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    NR4A1 nuclear receptor subfamily 4 group A member 1 [ Homo sapiens (human) ]

    Gene ID: 3164, updated on 6-Sep-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Nur77 deficiency exacerbates cardiac fibrosis after myocardial infarction by promoting endothelial-to-mesenchymal transition.

    Nur77 deficiency exacerbates cardiac fibrosis after myocardial infarction by promoting endothelial-to-mesenchymal transition.
    Chen J, Jia J, Ma L, Li B, Qin Q, Qian J, Ge J.

    08/28/2021
    Hypoxia-induced Nur77 activates PI3K/Akt signaling via suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition.

    Hypoxia-induced Nur77 activates PI3K/Akt signaling <i>via</i> suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition.
    Shi Z, To SKY, Zhang S, Deng S, Artemenko M, Zhang M, Tang J, Zeng JZ, Wong AST., Free PMC Article

    07/24/2021
    The NR4A agonist, Cytosporone B, attenuates pro-inflammatory mediators in human colorectal cancer tissue ex vivo.

    The NR4A agonist, Cytosporone B, attenuates pro-inflammatory mediators in human colorectal cancer tissue ex vivo.
    Ismaiel M, Murphy B, Aldhafiri S, Giffney HE, Thornton K, Mukhopadhya A, Keogh CE, Fattah S, Mohan HM, Cummins EP, Murphy EP, Winter DC, Crean D.

    07/17/2021
    Endothelium-specific endothelin-1 expression promotes pro-inflammatory macrophage activation by regulating miR-33/NR4A axis.

    Endothelium-specific endothelin-1 expression promotes pro-inflammatory macrophage activation by regulating miR-33/NR4A axis.
    Zhang J, Zhao WS, Xu L, Wang X, Li XL, Yang XC.

    06/19/2021
    Interplay between transforming growth factor-beta and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis.

    Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis.
    Niu B, Liu J, Lv B, Lin J, Li X, Wu C, Jiang X, Zeng Z, Zhang XK, Zhou H., Free PMC Article

    06/5/2021
    Glycerol kinase enhances hepatic lipid metabolism by repressing nuclear receptor subfamily 4 group A1 in the nucleus.

    Glycerol kinase enhances hepatic lipid metabolism by repressing nuclear receptor subfamily 4 group A1 in the nucleus.
    Miao L, Su F, Yang Y, Liu Y, Wang L, Zhan Y, Yin R, Yu M, Li C, Yang X, Ge C.

    02/27/2021
    Nur77-activated lncRNA WFDC21P attenuates hepatocarcinogenesis via modulating glycolysis.

    Nur77-activated lncRNA WFDC21P attenuates hepatocarcinogenesis via modulating glycolysis.
    Guan YF, Huang QL, Ai YL, Chen QT, Zhao WX, Wang XM, Wu Q, Chen HZ., Free PMC Article

    01/16/2021
    Blocking PPARgamma interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression.

    Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression.
    Yang PB, Hou PP, Liu FY, Hong WB, Chen HZ, Sun XY, Li P, Zhang Y, Ju CY, Luo LJ, Wu SF, Zhou JX, Wang ZJ, He JP, Li L, Zhao TJ, Deng X, Lin T, Wu Q., Free PMC Article

    01/9/2021
    Nur77 promotes embryo adhesion by transcriptionally regulating HOXA10 expression.

    Nur77 promotes embryo adhesion by transcriptionally regulating HOXA10 expression.
    Shen J, Zhu X, Zhang M, Jiang Y, Yan G, Wang Z, Sun L, Zhang Q.

    01/9/2021
    Targeting Oncogenic Super Enhancers in MYC-Dependent AML Using a Small Molecule Activator of NR4A Nuclear Receptors.

    Targeting Oncogenic Super Enhancers in MYC-Dependent AML Using a Small Molecule Activator of NR4A Nuclear Receptors.
    Call SG, Duren RP, Panigrahi AK, Nguyen L, Freire PR, Grimm SL, Coarfa C, Conneely OM., Free PMC Article

    11/21/2020
    C. elegans protein interaction network analysis probes RNAi validated pro-longevity effect of nhr-6, a human homolog of tumor suppressor Nr4a1.

    C. elegans protein interaction network analysis probes RNAi validated pro-longevity effect of nhr-6, a human homolog of tumor suppressor Nr4a1.
    Akhoon BA, Gupta SK, Tiwari S, Rathor L, Pant A, Singh N, Gupta SK, Dandekar T, Pandey R., Free PMC Article

    11/21/2020
    Prevention of progression of pulmonary hypertension by the Nur77 agonist 6-mercaptopurine: role of BMP signalling.

    Prevention of progression of pulmonary hypertension by the Nur77 agonist 6-mercaptopurine: role of BMP signalling.
    Kurakula K, Sun XQ, Happé C, da Silva Goncalves Bos D, Szulcek R, Schalij I, Wiesmeijer KC, Lodder K, Tu L, Guignabert C, de Vries CJM, de Man FS, Vonk Noordegraaf A, Ten Dijke P, Goumans MJ, Bogaard HJ.

    10/24/2020
    Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter.

    Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter.
    Jiang L, Wei H, Yan N, Dai S, Li J, Qu L, Chen X, Guo M, Chen Z, Chen Y.

    09/12/2020
    Lnc-NA inhibits proliferation and metastasis in endometrioid endometrial carcinoma through regulation of NR4A1.

    Lnc-NA inhibits proliferation and metastasis in endometrioid endometrial carcinoma through regulation of NR4A1.
    Sun L, Zhou R, Dong J, Liu S, Jiao Y, Wang L, Hu S, He P, Liu X, Zhao X, Jiang G, Zhao Y., Free PMC Article

    08/13/2020
    These data elucidate the mechanism by which NR4A1 inhibition functions to inhibit the proliferation, survival, and migration of rhabdomyosarcoma (RMS) cells.

    Inhibition of NR4A1 Promotes ROS Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma.
    Hedrick E, Mohankumar K, Lacey A, Safe S., Free PMC Article

    08/1/2020
    NUR77 promoted PGF expression during trophoblast fusion.

    The orphan nuclear receptor NUR77 promotes trophoblast invasion at early pregnancy through paracrine placental growth factor.
    Li XC, Yin XJ, Hong W, Liu J, Jin F, Wang BY, Wang YM, Tian FJ.

    06/20/2020
    mitochondrial fission was involved in NR4A1mediated chondrocyte injury via regulation of mitochondrial dysfunction, mPTP openinginduced cell death and Factinrelated migratory inhibition.

    NR4A1 promotes TNF‑α‑induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway.
    Zheng Z, Xiang S, Wang Y, Dong Y, Li Z, Xiang Y, Bian Y, Feng B, Yang B, Weng X., Free PMC Article

    06/13/2020
    NR4A1 suppresses hyperhomocysteinemia-induced hepatic steatosis in vitro and in vivo. --- Homocysteine enhanced p300 and decreased HDAC7 recruitment to the NR4A1 promoter, resulting in histone H3K27 hyperacetylation and NR4A1 upregulation.

    Orphan nuclear receptor NR4A1 suppresses hyperhomocysteinemia-induced hepatic steatosis in vitro and in vivo.
    Liang H, Xie X, Song X, Huang M, Su T, Chang X, Liang B, Huang D.

    06/6/2020
    The ability of NR4A1 to induce autophagic cell death is impaired when SUMOylation is reduced. Autophagic cell death could be triggered by specific molecular interactions of SUMOylated NR4A1 in the cytoplasm or in the nucleus.

    The nuclear receptor NR4A1 is regulated by SUMO modification to induce autophagic cell death.
    Zárraga-Granados G, Muciño-Hernández G, Sánchez-Carbente MR, Villamizar-Gálvez W, Peñas-Rincón A, Arredondo C, Andrés ME, Wood C, Covarrubias L, Castro-Obregón S., Free PMC Article

    05/30/2020
    Our results identify BI1071 as a novel Nur77-binding modulator of the Nur77-Bcl-2 apoptotic pathway, which may serve as a promising lead for treating cancers with overexpression of Bcl-2.

    BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway.
    Chen X, Cao X, Tu X, Alitongbieke G, Xia Z, Li X, Chen Z, Yin M, Xu D, Guo S, Li Z, Chen L, Zhang X, Xu D, Gao M, Liu J, Zeng Z, Zhou H, Su Y, Zhang XK., Free PMC Article

    03/28/2020
    Results found deregulated expression of NR4A1 in non-small cell lung cancer (NSCLC) tissues to be associated with poor clinical outcome.

    Metabolic gene NR4A1 as a potential therapeutic target for non-smoking female non-small cell lung cancer patients.
    Sun R, Bao MY, Long X, Yuan Y, Wu MM, Li X, Bao JK., Free PMC Article

    03/28/2020
    Study presents the first description that TFAP2A and ETS family signaling networks are involved in the androgen-mediated transcriptional regulation of NR4A1, which contributes to the understanding of the molecular mechanisms involved in the TFAP2A-NR4A1 and ETS-NR4A1 signaling networks in PCOS.

    Androgen upregulates NR4A1 via the TFAP2A and ETS signaling networks.
    Song J, Diao F, Ma X, Xu S, Cui Y, Jiang S, Liu J.

    03/21/2020
    The Trim13-mediated ubiquitination of Nur77 was optimal in the presence of the E2 enzyme UbcH5. Importantly, in addition to Trim13-mediated ubiquitination, the stability of Nur77 was also regulated by casein kinase 2alpha

    The E3 ubiquitin ligase Trim13 regulates Nur77 stability via casein kinase 2α.
    Huang B, Pei HZ, Chang HW, Baek SH., Free PMC Article

    12/14/2019
    These data indicate that high cytoplasmic NR4A1 is associated with a favourable lymphoma-specific survival and highlights the importance of NR4A1 expression patterns as potential prognostic marker for risk assessment in aggressive lymphomas.

    Cytoplasmic location of NR4A1 in aggressive lymphomas is associated with a favourable cancer specific survival.
    Fechter K, Feichtinger J, Prochazka K, Unterluggauer JJ, Pansy K, Steinbauer E, Pichler M, Haybaeck J, Prokesch A, Greinix HT, Beham-Schmid C, Neumeister P, Thallinger GG, Deutsch AJA., Free PMC Article

    11/16/2019
    This review addresses the mechanisms that control Nur77 as well as its known roles in inflammation-related lung diseases.

    Key Functions and Therapeutic Prospects of Nur77 in Inflammation Related Lung Diseases
    Banno A, Lakshmi SP, Reddy AT, Kim SC, Reddy RC., Free PMC Article

    11/16/2019
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