| TRPA1 deficiency attenuates cardiac fibrosis via regulating GRK5/NFAT signaling in diabetic rats. | TRPA1 deficiency attenuates cardiac fibrosis via regulating GRK5/NFAT signaling in diabetic rats.
Wang M, Zhao M, Xu S, Zheng Z, Zhang J, Pan W, Yin Z, Liu J, Wei C, Wan J, Xu Y. | 08/2/2023 |
| LncRNA CCAT1 Protects Astrocytes Against OGD/R-Induced Damage by Targeting the miR-218/NFAT5-Signaling Axis. | LncRNA CCAT1 Protects Astrocytes Against OGD/R-Induced Damage by Targeting the miR-218/NFAT5-Signaling Axis.
Xia X, Niu H, Ma Y, Qu B, He M, Yu K, Wang E, Zhang L, Gu J, Liu G. | 06/26/2021 |
| NFAT5 promotes arteriogenesis via MCP-1-dependent monocyte recruitment. | NFAT5 promotes arteriogenesis via MCP-1-dependent monocyte recruitment.
Lin XC, Pan M, Zhu LP, Sun Q, Zhou ZS, Li CC, Zhang GG., Free PMC Article | 04/24/2021 |
| ANGII increases Annexin-A2 nucleic acid-binding activity and elevates protein levels of the NFAT5 transcription factor in kidneys of hypertensive rats. | NFAT5 regulates renal gene expression in response to angiotensin II through Annexin-A2-mediated posttranscriptional regulation in hypertensive rats.
Fähling M, Paliege A, Jönsson S, Becirovic-Agic M, Melville JM, Skogstrand T, Hultström M. | 11/30/2019 |
| the present results suggested that the AngII/TRPC6/NFAT axis may be a crucial signaling pathway in podocytes that is necessary for maintaining the integrity of the glomerular filtration barrier | Participation of the AngII/TRPC6/NFAT axis in the pathogenesis of podocyte injury in rats with type 2 diabetes.
Ma R, Xu Y, Zhou H, Zhang D, Yao D, Song L, Liu Y. | 05/25/2019 |
| our results suggest that increases in extracellular osmolarity and TonEBP do not play a role in controlling autophagy in NP cells. | Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus.
Liu C, Choi H, Johnson ZI, Tian J, Shapiro IM, Risbud MV., Free PMC Article | 01/12/2019 |
| TonEBP expression correlated with canonical osmoregulatory targets TauT/SLC6A6, SMIT/SLC5A3, and AR/AKR1B1, supporting in vitro findings that the inflammatory milieu during IDD does not interfere with TonEBP osmoregulation. In summary, whereas TonEBP participates in the proinflammatory response to TNF-alpha | TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells.
Johnson ZI, Doolittle AC, Snuggs JW, Shapiro IM, Le Maitre CL, Risbud MV., Free PMC Article | 10/28/2017 |
| Together these results show that the expression of TonEBP is regulated by inflammatory signals in mammalian brain, suggesting that TonEBP might play a part during neuroinflammation. | Inflammatory signals induce the expression of tonicity-responsive enhancer binding protein (TonEBP) in microglia.
Jeong GR, Im SK, Bae YH, Park ES, Jin BK, Kwon HM, Lee BJ, Bu Y, Hur EM, Lee BD. | 08/19/2017 |
| NFAT5 serves an important pathophysiological role in seawater inhalationinduced acute lung injury by modulating NFkappaB activity. | NFAT5 participates in seawater inhalation‑induced acute lung injury via modulation of NF-κB activity.
Li C, Liu M, Bo L, Liu W, Liu Q, Chen X, Xu D, Li Z, Jin F., Free PMC Article | 04/8/2017 |
| Overexpression of NFAT5 promoted survival of the astrocytes and SIRT1 activation under oxygen-glucose-serum deprivation/restoration damage and inhibited cell apoptosis. | NFAT5 protects astrocytes against oxygen-glucose-serum deprivation/restoration damage via the SIRT1/Nrf2 pathway.
Xia X, Qu B, Li YM, Yang LB, Fan KX, Zheng H, Huang HD, Gu JW, Kuang YQ, Ma Y. | 04/1/2017 |
| Therefore, we suggest that there is a regional heterogeneity of regulation of renal NPRs, TonEBP, and APQ-2 mRNA in acute kidney injury . | Regional heterogeneity of expression of renal NPRs, TonEBP, and AQP-2 mRNAs in rats with acute kidney injury.
Cha SA, Park BM, Jung YJ, Kim SM, Kang KP, Kim W, Kim SH. | 03/5/2016 |
| NFAT5 is necessary for the transcriptional regulation of AQP4 expression and for local astrocyte swelling with accompanying restriction of the neuropil extracellular space in vivo. | NFAT5-dependent expression of AQP4 in astrocytes.
Yi MH, Lee YS, Kang JW, Kim SJ, Oh SH, Kim YM, Lee YH, Lee SD, Kim DW. | 08/10/2013 |
| NFAT5 is induced by hypoxia and could be a protective factor against ischemic damage. | NFAT5 is activated by hypoxia: role in ischemia and reperfusion in the rat kidney.
Villanueva S, Suazo C, Santapau D, Pérez F, Quiroz M, Carreño JE, Illanes S, Lavandero S, Michea L, Irarrazabal CE., Free PMC Article | 11/17/2012 |
| Identify NFAT5 as a novel regulator of vascular smooth muscle cell phenotypic modulation. | Nuclear factor of activated T cells 5 regulates vascular smooth muscle cell phenotypic modulation.
Halterman JA, Kwon HM, Zargham R, Bortz PD, Wamhoff BR., Free PMC Article | 11/12/2011 |
| High NaCl-induced increase of the overall abundance of TonEBP/OREBP, by itself, eventually raises its effective level in the nucleus, but its rapid CDK5-dependent nuclear localization accelerates the process. | High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization.
Gallazzini M, Heussler GE, Kunin M, Izumi Y, Burg MB, Ferraris JD., Free PMC Article | 06/18/2011 |
| c-Abl is the kinase responsible for high NaCl-induced phosphorylation of TonEBP/OREBP-Y143, which contributes to its increased activity | c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP.
Gallazzini M, Yu MJ, Gunaratne R, Burg MB, Ferraris JD., Free PMC Article | 01/1/2011 |
| Investigation of molecular regulation of MCP1 in response to hypertonicity reveals novel cis-acting element element MCP1-TonE/ORE in the 5'-flanking region of the MCP1 gene. | Hypertonicity-induced expression of monocyte chemoattractant protein-1 through a novel cis-acting element and MAPK signaling pathways.
Kojima R, Taniguchi H, Tsuzuki A, Nakamura K, Sakakura Y, Ito M. | 07/5/2010 |
| phagocyte-driven tonicity-responsive enhancer binding protein/vascular endothelial growth factor C-mediated hyperplasia of interstitial lymph capillaries, and increased endothelial NO synthase protein expression in skin interstitium | Mononuclear phagocyte system depletion blocks interstitial tonicity-responsive enhancer binding protein/vascular endothelial growth factor C expression and induces salt-sensitive hypertension in rats.
Machnik A, Dahlmann A, Kopp C, Goss J, Wagner H, van Rooijen N, Eckardt KU, Müller DN, Park JK, Luft FC, Kerjaschki D, Titze J. | 03/22/2010 |
| Results of these studies suggest that, in nucleus pulposus cells, osmotic pressure and calcium modulate AQP2 expression through TonEBP and are independent of the calcineurin-NFAT pathway | Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral disc.
Gajghate S, Hiyama A, Shah M, Sakai D, Anderson DG, Shapiro IM, Risbud MV., Free PMC Article | 01/21/2010 |
| TonEBP activation by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc | Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc.
Hiyama A, Gajghate S, Sakai D, Mochida J, Shapiro IM, Risbud MV., Free PMC Article | 01/21/2010 |
| TonEBP expression in the renal medulla is stimulated by interstitial hypertonicity | Interstitial tonicity controls TonEBP expression in the renal medulla.
Sheen MR, Kim JA, Lim SW, Jung JY, Han KH, Jeon US, Park SH, Kim J, Kwon HM. | 01/21/2010 |
| Changes in CLC-K1, UT-A1, UT-A3, and TonEBP play important roles in the renal response to osmotic diuresis in an attempt to minimize changes in plasma osmolality and maintain water homeostasis. | Urea and NaCl regulate UT-A1 urea transporter in opposing directions via TonEBP pathway during osmotic diuresis.
Kim YM, Kim WY, Lee HW, Kim J, Kwon HM, Klein JD, Sands JM, Kim D., Free PMC Article | 01/21/2010 |
| Hypoxia increases resistin expression in cultured rat vascular smooth muscle cells under hypoxia. Hypoxia-induced resistin is mediated through reactive oxygen species, ERK MAP kinase, and nuclear factor of activating T cells (NFAT) pathway. | The molecular regulation of resistin expression in cultured vascular smooth muscle cells under hypoxia.
Hung HF, Wang BW, Chang H, Shyu KG. | 01/21/2010 |
| These results indicated that TonEBP controls osmoregulatory mechanisms in cardiomyocytes. | Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes.
Navarro P, Chiong M, Volkwein K, Moraga F, Ocaranza MP, Jalil JE, Lim SW, Kim JA, Kwon HM, Lavandero S., Free PMC Article | 01/21/2010 |
| TRPC6 is upregulated by Galpha12/13 and negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation | Galpha12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation.
Nishida M, Onohara N, Sato Y, Suda R, Ogushi M, Tanabe S, Inoue R, Mori Y, Kurose H. | 01/21/2010 |