| CHD7 variants associated with hearing loss and enlargement of the vestibular aqueduct. | CHD7 variants associated with hearing loss and enlargement of the vestibular aqueduct.
Roux I, Fenollar-Ferrer C, Lee HJ, Chattaraj P, Lopez IA, Han K, Honda K, Brewer CC, Butman JA, Morell RJ, Martin DM, Griffith AJ., Free PMC Article | 09/22/2023 |
| Chromatin remodeler Chd7 regulates photoreceptor development and outer segment length. | Chromatin remodeler Chd7 regulates photoreceptor development and outer segment length.
Krueger LA, Bills JD, Lim ZY, Skidmore JM, Martin DM, Morris AC., Free PMC Article | 01/14/2023 |
| Loss of the chromatin remodeler CHD7 impacts glial cells and myelination in the mouse cochlear spiral ganglion. | Loss of the chromatin remodeler CHD7 impacts glial cells and myelination in the mouse cochlear spiral ganglion.
Ritter KE, Lynch SM, Gorris AM, Beyer LA, Kabara L, Dolan DF, Raphael Y, Martin DM., Free PMC Article | 12/10/2022 |
| Characterization of Two Mouse Chd7 Heterozygous Loss-of-Function Models Shows Dysgenesis of the Corpus Callosum and Previously Unreported Features of CHARGE Syndrome. | Characterization of Two Mouse Chd7 Heterozygous Loss-of-Function Models Shows Dysgenesis of the Corpus Callosum and Previously Unreported Features of CHARGE Syndrome.
Collins SC, Vancollie VE, Mikhaleva A, Wagner C, Balz R, Lelliott CJ, Yalcin B., Free PMC Article | 10/22/2022 |
| CHD7 regulates bone-fat balance by suppressing PPAR-gamma signaling. | CHD7 regulates bone-fat balance by suppressing PPAR-γ signaling.
Liu C, Xiong Q, Li Q, Lin W, Jiang S, Zhang D, Wang Y, Duan X, Gong P, Kang N., Free PMC Article | 04/30/2022 |
| CHARGE syndrome-associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms. | CHARGE syndrome-associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms.
Bélanger C, Cardinal T, Leduc E, Viger RS, Pilon N., Free PMC Article | 03/5/2022 |
| The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration. | The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration.
Ahmed M, Moon R, Prajapati RS, James E, Basson MA, Streit A., Free PMC Article | 12/18/2021 |
| CHD7 promotes neural progenitor differentiation in embryonic stem cells via altered chromatin accessibility and nascent gene expression. | CHD7 promotes neural progenitor differentiation in embryonic stem cells via altered chromatin accessibility and nascent gene expression.
Yao H, Hannum DF, Zhai Y, Hill SF, Albanus RD', Lou W, Skidmore JM, Sanchez G, Saiakhova A, Bielas SL, Scacheri P, Ljungman M, Parker SCJ, Martin DM., Free PMC Article | 03/13/2021 |
| CHD7 regulates cardiovascular development through ATP-dependent and -independent activities. | CHD7 regulates cardiovascular development through ATP-dependent and -independent activities.
Yan S, Thienthanasit R, Chen D, Engelen E, Brühl J, Crossman DK, Kesterson R, Wang Q, Bouazoune K, Jiao K., Free PMC Article | 01/16/2021 |
| CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. | CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation.
Hsu J, Huang HT, Lee CT, Choudhuri A, Wilson NK, Abraham BJ, Moignard V, Kucinski I, Yu S, Hyde RK, Tober J, Cai X, Li Y, Guo Y, Yang S, Superdock M, Trompouki E, Calero-Nieto FJ, Ghamari A, Jiang J, Gao P, Gao L, Nguyen V, Robertson AL, Durand EM, Kathrein KL, Aifantis I, Gerber SA, Tong W, Tan K, Cantor AB, Zhou Y, Liu PP, Young RA, Göttgens B, Speck NA, Zon LI., Free PMC Article | 11/21/2020 |
| Study using human SH-SY5Y neuroblastoma and 293T cells and transgenic mouse model show that CHD7 directly regulates expression of retinoic acid synthetic enzyme ALDH1A3. Results indicate that ALDH1A3 acts with CHD7 in a common genetic pathway to regulate inner ear development, providing insights for exploration of the pathogenic mechanisms underlying CHARGE syndrome. | CHD7 represses the retinoic acid synthesis enzyme ALDH1A3 during inner ear development.
Yao H, Hill SF, Skidmore JM, Sperry ED, Swiderski DL, Sanchez GJ, Bartels CF, Raphael Y, Scacheri PC, Iwase S, Martin DM., Free PMC Article | 12/7/2019 |
| Data show that chromodomain helicase DNA-binding protein 7 (Chd7) is required for the maintenance of open chromatin and thus activation of genes essential for granule neuron differentiation. | Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme.
Feng W, Kawauchi D, Körkel-Qu H, Deng H, Serger E, Sieber L, Lieberman JA, Jimeno-González S, Lambo S, Hanna BS, Harim Y, Jansen M, Neuerburg A, Friesen O, Zuckermann M, Rajendran V, Gronych J, Ayrault O, Korshunov A, Jones DT, Kool M, Northcott PA, Lichter P, Cortés-Ledesma F, Pfister SM, Liu HK., Free PMC Article | 12/22/2018 |
| CHD7 and CHD8 bind in Oligodendrocyte precursor cells to a majority of ASD risk-associated genes, suggesting an implication of oligodendrocyte lineage cells in ASD neurological defects. | Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8.
Marie C, Clavairoly A, Frah M, Hmidan H, Yan J, Zhao C, Van Steenwinckel J, Daveau R, Zalc B, Hassan B, Thomas JL, Gressens P, Ravassard P, Moszer I, Martin DM, Lu QR, Parras C., Free PMC Article | 10/6/2018 |
| Findings extend current knowledge of the role of BMI1 and CHD7 in medulloblastoma pathogenesis, and they raise the possibility that pharmacological targeting of BMI1 or ERK may be particularly indicated in a subgroup of MB with low expression levels of CHD7. | Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma.
Badodi S, Dubuc A, Zhang X, Rosser G, Da Cunha Jaeger M, Kameda-Smith MM, Morrissy AS, Guilhamon P, Suetterlin P, Li XN, Guglielmi L, Merve A, Farooq H, Lupien M, Singh SK, Basson MA, Taylor MD, Marino S., Free PMC Article | 07/21/2018 |
| we have identified mild cerebellar hypoplasia and distinct cerebellar foliation anomalies in Chd7 gt/+ mice. Our findings imply a specific function for CHD7 in controlling the spatiotemporal initiation of cerebellar fissures and show that normal fissure formation requires bi-allelic Chd7 expression, consistent with the haploinsuffi- cient nature of CHARGE syndrome. | Distinct cerebellar foliation anomalies in a CHD7 haploinsufficient mouse model of CHARGE syndrome.
Whittaker DE, Kasah S, Donovan APA, Ellegood J, Riegman KLH, Volk HA, McGonnell I, Lerch JP, Basson MA., Free PMC Article | 06/23/2018 |
| Chd7 deficiency delays leukemia initiation induced by Cbfb-MYH11. | Chd7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11.
Zhen T, Kwon EM, Zhao L, Hsu J, Hyde RK, Lu Y, Alemu L, Speck NA, Liu PP., Free PMC Article | 12/23/2017 |
| CHD7 is an important factor in the proliferation and stemness maintenance of neural stem/progenitor cells. | CHD7 promotes proliferation of neural stem cells mediated by MIF.
Ohta S, Yaguchi T, Okuno H, Chneiweiss H, Kawakami Y, Okano H., Free PMC Article | 11/18/2017 |
| Chd7 regulates the proliferation and identity of oligodendrocyte precursor cells after spinal cord injury. | Chd7 Collaborates with Sox2 to Regulate Activation of Oligodendrocyte Precursor Cells after Spinal Cord Injury.
Doi T, Ogata T, Yamauchi J, Sawada Y, Tanaka S, Nagao M., Free PMC Article | 11/11/2017 |
| CHD7 is necessary for maintaining an open, accessible chromatin state at the Reln locus. Taken together, this study shows that Reln gene expression is regulated by chromatin remodeling, identifies CHD7 as a previously unrecognized upstream regulator of Reln, and provides direct in vivo evidence that a mammalian CHD protein can control brain development | The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression.
Whittaker DE, Riegman KL, Kasah S, Mohan C, Yu T, Pijuan-Sala B, Hebaishi H, Caruso A, Marques AC, Michetti C, Smachetti ME, Shah A, Sabbioni M, Kulhanci O, Tee WW, Reinberg D, Scattoni ML, Volk H, McGonnell I, Wardle FC, Fernandes C, Basson MA., Free PMC Article | 09/9/2017 |
| Chd7 coordinates with Sox10 to regulate the initiation of myelinogenesis and acts as a molecular nexus of regulatory networks that account for the development of a seemingly diverse array of lineages, including oligodendrocytes and osteoblasts, pointing to previously uncharacterized Chd7 functions. | Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination.
He D, Marie C, Zhao C, Kim B, Wang J, Deng Y, Clavairoly A, Frah M, Wang H, He X, Hmidan H, Jones BV, Witte D, Zalc B, Zhou X, Choo DI, Martin DM, Parras C, Lu QR., Free PMC Article | 09/2/2017 |
| Chd7 mutant mice are models for determining the molecular etiology of ocular defects in CHARGE syndrome. | Mouse Models for the Dissection of CHD7 Functions in Eye Development and the Molecular Basis for Ocular Defects in CHARGE Syndrome.
Gage PJ, Hurd EA, Martin DM., Free PMC Article | 05/19/2016 |
| This work reveals the importance of CHD7 in the cardiogenic mesoderm for multiple processes during cardiovascular development. | A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development.
Payne S, Burney MJ, McCue K, Popal N, Davidson SM, Anderson RH, Scambler PJ., Free PMC Article | 10/31/2015 |
| Findings directly link CHD7 to pathways involved in NSC quiescence and identify the first chromatin-remodeling factor with a role in NSC quiescence and maintenance. | CHD7 maintains neural stem cell quiescence and prevents premature stem cell depletion in the adult hippocampus.
Jones KM, Sarić N, Russell JP, Andoniadou CL, Scambler PJ, Basson MA., Free PMC Article | 09/26/2015 |
| Conditional deletion of Chd7 in ectodermal and endodermal derivatives or migrating neural crest cells results in varied and severe craniofacial defects. | The chromatin remodeling protein CHD7, mutated in CHARGE syndrome, is necessary for proper craniofacial and tracheal development.
Sperry ED, Hurd EA, Durham MA, Reamer EN, Stein AB, Martin DM., Free PMC Article | 05/16/2015 |
| CHD7 gene mutation is associated with CHARGE syndrome. | CHD7, the gene mutated in CHARGE syndrome, regulates genes involved in neural crest cell guidance.
Schulz Y, Wehner P, Opitz L, Salinas-Riester G, Bongers EM, van Ravenswaaij-Arts CM, Wincent J, Schoumans J, Kohlhase J, Borchers A, Pauli S. | 09/6/2014 |