| Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis | Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis.
Okada Y, Suzuki A, Ikari K, Terao C, Kochi Y, Ohmura K, Higasa K, Akiyama M, Ashikawa K, Kanai M, Hirata J, Suita N, Teo YY, Xu H, Bae SC, Takahashi A, Momozawa Y, Matsuda K, Momohara S, Taniguchi A, Yamada R, Mimori T, Kubo M, Brown MA, Raychaudhuri S, Matsuda F, Yamanaka H, Kamatani Y, Yamamoto K., Free PMC Article | 05/13/2017 |
| pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity. | pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity.
Jiang W, Strohman MJ, Somasundaram S, Ayyangar S, Hou T, Wang N, Mellins ED., Free PMC Article | 09/24/2016 |
| significant association was found between white wine liking and rs9276975:C>T polymorphism in the HLA-DOA gene. | Genome-wide association analysis on five isolated populations identifies variants of the HLA-DOA gene associated with white wine liking.
Pirastu N, Kooyman M, Traglia M, Robino A, Willems SM, Pistis G, Amin N, Sala C, Karssen LC, van Duijn CM, Toniolo D, Gasparini P., Free PMC Article | 08/27/2016 |
| TAP2, HLA-DOA, HLA-DOB, and tapasin loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population | Association of polymorphisms in HLA antigen presentation-related genes with the outcomes of HCV infection.
Huang P, Zhang Y, Lu X, Xu Y, Wang J, Zhang Y, Yu R, Su J., Free PMC Article | 01/30/2016 |
| HLA-DO regulates surface presentation of human leukocyte antigen class II-restricted antigens on B cell malignancies. | Human leukocyte antigen-DO regulates surface presentation of human leukocyte antigen class II-restricted antigens on B cell malignancies.
Kremer AN, van der Meijden ED, Honders MW, Pont MJ, Goeman JJ, Falkenburg JH, Griffioen M. | 11/29/2014 |
| HLA-DOA, HLA-DRA, and HLA-DQA1 associated with spontaneous autoimmunity | Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease.
He S, Tan W, Wang S, Wu C, Wang P, Wang B, Su X, Zhao J, Guo X, Xiang Y. | 06/28/2014 |
| results show that HLA-DO inhibits HLA-DM function by acting as a substrate mimic, and the findings also limit the possible functional roles for HLA-DO in antigen presentation | HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.
Guce AI, Mortimer SE, Yoon T, Painter CA, Jiang W, Mellins ED, Stern LJ., Free PMC Article | 03/2/2013 |
| analysis of the HLA-DO/HLA-DM complex by FRET and mutagenesis | Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis.
Yoon T, Macmillan H, Mortimer SE, Jiang W, Rinderknecht CH, Stern LJ, Mellins ED., Free PMC Article | 10/6/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| HLA-DOA polymorphisms are associated with Diabetes Mellitus, Type 1. | Exploring the diabetogenicity of the HLA-B18-DR3 CEH: independent association with T1D genetic risk close to HLA-DOA.
Santin I, Castellanos-Rubio A, Aransay AM, Gutierrez G, Gaztambide S, Rica I, Vicario JL, Noble JA, Castaño L, Bilbao JR., Free PMC Article | 01/21/2010 |
| minor allele of the SNP rs9296068 is significantly associated with liver transplantation rejection and with enhanced B-lymphocyte participation in rejection, likely because of a dysfunctional HLA-DOA gene product. | Genetic variants in major histocompatibility complex-linked genes associate with pediatric liver transplant rejection.
Sindhi R, Higgs BW, Weeks DE, Ashokkumar C, Jaffe R, Kim C, Wilson P, Chien N, Glessner J, Talukdar A, Mazariegos G, Barmada MM, Frackleton E, Petro N, Eckert A, Hakonarson H, Ferrell R, Sindhi R, Higgs BW, Weeks DE, Ashokkumar C, Jaffe R, Kim C, Wilson P, Chien N, Glessner J, Talukdar A, Mazariegos G, Barmada MM, Frackleton E, Petro N, Eckert A, Hakonarson H, Ferrell R., Free PMC Articles: PMC2956436, PMC2956436 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (5) articlesNew genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA. Genetic association of htSNPs across the major histocompatibility complex with rheumatoid arthritis in an African-American population.
Reynolds RJ, Kelley JM, Hughes LB, Yi N, Bridges SL Jr, CLEAR Investigators. Genetic variants in major histocompatibility complex-linked genes associate with pediatric liver transplant rejection.
Sindhi R, Higgs BW, Weeks DE, Ashokkumar C, Jaffe R, Kim C, Wilson P, Chien N, Glessner J, Talukdar A, Mazariegos G, Barmada MM, Frackleton E, Petro N, Eckert A, Hakonarson H, Ferrell R, Sindhi R, Higgs BW, Weeks DE, Ashokkumar C, Jaffe R, Kim C, Wilson P, Chien N, Glessner J, Talukdar A, Mazariegos G, Barmada MM, Frackleton E, Petro N, Eckert A, Hakonarson H, Ferrell R. | 07/30/2008 |
| Observational study of genetic testing. (HuGE Navigator) | A flexible array format for large-scale, rapid blood group DNA typing.
Hashmi G, Shariff T, Seul M, Vissavajjhala P, Hue-Roye K, Charles-Pierre D, Lomas-Francis C, Chaudhuri A, Reid ME. | 03/13/2008 |
| In transgenic mice expressing human HLA-DOA & HLA-DOB from a DC-specific promoter, as DO increased, A(b)-CLIP increased & class II-peptides decreased. DO impaired H-2M function, causing Ag-specific downmodulation of class II Ag processing/presentation. | Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation.
Fallas JL, Tobin HM, Lou O, Guo D, Sant'Angelo DB, Denzin LK. | 01/21/2010 |
| four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, were identified by sequence-based typing | Identification of four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, by sequence-based typing*.
Moon SM, Gu H, Ryu HJ, Kim JJ, Kim HT, Han BG, Kimm K, Lee JK, Oh B. | 01/21/2010 |
| HLA-DOA mutations were analyzed for association with autoimmune diseases and B-cell leukemias. | Novel polymorphisms in HLA-DOA and HLA-DOB in B-cell malignancies.
van Lith M, van Ham M, Neefjes J. | 01/21/2010 |
| These results show that transduced DO modulates antigen presentation in human mature MoDC, evoking the possible use of this chaperone for immunotherapy. | HLA-DO transduced in human monocyte-derived dendritic cells modulates MHC class II antigen processing.
Bellemare-Pelletier A, Tremblay J, Beaulieu S, Boulassel MR, Routy JP, Massie B, Lapointe R, Thibodeau J. | 01/21/2010 |