| Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment. | Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment.
Ma J, Al Moussawi K, Lou H, Chan HF, Wang Y, Chadwick J, Phetsouphanh C, Slee EA, Zhong S, Leissing TM, Roth A, Qin X, Chen S, Yin J, Ratnayaka I, Hu Y, Louphrasitthiphol P, Taylor L, Bettencourt PJG, Muers M, Greaves DR, McShane H, Goldin R, Soilleux EJ, Coleman ML, Ratcliffe PJ, Lu X., Free PMC Article | 03/5/2024 |
| The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism. | The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism.
Ruiz-Serrano A, Boyle CN, Monné Rodríguez JM, Günter J, Jucht AE, Pfundstein S, Bapst AM, Lutz TA, Wenger RH, Scholz CC., Free PMC Article | 03/19/2022 |
| Knockout of Factor-Inhibiting HIF (Hif1an) in Colon Epithelium Attenuates Chronic Colitis but Does Not Reduce Colorectal Cancer in Mice. | Knockout of Factor-Inhibiting HIF (Hif1an) in Colon Epithelium Attenuates Chronic Colitis but Does Not Reduce Colorectal Cancer in Mice.
Schützhold V, Gravemeyer J, Bicker A, Hager T, Padberg C, Schäfer J, Wrobeln A, Steinbrink M, Zeynel S, Hankeln T, Becker JC, Fandrey J, Winning S. | 03/12/2022 |
| FIH-1-modulated HIF-1alpha C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling. | FIH-1-modulated HIF-1α C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling.
Li ZL, Wang B, Lv LL, Tang TT, Wen Y, Cao JY, Zhu XX, Feng ST, Crowley SD, Liu BC., Free PMC Article | 02/5/2022 |
| MicroRNA-1-3p enhances osteoblast differentiation of MC3T3-E1 cells by interacting with hypoxia-inducible factor 1 alpha inhibitor (HIF1AN). | MicroRNA-1-3p enhances osteoblast differentiation of MC3T3-E1 cells by interacting with hypoxia-inducible factor 1 α inhibitor (HIF1AN).
Zhou L, Qiu M, Yang L, Yang L, Zhang Y, Mu S, Song H. | 05/29/2021 |
| miR212 promotes renal interstitial fibrosis by inhibiting hypoxiainducible factor 1alpha inhibitor. | miR‑212 promotes renal interstitial fibrosis by inhibiting hypoxia‑inducible factor 1‑α inhibitor.
Zhang Y, Zhang GX, Che LS, Shi SH, Li YT., Free PMC Article | 05/8/2021 |
| HIF1AN was confirmed as a direct target of miR-135-5p. [miR-135-5p] | MiR-135-5p promotes osteoblast differentiation by targeting HIF1AN in MC3T3-E1 cells.
Yin N, Zhu L, Ding L, Yuan J, Du L, Pan M, Xue F, Xiao H., Free PMC Article | 04/11/2020 |
| FIH-1 has a role in disrupting the LRRK1/EGFR complex to positively regulate keratinocyte migration | FIH-1 disrupts an LRRK1/EGFR complex to positively regulate keratinocyte migration.
Peng H, Kaplan N, Yang W, Getsios S, Lavker RM., Free PMC Article | 08/15/2015 |
| miR-31/FIH1 pathway associates with liver fibrosis, perhaps by participation in the TGF-beta/Smad3 signalling of hepatic stellate cells. | The role of the miR-31/FIH1 pathway in TGF-β-induced liver fibrosis.
Hu J, Chen C, Liu Q, Liu B, Song C, Zhu S, Wu C, Liu S, Yu H, Yao D, Kang J, Zhu L. | 08/8/2015 |
| gankyrin binds to and sequester factor inhibiting hypoxia-inducible factor-1 (FIH-1), which results in decreased interaction between FIH-1 and hypoxia-inducible factor-1alpha (HIF-1alpha) and increased activity of HIF-1 to promote VEGF production. | Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1.
Liu Y, Higashitsuji H, Higashitsuji H, Itoh K, Sakurai T, Koike K, Hirota K, Fukumoto M, Fujita J. | 09/21/2013 |
| Our results define a previously unknown mechanism for keratinocyte fate decisions where Notch signaling potential is, in part, controlled through a miR-31/FIH-1 nexus. | microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation.
Peng H, Kaplan N, Hamanaka RB, Katsnelson J, Blatt H, Yang W, Hao L, Bryar PJ, Johnson RS, Getsios S, Chandel NS, Lavker RM., Free PMC Article | 12/22/2012 |
| Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C in osteosarcoma. | Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C.
Kuzmanov A, Wielockx B, Rezaei M, Kettelhake A, Breier G. | 09/22/2012 |
| FIH recognizes distinct molecular features within HIF-alpha1 versus ankyrin repeat containing substrates Notch1/4 and Gankyrin. | Factor inhibiting HIF (FIH) recognizes distinct molecular features within hypoxia-inducible factor-α (HIF-α) versus ankyrin repeat substrates.
Wilkins SE, Karttunen S, Hampton-Smith RJ, Murchland I, Chapman-Smith A, Peet DJ., Free PMC Article | 06/16/2012 |
| Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation. | Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation.
Singleton RS, Trudgian DC, Fischer R, Kessler BM, Ratcliffe PJ, Cockman ME., Free PMC Article | 11/26/2011 |
| FIH1 appears to be a suppressor of oxygen-dependent genes in the kidney, operating through HIF-dependent and -independent mechanisms. | Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells.
Schödel J, Bohr D, Klanke B, Schley G, Schlötzer-Schrehardt U, Warnecke C, Kurtz A, Amann K, Eckardt KU, Willam C. | 02/26/2011 |
| Lackin of hypoxia-inducible factor 1 alpha subunit inhibitor exhibit reduced body weight, elevated metabolic rate, hyperventilation, and improved glucose and lipid homeostasis and are resistant to high-fat-diet-induced weight gain and hepatic steatosis. | The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism.
Zhang N, Fu Z, Linke S, Chicher J, Gorman JJ, Visk D, Haddad GG, Poellinger L, Peet DJ, Powell F, Johnson RS., Free PMC Article | 08/9/2010 |