| Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere. | Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere.
Li C, Warren DT, Zhou C, De Silva S, Wilson DGS, Garcia-Maya M, Wheeler MA, Meinke P, Sawyer G, Ehler E, Wehnert M, Rao L, Zhang Q, Shanahan CM., Free PMC Article | 06/11/2024 |
| Nesprins are mechanotransducers that discriminate epithelial-mesenchymal transition programs. | Nesprins are mechanotransducers that discriminate epithelial-mesenchymal transition programs.
Déjardin T, Carollo PS, Sipieter F, Davidson PM, Seiler C, Cuvelier D, Cadot B, Sykes C, Gomes ER, Borghi N., Free PMC Article | 03/28/2021 |
| Study found the lack of an overt retinal phenotype in Syne-2/Nesprin-2 KO mice suggests the usage of alternative translational start sites, producing Syne-2 splice variants with an intact Pcnt interaction site. | Lack of a Retinal Phenotype in a Syne-2/Nesprin-2 Knockout Mouse Model.
Falk N, Joachimsthaler A, Kessler K, Lux UT, Noegel AA, Kremers J, Brandstätter JH, Gießl A, Falk N, Joachimsthaler A, Kessler K, Lux UT, Noegel AA, Kremers J, Brandstätter JH, Gießl A., Free PMC Article | 07/18/2020 |
| Nesprin-2G knockout fibroblasts exhibit reduced migration, changes in focal adhesion composition, and reduced ability to generate traction forces. | Nesprin-2G knockout fibroblasts exhibit reduced migration, changes in focal adhesion composition, and reduced ability to generate traction forces.
Woychek A, Jones JCR. | 07/4/2020 |
| CRISPR/Cas9-mediated knockout of Syne-2 in cell culture led to an overexpression and mislocalization of Pcnt and to ciliogenesis defects. This suggests that the Pcnt-Syne-2 complex is important for ciliogenesis and outer segment formation during retinal development and plays a role in nuclear migration. | Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis.
Falk N, Kessler K, Schramm SF, Boldt K, Becirovic E, Michalakis S, Regus-Leidig H, Noegel AA, Ueffing M, Thiel CT, Roepman R, Brandstätter JH, Gießl A. | 11/30/2019 |
| The Nesprin-2 gene function is crucial during embryonic growth, differentiation and organogenesis. | Depletion of Nesprin-2 is associated with an embryonic lethal phenotype in mice.
Mroß C, Marko M, Munck M, Glöckner G, Motameny S, Altmüller J, Noegel AA, Eichinger L, Peche VS, Neumann S., Free PMC Article | 09/21/2019 |
| nesprin-2G is subject to mechanical tension in adherent fibroblasts | Nesprin-2G, a Component of the Nuclear LINC Complex, Is Subject to Myosin-Dependent Tension.
Arsenovic PT, Ramachandran I, Bathula K, Zhu R, Narang JD, Noll NA, Lemmon CA, Gundersen GG, Conway DE., Free PMC Article | 10/8/2016 |
| SYNE2 is important for normal retinal development. We have determined that not only is photoreceptor nuclear migration affected, but also the positions of Muller glia and secondary neurons are disturbed early in retinal development | A Mutation in Syne2 Causes Early Retinal Defects in Photoreceptors, Secondary Neurons, and Müller Glia.
Maddox DM, Collin GB, Ikeda A, Pratt CH, Ikeda S, Johnson BA, Hurd RE, Shopland LS, Naggert JK, Chang B, Krebs MP, Nishina PM., Free PMC Article | 09/5/2015 |
| nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development. | Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.
Wilson MH, Holzbaur EL., Free PMC Article | 02/21/2015 |
| Loss of Nesprin 1 or 2, or both, led to impairment of gene expression changes in response to biomechanical stimuli. These data suggest a model whereby biomechanical signals are communicated from proteins of the outer nuclear membrane | Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.
Banerjee I, Zhang J, Moore-Morris T, Pfeiffer E, Buchholz KS, Liu A, Ouyang K, Stroud MJ, Gerace L, Evans SM, McCulloch A, Chen J., Free PMC Article | 12/20/2014 |
| ectopic expression of BRAP2 inhibits nuclear localization of HMG20A and NuMA1, and prevents nuclear envelope accumulation of SYNE2 | The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins.
Davies RG, Wagstaff KM, McLaughlin EA, Loveland KL, Jans DA. | 03/1/2014 |
| Data indicate roles for linkers of nucleus to cytoskeleton (LINC) molecules nesprin2giant and nesprin3, which anchor actin cap fibers to the nucleus. | The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction.
Chambliss AB, Khatau SB, Erdenberger N, Robinson DK, Hodzic D, Longmore GD, Wirtz D., Free PMC Article | 06/29/2013 |
| functions for Nesprin-2 at the nuclear envelope (NE) in gene regulation and in regulation of the actin cytoskeleton which impact on wound healing | The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing.
Rashmi RN, Eckes B, Glöckner G, Groth M, Neumann S, Gloy J, Sellin L, Walz G, Schneider M, Karakesisoglou I, Eichinger L, Noegel AA., Free PMC Article | 11/17/2012 |
| Syne-2, SUN1 and SUN2 play critical roles during interkinetic nuclear migration and photoreceptor cell migration in the mouse retina development. | KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.
Yu J, Lei K, Zhou M, Craft CM, Xu G, Xu T, Zhuang Y, Xu R, Han M., Free PMC Article | 06/25/2011 |
| The p104 protein interacts with p85alpha and is involved in the regulation of p27(Kip1) expression for the reduction of cellular proliferation. | Novel p104 protein regulates cell proliferation through PI3K inhibition and p27(Kip1) expression.
Han SJ, Lee JH, Choi KY, Hong SH. | 12/16/2010 |
| Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development | Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.
Randles KN, Lam le T, Sewry CA, Puckelwartz M, Furling D, Wehnert M, McNally EM, Morris GE., Free PMC Article | 12/11/2010 |
| The SUN-domain proteins SUN1 and SUN2 and the KASH-domain proteins Syne-1/Nesprin-1 and Syne-2/Nesprin-2 play critical roles in neurogenesis and neuronal migration in mice | SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.
Zhang X, Lei K, Yuan X, Wu X, Zhuang Y, Xu T, Xu R, Han M., Free PMC Article | 01/21/2010 |
| TorsinA also associated with the KASH domains of nesprin-1 and -2 | TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.
Nery FC, Zeng J, Niland BP, Hewett J, Farley J, Irimia D, Li Y, Wiche G, Sonnenberg A, Breakefield XO., Free PMC Article | 01/21/2010 |
| The Nesprin-2 the conserved C-terminal amino acids PPPX is essential for the interaction with a C-terminal region in Sun1. | The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.
Padmakumar VC, Libotte T, Lu W, Zaim H, Abraham S, Noegel AA, Gotzmann J, Foisner R, Karakesisoglou I. | 01/21/2010 |
| The KASH-domain-containing proteins Syne-1 and Syne-2 play crucial roles in anchoring both synaptic and non-synaptic myonuclei that are important for proper motor neuron innervation and respiration. | Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.
Zhang X, Xu R, Zhu B, Yang X, Ding X, Duan S, Xu T, Zhuang Y, Han M. | 01/21/2010 |
| SUN1 interacts with nuclear lamin A and cytoplasmic nesprins (nesprin-1 and nesprin-2)to provide a physical connection between the nuclear lamina and the cytoskeleton. | SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.
Haque F, Lloyd DJ, Smallwood DT, Dent CL, Shanahan CM, Fry AM, Trembath RC, Shackleton S., Free PMC Article | 01/21/2010 |