleacetic acid-ribotide induces depression of synaptic responses in hippocampus through activation of imidazoline receptors.
Bozdagi O, Wang XB, Martinelli GP, Prell G, Friedrich VL Jr, Huntley GW, Holstein GR., Free PMC Article | 07/23/2011 |
| Agmatine and imidazoline receptor system may be implicated in ethanol-induced anxiolysis and withdrawal anxiety in rats | Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats.
Taksande BG, Kotagale NR, Patel MR, Shelkar GP, Ugale RR, Chopde CT. | 09/13/2010 |
| Report biphasic dose-dependent modulation of cardiac parasympathetic activity by moxonidine, an imidazoline I1-receptor agonist. | Biphasic dose-dependent modulation of cardiac parasympathetic activity by moxonidine, an imidazoline I1-receptor agonist.
Turcani M. | 01/21/2010 |
| This is the first evidence in vivo that nischarin plays a critical role in I(1) receptor-mediated pERK1/2 production in the rostral ventrolateral medulla and the subsequent hypotension. | Inhibition of nischarin expression attenuates rilmenidine-evoked hypotension and phosphorylated extracellular signal-regulated kinase 1/2 production in the rostral ventrolateral medulla of rats.
Zhang J, Abdel-Rahman AA., Free PMC Article | 01/21/2010 |
| Patch-clamp recordings were made from medium spiny neurons in dorsal striatum slices from the rat brain, and the roles of I1-imidazoline receptors in the modulation of synaptic transmission studied. | Presynaptic I1-imidazoline receptors reduce GABAergic synaptic transmission in striatal medium spiny neurons.
Tanabe M, Kino Y, Honda M, Ono H., Free PMC Article | 01/21/2010 |
| Cardiac I(1)-imidazoline receptors play an important role in the regulation of blood pressure. | Augmentation of moxonidine-induced increase in ANP release by atrial hypertrophy.
Cao C, Kang CW, Kim SZ, Kim SH. | 01/21/2010 |
| Results suggest that I(1)-imidazoline receptors mediate mechanism of noradrenaline release in pithed spontaneous hypertensive rats. | Norepinephrine release is reduced by I(1)-receptors in addition to alpha(2)-adrenoceptors.
Raasch W, Jungbluth B, Schäfer U, Häuser W, Dominiak P. | 01/21/2010 |
| Data suggest that in a rat model of metabolic syndrome X, I(1)-imidazoline receptors (I1IR) may mediate the persistent long-term improvements in glucose tolerance. | The role of I(1)-imidazoline receptors and alpha(2)-adrenergic receptors in the modulation of glucose and lipid metabolism in the SHROB model of metabolic syndrome X.
Koletsky RJ, Velliquette RA, Ernsberger P. | 01/21/2010 |