| Calcineurin/NFATc3 pathway mediates myocardial fibrosis in diabetes by impairing enhancer of zeste homolog 2 of cardiac fibroblasts. | Calcineurin/NFATc3 pathway mediates myocardial fibrosis in diabetes by impairing enhancer of zeste homolog 2 of cardiac fibroblasts.
Zhang L, Liu HH, Yang F, Zhang ZY, Wu Y, Li F, Dang SP, Zhang ZY, Qian LL, Wang RX., Free PMC Article | 09/27/2023 |
| Protective mechanism of the EZH2/microRNA-15a-5p/CXCL10 axis in rats with depressive-like behaviors. | Protective mechanism of the EZH2/microRNA-15a-5p/CXCL10 axis in rats with depressive-like behaviors.
Huang X, Yang C, Huang M. | 09/15/2023 |
| Histone methyltransferase enzyme enhancer of zeste homolog 2 counteracts ischemic brain injury via H3K27me3-mediated regulation of PI3K/AKT/mTOR signaling pathway. | Histone methyltransferase enzyme enhancer of zeste homolog 2 counteracts ischemic brain injury via H3K27me3-mediated regulation of PI3K/AKT/mTOR signaling pathway.
Chen M, Fan L, Wu G, Wang H, Gu S. | 08/9/2023 |
| Inhibition of EZH2 mitigates peritoneal fibrosis and lipid precipitation in peritoneal mesothelial cells mediated by klotho. | Inhibition of EZH2 mitigates peritoneal fibrosis and lipid precipitation in peritoneal mesothelial cells mediated by klotho.
Wang Q, Sun J, Wang R, Sun J., Free PMC Article | 02/11/2023 |
| EZH2 promotes angiogenesis in peritoneal dialysis by epigenetically activating SP4 expression in the IL-6/sIL-6R signalling pathway. | EZH2 promotes angiogenesis in peritoneal dialysis by epigenetically activating SP4 expression in the IL-6/sIL-6R signalling pathway.
Zhu N, Guan H, Wang X, Zhang Y, Gu L, Jia J, Wang L, Yuan W., Free PMC Article | 01/14/2023 |
| EZH2-mediated suppression of CLDN1 leads to barrier dysfunction in PPI-refractory gastroesophageal reflux disease. | EZH2-mediated suppression of CLDN1 leads to barrier dysfunction in PPI-refractory gastroesophageal reflux disease.
Ma T, Gu J, Zhao Y, Li S, Zou D, Ge D. | 06/11/2022 |
| EZH2 upregulates the expression of MAPK1 to promote intervertebral disc degeneration via suppression of miR-129-5p. | EZH2 upregulates the expression of MAPK1 to promote intervertebral disc degeneration via suppression of miR-129-5p.
Zhou M, He SJ, Liu W, Yang MJ, Hou ZY, Meng Q, Qian ZL. | 04/23/2022 |
| Histone methyltransferase enhancer of zeste 2 polycomb repressive complex 2 subunit exacerbates inflammation in depression rats by modulating microglia polarization. | Histone methyltransferase enhancer of zeste 2 polycomb repressive complex 2 subunit exacerbates inflammation in depression rats by modulating microglia polarization.
Huang X, Yang Q, Xie L, Lei S., Free PMC Article | 04/16/2022 |
| EZH2 Mediates miR-146a-5p/HIF-1alpha to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury. | EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury.
Ni S, Yang B, Xia L, Zhang H., Free PMC Article | 12/25/2021 |
| Calcitonin gene-related peptide regulates spinal microglial activation through the histone H3 lysine 27 trimethylation via enhancer of zeste homolog-2 in rats with neuropathic pain. | Calcitonin gene-related peptide regulates spinal microglial activation through the histone H3 lysine 27 trimethylation via enhancer of zeste homolog-2 in rats with neuropathic pain.
An Q, Sun C, Li R, Chen S, Gu X, An S, Wang Z., Free PMC Article | 12/4/2021 |
| Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis. | Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis.
Jiang Y, Xiang C, Zhong F, Zhang Y, Wang L, Zhao Y, Wang J, Ding C, Jin L, He F, Wang H., Free PMC Article | 08/7/2021 |
| Increased EZH2 Levels in Anterior Cingulate Cortex Microglia Aggravate Neuropathic Pain by Inhibiting Autophagy Following Brachial Plexus Avulsion in Rats. | Increased EZH2 Levels in Anterior Cingulate Cortex Microglia Aggravate Neuropathic Pain by Inhibiting Autophagy Following Brachial Plexus Avulsion in Rats.
Meng XL, Fu P, Wang L, Yang X, Hong G, Zhao X, Lao J., Free PMC Article | 07/24/2021 |
| The protective effects of microRNA-26a in steroid-induced osteonecrosis of the femoral head by repressing EZH2. | The protective effects of microRNA-26a in steroid-induced osteonecrosis of the femoral head by repressing EZH2.
Li G, Liu H, Zhang X, Liu X, Zhang G, Liu Q., Free PMC Article | 05/29/2021 |
| Implication of EZH2 in the Pro-Proliferative and Apoptosis-Resistant Phenotype of Pulmonary Artery Smooth Muscle Cells in PAH: A Transcriptomic and Proteomic Approach. | Implication of EZH2 in the Pro-Proliferative and Apoptosis-Resistant Phenotype of Pulmonary Artery Smooth Muscle Cells in PAH: A Transcriptomic and Proteomic Approach.
Habbout K, Omura J, Awada C, Bourgeois A, Grobs Y, Krishna V, Breuils-Bonnet S, Tremblay E, Mkannez G, Martineau S, Nadeau V, Roux-Dalvai F, Orcholski M, Jeyaseelan J, Gutstein D, Potus F, Provencher S, Bonnet S, Paulin R, Boucherat O., Free PMC Article | 05/1/2021 |
| Ezh2-dependent H3K27me3 modification dynamically regulates vitamin D3-dependent epigenetic control of CYP24A1 gene expression in osteoblastic cells. | Ezh2-dependent H3K27me3 modification dynamically regulates vitamin D3-dependent epigenetic control of CYP24A1 gene expression in osteoblastic cells.
Moena D, Nardocci G, Acevedo E, Lian J, Stein G, Stein J, Montecino M., Free PMC Article | 03/13/2021 |
| Inhibition of EZH2 (Enhancer of Zeste Homolog 2) Attenuates Neuroinflammation via H3k27me3/SOCS3/TRAF6/NF-kappaB (Trimethylation of Histone 3 Lysine 27/Suppressor of Cytokine Signaling 3/Tumor Necrosis Factor Receptor Family 6/Nuclear Factor-kappaB) in a Rat Model of Subarachnoid Hemorrhage. | Inhibition of EZH2 (Enhancer of Zeste Homolog 2) Attenuates Neuroinflammation via H3k27me3/SOCS3/TRAF6/NF-κB (Trimethylation of Histone 3 Lysine 27/Suppressor of Cytokine Signaling 3/Tumor Necrosis Factor Receptor Family 6/Nuclear Factor-κB) in a Rat Model of Subarachnoid Hemorrhage.
Luo Y, Fang Y, Kang R, Lenahan C, Gamdzyk M, Zhang Z, Okada T, Tang J, Chen S, Zhang JH., Free PMC Article | 02/20/2021 |
| Pb exposure diminished H3K27me3 levels in vivo by suppressing EZH2 (enhancer of zeste homolog 2) expression at an early stage. Furthermore, miR-137 and EZH2 constitute mutually inhibitory loop to regulate the H3K27me3 level, and this feedback regulation could be specifically activated by Pb treatment. | Interplay of miR-137 and EZH2 contributes to the genome-wide redistribution of H3K27me3 underlying the Pb-induced memory impairment.
Gu X, Xu Y, Xue WZ, Wu Y, Ye Z, Xiao G, Wang HL., Free PMC Article | 08/15/2020 |
| High EZH2 expression is associated with neuropathic pain. | miR-124-3p attenuates neuropathic pain induced by chronic sciatic nerve injury in rats via targeting EZH2.
Zhang Y, Liu HL, An LJ, Li L, Wei M, Ge DJ, Su Z. | 07/25/2020 |
| We found abundant GAS5 expression and a reduction in RGC density in the retinal tissues of glaucoma rats. Silencing of GAS5 led to increased EZH2 expression and decreased ABCA1 expression in RGCs. In addition, upregulation of EZH2 promoted trimethylation of lysine 27 on histone H3, thereby suppressing ABCA1 expression and eventually leading to the inhibition of RGC apoptosis. | Silencing of GAS5 Alleviates Glaucoma in Rat Models by Reducing Retinal Ganglion Cell Apoptosis.
Zhou RR, Li HB, You QS, Rong R, You ML, Xiong K, Huang JF, Xia XB, Ji D. | 06/6/2020 |
| Deletion of Ezh2 by RNA interference approach promoted differentiation of dopaminergic neurons during midbrain development. Overexpression of Ezh2 enhanced cell self-renewal and did not affect differentiation of dopaminergic neurons. | Inhibition of Ezh2 In Vitro and the Decline of Ezh2 in Developing Midbrain Promote Dopaminergic Neurons Differentiation Through Modifying H3K27me3.
Hong F, Zhao M, Zhang L, Feng L. | 05/2/2020 |
| Retrieval of a contextual fear memory transiently increased EZH2 levels along with increased H3K27me3 levels, which correlated with decreased levels of Pten via transcriptional silencing of the Pten gene. Knockdown of Ezh2 in area CA1 before retrieval impaired memory. EZH2-mediated H3K27me3 represses Pten transcription necessary for AKT-mTOR activation and memory reconsolidation following retrieval. | EZH2 Methyltransferase Activity Controls Pten Expression and mTOR Signaling during Fear Memory Reconsolidation.
Jarome TJ, Perez GA, Hauser RM, Hatch KM, Lubin FD., Free PMC Article | 10/19/2019 |
| OPN-mediated bone marrow-derived mesenchymal stem cells (BMSCs) migration leads to elevated levels of heterochromatin marker histone H3 lysine 27 trimethylation (H3K27me3) through the methyltransferase EZH2. The expression of EZH2 reorganizes the chromatin structure of BMSCs. | Chromatin organization regulated by EZH2-mediated H3K27me3 is required for OPN-induced migration of bone marrow-derived mesenchymal stem cells.
Liu L, Luo Q, Sun J, Ju Y, Morita Y, Song G. | 01/5/2019 |
| single-dose (137)CS irradiation induces bone mineral density loss and the deterioration of bone microarchitecture in the rat skeleton; EZH2 expression increased and osteoblastogenesis decrease after irradiation | Increased EZH2 and decreased osteoblastogenesis during local irradiation-induced bone loss in rats.
Guo C, Li C, Yang K, Kang H, Xu X, Xu X, Deng L., Free PMC Article | 06/23/2018 |
| Results suggest that both enhancer of zeste homolog 2 protein (EZH2) and dickkopf-1 protein (Dkk1) might play an essential role in the pathogenesis of hepatic fibrosis. | EZH2-mediated repression of Dkk1 promotes hepatic stellate cell activation and hepatic fibrosis.
Yang Y, Chen XX, Li WX, Wu XQ, Huang C, Xie J, Zhao YX, Meng XM, Li J., Free PMC Article | 06/9/2018 |
| Knockdown of Ezh2 increased anxiety-like behavior in rats. Ezh2 is targeted by mir-101a. | Amygdalar expression of the microRNA miR-101a and its target Ezh2 contribute to rodent anxiety-like behaviour.
Cohen JL, Jackson NL, Ballestas ME, Webb WM, Lubin FD, Clinton SM., Free PMC Article | 05/26/2018 |