| Heme oxygenase-2 (HO-2) binds and buffers labile ferric heme in human embryonic kidney cells. | Heme oxygenase-2 (HO-2) binds and buffers labile ferric heme in human embryonic kidney cells.
Hanna DA, Moore CM, Liu L, Yuan X, Dominic IM, Fleischhacker AS, Hamza I, Ragsdale SW, Reddi AR., Free PMC Article | 05/14/2022 |
| Heme oxygenase-1 & 2 and their potential contribution in heme induced colorectal carcinogenesis. | Heme oxygenase-1 & 2 and their potential contribution in heme induced colorectal carcinogenesis.
Gamage SMK, Nanayakkara S, Macfarlane L, Hewage D, Cheng T, Aktar S, Lu CT, Dissabandara L, Islam F, Lam AK, Gopalan V. | 05/7/2022 |
| Immune Modulation by Inhibitors of the HO System. | Immune Modulation by Inhibitors of the HO System.
Fernández-Fierro A, Funes SC, Rios M, Covián C, González J, Kalergis AM., Free PMC Article | 09/18/2021 |
| Heme oxygenase promotes B-Raf-dependent melanosphere formation. | Heme oxygenase promotes B-Raf-dependent melanosphere formation.
Jasmer KJ, Hou J, Mannino P, Cheng J, Hannink M., Free PMC Article | 08/14/2021 |
| Heme oxygenase-2 is post-translationally regulated by heme occupancy in the catalytic site. | Heme oxygenase-2 is post-translationally regulated by heme occupancy in the catalytic site.
Liu L, Dumbrepatil AB, Fleischhacker AS, Marsh ENG, Ragsdale SW., Free PMC Article | 03/20/2021 |
| results highlight significant dynamic and structural differences between HO2 and HO1 and indicate that their dissimilar C-terminal regions play a major role in controlling the structural dynamics of these two proteins. | Dynamic and structural differences between heme oxygenase-1 and -2 are due to differences in their C-terminal regions.
Kochert BA, Fleischhacker AS, Wales TE, Becker DF, Engen JR, Ragsdale SW., Free PMC Article | 12/14/2019 |
| REVIEW: Redox Regulation of Heme Oxygenase-2 and the Transcription Factor, Rev-Erb, Through Heme Regulatory Motifs | Redox Regulation of Heme Oxygenase-2 and the Transcription Factor, Rev-Erb, Through Heme Regulatory Motifs.
Fleischhacker AS, Carter EL, Ragsdale SW., Free PMC Article | 10/5/2019 |
| The frequencies of genotype and allelic variants of ALAD rs1800435 did not differ significantly between patients with essential tremor (ET) and controls, and were not influenced by gender. Subjects carrying the ALAD rs1800435CC genotype (wild-type) and the HMOX2 rs1051308GG genotype or the HMOX2 rs1051308G allele had significantly decreased risk for ET. | Delta-amino-levulinic acid dehydratase gene and essential tremor.
Agúndez JAG, García-Martín E, Alonso-Navarro H, Ayuso P, Esguevillas G, Benito-León J, Ortega-Cubero S, Pastor P, López-Alburquerque T, Jiménez-Jiménez FJ. | 03/17/2018 |
| The domains involved in HO-1 translocation have been identified, and it was shown that SPP-mediated HO-1 cleavage is isoform-specific (HO-1 vs HO-2) and independent of heme oxygenase activity. | Insights into the mechanism of isoenzyme-specific signal peptide peptidase-mediated translocation of heme oxygenase.
Schaefer B, Moriishi K, Behrends S., Free PMC Article | 12/23/2017 |
| HO-2 is a cellular myristate-binding protein that negatively regulates both virus replication and host inflammatory responses. | Heme Oxygenase 2 Binds Myristate to Regulate Retrovirus Assembly and TLR4 Signaling.
Zhu Y, Luo S, Sabo Y, Wang C, Tong L, Goff SP., Free PMC Article | 09/16/2017 |
| Our results suggest that rs1051308 is associated with risk of developing Parkinson disease in Han Chinese, and further studies involving various ethnicities are needed to validate the association. | Association between a heme oxygenase-2 genetic variant and risk of Parkinson's disease in Han Chinese.
Tian S, Yang X, Zhao Q, Zheng J, Huang H, Chen Y, An R, Xu Y. | 09/9/2017 |
| High HMOX2 expression is associated with bladder cancer. | Exploring the FGFR3-related oncogenic mechanism in bladder cancer using bioinformatics strategy.
Cao W, Ma E, Zhou L, Yuan T, Zhang C., Free PMC Article | 08/19/2017 |
| The present study suggests a weak association between HMOX2 rs1051308 polymorphism and the risk to develop multiple sclerosis (MS) in Spanish Caucasian men and a trend towards association between the HMOX1 rs2071746A and MS risk. | Heme Oxygenase-1 and 2 Common Genetic Variants and Risk for Multiple Sclerosis.
Agúndez JA, García-Martín E, Martínez C, Benito-León J, Millán-Pascual J, Díaz-Sánchez M, Calleja P, Pisa D, Turpín-Fenoll L, Alonso-Navarro H, Pastor P, Ortega-Cubero S, Ayuso-Peralta L, Torrecillas D, García-Albea E, Plaza-Nieto JF, Jiménez-Jiménez FJ., Free PMC Article | 12/31/2016 |
| HMOX2 contributes to high-altitude adaptation in Tibetans by functioning as a modifier in the regulation of hemoglobin metabolism. | HMOX2 Functions as a Modifier Gene for High-Altitude Adaptation in Tibetans.
Yang D, Peng Y, Ouzhuluobu, Bianbazhuoma, Cui C, Bianba, Wang L, Xiang K, He Y, Zhang H, Zhang X, Liu J, Shi H, Pan Y, Duojizhuoma, Dejiquzong, Cirenyangji, Baimakangzhuo, Gonggalanzi, Liu S, Gengdeng, Wu T, Chen H, Qi X, Su B. | 10/22/2016 |
| The same mechanism of heme hydroxylation to alpha-meso-hydroxyheme is employed by both isoforms HO-1 and HO-2. | Comparison of the Mechanisms of Heme Hydroxylation by Heme Oxygenases-1 and -2: Kinetic and Cryoreduction Studies.
Davydov R, Fleischhacker AS, Bagai I, Hoffman BM, Ragsdale SW., Free PMC Article | 05/14/2016 |
| a weak association between HMOX2 rs1051308 polymorphisms and the risk to develop essential tremor in the Spanish population. | Heme Oxygenase 1 and 2 Common Genetic Variants and Risk for Essential Tremor.
Ayuso P, Agúndez JAG, Alonso-Navarro H, Martínez C, Benito-León J, Ortega-Cubero S, Lorenzo-Betancor O, Pastor P, López-Alburquerque T, García-Martín E, Jiménez-Jiménez FJ., Free PMC Article | 11/21/2015 |
| Taken together with EPR measurements, which show the appearance of a new low-spin heme signal in reduced HO2, it appears that a cysteine residue(s) in the HRMs directly interacts with a second bound heme | Spectroscopic studies reveal that the heme regulatory motifs of heme oxygenase-2 are dynamically disordered and exhibit redox-dependent interaction with heme.
Bagai I, Sarangi R, Fleischhacker AS, Sharma A, Hoffman BM, Zuiderweg ER, Ragsdale SW., Free PMC Article | 07/25/2015 |
| HO-2 protein is expressed in the cytosols of skin cancer cells. | The heme oxygenase/biliverdin reductase system in skin cancers.
Arena V, Pennacchia I, Guerriero G, Mancuso C. | 06/27/2015 |
| Interactions of HO-2 with CPR and BVR, were evaluated. | Protein/protein interactions in the mammalian heme degradation pathway: heme oxygenase-2, cytochrome P450 reductase, and biliverdin reductase.
Spencer AL, Bagai I, Becker DF, Zuiderweg ER, Ragsdale SW., Free PMC Article | 02/14/2015 |
| We believe that a dysfunctional HO-ferritin system leads to increased levels of proinflammatory mediators, thus contributing to the inflammation characteristic of pterygia. | Dysregulated heme oxygenase-ferritin system in pterygium pathogenesis.
Fox T, Gotlinger KH, Dunn MW, Lee OL, Milman T, Zaidman G, Schwartzman ML, Bellner L., Free PMC Article | 02/1/2014 |
| increased expression of nucleated RBC, HSP90alpha and corresponding decreased expression of HO-2 in such hypoxic condition may play a protective role; to prevent cord blood RBC against stress induced damage during preeclampsia. | Differential expression of HSP90α and heme oxygenase in cord blood RBC during preeclampsia.
Ekambaram P, Jayachandran T, Dhakshinamoorthy L. | 07/6/2013 |
| PFKFB4 and HO-2 are expressed in a coordinated manner to maintain glucose homeostasis. | Coordinated expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 and heme oxygenase 2: evidence for a regulatory link between glycolysis and heme catabolism.
Li B, Takeda K, Ishikawa K, Yoshizawa M, Sato M, Shibahara S, Furuyama K. | 03/30/2013 |
| HO-1 and HO-2 contribute little in the pathophysiology of adenomyosis. | Expression of heme oxygenase in the eutopic and ectopic endometrium in patients with adenomyosis.
Iwahara Y, Nagai A, Yoshiki N, Igarashi K, Yamashita K, Kubota T. | 03/23/2013 |
| Role of cysteine residues in heme binding to human heme oxygenase-2 elucidated by two-dimensional NMR spectroscopy. | Role of cysteine residues in heme binding to human heme oxygenase-2 elucidated by two-dimensional NMR spectroscopy.
Varfaj F, Lampe JN, Ortiz de Montellano PR., Free PMC Article | 01/5/2013 |
| Although the carboxy-terminal deletion mutant of HO-2 is found in the nucleus, translocation of HO-2 to the nucleus does not occur under conditions of hypoxia. | Heme oxygenase isoforms differ in their subcellular trafficking during hypoxia and are differentially modulated by cytochrome P450 reductase.
Linnenbaum M, Busker M, Kraehling JR, Behrends S., Free PMC Article | 09/1/2012 |