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    POLR1H RNA polymerase I subunit H [ Homo sapiens (human) ]

    Gene ID: 30834, updated on 3-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Expression of RNA polymerase I catalytic core is influenced by RPA12.

    Expression of RNA polymerase I catalytic core is influenced by RPA12.
    Ford BL, Wei T, Liu H, Scull CE, Najmi SM, Pitts S, Fan W, Schneider DA, Laiho M., Free PMC Article

    06/2/2023
    RNA polymerase I subunit 12 plays opposite roles in cell proliferation and migration.

    RNA polymerase I subunit 12 plays opposite roles in cell proliferation and migration.
    Yin X, Zhang K, Wang J, Zhou X, Zhang C, Song X, Wu Z, Du J, Chen Q, Zhang S, Deng W.

    08/28/2021
    ZNRD1 and Its Antisense Long Noncoding RNA ZNRD1-AS1 Are Oppositely Regulated by Cold Atmospheric Plasma in Breast Cancer Cells.

    ZNRD1 and Its Antisense Long Noncoding RNA ZNRD1-AS1 Are Oppositely Regulated by Cold Atmospheric Plasma in Breast Cancer Cells.
    Kim HW, Jeong D, Ham J, Kim H, Ji HW, Choi EH, Kim SJ., Free PMC Article

    01/9/2021
    ZNRD1-AS and RP11-819C21.1 long non-coding RNA changes following painful laser stimulation correlate with laser-evoked potential amplitude and habituation in healthy subjects: A pilot study.

    ZNRD1-AS and RP11-819C21.1 long non-coding RNA changes following painful laser stimulation correlate with laser-evoked potential amplitude and habituation in healthy subjects: A pilot study.
    Santoro M, Vollono C, Pazzaglia C, Di Sipio E, Giordano R, Padua L, Arendt-Nielsen L, Valeriani M.

    11/28/2020
    MiR-26b suppresses hepatocellular carcinoma development by negatively regulating ZNRD1 and Wnt/beta-catenin signaling.

    MiR-26b suppresses hepatocellular carcinoma development by negatively regulating ZNRD1 and Wnt/β-catenin signaling.
    Hu X, Wang R, Ren Z, Liu X, Gu J, Cui G, Li Q., Free PMC Article

    09/26/2020
    Findings suggest a tumor suppressor function for ZNRD1 gene and a tumor contributor function for long noncoding RNAs (IncRNAs) ZNRD1-AS1 in the process of carcinogenesis of lung cancer.

    Strong evidence for LncRNA ZNRD1-AS1, and its functional Cis- eQTL locus contributing more to the susceptibility of lung cancer.
    Li D, Song L, Wen Z, Li X, Jie J, Wang Y, Peng L., Free PMC Article

    12/30/2017
    The minor alleles of rs2395029, rs9264942, and rs3689068 in the HCP5 and HLA-C, and ZNRD1 genes associate with lower viral loads (VL) among antiretroviral-naive individuals and with shorter time to first VL less 51 copies/ml during anti-HIV therapy.

    Impact of polymorphisms in the HCP5 and HLA-C, and ZNRD1 genes on HIV viral load.
    Thørner LW, Erikstrup C, Harritshøj LH, Larsen MH, Kronborg G, Pedersen C, Larsen CS, Pedersen G, Gerstoft J, Obel N, Ullum H.

    10/7/2017
    ZNRD1 regulatory SNPs may be susceptibility makers for risk of both chronic HBV infection and HCC.

    Expression quantitative trait loci in long non-coding RNA ZNRD1-AS1 influence both HBV infection and hepatocellular carcinoma development.
    Wen J, Liu Y, Liu J, Liu L, Song C, Han J, Zhu L, Wang C, Chen J, Zhai X, Shen H, Hu Z.

    02/6/2016
    This study provides novel evidence that ZNRD1 polymorphism may confer host resistance to HIV-1 acquisition.

    Regulatory variation in HIV-1 dependency factor ZNRD1 associates with host resistance to HIV-1 acquisition.
    An P, Goedert JJ, Donfield S, Buchbinder S, Kirk GD, Detels R, Winkler CA., Free PMC Article

    12/20/2014
    A miR-508-5p/ZNRD1/ABCB1 regulatory loop has a critical role in MDR in gastric cancer.

    miR-508-5p regulates multidrug resistance of gastric cancer by targeting ABCB1 and ZNRD1.
    Shang Y, Zhang Z, Liu Z, Feng B, Ren G, Li K, Zhou L, Sun Y, Li M, Zhou J, An Y, Wu K, Nie Y, Fan D.

    09/6/2014
    Variants in ZNRD1 gene predict HIV-1/AIDS disease progression in a Han Chinese population in Taiwan.

    Variants in ZNRD1 gene predict HIV-1/AIDS disease progression in a Han Chinese population in Taiwan.
    Lin YJ, Lan YC, Hung CH, Lin TH, Huang SM, Liao CC, Lin CW, Lai CH, Tien N, Liu X, Ho MW, Chien WK, Chen JH, Wang JH, Tsai FJ., Free PMC Article

    03/1/2014
    Nominal associations were found between ZNRD1 rs1150740 and risk of AERD via codominant and dominant genetic inheritance (P=.03; odds ratio, 1.14 [1.14-10.16]).

    A possible association between ZNRD1 and aspirin-induced airway bronchoconstriction in a Korean population.
    Pasaje CF, Bae JS, Park BL, Cheong HS, Jang AS, Uh ST, Kim MK, Kim JH, Park TJ, Lee JS, Kim Y, Park CS, Shin HD.

    07/18/2013
    The results of human miRNA array and real-time PCR showed that ZNRD1 could significantly up-regulate the expression of miR-214 and down-regulate the expression of miR-296.

    Role of ZNRD1 (zinc ribbon domain-containing 1) in angiogenesis of leukaemia cells.
    Hong L, Han Y, Li S, Yang J, Gong T, Li J, Zheng J, Zhang H, Zhao Q, Wu K, Fan D.

    07/16/2011
    siRNA-based functional analysis showed that ZNRD1 down-regulation by siRNA or shRNA impaired HIV-1 replication at the transcription level in both lymphoid and nonlymphoid cells.

    ZNRD1 (zinc ribbon domain-containing 1) is a host cellular factor that influences HIV-1 replication and disease progression.
    Ballana E, Senserrich J, Pauls E, Faner R, Mercader JM, Uyttebroeck F, Palou E, Mena MP, Grau E, Clotet B, Ruiz L, Telenti A, Ciuffi A, Esté JA, Ballana E, Senserrich J, Pauls E, Faner R, Mercader JM, Uyttebroeck F, Palou E, Mena MP, Grau E, Clotet B, Ruiz L, Telenti A, Ciuffi A, Esté JA.

    06/14/2010
    ZNRD1 gene displays high expression in VCR resistant gastric cancer cells.

    [Expression and function of zinc ribbon gene ZNRD1 in drug-resistant gastric cancer cells].
    Zhang YM, Zhao YQ, Yan QJ, Pan YL, Yi H, Fan DM.

    06/14/2010
    ZNRD1-expressing cells exhibited enhanced DNA repair capacity and overexpression could upregulate the expression of excision repair cross-complementing 1 (ERCC1) gene

    ZNRD1 might mediate UV irradiation related DNA damage and repair in human esophageal cancer cells by regulation of ERCC1.
    Guo W, Zhao YP, Jiang YG, Wang RW, Hong L, Fan DM.

    01/21/2010
    ZNRD1 was down-regulated in esophageal cancer tissues compared to adjacent non-neoplastic tissues.

    Expression and prognostic value of ZNRD1 in esophageal squamous cell carcinoma.
    Zhao Y, Hong L, Wang R, Fan D.

    01/21/2010
    Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)

    Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).
    Limou S, Le Clerc S, Coulonges C, Carpentier W, Dina C, Delaneau O, Labib T, Taing L, Sladek R, Deveau C, Ratsimandresy R, Montes M, Spadoni JL, Lelièvre JD, Lévy Y, Therwath A, Schächter F, Matsuda F, Gut I, Froguel P, Delfraissy JF, Hercberg S, Zagury JF, ANRS Genomic Group.

    02/11/2009
    Data demonstrate that the influence of ZNRD1 alleles on disease progression rates are attributable to HLA-A10, help clarify the relationship between the HCP5, HLA-C and HLA-B*57 alleles, and reaffirm a critical role of HLA-B*57 alleles in HIV disease.

    HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles.
    Catano G, Kulkarni H, He W, Marconi VC, Agan BK, Landrum M, Anderson S, Delmar J, Telles V, Song L, Castiblanco J, Clark RA, Dolan MJ, Ahuja SK, Catano G, Kulkarni H, He W, Marconi VC, Agan BK, Landrum M, Anderson S, Delmar J, Telles V, Song L, Castiblanco J, Clark RA, Dolan MJ, Ahuja SK., Free PMC Articles: PMC2574440, PMC2574440

    01/21/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (6) articles

    Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.
    Ucisik-Akkaya E, Davis CF, Do TN, Morrison BA, Stemmer SM, Amadio WJ, Dorak MT.

    ZNRD1 (zinc ribbon domain-containing 1) is a host cellular factor that influences HIV-1 replication and disease progression.
    Ballana E, Senserrich J, Pauls E, Faner R, Mercader JM, Uyttebroeck F, Palou E, Mena MP, Grau E, Clotet B, Ruiz L, Telenti A, Ciuffi A, Esté JA, Ballana E, Senserrich J, Pauls E, Faner R, Mercader JM, Uyttebroeck F, Palou E, Mena MP, Grau E, Clotet B, Ruiz L, Telenti A, Ciuffi A, Esté JA.

    High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
    Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA.

    The HLA-B/-C haplotype block contains major determinants for host control of HIV.
    Trachtenberg E, Bhattacharya T, Ladner M, Phair J, Erlich H, Wolinsky S.

    Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection.
    van Manen D, Kootstra NA, Boeser-Nunnink B, Handulle MA, van't Wout AB, Schuitemaker H.

    HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles.
    Catano G, Kulkarni H, He W, Marconi VC, Agan BK, Landrum M, Anderson S, Delmar J, Telles V, Song L, Castiblanco J, Clark RA, Dolan MJ, Ahuja SK, Catano G, Kulkarni H, He W, Marconi VC, Agan BK, Landrum M, Anderson S, Delmar J, Telles V, Song L, Castiblanco J, Clark RA, Dolan MJ, Ahuja SK.

    11/19/2008
    The up-regulation of ZNRD1 significantly inhibited the drug sensitivity of gastric cancer cells over-expressing DARPP-32, indicating that ZNRD1 may be important in the DARPP-32-mediated MDR of gastric cancer

    Reversal of multidrug resistance of adriamycin-resistant gastric adenocarcinoma cells through the up-regulation of DARPP-32.
    Hong L, Zhao Y, Wang J, Han Y, Guo W, Jin H, Zhai H, Bai F, Zhang X, Qiao T, Chen Z, Fan D.

    01/21/2010
    DARPP-32 mediates multidrug resistance of gastric cancer through regulation of P-gp and ZNRD1.

    DARPP-32 mediates multidrug resistance of gastric cancer through regulation of P-gp and ZNRD1.
    Hong L, Wang J, Zhao Y, Han Z, Zhou X, Guo W, Zhang X, Jin H, Wu K, Ding J, Fan D.

    01/21/2010
    ZNRD1 significantly inhibits the in vitro and in vivo growth of human gastric cancer cell line MKN28 by targeting cell cycle-related genes and reducing tumor angiogenesis.

    Mechanisms of growth arrest by zinc ribbon domain-containing 1 in gastric cancer cells.
    Hong L, Zhao Y, Han Y, Guo W, Jin H, Qiao T, Che Z, Fan D.

    01/21/2010
    This study clearly demonstrates that ZNRD1 may play an important role in the control of human gastric cancer development by regulating cell proliferation.

    Suppression of the cell proliferation in stomach cancer cells by the ZNRD1 gene.
    Hong L, Zhang Y, Liu N, Liu C, Zhi M, Pan Y, Lan M, Sun L, Fan D.

    01/21/2010
    overexpression of ZNRD1 could promote multidrug-resistant phenotype of gastric cancer cells through upregulation of P-glycoprotein

    Overexpression of ZNRD1 promotes multidrug-resistant phenotype of gastric cancer cells through upregulation of P-glycoprotein.
    Shi Y, Zhang Y, Zhao Y, Hong L, Liu N, Jin X, Pan Y, Fan D.

    01/21/2010
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